Medicine and Health Sciences Commons^™

Immunological Compatibility Status Of Placenta-Derived Stem Cells Is Mediated By Scaffold 3d Structure, Sara Azizian, Fatemeh Katami, Khashayar Modaresifar, Nariman Mosaffa, Habibollah Peirovi, Lobat Tayebi, Soheyl Bahrami, Heinz Redl, Hassan Niknejad

School of Dentistry Faculty Research and Publications

Placenta-derived amniotic epithelial cells (AECs), a great cell source for tissue engineering and stem cell therapy, are immunologically inert in their native state; however, immunological changes in these cells after culture and differentiation have challenged their applications. The aim of this study was to investigate the effect of 2D and 3D scaffolds on human lymphocyte antigens (HLA) expression by AECs. The effect of different preparation parameters including pre-freezing time and temperature was evaluated on 3D chitosan–gelatine scaffolds properties. Evaluation of MHC class I, HLA-DR and HLA-G expression in AECs after 7 d culture on 2D bed and 3D scaffold of …

Barriers To Addressing Hiv-Associated Neurocognitive Disorder (Hand): Community-Based Service Provider Perspectives, Renato M. Liboro, Francisco Ibanez-Carrasco, Sean B. Rourke, Andrew Easton, Claudia Medina, Daniel Pugh, Allan Rae, Lori E. Ross, Paul A. Shuper

Psychology Faculty Research

HIV-Associated Neurocognitive Disorder (HAND) is an emergent public health issue in developed countries. Consequently, people living with HIV who experience HAND will increasingly require support from community-based HIV service providers. The objective of our qualitative study was to identify barriers service providers face in addressing HAND among people living with HIV. Thirty-three providers from 22 AIDS service organizations across Ontario, Canada, were interviewed. Using thematic analysis, three types of barriers were identified: (a) personal/professional, (b) service access, and (c) systemic. This paper draws attention to HAND-related obstacles that service providers encounter in their work and presents options to overcome them.

Seeking Surrogacy: The Ethics Of Assisting Life’S Creation, Elisa Berndt

Brindle Award in Medical Ethics Papers

No abstract provided.

The Santa Clara, 2018-02-22, Santa Clara University

The Santa Clara

No abstract provided.

Pharmaceutics Ii Bps 315, Joanna Burkhardt

Library Impact Statements

No abstract provided.

Efficacy Of Larotrectinib In Trk Fusion-Positive Cancers In Adults And Children, Alexander Drilon, Theodore W. Laetsch, Shivaani Kummar, Steven G. Dubois, Ulrik N. Lassen, George D. Demetri, Michael Nathenson, Robert C. Doebele, Anna F. Farago, Alberto S. Pappo, Brian Turpin, Afshin Dowlati, Marcia S. Brose, Leo Mascarenhas, Noah Federman, Jordan Berlin, Wafik S. El-Deiry, Christina Baik, John Deeken, Valentina Boni, Ramamoorthy Nagasubramanian, Matthew Taylor, Erin R. Rudzinski, Funda Meric-Bernstam, Davendra P. S. Sohal, Patrick C. Ma, Luis E. Raez, Jaclyn F. Hechtman, Ryma Benayed, Marc Ladanyi, Brian B. Tuch, Kevin Ebata, Scott Cruickshank, Nora C. Ku, Michael C. Cox, Douglas S. Hawkins, David S. Hong, David M. Hyman

Clinical and Translational Science Institute

BACKGROUND—Fusions involving one of three tropomyosin receptor kinases (TRK) occur in diverse cancers in children and adults. We evaluated the efficacy and safety of larotrectinib, a highly selective TRK inhibitor, in adults and children who had tumors with these fusions. METHODS—We enrolled patients with consecutively and prospectively identified TRK fusion– positive cancers, detected by molecular profiling as routinely performed at each site, into one of three protocols: a phase 1 study involving adults, a phase 1–2 study involving children, or a phase 2 study involving adolescents and adults. The primary end point for the combined analysis was the overall response …

