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2018

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Articles 6541 - 6570 of 15442

Full-Text Articles in Medicine and Health Sciences

Development Of Blended Polymeric Fibers To Alter The Release Of Peptide Targeting Porphyromonas Gingivalis., Sonali Suresh Sapare May 2018

Development Of Blended Polymeric Fibers To Alter The Release Of Peptide Targeting Porphyromonas Gingivalis., Sonali Suresh Sapare

Electronic Theses and Dissertations

Periodontitis is a chronic inflammatory disease that infects the tissues of the periodontium. It is estimated that 47.2% or 67.2 million American adults suffer from mild, moderate and severe periodontitis. Globally, 30-50% of the adult population is afflicted with periodontal disease, making it one of the most prevalent infectious diseases in the world. Therapeutics targeting P. gingivalis may be effective to alter periodontitis progression. However, the current treatment modalities that target critical pathogens to maintain host-biofilm homeostasis are limited, urging the development of specifically targeted therapeutics to limit P. gingivalis recolonization of the oral cavity after periodontal treatment and healing. …

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Therapeutic Potential Of A Plant-Made Cholera Toxin B Subunit Variant For The Treatment Of Ulcerative Colitis., Joshua Mark Royal May 2018

Therapeutic Potential Of A Plant-Made Cholera Toxin B Subunit Variant For The Treatment Of Ulcerative Colitis., Joshua Mark Royal

Electronic Theses and Dissertations

Cholera toxin B subunit (CTB) is a mucosal immunomodulatory protein that induces robust mucosal and systemic antibody responses. This well-known biological activity has been exploited in cholera prevention (as a component of Dukoral® vaccine) and vaccine development for decades. On the other hand, several studies have investigated CTB’s immunotherapeutic potential in the treatment of inflammatory diseases such as Crohn’s disease and asthma. Furthermore, we recently found that a plant-made variant of CTB (CTBp) could induce colon epithelial wound healing in mouse colitis models. In this thesis, it is revealed that the wound healing effects are unique to the plant-made variant, …

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A Study Of Gpr3, Gpr6, Of Gpr12 As Novel Molecular Targets For Cannabidiol., Alyssa S. Laun May 2018

A Study Of Gpr3, Gpr6, Of Gpr12 As Novel Molecular Targets For Cannabidiol., Alyssa S. Laun

Electronic Theses and Dissertations

The G protein-coupled receptors 3, 6, and 12 (GPR3, GPR6, and GPR12) comprise a family of closely related orphan receptors with no confirmed endogenous ligands. These receptors are constitutively active, capable of signaling through G protein and non-G protein mediated mechanisms. These orphan receptors have previously been reported to play important roles in many normal physiological functions and to be involved in a variety of pathological conditions. Although they are orphans, GPR3, GPR6, and GPR12 are phylogenetically most closely related to the cannabinoid receptors. Using β-arrestin2 recruitment and cAMP accumulation assays, we have recently found that the non-psychoactive phytocannabinoid cannabidiol …

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The Effects Of Polychlorinated Biphenyls Exposure On Non-Alcoholic Fatty Liver Disease : Role Of Aryl Hydrocarbon Receptor., Hongxue Shi May 2018

The Effects Of Polychlorinated Biphenyls Exposure On Non-Alcoholic Fatty Liver Disease : Role Of Aryl Hydrocarbon Receptor., Hongxue Shi

Electronic Theses and Dissertations

Polychlorinated biphenyls (PCBs) are detectable in serum of 100% of adults in US, and has been associated with fatty liver disease in epidemiological studies. PCBs are classified as either dioxin-like (DL) or non-dioxin-like (NDL) PCB based on their ability to activate the aryl hydrocarbon receptor (AhR). We used exposures that reflect human bioaccumulation patterns, which resembles Aroclor 1260 with a low level of the DL-PCB, PCB 126. Our aim was to determine if this exposure will activate the human and mouse AhR and examine if receptor activation influences these steatotic responses due to PCB exposures. DL-PCBs exposure-induced AhR activation in …

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Inflammasome Independent Leukotriene-B4 Production Drives Crystalline Silica Induced Sterile Inflammation., Bindu Hegde May 2018

