Medicine and Health Sciences Commons^™

Accelerometer-Determined Physical Activity And Sedentary Behavior Among Majority-Minority Sample Of Adults: The Houston Train Study, Ashleigh Johnson, Kelley Pettee Gabriel, Deborah Salvo, Erin Dooley, Casey Philip Durand, Gregory Knell, Samantha Kreis, Harold W. Kohl Iii

International Journal of Exercise Science: Conference Proceedings

Based on self-reported data, minority populations are often found to be less active compared to whites, which may contribute to overall health disparities. The Houston Travel Related Activity in Neighborhoods (TRAIN) Study provides an opportunity to examine differences in accelerometer-determined physical activity levels among a majority-minority sample of adults. PURPOSE: To describe and examine differences in accelerometer-determined physical activity and sedentary behavior among TRAIN participants at baseline, by race/ethnic groups and sex. METHODS: Study participants were part of an ongoing natural experiment of transportation-related physical activity. At baseline, a group of participants self-selected to wear an ActiGraph wGT3X-BT …

Accuracy Of Fitbit Charge 2 At Estimating Vo2max, Calories, And Steps On A Treadmill, Naomi D. Lucio, Elvia V. Salazar, Ivan A. Figueroa, Jose L. Gamez, Ryan D. Russell, Merrill D. Funk

International Journal of Exercise Science: Conference Proceedings

Current fitness activity trackers can account for steps, calories burned, heart rate, and distance traveled. A new feature has recently been introduced on the Fitbit Charge 2, “Cardio Fitness Level,” which is comparable to a VO2max score in that it allows consumers to be aware of their aerobic fitness level. PURPOSE: To assess the accuracy of the Fitbit Charge 2 at estimating VO2 score (“Cardio Fitness Level”), calories, and steps when compared to indirect calorimetry and video analyzed steps, respectively. METHODS: Twenty-two healthy adults (Mean±SD; 24.1±4.2yrs; 16.9±9.0%fat; 15 male) completed two separate visits. On the first visit, anthropometric measurements were …

Diet And Sex Differences Induce Unique Alterations Of Markers For Blood Brain Barrier Integrity In Age-Accelerated Mice, Dakota R. Kamm, Kenneth A. Witt, Karin E. Sandoval, Megan L. Schaller, Matthew P. Harris, Joshua S. Wooten

International Journal of Exercise Science: Conference Proceedings

The role of diet on brain health has received significant attention, with the Western diet (WD) contributing to cerebrovascular alterations and neurodegenerative disease. The blood-brain barrier (BBB) may play a particularly important role as it forms the interface between the peripheral circulation and the central nervous system. The WD has been shown to negatively impact the BBB. Whether there are sex specific differences with diet on BBB integrity remains unclear. PURPOSE: To determine the effect of diet and sex on the mRNA expression of markers of BBB integrity in an age-accelerated mouse model. METHODS: Male and female Senescence …

What Determines The Metabolic Cost Of Human Running Across A Wide Range Of Velocities?, Shalaya Kipp, Alena Marie Grabowski, Rodger Kram

International Journal of Exercise Science: Conference Proceedings

The cost of generating force hypothesis proposes that the metabolic rate during running is determined by the rate of muscle force development (1/t_c, t_c=contact time) and volume of active leg muscle. A previous study assumed a constant recruited muscle volume and reported that the rate of force development alone explains ~70% of the increase in metabolic rate for human runners across a moderate velocity range (2-4 m s^-1). PURPOSE: We performed a more systematic analysis of the effective mechanical advantage (EMA) of the lower leg over a wide velocity range to determine if …

Validity Of Cardiorespiratory Fitness Assessment In Adolescents Using The Non-Exercise Test, Pacer, And The K4b2 Portable Metabolic System, Pedro Migliano, Megan James, Allison Hall, Amy Fruge, Anna Flipse

International Journal of Exercise Science: Conference Proceedings

Cardiorespiratory fitness (CRF) is an important indicator of adolescent cardiovascular and future cardiometabolic health. The PACER test is often used to measure CRF in adolescents but is not feasible with pediatric populations unable to perform physical testing secondary to physical impairments. The non-exercise test (NET) has been recommended as a proxy for estimating VO₂ in individuals not able to perform physical tests by using variables such as gender, age, body mass index, resting HR, and self-reported habitual physical activity levels. PURPOSE: The purpose of this study was estimate the concurrent validity of the NET for adolescents against the PACER …

