Medicine and Health Sciences Commons^™

Patient Perspectives On Adherence To The New Hepatitis C Antiviral Medications: ‘A New Lease On Life’, Nicole M. Giordano, Anthony J. Brinn, Guadalupe Garcia-Tsao, Steve Martino

The Qualitative Report

This study explored patients’ perspectives about taking the new direct-acting antivirals (DAAs) for the treatment of Hepatitis C (i.e., sofosbuvir, simeprevir, ledipasvir/sofosbuvir, ombitasvir/paritraprevir/ritonavir and dasabuvir) to identify facilitators of medication adherence. The project was conducted using semi-structured interviews with 12 Veterans who successfully completed a treatment course on the new DAAs. The Veterans were recruited using purposive sampling. The data collected from the semi-structured interviews was analyzed using an adapted open coding method outlined by Auerbach and Silverstein (2003), with identification of relevant text sub-grouped into repeating ideas, and then creation of overarching themes and constructs. Results obtained provide insight …

Dynamic Cycling Of T-Snare Acylation Regulates Platelet Exocytosis, Jinchao Zhang, Yunjie Huang, Jing Chen, Haining Zhu, Sidney W. Whiteheart

Molecular and Cellular Biochemistry Faculty Publications

Platelets regulate vascular integrity by secreting a host of molecules that promote hemostasis and its sequelae. Given the importance of platelet exocytosis, it is critical to understand how it is controlled. The t-SNAREs, SNAP-23 and syntaxin-11, lack classical transmembrane domains (TMDs), yet both are associated with platelet membranes and redistributed into cholesterol-dependent lipid rafts when platelets are activated. Using metabolic labeling and hydroxylamine (HA)/HCl treatment, we showed that both contain thioester-linked acyl groups. Mass spectrometry mapping further showed that syntaxin-11 was modified on cysteine 275, 279, 280, 282, 283, and 285, and SNAP-23 was modified on cysteine 79, 80, 83, …

Readmission Rates In Not-For-Profit Vs. Proprietary Hospitals Before And After The Hospital Readmission Reduction Program Implementation., Lauren E. Birmingham, Willie H. Oglesby Phd, Msph, Fache

College of Population Health Faculty Papers

BACKGROUND: The Patient Protection and Affordable Care Act established the Hospital Readmission Reduction Program (HRRP) to penalize hospitals with excessive 30-day hospital readmissions of Medicare enrollees for specific conditions. This policy was aimed at increasing the quality of care delivered to patients and decreasing the amount of money paid for potentially preventable hospital readmissions. While it has been established that the number of 30-day hospital readmissions decreased after program implementation, it is unknown whether this effect occurred equally between not-for-profit and proprietary hospitals. The aim of this study was to determine whether or not the HRRP decreased readmission rates equally …

Emergency Medicine Resident Perceptions About The Need For Increased Training In Communicating Diagnostic Uncertainty., Kristin L Rising, Dimitrios Papanagnou, Danielle Mccarthy, Alexzandra Gentsch, Rhea Powell

Department of Emergency Medicine Faculty Papers

Introduction Diagnostic uncertainty is common in healthcare encounters. Effective communication is important to help patients and providers navigate diagnostic uncertainty, especially at transitions of care. This study sought to assess the experience and training of emergency medicine (EM) residents with communication of diagnostic uncertainty. Methods This was a survey study of a national sample of EM residents. The survey questions elicited quantitative and qualitative responses about experiences with and educational preparation for communication with patients in the setting of diagnostic uncertainty. Results A sample of 263 emergency medicine residents who had trained at over 87 medical schools and 37 residency …

Emotion Regulation And Positive Affect In The Context Of Salivary Alpha-Amylase Response To Pain In Children With Cancer, Brooke N. Jenkins, Douglas A. Granger, Ryan J. Roemer, Ariana Martinez, Tara K. Torres, Michelle A. Fortier

Psychology Faculty Articles and Research

Background

Children with cancer routinely undergo painful medical procedures invoking strong physiological stress responses. Resilience to this pain may be conferred through resources such as emotion regulation strategies and positive affect.