Inflammasome Independent Leukotriene-B4 Production Drives Crystalline Silica Induced Sterile Inflammation., Bindu Hegde

Electronic Theses and Dissertations

Silicosis is an irreversible lung inflammatory disease caused by chronic exposure to crystalline silica (CS) and is one of the most prevalent occupational diseases worldwide. Lipid chemoattractant Leukotriene B4 (LTB4) plays an important role in neutrophilic inflammation that drives silicosis and promotes lung cancer. Previous studies in our laboratory have demonstrated that CS-induced neutrophilic inflammation and lung tumor burden in K-rasLA1 mice is abrogated in the LTB4-receptor deficient mice. Another pathway whose importance is well studied in the progression of silicosis is the Nalp3 inflammasome pathway. Studies have shown inflammasome- dependent IL-1b to be …

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Nutritional Virulence Of Legionella Pneumophila., Ashley M. Best May 2018

Nutritional Virulence Of Legionella Pneumophila., Ashley M. Best

Electronic Theses and Dissertations

Legionella pneumophila is an environment organism that parasitizes a wide range of protozoa. Growth within the environmental host primes L. pneumophila for infection of human alveolar macrophages when contaminated aerosols are inhaled. Intracellular replication within either host requires the establishment a replicative niche, known as the Legionella-containing vacuole (LCV). Biogenesis of the LCV depends on the type IVb translocation system, the Dot/Icm, to translocation >320 effectors into the host cytosol. Effectors are responsible for preventing lysosome fusion to the LCV, recruitment of ER-derived vesicles to the LCV, and modulation of a plethora of host processes to promote the intracellular …

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Functional And Structural Impact Of The Loss Of The Leucine-Rich Repeat Protein Lrit1 In The Mouse Retina., Catherine Ann Cobb May 2018

Functional And Structural Impact Of The Loss Of The Leucine-Rich Repeat Protein Lrit1 In The Mouse Retina., Catherine Ann Cobb

Electronic Theses and Dissertations

Mutations in genes encoding the leucine-rich repeat (LRR) proteins nyctalopin and LRIT3 lead to complete congenital stationary night blindness because they are critical to depolarizing bipolar cell function in the retina. LRIT3 has two closely related family members, LRIT1 and LRIT2. In silico analyses of publicly available RNA-Seq data showed that Lrit1 was highly expressed in the retina. Here I describe the expression pattern and impact of loss of LRIT1 on retinal function. To enable these studies, we used CRISPR/Cas9 technology to create an Lrit1-/- mouse line. Retinal morphology and morphometry analyses showed no gross changes in retinal structure …

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Divergent Evolution Of Di-Lysine Er Retention Vs. Farnesylation Motif-Mediated Anchoring Of The Ankb Virulence Effector., John David Perpich May 2018

Divergent Evolution Of Di-Lysine Er Retention Vs. Farnesylation Motif-Mediated Anchoring Of The Ankb Virulence Effector., John David Perpich

Electronic Theses and Dissertations

Legionella pneumophila is an aquatic organism capable of intracellular replication within a wide range of protozoan hosts and within human macrophages where it causes Legionnaires’ Disease. L. pneumophila manipulates a variety of host cell processes by translocating, into the host cell cytosol, more than 300 effector proteins via the type IVB secretion system (T4SS). The AnkB effector from the AA100/130b strain (AnkB-AA100) contains a C-terminal CaaX motif that rapidly becomes farnesylated upon translocation into the host cell and anchored to the cytosolic face of the Legionella-containing vacuole (LCV) membrane, which is essential for intracellular replication. We show that a …

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A New Surgical Approach For O-C2 Fusion, Solving The Problem Of Dysphagia., M. Kathryn Mcclure May 2018

A New Surgical Approach For O-C2 Fusion, Solving The Problem Of Dysphagia., M. Kathryn Mcclure

Electronic Theses and Dissertations

The fusion of the second cervical vertebrae to the occipital bone (O-C2 fusion) for head stabilization can result in postoperative dysphagia and dyspnea, negatively impacting the patient’s quality of life. Currently, the O-C2 angle is used for head placement, which may not place the head neutrally. We hypothesize that aligning the external auditory meatus with midline of the C2 will reduce oropharyngeal stenosis, reducing dysphagia. One male patient with poor swallow quality of life who required a revision of a previous O-C2 surgery was evaluated via videofluoroscopy and completed the standard swallow quality of life questionnaire (SWAL-QOL) before and after …

