Medicine and Health Sciences Commons^™

The Role Of Objectively Measured, Altered Physical Activity Patterns For Body Mass Index Change During Inpatient Treatment In Female Patients With Anorexia Nervosa, C. S. Lehmann, T. Hofmann, U. Elbelt, M. Rose, C. U. Correll, A. Stengel, V. Haas

Journal Articles

No abstract provided.

Cerebello-Thalamo-Cortical Hyperconnectivity As A State-Independent Functional Neural Signature For Psychosis Prediction And Characterization, H. Cao, O. Y. Chen, Y. Chung, J. K. Forsyth, S. C. Mcewen, D. G. Gee, C. E. Bearden, B. A. Cornblatt, R. E. Carrion, T. D. Cannon, +16 Additional Authors

Journal Articles

No abstract provided.

Successful Switching Of Patients With Acute Schizophrenia From Another Antipsychotic To Brexpiprazole: Comparison Of Clinicians' Choice Of Cross-Titration Schedules In A Post Hoc Analysis Of A Randomized, Double-Blind, Maintenance Treatment Study, C. U. Correll, L. Shi, C. Weiss, M. Hobart, A. Eramo, R. A. Duffy, E. Weiller, R. A. Baker

Journal Articles

© Cambridge University Press 2018. Objective To compare the tolerability and efficacy of different antipsychotic cross-titration schedules, using data from a brexpiprazole study (Equator; NCT01668797).MethodsPatients with schizophrenia were cross-titrated from other antipsychotics to brexpiprazole monotherapy in a 1-4 week open-label conversion phase, then entered a single-blind brexpiprazole treatment phase. Patients were stratified into four "conversion groups," according to the amount of time spent in the conversion phase. Discontinuation rates, treatment-emergent adverse events (TEAEs), and efficacy (Positive and Negative Syndrome Scale [PANSS]) were compared between conversion groups.ResultsOf the 404 patients treated with brexpiprazole, the majority (72.0%) spent 22-33 days in the …

Automated Real-Time Collection Of Pathogen-Specific Diagnostic Data: Syndromic Infectious Disease Epidemiology, L. Meyers, C. C. Ginocchio, A. N. Faucett, F. S. Nolte, P. H. Gesteland, A. Leber, D. Janowiak, V. Donovan, S. Juretschko, M. A. Poritz, +23 Additional Authors

Journal Articles

© Lindsay Meyers, Christine C Ginocchio, Aimie N Faucett, Frederick S Nolte, Per H Gesteland, Amy Leber, Diane Janowiak,. Background: Health care and public health professionals rely on accurate, real-time monitoring of infectious diseases for outbreak preparedness and response. Early detection of outbreaks is improved by systems that are comprehensive and specific with respect to the pathogen but are rapid in reporting the data. It has proven difficult to implement these requirements on a large scale while maintaining patient privacy. Objective: The aim of this study was to demonstrate the automated export, aggregation, and analysis of infectious disease diagnostic test …

Predicting The Incidence And Timing Of Central Nervous System Disease In Metastatic Melanoma: Implications For Surveillance And Preventative Therapy, G. B. Deutsch, R. Tyrell, S. Yost, M. B. Deutsch, G. Barkhoudarian, D. F. Kelly, M. B. Faries

Journal Articles

No abstract provided.

Obesity In The Workplace: Impact, Outcomes, And Recommendations, C. M. Yarborough, S. Brethauer, W. N. Burton, R. J. Fabius, P. Hymel, S. Kothari, R. F. Kushner, J. M. Morton, M. S. Roslin, J. Ording, +8 Additional Authors

Journal Articles

Copyright © 2017 American College of Occupational and Environmental Medicine. Objective: To conduct a comprehensive literature review to develop recommendations for managing obesity among workers to improve health outcomes and to explore the impact of obesity on health costs to determine whether a case can be made for surgical interventions and insurance coverage. Methods: We searched PubMed from 2011 to 2016, and CINAHL, Scopus, and Cochrane Registry of Clinical Trials for interventions addressing obesity in the workplace. Results: A total of 1419 articles were screened, resulting in 275 articles being included. Several areas were identified that require more research and …

Combining Autologous Breast Reconstruction And Vascularized Lymph Node Transfer, E. I. Chang, J. Masià, M. L. Smith

