Medicine and Health Sciences Commons^™

Correction To: Minimum Quality Threshold In Pre-Clinical Sepsis Studies (Mqtipss): An International Expert Consensus Initiative For Improvement Of Animal Modeling In Sepsis (Infection, (2018), 10.1007/S15010-018-1183-8), M. F. Osuchowski, A. Ayala, S. Bahrami, M. Bauer, M. Boros, J. M. Cavaillon, I. H. Chaudry, C. Deutschman, P. Wang, B. Zingarelli, +21 Additional Authors

Journal Articles

© 2018, The Author(s). The original version of this article unfortunately contained mistakes.

Translational Research: The Model Matters, C. S. Deutschman

Journal Articles

No abstract provided.

An Eqtl Landscape Of Kidney Tissue In Human Nephrotic Syndrome, C. E. Gillies, R. Putler, R. Menon, E. Otto, K. Yasutake, V. Nair, P. Hoover, D. Lieb, C. Sethna, K. Abbott, +89 Additional Authors

Journal Articles

© 2018 American Society of Human Genetics Expression quantitative trait loci (eQTL) studies illuminate the genetics of gene expression and, in disease research, can be particularly illuminating when using the tissues directly impacted by the condition. In nephrology, there is a paucity of eQTL studies of human kidney. Here, we used whole-genome sequencing (WGS) and microdissected glomerular (GLOM) and tubulointerstitial (TI) transcriptomes from 187 individuals with nephrotic syndrome (NS) to describe the eQTL landscape in these functionally distinct kidney structures. Using MatrixEQTL, we performed cis-eQTL analysis on GLOM (n = 136) and TI (n = 166). We used the Bayesian …

Pilot Study Comparing The Childhood Arthritis And Rheumatology Research Alliance Consensus Treatment Plans For Induction Therapy Of Juvenile Proliferative Lupus Nephritis, J. C. Cooper, K. Rouster-Stevens, T. B. Wright, J. J. Hsu, M. S. Klein-Gitelman, S. P. Ardoin, L. E. Schanberg, H. I. Brunner, B. A. Eberhard, E. Von Scheven, +6 Additional Authors

Journal Articles

BACKGROUND: To reduce treatment variability and facilitate comparative effectiveness studies, the Childhood Arthritis and Rheumatology Research Alliance (CARRA) published consensus treatment plans (CTPs) including one for juvenile proliferative lupus nephritis (LN). Induction immunosuppression CTPs outline treatment with either monthly intravenous (IV) cyclophosphamide (CYC) or mycophenolate mofetil (MMF) in conjunction with one of three corticosteroid (steroid) CTPs: primarily oral, primarily IV or mixed oral/IV. The acceptability and in-practice use of these CTPs are unknown. Therefore, the primary aims of the pilot study were to demonstrate feasibility of adhering to the LN CTPs and delineate barriers to implementation in clinical care in …

Age Restriction Warning Label Efficacy And High School Student Consumption Of Highly-Caffeinated Products., J. Goldman, M. Zhu, T. B. Pham, R. Milanaik

Journal Articles

Age restriction warning labels (ARLs) are placed on highly-caffeinated food and drinks, such as Red Bull, to deter consumption by minors who are especially vulnerable to the risks of excessive caffeine consumption. Previous studies have shown that ARLs on media like TV programs and video games fail to discourage minors. However, it is unclear how ARLs on food and drink packages affect minors' purchasing behavior. High school students aged 14 to 17 years (n = 150, M

Realizing Effectiveness Across Continents With Hydroxyurea: Enrollment And Baseline Characteristics Of The Multicenter Reach Study In Sub-Saharan Africa., P. T. Mcgann, T. N. Williams, P. Olupot-Olupot, G. A. Tomlinson, A. Lane, J. Luís Reis Da Fonseca, R. Kitenge, G. Mochamah, B. Aygun, R. E. Ware, +7 Additional Authors

Journal Articles

Despite its well-described safety and efficacy in the treatment of sickle cell anemia (SCA) in high-income settings, hydroxyurea remains largely unavailable in sub-Saharan Africa, where more than 75% of annual SCA births occur and many comorbidities exist. Realizing Effectiveness Across Continents with Hydroxyurea (REACH, ClinicalTrials.gov NCT01966731) is a prospective, Phase I/II open-label trial of hydroxyurea designed to evaluate the feasibility, safety, and benefits of hydroxyurea treatment for children with SCA in four sub-Saharan African countries. Following comprehensive training of local research teams, REACH was approved by local Ethics Committees and achieved full enrollment ahead of projections with 635 participants enrolled …