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Designing Interactive Virtual Environments With Feedback In Health Applications., Yi Li May 2018

Designing Interactive Virtual Environments With Feedback In Health Applications., Yi Li

Electronic Theses and Dissertations

One of the most important factors to influence user experience in human-computer interaction is the user emotional reaction. Interactive environments including serious games that are responsive to user emotions improve their effectiveness and user satisfactions. Testing and training for user emotional competence is meaningful in healthcare field, which has motivated us to analyze immersive affective games using emotional feedbacks. In this dissertation, a systematic model of designing interactive environment is presented, which consists of three essential modules: affect modeling, affect recognition, and affect control. In order to collect data for analysis and construct these modules, a series of experiments were …

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Swallow And Breathing Coordination Following Suprahyoid Muscle Injury., Bradley Kimbel May 2018

Swallow And Breathing Coordination Following Suprahyoid Muscle Injury., Bradley Kimbel

Electronic Theses and Dissertations

Swallowing motility disorders (dysphagia) are a major complication following radiation treatment for head and neck cancer, affecting ~50% of those treated. One reason for this is that radiation causes muscle damage, provoking sensorimotor pathologies. Previous work has suggested that injury may cause discoordination between breathing and swallowing behaviors. We sought to determine if muscle injury provokes changes in this behavior. We hypothesized that acute suprahyoid muscle damage would alter cross-behavior excitability, causing destabilization of the respiratory-swallow pattern. Swallowing was evoked in anesthetized spontaneously breathing cats via injection of a 3cc bolus of water into the oropharyngeal cavity. A suprahyoid injury …

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Traumatic Brain Injury : Investigating Misconceptions Among Graduate Students In Physical Therapy, Occupational Therapy, And Speech-Language Pathology., Michael Frazure May 2018

Traumatic Brain Injury : Investigating Misconceptions Among Graduate Students In Physical Therapy, Occupational Therapy, And Speech-Language Pathology., Michael Frazure

Electronic Theses and Dissertations

This study utilized a convenience sample (n = 510) to investigate misconceptions of traumatic brain injury (TBI) among first and second year graduate students in physical therapy (PT), occupational therapy (OT), and speech-language pathology (SLP) training programs. Eighty-six-point-seven percent of participants were female, and 87.70% were white. All participants completed a survey comprised of items relating to general information about TBI, coma and unconsciousness, memory loss, recovery, and concussion. Descriptive and summary statistics indicated the persistence of misconceptions regarding coma and unconsciousness, memory loss, recovery, and concussion among graduate students in PT, OT, and SLP training programs. Group comparisons …

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Autism Spectrum Disorder : Investigating Predictive Diagnostic Relationships In Children Three Years-Of-Age And Younger., Kaitlin Juergensen May 2018

Autism Spectrum Disorder : Investigating Predictive Diagnostic Relationships In Children Three Years-Of-Age And Younger., Kaitlin Juergensen

Electronic Theses and Dissertations

Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder whose symptoms may involve deficits across three domains: communication, socialization, and atypical behaviors or interests. With a high prevalence across populations and a tendency to impact males more so than females, early and accurate diagnosis appears critical. The most current literature on ASD provides a myriad of difficulties associated with diagnosis under the age of three years. The purpose of this study was to determine if a predictive relationship exists between a child’s individual developmental domain standard deviation (SD) subscale scores (motor, language, cognitive, social-emotional, and adaptive skills) on the Bayley …

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Eye Gaze And Cortisol Levels In Socially Anxious Young Adults During An Interactive Real World Task, Chelsea M. Colson May 2018

Eye Gaze And Cortisol Levels In Socially Anxious Young Adults During An Interactive Real World Task, Chelsea M. Colson

Senior Honors Theses

Social anxiety is a disorder where people fear social interactions and is associated with physiological changes. Eye tracking studies have shown that people with social anxiety spent more time gazing at emotional faces presented on a computer screen and spent more time gazing at the eye region. There has been limited studies on tracking eye gaze in a real-life setting interacting with another person. We used a wearable eye tracker during a brief one-on-one interview about participants’ challenges faced at work or school. Along with self-report psychological measures about social anxiety and shyness, we also measured participants’ salivary cortisol as …