Procedure

This study measured dispositional positive affect in children with cancer (N = 73) and randomly assigned participants to one of three emotion regulation strategy conditions (distraction, reappraisal, or reassurance). Children applied their assigned strategy during an experimental pain procedure (the cold pressor task [CPT]) and provided saliva samples before, immediately after, and 15 min after the CPT. Saliva samples were later assayed for salivary alpha amylase (sAA)—a surrogate …

Girls In The Boat: Sex Differences In Rowing Performance And Participation, Kevin G. Keenan, Jonathon Senefeld, Sandra K. Hunter

Exercise Science Faculty Research and Publications

Men outperform women in many athletic endeavors due to physiological and anatomical differences (e.g. larger and faster muscle); however, the observed sex differences in elite athletic performance are typically larger than expected, and may reflect sex-related differences in opportunity or incentives. As collegiate rowing in the United States has been largely incentivized for women over the last 20 years, but not men, the purpose of this study was to examine sex differences in elite rowing performance over that timeframe. Finishing times from grand finale races for collegiate championship on-water performances (n = 480) and junior indoor performances (n = 1,280) …

Adults With Cystic Fibrosis: Self-Management And Health Outcomes, Amanda Rose Lambie

Theses and Dissertations

This dissertation is comprised of three manuscripts for publication reporting on adults living with cystic fibrosis, self-management behaviors and health outcomes. Chapter I explores what is known about adults living with cystic fibrosis (CF) and the factors impacting their self-management, including the complexities of a health maintenance regime required for survival while integrating and balancing the realities of adulthood. The review of literature provides direction for future research and implications for adult-focused CF studies. Chapter II is a manuscript describing the characteristics of prognostic survival models utilized in adult CF research and provides an overview of their development, validation, predictive …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Georgia Southern Investigates Kernel Density Based Mode Estimation
• Georgia Southern Examines Operational and Financial Performance of Georgias Critical Access Hospitals

Health Policy & Management News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• Georgia Southern Examines Operational and Financial Performance of Georgia’s Critical Access Hospitals

Teaching Healthcare Ethics Students How To Cope With Gun Violence, Peter G. Holub

Internet Journal of Allied Health Sciences and Practice

Buchbinder (2017) provides assignments for Financial Management, Epidemiology, Health Policy, Leadership, and Human Resources classes to help students process the physical and emotional effects of gun violence in America. The following additional assignments are provided for bachelor’s, master’s and doctoral level Medical Ethics classes.

The Santa Clara, 2018-01-18, Santa Clara University

The Santa Clara

No abstract provided.

Toxicdocs: A New Resource For Assessing The Impact Of Corporate Practices On Health, Nicholas Freudenberg

Publications and Research

In the past century, corporations have contributed to premature death and preventable illnesses globally. A growing body of evidence shows how the practices of corporations and their allies contribute to chronic diseases, injuries, and toxic exposures [1–3]. Public health researchers can chart how business practices such as marketing, product formulation and pricing, and corporate political activity such as lobbying, election campaign contributions, sponsored research, and public relations promote the behaviors, environments, and policies that shape patterns of health and disease [4–6].

Liver Transplantation For Unresectable Colorectal Cancer Metastases Confined To The Liver. Bonmots 24 Jan 18, Vivian Mcalister

Data and Test Instruments

Webcast available here

Factors Affecting Effective Ventilation During Newborn Resuscitation: A Qualitative Study Among Midwives In Rural Tanzania, R. Moshiro, H. L. Ersdal, P. Mdoe, H. L. Kidanto, Columba Mbekenga

School of Nursing & Midwifery, East Africa

Background: Intrapartum-related hypoxia accounts for 30% of neonatal deaths in Tanzania. This has led to the introduction and scaling-up of the Helping Babies Breathe (HBB) programme, which is a simulation-based learning programme in newborn resuscitation skills. Studies have documented ineffective ventilation of non-breathing newborns and the inability to follow the HBB algorithm among providers.

Objective: This study aimed at exploring barriers and facilitators to effective bag mask ventilation, an essential component of the HBB algorithm, during actual newborn resuscitation in rural Tanzania.

Methods: Eight midwives, each with more than one year’s working experience in the labour ward, were interviewed individually …

Liposomal Tricurin, A Synergistic Combination Of Curcumin, Epicatechin Gallate And Resveratrol, Repolarizes Tumor-Associated Microglia/Macrophages, And Eliminates Glioblastoma (Gbm) And Gbm Stem Cells, Sumit Mukherjee, Juliet N. E. Baidoo, Samay Sampat, Andrew Manusco, Lovena David, Leah S. Cohen, Shuiqin Zhou, Probal Banerjee

Publications and Research

Glioblastoma (GBM) is a deadly brain tumor with a current mean survival of 12–15 months. Despite being a potent anti-cancer agent, the turmeric ingredient curcumin (C) has limited anti-tumor efficacy in vivo due to its low bioavailability. We have reported earlier a strategy involving the use two other polyphenols, epicatechin gallate (E) from green tea and resveratrol (R) from red grapes at a unique, synergistic molar ratio with C (C:E:R: 4:1:12.5, termed TriCurin) to achieve superior potency against HPV+ tumors than C alone at C:E:R (M): 32:8:100 (termed 32 M+ TriCurin). We have now prepared liposomal TriCurin (TrLp) and demonstrated …