Effects Of Exercise On Appetite-Regulating Hormones, Perceived Hunger, And Energy Intake: A Narrative Overview, Marsa Gleason, Basil H. Aboul-Enein, Josh Bernstein, Joanna Kruk

Health & Wellness Department Faculty Publications and Research

Controlling appetite, perceived hunger, and energy intake are important factors in weight management. This narrative review examines the effect of different forms, intensities and duration of exercise on the appetite-regulating hormones leptin, acylated ghrelin, glucagon like peptide-1 (GLP-1) and peptide tyrosine tyrosine3-36 (PYY3-36), perceptions of hunger, and energy intake in overweight/obese, and normal weight populations. The studies reviewed compared exercise intensities- low, moderate, and high intensity, and modes of exercise- aerobic and resistance training. The studies selected in this narrative review included participants that ranged in age from 13-57 years old, male and female, previously sedentary and physically active, and …

Free-Breathing Pulmonary Mr Imaging To Quantify Regional Ventilation, Dante P I Capaldi, Rachel L Eddy, Sarah Svenningsen, Fumin Guo, John S H Baxter, A Jonathan Mcleod, Parameswaran Nair, David G Mccormack, Grace Parraga

Medical Biophysics Publications

Purpose: To measure regional specific ventilation with free-breathing hydrogen 1 (1H) magnetic resonance (MR) imaging without exogenous contrast material and to investigate correlations with hyperpolarized helium 3 (3He) MR imaging and pulmonary function test measurements in healthy volunteers and patients with asthma.

Materials and Methods: Subjects underwent free-breathing 1H and static breath-hold hyperpolarized 3He MR imaging as well as spirometry and plethysmography; participants were consecutively recruited between January and June 2017. Free-breathing 1H MR imaging was performed with an optimized balanced steady-state free-precession sequence; images were retrospectively grouped into tidal inspiration or tidal expiration volumes with exponentially weighted phase interpolation. …

Patient Perspectives On Improving Osteoarthritis Management In Urban And Rural Communities, Shabana Amanda Ali, Kathleen Ellen Walsh, Marita Kloseck

Bone and Joint Institute

© 2018 Ali et al. Introduction: Although there is no cure for osteoarthritis (OA), there are lifestyle modifications that can mitigate symptoms such as pain, and improve management of the disease. This information is not always translated to community-dwelling seniors. Individuals in rural areas often face additional challenges due to geographic isolation and decreased access to community services. Methods: We used qualitative research methodology (hermeneutic phenomenology) to better understand the lived experiences of urban and rural community-dwelling seniors diagnosed with OA. We explored their sources of information about OA, how they manage their OA pain, and how OA management could …

Position Statement Of The Arthroscopy Association Of Canada (Aac) Concerning Arthroscopy Of The Knee Joint—September 2017, Ivan Wong, Laurie Hiemstra, Olufemi R. Ayeni, Alan Getgood, Cole Beavis, Monika Volesky, Ross Outerbridge, Brendan Sheehan, Robert Mccormack, Robert Litchfield, Daniel Whelan, Nicholas Mohtadi, Catherine Coady, Peter B. Macdonald

Bone and Joint Institute

No abstract provided.

A Computational Assessment Of Target Engagement In The Treatment Of Auditory Hallucinations With Transcranial Direct Current Stimulation, Won Hee Lee, Nigel I. Kennedy, Marom Bikson, Sophia Frangou

Publications and Research

We use auditory verbal hallucinations (AVH) to illustrate the challenges in defining and assessing target engagement in the context of transcranial direct current stimulation (tDCS) for psychiatric disorders. We defined the target network as the cluster of regions of interest (ROIs) that are consistently implicated in AVH based on the conjunction of multimodal meta-analytic neuroimaging data. These were prescribed in the New York Head (a population derived model) and head models of four single individuals. We appraised two potential measures of target engagement, tDCS-induced peak electric field strength and tDCS-modulated volume defined as the percentage of the volume of the …