Assessment Of A Renal Angina Index For Prediction Of Severe Acute Kidney Injury In Critically Ill Children: A Multicentre, Multinational, Prospective Observational Study., R. K. Basu, A. Kaddourah, S. L. Goldstein, A. Akcan-Arikan, M. Arnold, C. Cruz, J. Schneider, T. Sweberg, A. Kessel, J. Zaritsky, +73 Additional Authors

Journal Articles

Background: Acute kidney injury (AKI) occurs in one in four children admitted to the intensive care unit (ICU) and AKI severity is independently associated with increased patient morbidity and mortality. Early prediction of AKI has the potential to improve outcomes. In smaller, single center populations, we have previously derived and validated the performance of the renal angina index (RAI), a context driven risk stratification system, to predict severe AKI.

Methods: A prospective, observational study (AWARE

Findings: The 1590 patients studied were 55% male and had median age of 54.5 months. 286 patients (17.9%) were RA+. AKI

Interpretation: Earlier, better prediction …

Congenital Adrenal Hyperplasia Due To Steroid 21-Hydroxylase Deficiency: An Endocrine Society Clinical Practice Guideline, P. W. Speiser, W. Arlt, R. J. Auchus, L. S. Baskin, G. S. Conway, D. P. Merke, H. F. Meyer-Bahlburg, W. L. Miller, M. H. Murad, S. E. Oberfield, P. C. White

Journal Articles

Objective: To update the congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency clinical practice guideline published by the Endocrine Society in 2010.Conclusions: The writing committee presents updated best practice guidelines for the clinical management of congenital adrenal hyperplasia based on published evidence and expert opinion with added considerations for patient safety, quality of life, cost, and utilization.

Arthroscopic Wrist Debridement And Radial Styloidectomy For Advanced Scapholunate Advanced Collapse Wrist: Long-Term Follow-Up, P. C. Noback, M. Seetharaman, J. R. Danoff, M. Birman, M. P. Rosenwasser

Journal Articles

© The Author(s) 2017. Background: Symptomatic stage 2 or 3 scapholunate advanced collapse (SLAC) wrist is aggressively treated with salvage procedures, such as proximal row carpectomy or partial wrist fusion with resultant pain relief but limited motion. We hypothesize that arthroscopic synovectomy, radial styloidectomy, and neurectomy will preserve wrist motion, relieve pain, and delay or avoid salvage procedures. Methods: We evaluated outcomes in 13 wrists through questionnaires and 11 of these through additional physical examination at a mean follow-up of 5.0 years. Eight wrists were stage 2 and 5 were stage 3. Data at final follow-up included mobility/strength measurements, subjective …

Declining Medicaid Fees And Primary Care Appointment Availability For New Medicaid Patients, M. Candon, S. Zuckerman, D. Wissoker, B. Saloner, G. M. Kenney, K. Rhodes, D. Polsky

Journal Articles

No abstract provided.

Erratum: Specificity Of Incident Diagnostic Outcomes In Patients At Clinical High Risk For Psychosis (Schizophrenia Bulletin (2015) 41 (1066-1075) Doi: 10.1093/Schbul/Sbv091), J. R. Webb, J. Addington, D. O. Perkins, C. E. Bearden, K. S. Cadenhead, T. D. Cannon, B. A. Cornblatt, R. K. Heinssen, L. J. Seidman, S. W. Woods, +4 Additional Authors

Journal Articles

© The Author(s) 2018. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. An error in statistical syntax defining baseline disorder led to misidentification of baseline anxiety disorder in five cases in one of the two reported samples (PREDICT). NAPLS-1 data and previous publications of PREDICT data were not affected. The error affected rows in Table 1 labeled 'DSM-IV anxiety' and 'Any mood/anx disorder' and rows in Table 3 labeled 'Baseline Anxiety Excluded' and 'Any Baseline Mood/ Anxiety Excluded.' Corrected Tables are shown below with corrected numbers in bold. Tables S1-S5 in the …

Management Of Acute Pancreatitis In The Pediatric Population: A Clinical Report From The North American Society For Pediatric Gastroenterology, Hepatology And Nutrition Pancreas Committee., M. Abu-El-Haija, S. Kumar, J. A. Quiros, K. Balakrishnan, B. Barth, S. Bitton, J. F. Eisses, E. J. Foglio, V. Fox, V. D. Morinville, +10 Additional Authors