Comprendre L’Influence De La Régulation Des Contraintes Temporelles Sur L’Appropriation Des Principes Généraux De Déplacement Sécuritaire Des Bénéficiaires Par Les Recrues Préposés Aux Bénéficiaires, François Aubry, Isabelle Feillou, Monica Torres, Élise Ledoux, Yves Couturier, Lise Desmarais

Rapports de recherche scientifique

Les préposés aux bénéficiaires (PAB) ont comme mandat de réaliser l’ensemble des activités d’assistance envers les résidents des centres d’hébergement et de soins de longue durée (CHSLD) au Québec. Ils exercent une fonction indispensable dans les CHSLD, alors que le vieillissement de la population s’accentue, que les problématiques physiques et cognitives des résidents s’aggravent et que la réponse à leurs besoins se complexifie. Les PAB forment également une catégorie professionnelle fragilisée dans le réseau de la santé et des services sociaux du Québec, notamment sur le plan de la santé et de la sécurité au travail (SST). À cet égard, …

Effets Psychologiques Et Biomécaniques Immédiats De Deux Catégories De Ceintures Lombaires Chez Des Travailleurs En Santé Et Des Travailleurs Avec Maux De Dos, Christian Larivière, Michael Sullivan, Richard Preuss, Alessia Negrini

Rapports de recherche scientifique

Bien que les ceintures lombaires (CL) soient inefficaces pour prévenir un premier épisode de lombalgie, l’avancement des connaissances soutient leur utilisation chez les travailleurs souffrant déjà de ce mal. Dans la perspective où un retour au travail tardif risque de nuire à la condition de santé des travailleurs, l’option du port de la CL peut potentiellement être avantageuse, car elle pourrait permettre, lors du retour progressif au travail, d’apporter un soutien psychologique afin de rassurer le patient. Cela pourrait donc représenter un outil additionnel, parmi les moyens entrepris pour intervenir sur les facteurs psychosociaux reliés à l’individu et son environnement …

Systematic In Vivo Evaluation Of The Time-Dependent Inflammatory Response To Steel And Teflon Insulin Infusion Catheters., Jasmin R. Hauzenberger, Julia Münzker, Petra Kotzbeck, Martin Asslaber, Vladimir Bubalo, Jeffrey I. Joseph, Thomas R. Pieber

Department of Anesthesiology Faculty Papers

Continuous subcutaneous insulin infusion (CSII) catheters are considered the weak link of insulin pump therapy. Wear-time considerably varies between patients and the choice of catheter material is based on personal preferences rather than scientific facts. Therefore, we systematically assessed and quantified the inflammatory tissue response to steel versus Teflon CSII catheters over a maximum wear-time of 7 days in swine. Tissue surrounding catheters was analysed using histopathology and quantitative real-time PCR. The area of inflammation increased significantly over time independent of material which was confirmed by an increase in CD68 expression and an increase in mononuclear and neutrophil cell infiltrate …

Z-Can: Prevention Of Unintended Pregnancy In An Emergency Setting, Marleen Temmerman, Cora Nally

Obstetrics and Gynaecology, East Africa

Prevention of unintended pregnancy is a primary strategy to reduce adverse pregnancy and birth outcomes related to Zika virus infection. Infection during pregnancy, either through a mosquito bite or sex with an infected partner, increases the risk of the child developing congenital microcephaly and other fetal brain abnormalities, resulting in the birth of a child with severe disabilities that will necessitate lifelong care.1,2

Approaches To Integrating Service Learning In The Public Health Administration Course, Sandra Liu, Ali Bianco

Engagement & Service-Learning Summit

No abstract provided.

Pharmacy Practice And Research: The Development Of A University Collaboration In Colombia, Ellen Schellhase

Engagement & Service-Learning Summit

No abstract provided.

Water Supply In Developing Countries, Jason K. Hawes, Ernest R. Blatchley Iii, Audrey Caprio, Andrew T. Kanach

Engagement & Service-Learning Summit

No abstract provided.

Safety And Service-Learning: Engaging Pharmacy Students To Make Safer Communities, Patricia Darbishire, Chelsea Anderson

Engagement & Service-Learning Summit

Poster Abstract

Objective:

To evaluate student perceptions of a service-learning experience for potential implementation in the curriculum.