Journal Articles

© 2018 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Breast cancer patients are at risk for developing postmastectomy lymphedema syndrome of the ipsilateral upper extremity following treatment for breast cancer in the setting of an axillary dissection, postoperative radiation, and chemotherapy. For patients suffering from lymphedema who are also seeking breast reconstruction, combining an autologous abdominal free flap with a vascularized inguinal lymph node transfer provides patients the opportunity to have an aesthetic breast reconstruction as well as the potential to improve their lymphedema in a single operation. The present article aims to provide …

Pdz-Rhogef Is A Signaling Effector For Troy-Induced Glioblastoma Cell Invasion And Survival, Z. Ding, H. Dhruv, A. Kwiatkowska-Piwowarczyk, R. Ruggieri, J. Kloss, M. Symons, P. Pirrotte, J. M. Eschbacher, N. L. Tran, J. C. Loftus

Journal Articles

© 2018 The Authors Glioblastoma multiforme (GBM) is the most common type of malignant brain tumors in adults and has a dismal prognosis. The highly aggressive invasion of malignant cells into the normal brain parenchyma renders complete surgical resection of GBM tumors impossible, increases resistance to therapeutic treatment, and leads to near-universal tumor recurrence. We have previously demonstrated that TROY (TNFRSF19) plays an important role in glioblastoma cell invasion and therapeutic resistance. However, the potential downstream effectors of TROY signaling have not been fully characterized. Here, we identified PDZ-RhoGEF as a binding partner for TROY that potentiated TROY-induced nuclear factor …

Restricted Single Isocenter For Multiple Targets Dynamic Conformal Arc (Rsimt Dca) Technique For Brain Stereotactic Radiosurgery (Srs) Planning., J. Chang, A. G. Wernicke, S. C. Pano

Journal Articles

In stereotactic radiosurgery (SRS), the multiple isocenters for multiple targets dynamic conformal arc (MIMT DCA) technique is traditionally used to treat multiple brain metastases, with one isocenter for each target. The single isocenter for multiple targets (SIMT) technique has recently been adopted to reduce the treatment time at the cost of plan quality. The objective of this study was to develop a restricted single isocenter for multiple targets DCA (RSIMT DCA) technique that can significantly reduce the treatment time but still maintain similar plan quality as the MIMT DCA technique.Treating multiple brain metastases with a single isocenter poses a challenge …

Sts/Sca/Amsect Clinical Practice Guidelines: Anticoagulation During Cardiopulmonary Bypass, L. Shore-Lesserson, R. A. Baker, V. Ferraris, P. E. Greilich, D. Fitzgerald, P. Roman, J. Hammon

Journal Articles

© 2018 American Society of Extra-Corporeal Technology. All Rights Reserved. Despite more than a half century of "safe" cardio-pulmonary bypass (CPB), the evidence base surrounding the conduct of anticoagulation for CPB has not been organized into a succinct guideline. For this and other reasons, there is enormous practice variability relating to the use and dosing of heparin, monitoring heparin anticoagulation, reversal of anticoagulation, and the use of alternative anticoagulants. To address this and other gaps, the Society of Thoracic Surgeons (STS), the Society of Cardiovascular Anesthesiologists (SCA), and the American Society of Extracorporeal Technology (AmSECT) developed an Evidence Based Workgroup. …

Association Of Coronary Vessel Characteristics With Outcome In Patients With Percutaneous Coronary Interventions With Incomplete Revascularization, E. L. Hannan, Y. Zhong, P. B. Berger, A. K. Jacobs, G. Walford, F. S. K. Ling, F. J. Venditti, S. B. King

Journal Articles

© 2017 American Medical Association. All rights reserved. IMPORTANCE Many studies have compared outcomes for incomplete revascularization (IR) among patients undergoing percutaneous coronary interventions (PCI), but little is known about whether outcomes are related to the nature of the IR. OBJECTIVE To determine whether some coronary vessel characteristics are associated with worse outcomes in patients with PCI with IR. DESIGN, SETTING, AND PARTICIPANTS New York's PCI registrywas used to examine mortality (median follow-up, 3.4 years) as a function of the number of vessels that were incompletely revascularized, the stenosis in those vessels, and whether the proximal left anterior descending artery …