Journal Articles

BACKGROUND:Although the incidence of acute pancreatitis (AP) in children is increasing, management recommendations rely on adult published guidelines. Pediatric-specific recommendations are needed. METHODS:The North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Pancreas committee performed a MEDLINE review using several preselected key terms relating to management considerations in adult and pediatric AP. The literature was summarized, quality of evidence reviewed, and statements of recommendations developed. The authorship met to discuss the evidence, statements, and voted on recommendations. A consensus of at least 75% was required to approve a recommendation. RESULTS:The diagnosis of pediatric AP should follow the published INternational Study …

Metabolic Obesity Phenotypes And Risk Of Colorectal Cancer In Postmenopausal Women., G. C. Kabat, M. Y. Kim, M. Stefanick, G. Y. F. Ho, D. S. Lane, A. O. Odegaard, M. S. Simon, J. W. Bea, J. Luo, T. E. Wassertheil-Smoller

Journal Articles

Obesity has been postulated to increase the risk of colorectal cancer by mechanisms involving insulin resistance and the metabolic syndrome. We examined the associations of body mass index (BMI), waist circumference, the metabolic syndrome, metabolic obesity phenotypes and homeostasis model-insulin resistance (HOMA-IR-a marker of insulin resistance) with risk of colorectal cancer in over 21,000 women in the Women's Health Initiative CVD Biomarkers subcohort. Women were cross-classified by BMI (18.5-

Joint Representation Of Spatial And Phonetic Features In The Human Core Auditory Cortex, P. Patel, L. K. Long, J. L. Herrero, A. D. Mehta, N. Mesgarani

Journal Articles

No abstract provided.

The Influence Of Insurance Type On Stage At Presentation, Treatment, And Survival Between Asian American And Non-Hispanic White Lung Cancer Patients, A. Tantraworasin, E. Taioli, B. Liu, R. M. Flores, A. J. Kaufman

Journal Articles

© 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. The effect of insurance type on lung cancer diagnosis, treatment, and survival in Asian patients living in the United States is still under debate. We have analyzed this issue using the Surveillance, Epidemiology, and End Results database. There were 102,733 lung cancer patients age 18–64 years diagnosed between 2007 and 2013. Multilevel regression analysis was performed to identify the association between insurance types, stage at diagnosis, treatment modalities, and overall mortality in Asian and non-Hispanic White (NHW) patients. Clinical characteristics were significantly different between Asian and NHW …

Liver Cancer Disparities In New York City: A Neighborhood View Of Risk And Harm Reduction Factors, G. R. Kamath, E. Taioli, N. N. Egorova, J. M. Llovet, P. V. Perumalswami, J. J. Weiss, M. Schwartz, S. Ewala, N. A. Bickell

Journal Articles

© 2018 Kamath, Taioli, Egorova, Llovet, Perumalswami, Weiss, Schwartz, Ewala and Bickell. Introduction: Liver cancer is the fastest increasing cancer in the United States and is one of the leading causes of cancer-related death in New York City (NYC), with wide disparities among neighborhoods. The purpose of this cross-sectional study was to describe liver cancer incidence by neighborhood and examine its association with risk factors. This information can inform preventive and treatment interventions. Materials and methods: Publicly available data were collected on adult NYC residents (n = 6,407,022). Age-adjusted data on liver and intrahepatic bile duct cancer came from the …

Prevalence, Comorbidity, And Correlates Of Psychiatric And Substance Use Disorders And Associations With Hiv Risk Behaviors In A Multisite Cohort Of Women Living With Hiv, J. A. Cook, J. K. Burke-Miller, P. J. Steigman, R. M. Schwartz, N. A. Hessol, J. Milam, D. J. Merenstein, K. Anastos, E. T. Golub, M. H. Cohen

Journal Articles

© 2018, The Author(s). We used the World Health Organization’s Composite International Diagnostic Interview to determine the prevalence, comorbidity, and correlates of lifetime and 12-month behavioral health disorders in a multisite cohort of 1027 women living with HIV in the United States. Most (82.6%) had one or more lifetime disorders including 34.2% with mood disorders, 61.6% with anxiety disorders, and 58.3% with substance use disorders. Over half (53.9%) had at least one 12-month disorder, including 22.1% with mood disorders, 45.4% with anxiety disorders, and 11.1% with substance use disorders. Behavioral health disorder onset preceded HIV diagnosis by an average of …

Controversies On Lung Cancers Manifesting As Part-Solid Nodules., R. Yip, K. Li, L. Liu, D. Xu, K. Tam, D. F. Yankelevitz, E. Taioli, B. Becker, C. I. Henschke

Journal Articles

PURPOSE: Summarise survival of patients with resected lung cancers manifesting as part-solid nodules (PSNs).