Metabolic Responses To A Battling Rope Protocol Performed In The Seated Or Stance Positions, Dominisha Felder, Kasey Hogan, Reka Kovacs, Hannah Mitchell, Wayne Brewer

International Journal of Exercise Science: Conference Proceedings

Achieving the recommended amount of physical activity is a greater challenge for individuals who are disabled than those who are not disabled. Battling ropes is an intense exercise that has been shown to promote elevation of heart rate and increased oxygen consumption, and may be a beneficial exercise alternative for individuals with disabilities. PURPOSE: To compare the levels of perceived exertion (RPE), oxygen consumption (VO₂) and heart rate (HR) responses elicited by a treadmill (TM) or bicycle (BK) VO₂ max test with a standing or sitting battling rope protocol (BRP) (TM vs. standing BRP) (BK vs. …

The Comparison Of High-Intensity Interval Exercise Vs. Continuous Moderate-Intensity Exercise On C1q/Tnf-Related Protein-9 Expression And Flow-Mediated Vasodilation In Obese Individuals, Brandon G. Fico, Ryan S. Garten, Michael C. Zourdos, Michael Whitehurst, Peter J. Ferrandi, Katelyn M. Dodge, Gabriel Pena, Alexandra A. Rodriguez, Chun-Jung Huang

International Journal of Exercise Science: Conference Proceedings

PURPOSE: A recent novel adipocytokine, C1q/TNF-related protein-9 (CTRP9), has been shown to increase activation of endothelial nitric oxide synthase and reduce vasoconstrictors (e.g., endothelin-1). In addition, CTRP9 may play a compensatory role in obesity-related endothelial dysfunction. Although there is limited information regarding exercise-mediated CTRP9, high-intensity interval exercise (HIIE) has been shown to be as or more effective than continuous moderate-intensity exercise (CME) in improving indicators of endothelial function (e.g., brachial artery flow-mediated dilation [BAFMD]). Therefore, the purpose of this study was to investigate the effect of acute HIIE vs. CME on serum CTRP9 and BAFMD responses in obese individuals. METHODS: …

2018 February 20 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Fgf2-Dependent Mesenchyme And Laminin-111 Are Niche Factors In Salivary Gland Organoids, Zeinab F. Hosseini, Deirdre A. Nelson, Nicholas Moskwa, Lauren M. Sfakis, James Castracane, Melinda Larsen

Biological Sciences Faculty Scholarship

Epithelial progenitor cells are dependent upon a complex 3D niche to promote their proliferation and differentiation during development, which can be recapitulated in organoids. The specific requirements of the niche remain unclear for many cell types, including the proacinar cells that give rise to secretory acinar epithelial cells that produce saliva. Here, using ex vivo cultures of E16 primary mouse submandibular salivary gland epithelial cell clusters, we investigated the requirement for mesenchymal cells and other factors in producing salivary organoids in culture. Native E16 salivary mesenchyme, but not NIH3T3 cells or mesenchymal cell conditioned medium, supported robust protein expression of …

Trends Of Parent-Adolescent Drug Talk Styles In Early Adolescence, Youngju Shin, Jonathan Pettigrew, Michelle Miller-Day, Michael L. Hecht, Janice L. Krieger

Communication Faculty Articles and Research

The present study seeks to understand how parents as prevention agents approach substance use prevention messages during the period of early adolescence. Students (N = 410) in a drug prevention trial completed surveys from 7th to 9th grade. Using longitudinal data, a series of latent transition analyses was conducted to identify major trends of parent–adolescent drug talk styles (i.e., never talked, situated direct, ongoing direct, situated indirect, and ongoing indirect) in control and treatment conditions. Findings demonstrate a developmental trend in drug talk styles toward a situated style of talk as youth transitioned from 7th grade to 9th grade. …

An Exome-Wide Sequencing Study Of Lipid Response To High-Fat Meal And Fenofibrate In Caucasians From The Goldn Cohort, Xin Geng, Marguerite R. Irvin, Bertha Hidalgo, Stella Aslibekyan, Vinodh Srinivasasainagendra, Ping An, Alexis C. Frazier-Wood, Hemant K. Tiwari, Tushar Dave, Kathleen Ryan, Jose M. Ordovas, Robert J. Straka, Mary F. Feitosa, Paul N. Hopkins, Ingrid Borecki, Michael A. Province, Braxton D. Mitchell, Donna K. Arnett, Degui Zhi