Confronting System Barriers For St- Elevation Mi In Low And Middle Income Countries With A Focus On India, S. Mehta, C. Granger, C. L. Grines, A. Jacobs, T. D. Henry, I. Rokos, A. Lansky, A. Baumbach, R. Botelho, S. Hiremath, +8 Additional Authors

Journal Articles

© 2017 Our previous research found seven specific factors that cause system delays in ST-elevation Myocardial infarction management in developing countries. These delays, in conjunction with a lack of organized STEMI systems of care, result in inefficient processes to treat AMI in developing countries. In our present opinion paper, we have specifically explored the three most pertinent causes that afflict the seven specific factors responsible for system delays. In doing so, we incorporated a unique strategy of global STEMI expertise. With this methodology, the recommendations were provided by expert Indian cardiologist and final guidelines were drafted after comprehensive discussions by …

Is Transcatheter Aortic Valve Replacement Better Than Surgical Aortic Valve Replacement In Patients With Chronic Obstructive Pulmonary Disease? A Nationwide Inpatient Sample Analysis, T. Ando, O. Adegbala, E. Akintoye, S. Ashraf, M. Pahuja, A. Briasoulis, H. Takagi, C. L. Grines, L. Afonso, T. Schreiber

Journal Articles

No abstract provided.

A Core Domain Set For Hidradenitis Suppurativa Trial Outcomes: An International Delphi Process, L. Thorlacius, J. R. Ingram, B. Villumsen, S. Esmann, J. S. Kirby, A. B. Gottlieb, J. F. Merola, R. Dellavalle, A. Garg, G. B. E. Jemec, +2 Additional Authors

Journal Articles

No abstract provided.

Extremely Preterm (23 Weeks) Vaginal Cephalic Delivery En Caul And Subsequent Postpartum Intraventricular Hemorrhage And Respiratory Distress: A Teaching Case., R. Malik, A. Sarfraz, R. Faroqui, W. Onyebeke, J. Wanerman

Journal Articles

En caul deliveries are defined as a fetus that is delivered completely contained within an amniotic sac and are considered to be less common than 1 in 80,000 live births. Vaginal en caul births compared to abdominal or cesarean are the rarest subtype. Most en caul births are associated with prematurity and low gravida. The combination of prematurity, high gravida, vaginal en caul birth, and severe postpartum complications has not previously been described. We report a woman with gravida of 12 delivering vaginally a neonate female en caul at the extremely preterm gestational age of 23 weeks. The neonate subsequently …

Retinal Vasproliferative Tumor In A Case Of X-Linked Retinoschisis Detachment, N. A. Patel, D. Laura, K. D. Tran, S. Chang, G. Barile, A. M. Berrocal

Journal Articles

© 2018 Purpose: To describe the first published case of X-linked retinoschisis (XLRS) detachment with retinal vasoproliferative tumor (RVPT) and provide a literature review of the subject. Observations: The authors describe a case of a 17 year old male with X-linked retinoschisis who presented with a retinal detachment and a retinal vasoproliferative tumor. The patient was treated with pars plana vitrectomy, endolaser, subtenon's kenalog and anti-VEGF (vascular endothelial growth factor) intravitreal injections. He regained 20/60 vision with a flat macula and had significant resolution of the associated vasoproliferative leakage seen on fluorescein angiography. Conclusions and importance: This case adds XLRS …

Anti-Integrin Therapy For Inflammatory Bowel Disease, S. C. Park, Y. T. Jeen

Journal Articles

© The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. In inflammatory bowel disease (IBD), tumor necrosis factor plays an important role in mediating inflammation, but several other pathways are also involved in eliciting an inflammatory response. One such pathway is the invasion of the intestinal mucosa by leukocytes. Leukocytes within the systemic circulation move to sites of inflammation, and blocking this pathway could be an important treatment strategy for IBD. Antiintegrin therapy blocks the action of integrin on the surface of circulating immune cells and endothelial cell adhesion molecules, thereby inhibiting the interactions between leukocytes and …

A Clinical Approach To New-Onset Psychosis Associated With Immune Dysregulation: The Concept Of Autoimmune Psychosis, S. Najjar, J. Steiner, A. Najjar, K. Bechter

Journal Articles

No abstract provided.