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Investigating Invasion In Ductal Carcinoma In Situ With To Pographical Single Cell Genome Sequencing, Anna Casasent, Anna Casasent May 2018

Investigating Invasion In Ductal Carcinoma In Situ With To Pographical Single Cell Genome Sequencing, Anna Casasent, Anna Casasent

Dissertations and Theses (Open Access)

Synchronous Ductal Carcinoma in situ (DCIS-IDC) is an early stage breast cancer invasion in which it is possible to delineate genomic evolution during invasion because of the presence of both in situ and invasive regions within the same sample. While laser capture microdissection studies of DCIS-IDC examined the relationship between the paired in situ (DCIS) and invasive (IDC) regions, these studies were either confounded by bulk tissue or limited to a small set of genes or markers. To overcome these challenges, we developed Topographic Single Cell Sequencing (TSCS), which combines laser-catapulting with single cell DNA sequencing to measure genomic copy …

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Ptsd And Dysfunctional Parenting: Emotional And Biological Mechanisms, Molly Franz May 2018

Ptsd And Dysfunctional Parenting: Emotional And Biological Mechanisms, Molly Franz

Department of Psychology: Dissertations, Theses, and Student Research

Women are disproportionately at risk for developing PTSD following exposure to trauma. Among its many harmful effects, PTSD is associated with a range of negative family outcomes, including impairments in parenting behaviors. Despite the prevalence of PTSD and its impact on parenting, little is known about the mechanisms responsible for this association. The present project addressed this gap by examining the impact of PTSD on dysfunctional parenting behaviors in a lab setting. Based on prior theory and empirical evidence, I expected that a diagnosis of PTSD would be associated with more dysfunctional parenting (i.e., harsh/overreactive and lax/permissive behaviors) during routine …

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กายวิภาคศาสตร์ในศตวรรษที่ 21, สิทธิศักดิ์ หรรษาเวก May 2018

กายวิภาคศาสตร์ในศตวรรษที่ 21, สิทธิศักดิ์ หรรษาเวก

Chulalongkorn Medical Journal

No abstract provided.

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รำลึกพระคุณ ศาสตราจารย์กิตติคุณ นายแพทย์บุญรักษ์ กาญจนะโภคิน, มีชัย ศรีใส May 2018

รำลึกพระคุณ ศาสตราจารย์กิตติคุณ นายแพทย์บุญรักษ์ กาญจนะโภคิน, มีชัย ศรีใส

Chulalongkorn Medical Journal

No abstract provided.

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Resistant Starch Isolated From Luem-Pua Glutinous Rice Decreases Adipocyte Size Of Visceral Fat And Thickness Of Thoracic Aorta In High-Fat Diet-Fed Rats, Siwaporn Praman, Arunothai Wanta, Thaneeya Hawiset, Natthiya Sakulsak, Siam Popluechai, Keerakarn Somsuan May 2018

Resistant Starch Isolated From Luem-Pua Glutinous Rice Decreases Adipocyte Size Of Visceral Fat And Thickness Of Thoracic Aorta In High-Fat Diet-Fed Rats, Siwaporn Praman, Arunothai Wanta, Thaneeya Hawiset, Natthiya Sakulsak, Siam Popluechai, Keerakarn Somsuan

Chulalongkorn Medical Journal

Background : Luem-Pua glutinous rice has been reported to contain a high content ofresistant starch (RS). Previous studies showed weight loss, decreasedblood glucose and lipid profiles levels, as well as decreased hyperplasiaand hypertrophy of adipocytes in RS treatment. However, the study ofprotective effects of RS isolated from Luem-Pua glutinous rice on obesityis still needed to provide supportive information for potential use as dietarysupplements or development of therapeutic agents for the treatment obesity.Objective : We aimed to investigate the effects of RS isolated from Luem-Pua glutinousrice on body weight and visceral fat weight, blood parameters, histologicalchanges of visceral fat and thoracic …