Rural/Urban Disparities In Pneumococcal Vaccine Service Delivery Among The Fee-For-Service Medicare Population, Jeffery C. Talbert, Aric Schadler, Patricia R. Freeman

Rural & Underserved Health Research Center Publications

Overview of Key Findings

• In 2014, the overall mean vaccination rate in urban areas was 4.66 compared to a mean vaccination rate of 2.81 in rural areas, indicating a 40% lower mean vaccination rate in rural communities.
• The majority of pneumococcal vaccine services delivered to fee-for-service Medicare beneficiaries were provided by primary care providers, although pharmacy providers delivered close to one-fourth (22.2%) of these services.
• The proportion of pneumococcal vaccine services delivered by pharmacy providers was significantly greater in rural versus urban counties (29.4% vs. 21.1%).
• Consistent with previous literature, county characteristics positively associated with pneumococcal vaccine service delivery include …

The Epidemic Of Neonatal Abstinence Syndrome, Historical References Of Its Origins, Assessment, And Management, Enrique Gomez-Pomar, Loretta P. Finnegan

Pediatrics Faculty Publications

Neonatal abstinence syndrome (NAS) refers to a constellation of signs that are present in some newborn infants resulting from the abrupt cessation of passive transfer of maternal opioids used during pregnancy. The classic NAS refers to infants born to mothers who used opioids during pregnancy, but the term has broadened to include infants whose mothers have used or abused other psychoactive substances during pregnancy that contribute to the expression of the syndrome. Pregnant women who use opioids do so illicitly, and/or as medically prescribed for pain relief, and/or as medication assisted treatment for opioid dependence. The first case of NAS …

Oral Contraceptive Use And Risk For Development Of Breast Cancer In Women With High-Risk Breast Cancer Genes: A Case Study., Rebecca Pulkrabek

Nursing Capstones

No abstract provided.

Training University Teachers And Students In Sri Lanka On Gender Based Violence: Testing Of A Participatory Training Program [Version 1], Pia Axemo, Kumudu Wijewardena, Ruvani Fonseka, Sharika Cooray, Elisabeth Darj

Faculty Research, Scholarly, and Creative Activity

This article was migrated. The article was marked as recommended.
In all societies, violence is a social problem and violation of human rights. Changing attitudes and behaviors, which accept violence at individual and societal levels are key components in prevention strategies.
The aim of this study was to produce educational material on Gender Based Violence (GBV). A participatory study design including educators and university students was used to create four teaching modules. The teaching was evaluated by descriptive surveys before and after the training and focus group discussions followed the training session. The questionnaire covered attitudes to gender, violence and …

Phosphofructokinase And Mitochondria Partially Explain The High Ultimate Ph Of Broiler Pectoralis Major Muscle, Sulaiman K. Matarneh, Con-Ning Yen, Jennifer M. Elgin, Mariane Beline, Saulo Da Luz E Silva, Jordan C. Wicks, Eric M. England, Rami A. Dalloul, Michael E. Persia, Islam I. Omara, Hao Shi, David E. Gerrard

Nutrition, Dietetics, and Food Sciences Faculty Publications

During postmortem metabolism, muscle pH gradually declines to reach an ultimate pH near 5.6 across most meat species. Yet, broiler pectoralis major (P. major) muscle generates meat with high ultimate pH (pH ∼ 5.9). For better understanding of the underlying mechanism responsible for this phenomenon, we evaluated the involvement of breast muscle chilling on the extent of postmortem metabolism. Broiler breast muscles were either subjected to chilling treatment (control) or left at room temperature (RT) for 120 min. P. major muscle from the RT treatment had lower ultimate pH, greater glycogen degradation and lactate accumulation. While these findings suggest that …

Strategies To Adjust For Response Bias In Clinical Trials: A Simulation Study, Victoria R. Swaidan