Presurgical Language Fmri: Clinical Practices And Patient Outcomes In Epilepsy Surgical Planning, C. F. Benjamin, A. X. Li, H. Blumenfeld, R. T. Constable, R. Alkawadri, S. Bickel, Z. Z. Helmstaedter, S. Meletti, R. Bronen, L. J. Hirsch, +5 Additional Authors

Journal Articles

© 2018 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc. The goal of this study was to document current clinical practice and report patient outcomes in presurgical language functional MRI (fMRI) for epilepsy surgery. Epilepsy surgical programs worldwide were surveyed as to the utility, implementation, and efficacy of language fMRI in the clinic; 82 programs responded. Respondents were predominantly US (61%) academic programs (85%), and evaluated adults (44%), adults and children (40%), or children only (16%). Nearly all (96%) reported using language fMRI. Surprisingly, fMRI is used to guide surgical margins (44% of programs) as well as lateralize …

Intracranial Electrophysiology Reveals Reproducible Intrinsic Functional Connectivity Within Human Brain Networks, A. Kucyi, J. Schrouff, S. Bickel, B. L. Foster, J. M. Shine, J. Parvizi

Journal Articles

© 2018 the authors. Evidence for intrinsic functional connectivity (FC) within the human brain is largely from neuroimaging studies of hemodynamic activity. Data are lacking from anatomically precise electrophysiological recordings in the most widely studied nodes of human brain networks. Here we used a combination of fMRI and electrocorticography (ECoG) in five human neurosurgical patients with electrodes in the canonical “default” (medial prefrontal and posteromedial cortex), “dorsal attention” (frontal eye fields and superior parietal lobule), and “frontoparietal control” (inferior parietal lobule and dorsolateral prefrontal cortex) networks. In this unique cohort, simultaneous intracranial recordings within these networks were anatomically matched across …

100% Response Rate To Galcanezumab In Patients With Episodic Migraine: A Post Hoc Analysis Of The Results From Phase 3, Randomized, Double-Blind, Placebo-Controlled Evolve-1 And Evolve-2 Studies., N. Rosen, E. Pearlman, D. Ruff, K. Day, A. Jim Nagy

Journal Articles

OBJECTIVE:To characterize adult patients with episodic migraine who achieved 100% response to galcanezumab treatment. BACKGROUND:Galcanezumab is a humanized monoclonal antibody that selectively binds to the calcitonin gene-related peptide (CGRP) and has demonstrated efficacy in reducing migraine headache days (MHD) in patients with episodic and chronic migraine. METHODS:A post hoc analysis of the proportion of patients with 100% response (100% reduction from baseline in monthly MHD) was calculated for each month from pooled data of 2 double-blind, 6-month galcanezumab studies in patients with episodic migraine (4 to 14 MHD and ≥2 migraine attacks per month at baseline). The patients were randomized …

Incorporation Of An Interprofessional Palliative Care-Ethics Experience Into A Required Critical Care Acting Internship., G. R. Goldberg, J. Weiner, A. Fornari, R. E. B. Pearlman, G. A. Farina

Journal Articles

Introduction: The literature documents inadequate palliative medicine training in undergraduate and graduate medical education. As the population lives longer, many people will experience multiple chronic illnesses and the associated symptom burden. All physicians involved in clinical care of patients need to be equipped with the knowledge, attitudes, and skills necessary to provide palliative care, yet most physicians do not feel adequately prepared. We designed a curriculum to provide a meaningful palliative care-ethics (PCE) clinical experience to prepare senior medical students for future practice regardless of specialty choice.

Methods: The Zucker School of Medicine at Hofstra/Northwell integrated a PCE experience into …

Development Of Normal And Cleft Palate: A Central Role For Connective Tissue Growth Factor (Ctgf)/Ccn2, J. T. Tarr, A. G. Lambi, J. P. Bradley, M. F. Barbe, S. N. Popoff

Journal Articles

© 2018 by the authors. Development of the palate is the result of an organized series of events that require exquisite spatial and temporal regulation at the cellular level. There are a myriad of growth factors, receptors and signaling pathways that have been shown to play an important role in growth, elevation and/or fusion of the palatal shelves. Altered expression or activation of a number of these factors, receptors and signaling pathways have been shown to cause cleft palate in humans or mice with varying degrees of penetrance. This review will focus on connective tissue growth factor (CTGF) or CCN2, …

Improving Oratory Skills: An "American Idol" Presentation Competition For Residents., D. A. Hill, J. Jimenez, M. R. Price, S. M. Cohn