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Antioxidant Effects Of Unpolished Sung-Yod Sticky Rice On Prevention Of Ethylene Glycol-Induced Renal Pathology In Rats, Tistaya Semangoen, Witoon Khawsuk, Nattapon Simanon, Thararat Soiphet, Wirunwat Homjai, Buntita Boonchaleaw, Pornchanok Seangchan, Parinyaporn Nuurai May 2018

Antioxidant Effects Of Unpolished Sung-Yod Sticky Rice On Prevention Of Ethylene Glycol-Induced Renal Pathology In Rats, Tistaya Semangoen, Witoon Khawsuk, Nattapon Simanon, Thararat Soiphet, Wirunwat Homjai, Buntita Boonchaleaw, Pornchanok Seangchan, Parinyaporn Nuurai

Chulalongkorn Medical Journal

Background : Kidney stone is a chronic disease that is found worldwide. The highprevalence of the kidney stone in Thailand observed in the northeasternpart which was about 16.9%. The pathogenesis of calcium oxalate stoneformation originated from crystallization of calcium and oxalate ions in renaltubular fluid, overgrowth, aggregation and adhesion to renal epithelial cells.The adhesion of CaOx crystals to renal tubular cell is a critical step ofkidney stone formation. It can cause increased oxidative stress and resultin the renal tubular cells damage. Studying in natural products may be analternative way to prevent the pathogenesis of stone formation.Objective : To study the …

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Spinal Capillary Changes In Streptozotocin-Induced Diabetic Rats, Kanokporn Plaengrit, Sirinush Sricharoenvej, Passara Lanlua May 2018

Spinal Capillary Changes In Streptozotocin-Induced Diabetic Rats, Kanokporn Plaengrit, Sirinush Sricharoenvej, Passara Lanlua

Chulalongkorn Medical Journal

Background : Diabetic microangiopathy strongly associates with the developing complication of the nervous system, as in the spinal cord. The developments of spinal cord infarction, which is relevant to physical mobility impairment and loss of sensation in diabetic patients, have been reported. Thus, an insight investigation on spinal microvascular changes needed to be concentrated.Objective : This study aimed to investigate the alterations of spinal capillaries in streptozotocin (STZ)-induced diabetic rats by using light microscopy (LM) and transmission electron microscopy (TEM).Methods : Seventeen male Sprague-Dawley rats, 200 - 270 g, 5-8 weeks, were used. The animals were divided into two groups, …

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Inhibitory Effect Of Rhinacanthus Nasutus (L.) Kurz Leaf Extract On Melanogenesis In B16f10 Melanoma Cells, Benjamart Pratoomthai, Warachin Gangnonngiw, Jarinyaporn Naowaboot, Thanitsara Songtavisin May 2018

Inhibitory Effect Of Rhinacanthus Nasutus (L.) Kurz Leaf Extract On Melanogenesis In B16f10 Melanoma Cells, Benjamart Pratoomthai, Warachin Gangnonngiw, Jarinyaporn Naowaboot, Thanitsara Songtavisin

Chulalongkorn Medical Journal

Background : A previous study on the inhibitory effects of Rhinacanthus nasutus (L.)Kurz leaf ethanol extract on mushroom tyrosinase activity indicated that itcontains anti-melanogenesis properties. However, other solvents especiallywater had not been investigated with regards to their use as a skin whiteningagent.Objective : To investigate the inhibitory effect R. nasutus leaf water extract onmelanogenesis in B16F10 melanoma cells.Methods R. nasutus leaf was extracted with water and a determined amount ofthe phenolic and flavonoid contents by using Folin-Ciocalteu and aluminiumchloride colorimetric assay, respectively. The toxicity of R. nasutus leafextract in B16F10 melanoma cells was tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Its …

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Abnormalities Of Liver Cells In Streptozotocin Induced Diabetic Rats, Jitnapar Thongleart, Sureepon Nakaung, Sutisa Nudmamud-Thanoi, Samur Thanoi May 2018

Abnormalities Of Liver Cells In Streptozotocin Induced Diabetic Rats, Jitnapar Thongleart, Sureepon Nakaung, Sutisa Nudmamud-Thanoi, Samur Thanoi