USF Tampa Graduate Theses and Dissertations

Background: Response bias can distort treatment effect estimates and inferences in clinical trials. Although prevention, quantification, and adjustments have been developed, current methods are not applicable when subject-level reliability is used as the measure of response bias. Thus, the objective of the current study is to develop, test, and recommend a series of bias correction strategies for use in these cases. Methods: Monte Carlo simulation and logistic regression modeling were used to develop the strategies, examining the collective impact of sample size (N), effect size (ES), reliability distribution, and response style on estimating the treatment effect size in a series …

Adherence To Antiretroviral Therapy In A Clinical Cohort Of Hiv-Infected Children In East Africa, Rachel C. Vreeman, Samuel O. Ayaya, Beverly S. Musick, Constantin T. Yiannoutsos, Craig R. Cohen, Denis Nash, Deo Wabwire, Kara Wools-Kaloustian, Sarah E. Wiehe

Publications and Research

Objective To describe antiretroviral therapy (ART) adherence and associated factors for a large HIVinfected pediatric cohort followed by sites of the East Africa International Epidemiologic Databases to Evaluate AIDS (IeDEA) consortium.

Methods This study utilized prospectively collected clinical data from HIV-infected children less than 13 years of age who initiated ART within 4 clinical care programs (with 26 clinical sites) in Kenya, Uganda, and Tanzania and were followed for up to 6 years. Programs used one of 3 adherence measures, including 7-day quantitative recall, 7-day categorical recall, and clinician pill assessments. We fit a hierarchical, three-level, logistic-regression model to examine …

Wdph 2017 Summer Internship Report, Lauren Meininger

Mosakowski Institute for Public Enterprise

In the spring of 2014, the Worcester Division of Public Health, UMass Memorial Health Care, and Clark University’s Mosakowski Institute for Public Enterprise joined forces to begin developing a partnership that would combine academic resources, student input, and public health needs in the City of Worcester. Founders of this program were motivated to seek and implement innovative interventions for public health issues while simultaneously inspiring a new generation of public health professionals.

Each year, the Academic Health Collaborative of Worcester (AHCW) brings in student interns to work on the pressing public health issues of the moment. Interns work alongside epidemiologists, …

Process Evaluation Of The Healthesteps™ Lifestyle Prescription Program, Wendy Blunt, Dawn P. Gill, Brendan Riggin, Judith Belle Brown, Robert Petrella

Lifestyle Research Team

Background: Physical inactivity, sedentary behaviour, and poor diet are contributing to the rise in chronic disease rates throughout the world. HealtheSteps™ is a lifestyle prescription program focused on reducing risk factors for chronic disease through in-person coaching sessions, goal setting and tracking, and technology supports.

Purpose:A process evaluation was conducted alongside a pragmatic randomized controlled trial to: a) explore the acceptability of HealtheSteps™ program from coach and participant perspectives; and b) identify where the program can be improved.

Methods:Participants at risk or diagnosed with a chronic disease were recruited from five primary care/health services …

Ginsenoside Re Protects Methamphetamine-Induced Dopaminergic Neurotoxicity In Mice Via Upregulation Of Dynorphin-Mediated Κ-Opioid Receptor And Downregulation Of Substance P-Mediated Neurokinin 1 Receptor, Duy-Khanh Dang, Eun-Joo Shin, Dae-Joong Kim, Hai-Quyen Tran, Ji Hoon Jeong, Choon-Gon Jang, Seung-Yeol Nah, Jung Hwan Jeong, Jae Kyung Byun, Sung Kwon Ko, Guoying Bing, Jau-Shyong Hong, Hyoung-Chun Kim

Neuroscience Faculty Publications

Background: We previously reported that ginsenoside Re (GRe) attenuated against methamphetamine (MA)-induced neurotoxicity via anti-inflammatory and antioxidant potentials. We also demonstrated that dynorphin possesses anti-inflammatory and antioxidant potentials against dopaminergic loss, and that balance between dynorphin and substance P is important for dopaminergic neuroprotection. Thus, we examined whether GRe positively affects interactive modulation between dynorphin and substance P against MA neurotoxicity in mice.