METHODS: PubMed/MEDLINE and EMBASE databases were searched for all studies/clinical trials on CT-detected lung cancer in English before 21 December 2015 to identify surgically resected lung cancers manifesting as PSNs. Outcome measures were lung cancer-specific survival (LCS), overall survival (OS), or disease-free survival (DFS). All PSNs were classified by the percentage of solid component to the entire nodule diameter into category PSNs

RESULTS: Twenty studies reported on PSNs

CONCLUSION: A clear definition of the upper limit of solid component of a PSN is needed to avoid …

Gender Differences In Pain Experience And Treatment After Motor Vehicle Collisions: A Secondary Analysis Of The Crash Injury Study, T. E. Madsen, S. Mclean, W. Zhai, S. Linnstaedt, M. C. Kurz, R. Swor, P. Hendry, D. Peak, D. Lee, F. Beaudoin, +4 Additional Authors

Journal Articles

No abstract provided.

Implementation Of An Emergency Medicine Research Associates Program: Sharing 20 Years Of Experience, B. Abar, V. Derienzo, J. Glick, N. Wood, M. N. Shah, S. Schneider, D. Adler

Journal Articles

© 2018 Abar et al. Introduction: The use of research associates (RA) programs to facilitate study enrollment in the emergency department was initiated during the mid-1990s. The University of Rochester Medical Center (URMC) was an early adopting site for this model, which has experienced considerable growth and development over the past 20 years. Methods: Our goal was to detail the Emergency Department Research Associates (EDRA) program processes developed at the URMC that has led to our program’s sustainability and productivity. These processes, and the lessons learned during their development, can assist institutions seeking to establish an RA program or refine …

Correction To: The Toxicology Investigators Consortium Case Registry—The 2017 Annual Report., L. A. Farrugia, S. H. Rhyee, S. L. Campleman, B. Judge, L. Kao, A. Pizon, L. Porter, A. M. Riederer, N. Majlesi, A. Zosel, +89 Additional Authors

Journal Articles

No abstract provided.

Epidemiology Of Injuries In Tennis Players, M. C. Fu, T. S. Ellenbecker, P. A. Renstrom, G. S. Windler, D. M. Dines

Journal Articles

© 2018, Springer Science+Business Media, LLC, part of Springer Nature. Purpose of review: To review the recent literature regarding the epidemiology of tennis injuries at all levels of play, and to discuss recent findings in injury surveillance by the Association of Tennis Professionals (ATP). Recent findings: Following the release of a consensus statement in 2009 calling for standardized documentation and analysis of tennis-related injuries, multiple studies have been published describing longitudinal injury incidences at Grand Slam tournaments and the Davis Cup. Recent efforts by the ATP have further elucidated injury patterns on tour. There have also been recent high-quality studies …

Comparative Effectiveness Of A Technology-Facilitated Depression Care Management Model In Safety-Net Primary Care Patients With Type 2 Diabetes: 6-Month Outcomes Of A Large Clinical Trial., S. Wu, K. Ell, H. Jin, I. Vidyanti, C. P. Chou, P. J. Lee, S. Gross-Schulman, L. M. Sklaroff, M. Richman, J. Guterman, +20 Additional Authors

Journal Articles

BACKGROUND: Comorbid depression is a significant challenge for safety-net primary care systems. Team-based collaborative depression care is effective, but complex system factors in safety-net organizations impede adoption and result in persistent disparities in outcomes. Diabetes-Depression Care-management Adoption Trial (DCAT) evaluated whether depression care could be significantly improved by harnessing information and communication technologies to automate routine screening and monitoring of patient symptoms and treatment adherence and allow timely communication with providers.