Chulalongkorn Medical Journal

Background : Diabetes is a major health problem that affects population worldwide. Prevalence of diabetes in Thai population dramatically increases every year. Diabetes mellitus can cause structural changes and dysfunctions of the liver cells as well as affecting the pathway of protein synthesizes in the liver associated with DNA synthesis.Objective : This study aimed to evaluate structural changes and protein and DNA contents in liver cell (hepatocyte) of diabetic rats.Methods : Ma le Sprague Dawley rats induced diabetes by receiving streptozotocin (STZ) were studied for histopathology by Hematoxylin & Eosin staining and counted by ImageJ program. Studies of protein damage …

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Correlation Between Serotonin Receptor 5ht3a And Serotonin Transporter Expression In The Gastric Glands And Symptoms Of Patients With Functional Dyspepsia, Kanmanee Kaewklin, Wiroj Chonsungnoen, Sutisa Nudmamud-Thanoi, Samur Thanoi May 2018

Correlation Between Serotonin Receptor 5ht3a And Serotonin Transporter Expression In The Gastric Glands And Symptoms Of Patients With Functional Dyspepsia, Kanmanee Kaewklin, Wiroj Chonsungnoen, Sutisa Nudmamud-Thanoi, Samur Thanoi

Chulalongkorn Medical Journal

Background : Functional dyspepsia (FD) is one of the most common syndrome of gastrointestinal disorders. The sensation of pain or burning of the epigastrium including postprandial fullness and early satiation are the symptoms of FD,which were defined by ROME III criteria. Several factors have been suggested as the causes of FD including the functions of serotonin neurotransmission which has currently been featured in this study.Objective : The purpose of this study was to determine the association between the expression of 5HT3A receptor and serotonin transporter on gastric gland cells in patients with FD.Methods : Small pieces of the fundus, body …

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Shotgun Proteomics Analysis Of Protein Responding To Methamphetamine Addiction In Rat Cerebellum, Oranee Ritsayong, Sri-Arun Iamjan, Sittiruk Roytrakul, Samur Thanoi, Sutisa Nudmamud-Thanoi May 2018

Shotgun Proteomics Analysis Of Protein Responding To Methamphetamine Addiction In Rat Cerebellum, Oranee Ritsayong, Sri-Arun Iamjan, Sittiruk Roytrakul, Samur Thanoi, Sutisa Nudmamud-Thanoi

Chulalongkorn Medical Journal

Background : Methamphetamine (METH) is an addictive psychostimulant drug that induces damages several regions of the brain, including the cerebellum. METH can induce some proteins changes in synaptic neurotransmission and signal transduction underlying the mechanism of drug addiction in several brain regions such as the striatum, hippocampus and nucleus accumbens. Nevertheless, few studies have examined the effects of METH in the cerebellum.Objective : The aim of the current study was to investigate changes in the synaptic neurotransmission and signal transduction protein expression in rat cerebellum following METH exposure using proteomics technique.Methods : Male Sprague-Dawley rats were treated with an escalating …

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Evaluating The Relationship Between Empathy And Motivation For Medical Education In Medical Student At The Faculty Of Medicine Vajira Hospital, Benjamart Pratoomthai, Thirawass Phumyoo, Bongkoch Turathum, Waranya Imprasittichai, Gun Anantasomboon, Kanokporn Chayaburakul May 2018

Evaluating The Relationship Between Empathy And Motivation For Medical Education In Medical Student At The Faculty Of Medicine Vajira Hospital, Benjamart Pratoomthai, Thirawass Phumyoo, Bongkoch Turathum, Waranya Imprasittichai, Gun Anantasomboon, Kanokporn Chayaburakul

Chulalongkorn Medical Journal

Background : Empathy is considered as a crucial part of a doctor’s profession thatshould be mastered by medical graduates. Recently, however, many studiesreported the medical students’ empathy declines during their time atmedical school. Thus, the development of empathy in the period of formaleducation is essential. The involvement of factor such as motivation formedical education might play a role in the development of empathy.Objective : To evaluate the relationship between empathy and motivation for medicaleducation among medical students.Methods : This descriptive prospective study was conducted regarding first to fifthyear medical students of the Faculty of Medicine Vajira Hospital, Thailand(n = 215). …