Methods: We examined changes in dynorphin peptide level, prodynorphin mRNA, and substance P mRNA, substance P-immunoreactivity, homeostasis in enzymatic antioxidant system, oxidative parameter, microglial activation, and pro-apoptotic parameter after a neurotoxic dose of MA to clarify the …

Sociocultural And Health System Factors Associated With Mortality Among Febrile Inpatients In Tanzania: A Prospective Social Biopsy Cohort Study, Michael E. Snavely, Michael J. Maze, Charles Muiruri, Lilian Ngowi, Flora Mboya, Julia Beamesderfer, Glory F. Makupa, Anthon G. Mwingwa, Bingileki F. Lwezaula, Blandina T. Mmbaga, Venance P. Maro, John A. Crump, Jan Ostermann, Matthew P. Rubach

Faculty Publications

Introduction Communicable diseases are the leading causes of death in Tanzania despite the existence of effective treatment tools. We aimed to assess the sociocultural and health system factors associated with mortality from febrile illness in northern Tanzania.

Methods We interviewed febrile inpatients to determine prevalence of barriers in seeking or receiving care and grouped these barriers using the Three Delays model (delays at home, in transport and at healthcare facilities). We assessed 6-week mortality and, after matching on age, gender and severity of illness, measured the association between delays and mortality using conditional logistic regression.

Results We enrolled 475 children, …

Relationship Between The Cortisol-Estradiol Phase Difference And Affect In Women, Karyn Butler

Open Access Publishing Support Funded Articles

Affective disorders impact women’s health, with a lifetime prevalence of over twelve per cent. They have been correlated with reproductive cycle factors, under the regulation of hormonal circadian rhythms. In affective disorders, circadian rhythms may become desynchronized. The circadian rhythms of cortisol and estradiol may play a role in affective disorders. The purpose of this study was to explore the temporal relationship between the rhythms of cortisol and estradiol and its relationship to affect. It was hypothesized that a cortisol-estradiol phase difference (PD) exists that correlates with optimal affect. A small scale, comparative, correlational design was used to test the …

Stratified Multilevel Logistic Regression Modeling For Risk Factors Of Adolescent Obesity In Tennessee, Shimin Zheng, Sheryl Strasser, Nicole Holt, Megan Quinn, Ying Liu, Casey Morrell

ETSU Faculty Works

Background: US adolescent obesity rates have quadrupled over the past 3 decades. Research examining complex factors associatedwith obesity is limited.Objectives: The purpose of this study was to utilize a representative sample of students (grades 6 - 8) in Tennessee to determine theco-occurrence of risk behaviors with adolescent obesity prevalence and to analyze variations by strata. Methods: The 2010 youth risk behavior survey dataset was used to examine associations of obesity with variables related to sampledemographics, risk and protective behaviors, and region. Hierarchical logistic regression analyses stratified by demographics andregion were conducted to evaluate variation in obesity risk occurring on three …

Family History And Obesity In Youth, Their Effect On Acylcarnitine/Aminoacids Metabolomics And Non-Alcoholic Fatty Liver Disease (Nafld). Structural Equation Modeling Approach, Maria Elena Romero-Ibarguengoitia, Felipe Vadillo-Ortega, Augusto Enrique Caballero, Isabel Ibarra-Gonzalez, Arturo Herrera-Rosas, Maria Fabiola Serratos-Canales, Mireya Leon-Hernandez, Antonio Gonzalez-Chavez, Srinivas Mummidi, Ravindranath Duggirala, Juan Carlos Lopez Alvarenga

School of Medicine Publications

Background

Structural equation modeling (SEM) can help understanding complex functional relationships among obesity, non-alcoholic fatty liver disease (NAFLD), family history of obesity, targeted metabolomics and pro-inflammatory markers. We tested two hypotheses: 1) If obesity precedes an excess of free fatty acids that increase oxidative stress and mitochondrial dysfunction, there would be an increase of serum acylcarnitines, amino acids and cytokines in obese subjects. Acylcarnitines would be related to non-alcoholic fatty disease that will induce insulin resistance. 2) If a positive family history of obesity and type 2 diabetes are the major determinants of the metabolomic profile, there would be higher …