Epidemiology and Environmental Health Faculty Publications

Our understanding of genetic influences on the response of lipids to specific interventions is limited. In this study, we sought to elucidate effects of rare genetic variants on lipid response to a high-fat meal challenge and fenofibrate (FFB) therapy in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) cohort using an exome-wide sequencing-based association study. Our results showed that the rare coding variants in ITGA7, SIPA1L2, and CEP72 are significantly associated with fasting LDL cholesterol response to FFB (P = 1.24E-07), triglyceride postprandial area under the increase (AUI) (P = 2.31E-06), and triglyceride postprandial …

Differential Effects Of Parental “Drug Talk” Styles And Family Communication Environments On Adolescent Substance Use, Youngju Shin, Michelle Miller-Day, Michael L. Hecht

Communication Faculty Articles and Research

The current study examines the relationships among adolescent reports of parent–adolescent drug talk styles, family communication environments (e.g., expressiveness, structural traditionalism, and conflict avoidance), and adolescent substance use. ANCOVAs revealed that the 9th grade adolescents (N = 718) engaged in four styles of “drug talks” with parents (e.g., situated direct, ongoing direct, situated indirect, and ongoing indirect style) and these styles differed in their effect on adolescent substance use. Multiple regression analyses showed that expressiveness and structural traditionalism were negatively related to adolescent substance use, whereas conflict avoidance was positively associated with substance use. When controlling for family communication …

Halogenated Diarylacetylenes And Methods Of Treating Cancer, Vitaliy M. Sviripa, Wen Zhang, Chunming Liu, David S. Watt

Pharmaceutical Sciences Faculty Patents

Halogenated diarylacetylenes, e.g., diarylacetylenes having at least one halo substituent in one aryl ring and an amine in the opposing aryl ring, can inhibit the proliferation of LSI 74T colon cancer cells through the inhibition of c-myc and induction of the cyclin-dependent kinase inhibitor-I (i.e., p21(Wifl/Cipl)). Such compounds are useful as antineoplastic agents.

Hyperglycemia And Total Knee Arthroplasty Healing, Kristina Gresh

Nursing Capstones

No abstract provided.

Risk Scores-Medical Derivatives., Ronald S. Freudenberger Md

Department of Medicine

No abstract provided.

Emergence Of An Extensively Drug-Resistant Salmonella Enterica Serovar Typhi Clone Harboring A Promiscuous Plasmid Encoding Resistance To Fluoroquinolones And Third-Generation Cephalosporins, Rumina Hasan, Sadia Shakoor, Farah Naz Qamar, Dania Khalid Saeed, Ghazala Shaheen, Shahida Qureshi, Mohammad Tahir Yousafzai, Muhammad Khalid Salim, Zahra Hasan, Elizabeth J. Klemma, Andrew J. Page, Kim Judge, Vanessa K. Wong, Timothy J. Dallman, Satheesh Nair, Stephen Baker, Gordon Dougan

Department of Pathology and Laboratory Medicine

Antibiotic resistance is a major problem in Salmonella enterica serovar Typhi, the causative agent of typhoid. Multidrug-resistant (MDR) isolates are prevalent in parts of Asia and Africa and are often associated with the dominant H58 haplotype. Reduced susceptibility to fluoroquinolones is also widespread, and sporadic cases of resistance to third-generation cephalosporins or azithromycin have also been reported. Here, we report the first large-scale emergence and spread of a novel S. Typhi clone harboring resistance to three first-line drugs (chloramphenicol, ampicillin, and trimethoprim-sulfamethoxazole) as well as fluoroquinolones and third-generation cephalosporins in Sindh, Pakistan, which we classify as extensively drug resistant …

Acute Pressor Response To Psychosocial Stress Is Dependent On Endothelium‐Derived Endothelin‐1, Brandon M. Fox, Bryan K. Becker, Analia S. Loria, Kelly A. Hyndman, Chunhua Jin, Hannah Clark, Robin Johns, Masashi Yanagisawa, David M. Pollock, Jennifer S. Pollock

Pharmacology and Nutritional Sciences Faculty Publications

Background

Acute psychosocial stress provokes increases in circulating endothelin‐1 (ET‐1) levels in humans and animal models. However, key questions about the physiological function and cellular source of stress‐induced ET‐1 remain unanswered. We hypothesized that endothelium‐derived ET‐1 contributes to the acute pressor response to stress via activation of the endothelin A receptor.