Method:

A new 3-week intensive elective course was piloted in the Spring of 2017 at Purdue University College of Pharmacy. Seven third professional year students were included in the pilot and were divided into three groups. Each group of 2-3 students was assigned to one of 3 predetermined community partner sites. Students were taught how to perform a needs assessment and then designed a project targeted to improve safety at their site. Students completed a pre-post questionnaire that assessed their perceptions of the …

Implementation Of A Low-Cost Unna Boot Alternative As Adjunctive Treatment For Kaposi Sarcoma, Alexander Robert Mills, Edith Tonui, Sonak Pastakia, Rakhi Karwa, Phelix Were

Engagement & Service-Learning Summit

There are 6 million people living with HIV; 70% reside in Sub-Saharan Africa (SSA). Furthermore, 1.1 million deaths occur due to opportunistic infections (OIs) that can be minimized with antiretroviral therapy. In Kenya, Kaposi Sarcoma (KS) is an especially debilitating OI that presents with dermatologic lesions; magnifying the stigma that patients with HIV face physically and psychosocially. Dermatology research is underway to determine the effectiveness of an unna boot (medicated, layered compression dressing) to speed the healing of these lesions with anecdotal success. Commercially available unna boot products are too expensive and not readily available in SSA. Clinicians from Purdue …

Expansion Of Pharmacy Students’ Involvement In Global Health And International Clinical Rotations, Alice C. Chang, Monica L. Miller, Ellen M. Schellhase

Engagement & Service-Learning Summit

No abstract provided.

Making Music To Enhance Mental Health In Eldoret, Kenya, Michael Peters, Ethan Wahle, Ellen Schellhase

Engagement & Service-Learning Summit

After attending this session, participants will be appreciate the power of music and witness the level of engagement that street youth in a resource-limited country have as they unite behind a common goal. Street youth in Eldoret, Kenya are at a high risk of experiencing psychological conditions like Post-traumatic Stress Disorder with contributing factors including homelessness, an unstable family structure, and exposure to alcoholism and drug abuse in parent figures. Music therapy has shown benefits in children to alleviate and manage some of the symptoms of emotional disturbances. The goal was to create a sustainable music program in Eldoret, Kenya …

Zika, Pregnancy, And The Law, Sam F. Halabi

Arkansas Law Review

The public health emergency surrounding the spread of the Zika virus has resurrected and brought into sharp relief some of the most vexing questions surrounding the relationship between pregnancy and law: the appropriate circumstances, if any, in which fetal tissue research is permissible; when and how the government may sponsor statements intended to influence reproductive decisions; and how to balance the health and rights of both women and their unborn children when health threats target both.

Sertraline, Paroxetine, And Chlorpromazine Are Rapidly Acting Anthelmintic Drugs Capable Of Clinical Repurposing., Janis C Weeks, William M Roberts, Caitlyn Leasure, Brian M Suzuki, Kristin J Robinson, John M Hawdon, +Several Additional Authors

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Parasitic helminths infect over 1 billion people worldwide, while current treatments rely on a limited arsenal of drugs. To expedite drug discovery, we screened a small-molecule library of compounds with histories of use in human clinical trials for anthelmintic activity against the soil nematode Caenorhabditis elegans. From this screen, we found that the neuromodulatory drugs sertraline, paroxetine, and chlorpromazine kill C. elegans at multiple life stages including embryos, developing larvae and gravid adults. These drugs act rapidly to inhibit C. elegans feeding within minutes of exposure. Sertraline, paroxetine, and chlorpromazine also decrease motility of adult Trichuris muris whipworms, prevent hatching …

Idiopathic Intracranial Hypertension As A Presenting Sign Of Adrenal Insufficiency, Sandra Shenouda, Susan L. Flesher, Jenna B. Dolan M.D., Khaled Al-Farawi

Pediatrics

Idiopathic intracranial hypertension is a diagnosis of exclusion defined by elevated intracranial pressure without mass lesions or hydrocephalus. Causes of idiopathic intracranial hypertension include obesity, vitamin derangements, antibiotics, corticosteroids, and autoimmune disorders. Cushing’s disease and Addison’s disease have been associated with idiopathic intracranial hypertension. Secondary adrenal insufficiency following withdrawal of inhaled corticosteroids has been found to be a relatively common phenomenon. This case describes an 11-year-old boy who was previously on inhaled corticosteroids for severe asthma who presented with secondary adrenal insufficiency after withdrawal of steroids. The adrenal insufficiency presented as idiopathic intracranial hypertension. We described the hospital course and …

Frequency And Factors Associated With Adult Immunization In Patients Visiting Family Medicine Clinics At A Tertiary Care Hospital, Karachi, Samar Zaki, Asma Usman, Swaleha Tariq, Sameena Shah, Iqbal Azam Syed, Waris Qidwai, Kashmira Nanji

Department of Family Medicine

Objective: The goal of this study was to determine the frequency and factors associated with adult immunization in patients visiting family medicine clinics at a tertiary care hospital in Karachi.
Methods: A cross-sectional study was conducted from March 2014 to March 2015 in a tertiary care hospital in Karachi, Pakistan. Participants more than 18 years were invited to participate in the study. A pretested questionnaire was used to collect information. Data were entered and analyzed using IBM SPSS Statistics for Windows, version 19.0 (Armonk, NY: IBM Corp).
Results: A total of 340 patients were surveyed. The majority of patients …