Journal Articles

Background It is essential for physicians to master the ability to deliver high-quality oral presentations. Despite this, little time is dedicated throughout residency for training and refining this important skill. In order to solve this issue, we set out to design and implement a course which will improve the oratory skills of the resident physicians. Methods Senior surgical residents (postgraduate years three and four) were involved in a single-elimination tournament with the audience voting for the top presenters. Faculty provided feedback on oration, slide layout and overall presentation format throughout the course. Baseline and post-course survey responses were evaluated to …

Natural History Of Isolated Skull Fractures In Children., S. Hassan, A. Q. Alarhayema, S. M. Cohn, J. C. Wiersch, M. R. Price

Journal Articles

Head injury is the most common cause of neurologic disability and mortality in children. We had hypothesized that in children with isolated skull fractures (SFs) and a normal neurological examination on presentation, the risk of neurosurgical intervention is very low. We retrospectively reviewed the medical records of all children aged six to sixteen years presenting to our Level 1 trauma center with traumatic brain injuries between January 1, 2006 and December 31, 2014. We also analyzed the National Trauma Data Bank (NTDB) research data set for the years 2012-2014 using the same metrics. During this study period, our center admitted …

Young Adult Female Cancer Survivors' Concerns About Future Children's Health And Genetic Risk, N. J. Raghunathan, C. Benedict, B. Thom, D. N. Friedman, J. F. Kelvin

Journal Articles

No abstract provided.

Discovery And Functional Implications Of A Mir-29b-1/Mir-29a Cluster Polymorphism In Acute Myeloid Leukemia, A. Ngankeu, P. Ranganathan, V. Havelange, D. Nicolet, S. Volinia, B. L. Powell, J. E. Kolitz, G. L. Uy, R. M. Stone, R. Garzon, +4 Additional Authors

Journal Articles

© Ngankeu et al. We previously reported that microRNA (miR)-29b is down-regulated and has a tumor suppressor role in acute myeloid leukemia (AML). However, little is known about the mechanisms responsible for miR-29b expression downregulation in AML. In this work we screened for mutations that could affect miR-29b expression. Using Sanger sequencing, we identified a germline thymidine (T) base deletion within the miR-29b-1/miR-29a cluster precursor in 16% of AML patients. Remarkably we found a significant enrichment for the presence of the miR-29 polymorphism in core binding factor (CBF) newly diagnosed AML patients (n = 61/303; 20%) with respect to age, …

The Relationship Of Physical Performance And Osteoporosis Prevention With Vitamin D In Older African Americans (Poda), R. Dhaliwal, M. Mikhail, G. Usera, A. Stolberg, S. Islam, L. Ragolia, J. F. Aloia

Journal Articles

© 2017 Elsevier Inc. Rationale Vitamin D deficiency is associated with bone loss, poor muscle strength, falls and fracture. This information in older African Americans (AAs) is sparse. Objective The study of the relationship of Physical performance, Osteoporosis prevention with vitamin D in older African Americans (PODA) is a randomized, double-blind, placebo-controlled 3-year trial examining the effect of vitamin D on bone loss and physical performance in older AA women. Methods 260 healthy AA women aged > 60 years were assigned to receive placebo or vitamin D3. Initial vitamin D3dose was determined by the baseline serum 25OHD level, and adjusted further …

Strongyloides Stercoralis−Associated Tip Variant Focal Segmental Glomerulosclerosis, M. Merzkani, N. N. Uppal, D. W. Ross, P. Gautam-Goyal, P. Malhotra, H. H. Shah, K. D. Jhaveri, V. D. D'Agati

Journal Articles

No abstract provided.

Aerobic Physical Exercise Increases The Health-Related Quality Of Life In Older Adults, Patricia L. Parker

Doctor of Nursing Practice Projects

Abstract

Problem Description: Globally, the older adult population is expected to substantially increase in number throughout the next few decades. The aging process causes the body and mind to undergo many detrimental changes. Typically, older adults succumb to a more sedentary lifestyle due to factors such as decreased musculature and skeletal changes, chronic pain, socioeconomic and psychological stressors, and memory changes. Inevitably, health-related quality of life and overall independence dwindles in this population negating their perception of happiness and life satisfaction. There is significant research on preventing and/or managing cognitive disabilities in the older adult; however, Western medicine approaches, such …