Methods and Results

Adult male vascular endothelium‐specific ET‐1 knockout mice and control mice that were homozygous for the floxed allele were exposed to acute psychosocial stress in the form of cage switch stress (CSS), with blood pressure measured by telemetry. An acute pressor response was elicited by CSS in …

Notice Of 03-06-2018 Hsc Committee Meeting, Patrice Martin

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Exploring The Use Of The Timed Up And Go Test To Identify Patient Fall Risk In An Inpatient Geriatric Psychiatry Unit, Danielle Struble-Fitzsimmons

Seton Hall University Dissertations and Theses (ETDs)

Background: Patient falls during hospitalization influence healthcare costs and quality, and hospitals are mandated to complete fall risk assessments on all patients. Inpatient geriatric psychiatry units have the highest fall rates in the acute care setting, and most falls in this population occur during the mobility tasks of transfers and ambulation. The Timed Up and Go (TUG) test includes these two specific functional tasks, and has been used to predict falls in other geriatric populations, but has never been tested in an inpatient geriatric psychiatry unit. The purpose of this study was to determine if the TUG is a predictive …

Stigma Gets In My Way: Factors Affecting Client-Provider Communication Regarding Childbearing Among People Living With Hiv In Uganda., Jolly Beyeza-Kashesya, Rhoda K. Wanyenze, Kathy Goggin, Sarah Finocchario-Kessler, Mahlet Atakilt Woldetsadik, Deborah Mindry, Josephine Birungi, Glenn J. Wagner

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Many HIV-affected couples living in sub-Saharan Africa desire to have children, but few quantitative studies have examined support for their childbearing needs. Our study explored client-provider communication about childbearing and safer conception among HIV clients in Uganda.

METHODS: 400 Ugandan HIV clients in committed relationships and with intentions to conceive were surveyed. Knowledge, attitudes and practices related to childbearing, and use of safer conception methods were assessed, including communication with providers about childbearing needs, the correlates of which were examined with bivariate statistics and logistic multivariate analysis.

RESULTS: 75% of the sample was female; 61% were on antiretroviral therapy; …

Week Of February 20, 2018, New York Medical College

InTouch

• Biomedical Ethics Authority to Address the Class of 2018 at the 159th Commencement Exercises
• Doctor of Physical Therapy Program Hits The Mark Again...Twice
• Overseas Speech-Language Pathology Program Enriches Understanding of SLP in Other Cultures
• BioInc@NYMC Launches New Website

A Lin28b Tumor-Specific Transcript In Cancer, Weijie Guo, Zhixiang Hu, Yichao Bao, Yuchen Li, Shengli Li, Qiupeng Zheng, Dongbin Lyu, Di Chen, Tao Yu, Yan Li, Xiaodong Zhu, Jie Ding, Yingjun Zhao, Xianghuo He, Shenglin Huang

Markey Cancer Center Faculty Publications

The diversity and complexity of the cancer transcriptome may contain transcripts unique to the tumor environment. Here, we report a LIN28B variant, LIN28B-TST, which is specifically expressed in hepatocellular carcinoma (HCC) and many other cancer types. Expression of LIN28B-TST is associated with significantly poor prognosis in HCC patients. LIN28B-TST initiates from a de novo alternative transcription initiation site that harbors a strong promoter regulated by NFYA but not c-Myc. Demethylation of the LIN28B-TST promoter might be a prerequisite for its transcription and transcriptional regulation. LIN28B-TST encodes a protein isoform with additional N-terminal amino acids and is critical for cancer …

Mediating Effects Of Positive Thinking And Social Support On Suicide Resilience, Denise M. Matel-Anderson, Abir K. Bekhet, Mauricio Garnier-Villarreal

College of Nursing Faculty Research and Publications

Suicide has been the second leading cause of death for 18- to 24-year-olds in the United States since 2011. The stress experienced by undergraduate college students has the potential to increase one’s risk for suicide. Resilience theory was used as a theoretical framework to examine the interplay between risk and protective factors. A cross-sectional and correlational design was used to assess the mediating effects of positive thinking and/or social support on suicide resilience in 131 college students 18 to 24 years old who completed an online survey. The study found an indirect effect of self-esteem on suicide resilience through positive …

Pain Management: Time To Minimize Variations In Practice., Parag Bharadwaj, Brynn E Sheehan, Sunita Dodani, Charles F Von Gunten

Ambulatory and Primary Care Articles

There continue to be great variations in the management of pain in palliative care. Efforts need to be made within the field develop strategies to address this to avoid undue distress in patients.