OBJECTIVE: The aim of this study was to compare 6-month outcomes of a technology-facilitated care model with a usual care model and a supported care model that involved team-based …

Long Head Of Biceps Tendon Management: A Survey Of The American Shoulder And Elbow Surgeons, K. T. Corpus, G. H. Garcia, J. N. Liu, D. M. Dines, S. J. O’Brien, J. S. Dines, S. A. Taylor

Journal Articles

© 2017, Hospital for Special Surgery. Background:: Management of symptomatic long head of biceps tendon (LHBT) pathology remains a source of debate. Questions/Purposes:: The purpose of this study was to identify consensus trends for the treatment of LHBT pathology among specialists. Methods:: A survey was distributed to members of the American Shoulder and Elbow Society (ASES), consisting of three sections—demographics, case scenarios, and general LHBT pathology management. Cases presented common clinical scenarios, and surgeons reported their management preferences. Consensus responses were defined as > 50% of participants giving a single response. Results:: One hundred and forty-two of 417 (34%) surgeons completed …

Management Of Tiny Unruptured Intracranial Aneurysms: A Comparative Effectiveness Analysis, A. Malhotra, X. Wu, H. P. Forman, C. C. Matouk, D. Gandhi, P. Sanelli

Journal Articles

© 2017 American Medical Association. All rights reserved. Importance: Unruptured intracranial aneurysms (UIAs) are relatively common in the general population and are being increasingly diagnosed; a significant proportion are tiny (≤3 mm) aneurysms. There is significant heterogeneity in practice and lack of clear guidelines on the management of incidental, tiny UIAs. It is important to quantify the implications of different management strategies in terms of health benefits to patients. Objective: To evaluate the effectiveness of routine treatment (aneurysm coiling) vs 3 strategies for imaging surveillance compared with no preventive treatment or routine follow-up of tiny UIAs. Design, Setting, and Participants: …

Nuclear Medicine Imaging In Fever Of Unknown Origin: The New Paradigm, C. J. Palestro, C. Love

Journal Articles

No abstract provided.

Endoscopic Proximal Adductor Lengthening For Chronic Adductor-Related Groin Pain, S. Bharam, P. V. Bhagat, M. C. Spira, D. A. Klein

Journal Articles

© 2018 Arthroscopy Association of North America Proximal adductor injuries are relatively common groin injuries in athletes. Various tenotomy techniques have been described including open, partial, and percutaneous approaches. Current techniques help most athletes return to sport; however, many develop adductor weakness. Moreover, the procedures lack full visualization of the tendon and do not allow for return to athletes’ preinjury level of play. We describe an endoscopic z-lengthening of the proximal adductor tendon with the potential to minimize complications associated with open procedures such as incisional pain and neurovascular injury while affording a more complete tenotomy than current percutaneous techniques. …

Neuroimaging Of Meckel’S Cave In Normal And Disease Conditions, A. Malhotra, L. Tu, V. B. Kalra, X. Wu, A. Mian, R. Mangla, E. Michaelides, P. Sanelli, D. Gandhi

Journal Articles

© 2018, The Author(s). Abstract: Meckel’s cave is a dural recess in the posteromedial portion of the middle cranial fossa that acts as a conduit for the trigeminal nerve between the prepontine cistern and the cavernous sinus, and houses the Gasserian ganglion and proximal rootlets of the trigeminal nerve. It serves as a major pathway in perineural spread of pathologies such as head and neck neoplasms, automatically upstaging tumours, and is a key structure to assess in cases of trigeminal neuralgia. The purpose of this pictorial review is threefold: (1) to review the normal anatomy of Meckel’s cave; (2) to …

Open Access: Is There A Predator At The Door?, R. Chandra, E. W. Fisher, T. M. Jones, D. W. Kennedy, D. H. Kraus, J. H. Krouse, M. J. Link, L. R. Lustig, B. W. O'Malley, R. Youngs, +8 Additional Authors

Journal Articles

No abstract provided.

Thyroseq V3 Molecular Profiling For Tailoring The Surgical Management Of Hürthle Cell Neoplasms., S. Pearlstein, A. H. Lahouti, E. Opher, Y. E. Nikiforov, D. B. Kuriloff

Journal Articles

Hürthle cell predominant thyroid nodules often confound the diagnostic utility of fine needle aspiration biopsy (FNAB) with cytology often interpreted as a Hürthle cell lesion with an indeterminate risk of malignancy, Bethesda category (BC) III or IV. Molecular diagnostics for Hürthle cell predominant nodules has also been disappointing in further defining the risk of malignancy. We present a case of a slowly enlarging nodule within a goiter initially reported as benign on FNAB, BC II but on subsequent FNAB suspicious for a Hürthle cell neoplasm, BC IV. The patient had initially requested a diagnostic lobectomy for a definitive diagnosis despite …