Resveratrol And Pterostilbene Exhibit Anticancer Properties Involving The Downregulation Of Hpv Oncoprotein E6 In Cervical Cancer Cells, Kaushiki Chatterjee, Dina Alsharif, Christina Mazza, Palwasha Syar, Mohamed Al Sharif, Jimmie E. Fata

Publications and Research

Cervical cancer is one of the most common cancers in women living in developing countries. Due to a lack of affordable effective therapy, research into alternative anticancer compounds with low toxicity such as dietary polyphenols has continued. Our aim is to determine whether two structurally similar plant polyphenols, resveratrol and pterostilbene, exhibit anticancer and anti-HPV (Human papillomavirus) activity against cervical cancer cells. To determine anticancer activity, extensive in vitro analyses were performed. Anti-HPV activity, through measuring E6 protein levels, subsequent downstream p53 effects, and caspase-3 activation, were studied to understand a possible mechanism of action. Both polyphenols are effective agents …

Chdi's 13th Conference Promises Some Good News For The Huntington's Disease Community, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Adolescence And The Next Generation, George C. Patton, Craig A. Olsson, Vegard Skirbekk, Richard Saffery, Mary E. Wlodek, Peter S. Azzopardi, Marcin Stonawski, Bruce Rasmussen, Elizabeth Spry, Zulfiqar Ahmed Bhutta

Department of Paediatrics and Child Health

Adolescent growth and social development shape the early development of offspring from preconception through to the post-partum period through distinct processes in males and females. At a time of great change in the forces shaping adolescence, including the timing of parenthood, investments in today's adolescents, the largest cohort in human history, will yield great dividends for future generations.

Validity Of Bmi-Based Equations For Estimating Body Fat Percentage In Collegiate Male Soccer Players: A Three-Compartment Model Comparison, Alexandra Loredo, Kassandra A. Jaramillo, Brett S. Nickerson

International Journal of Exercise Science: Conference Proceedings

The ease of calculating body mass index (BMI)-based body fat percentage (BF%) is appealing in collegiate male soccer player who have limited time availability and strict training regimens. However, research has yet to evaluate whether BMI-based BF% equations are valid when compared to a criterion multi-compartment model. PURPOSE: The purpose of this study was to compare BMI-based BF% equations with a three-compartment (3C) model in collegiate male soccer players. METHODS: Sixteen NCAA Division II male soccer players (age = 21 ± 2 years; ht = 179.0 ± 8.2 cm; wt = 78.0 ± 8.5 kg) participated in this study. BMI …

Exercise-Induced Th17 Lymphocyte Response And Their Relationship To Cardiovascular Disease Risk Factors In Obese, Post-Menopausal Women, Maria A. Cardenas, Michael M. Levitt, Bryan Richie, Shaohan Lu, Elise Erickson, Carmen Cook, Jay Haynes, Andreas Kreutzer, Joel B. Mitchell, Melody D. Phillips

International Journal of Exercise Science: Conference Proceedings

Obesity-induced inflammation promotes type 2 diabetes and cardiovascular disease (CVD). A causative link between adaptive immunity and pathogenesis of obesity-associated diseases has been established. PURPOSE: To examine the effects of exercise on circulating T-helper (Th) 17 lymphocytes in overweight/obese post-menopausal women. METHODS: Twenty-seven overweight/obese women (BMI 32.7 ± 5.1 kg×m^-2, 55-75 yr) were randomly assigned to the exercise (EX, n=14) or education (ED, n=13) groups. EX performed a 25-min walk (75-80% HRR) and 2 sets of 8 resistance exercises (70-80% 1RM) with blood samples obtained at: pre-exercise, post-exercise, one-hour and two-hour post-exercise. Blood samples were obtained …