Cyp2a6 Is Associated With Obesity: Studies In Human Samples And A High Fat Diet Mouse Model, Kesheng Wang, Xue Chen, Stephen C. Ward, Ying Liu, Youssoufou Ouedraogo, Chun Xu, Arthur I. Cederbaum, Yongke Lu

Health & Biomedical Sciences Faculty Publications

Background/objectives

CYP2A6 (CYP2A5 in mice) is mainly expressed in the liver. Hepatic CYP2A6 expression is increased in patients with non-alcoholic fatty liver disease (NAFLD). In mice, hepatic CYP2A5 is induced by high fat diet (HFD) feeding. Hepatic CYP2A5 is also increased in monosodium glutamate-induced obese mice. NAFLD is associated with obesity. In this study, we examined whether obesity is related to CYP2A6.

Subjects/methods

Obesity genetic association study: The SAGE is a comprehensive genome-wide association study (GWAS) with case subjects having a lifetime history of alcohol dependence and control subjects never addicted to alcohol. We used 1030 control individuals with self-reported …

Protein Kinase D1 Regulates Subcellular Localisation And Metastatic Function Of Metastasis-Associated Protein 1, Aditya Ganju, Subhash C. Chauhan, Bilal B. Hafeez, Kyle Doxtater, Manish Tripathi, Nadeem Zafar, Murali M. Yallapu, Rakesh Kumar, Meena Jaggi

School of Medicine Publications

Background: Cancer progression and metastasis is profoundly influenced by protein kinase D1 (PKD1) and metastasis-associated protein 1 (MTA1) in addition to other pathways. However, the nature of regulatory relationship between the PKD1 and MTA1, and its resulting impact on cancer metastasis remains unknown. Here we present evidence to establish that PKD1 is an upstream regulatory kinase of MTA1.

Methods: Protein and mRNA expression of MTA1 in PKD1-overexpressing cells were determined using western blotting and reverse-transcription quantitative real-time PCR. Immunoprecipitation and proximity ligation assay (PLA) were used to determine the interaction between PKD1 and MTA1. PKD1-mediated nucleo-cytoplasmic export and polyubiquitin-dependent proteosomal …

Genetic And Environmental (Physical Fitness And Sedentary Activity) Interaction Effects On Cardiometabolic Risk Factors In Mexican American Children And Adolescents, Rector Arya, Vidya S. Farook, Roy G. Resendez, Srinivas Mummidi, Laura Almasy, Joanne E. Curran, Christopher P. Jenkinson, John Blangero, Ravindranath Duggirala, Vincent P. Diego

School of Medicine Publications

Knowledge on genetic and environmental (G × E) interaction effects on cardiometabolic risk factors (CMRFs) in children is limited. The purpose of this study was to examine the impact of G × E interaction effects on CMRFs in Mexican American (MA) children (n = 617, ages 6–17 years). The environments examined were sedentary activity (SA), assessed by recalls from “yesterday” (SAy) and “usually” (SAu) and physical fitness (PF) assessed by Harvard PF scores (HPFS). CMRF data included body mass index (BMI), waist circumference (WC), fat mass (FM), fasting insulin (FI), homeostasis model of assessment—insulin resistance (HOMA‐IR), high‐density lipoprotein cholesterol …

Ada News - 02/19/2018, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

What's Happening: February 19, 2018, Maine Medical Center

What's Happening

No abstract provided.

Medical School Watercooler Newsletter - February 18, 2018, Lindsey Lyle

Watercooler Newsletter

This is the February 18, 2018 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Rescheduled: USA Health Advanced Practice Provider Quarterly Meeting
• Mark Your Calendar: Gulf Coast Acute Care Surgery Symposium
• William A. L. Mitchell Endowed Lectureship to Feature Dr. David Spain