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Is Surface Anatomy Needed For Registered Nurses In Bali?, Pisit Poltana, I Made Sundayana, Paradorn Yingyoud, Supranee Pholtana, I Dewa Ayu Rismayanti, Ni Nyoman Ari Ratnadi, Napadon Leaudnakrob, Supawadee Chaidechatorn May 2018

Is Surface Anatomy Needed For Registered Nurses In Bali?, Pisit Poltana, I Made Sundayana, Paradorn Yingyoud, Supranee Pholtana, I Dewa Ayu Rismayanti, Ni Nyoman Ari Ratnadi, Napadon Leaudnakrob, Supawadee Chaidechatorn

Chulalongkorn Medical Journal

Background : Surface anatomy is important for implementation of health promotion, prevention, curation, and rehabilitation in clinical nursing practice.Objective : To in-depth interview based on self reports for applying surface anatomy of registered nurses in Bali.Methods : The 41 registered nurses from the public hospitals and educational institutions in Buleleng Regency, Bali, Indonesia. The samples were recruited according to criteria, including Bachelor degree of Nursing from the same institution and also curriculum consist of anatomy in the topic of surface anatomy, working in the hospitals and educational institutions throughout Bali, Indonesia, in March - May 2017. In-depth interview based on …

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Histological Assessment Of Liver Cells In Methamphetamine-Induced Rats, Plaiyfah Janthueng, Sri-Arun Iamjan, Samur Thanoi, Sutisa Nudmamud-Thanoi May 2018

Histological Assessment Of Liver Cells In Methamphetamine-Induced Rats, Plaiyfah Janthueng, Sri-Arun Iamjan, Samur Thanoi, Sutisa Nudmamud-Thanoi

Chulalongkorn Medical Journal

Background : Methamphetamine (METH) is a highly addictive psychostimulant drug which can distribute and toxic to multiple organs including liver. There have been reported that methamphetamine increase glycogen storage,mitochondrial aggregation and microvascular lipid, on the other hand, decrease total protein and glutathione peroxidase in the liver.Objectives : This study aimed to investigate morphological changes as well as the changes of protein and DNA contents in the liver cell (hepatocyte) in the liver of methamphetamine-induced male rat.Methods : Male Sprague-Dawley rats induced addiction by receiving methamphetamine was studied for morphological changes in the liver cells by Hematoxylin and Eosin staining. Study …

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Expression Of Recombinant Major Surface Protein 5 Of Anaplasma Marginale (A. Marginale) At Different Temperatures, Amaya Watthanadirek, Thunyaporn Doungdaolek, Preeyaporn Koedrith, Panat Anuracpreeda May 2018

Expression Of Recombinant Major Surface Protein 5 Of Anaplasma Marginale (A. Marginale) At Different Temperatures, Amaya Watthanadirek, Thunyaporn Doungdaolek, Preeyaporn Koedrith, Panat Anuracpreeda

Chulalongkorn Medical Journal

Background : Bovine anaplasmosis is an important tick-borne disease caused byAnaplasma marginale (A. marginale) and infected in ruminants, mostly incattle. This disease occurs in tropical and subtropical regions includingThailand and causes a major problem to livestock productions. The majorsurface protein 5 (MSP5) is one of outer membrane protein of A. marginalewhich as an immunodominant protein encoded by a single gene and alsohighly conserved gene.Objective : The aim of this study was to optimize the conditions for the expression ofrecombinant major surface protein 5 (rMSP5) of A. marginale.Methods : The msp5 gene of A. marginale was cloned into the pET100/D-TOPO®vector to …

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แนวโน้มความเพียงพอของร่างอาจารย์ใหญ่เพื่อสนับสนุนการศึกษาทางมหกายวิภาคศาสตร์ของมหาวิทยาลัยนเรศวร, รุ่งรัตน์ ฉันทพานิช, รัชนี ชนะสงค์, เทวรัตน์ คุ้มจันทึก, พงษ์พิทักษ์ ภูติวัตร์, ณัฐธิยา สกุลศักดิ์ May 2018

แนวโน้มความเพียงพอของร่างอาจารย์ใหญ่เพื่อสนับสนุนการศึกษาทางมหกายวิภาคศาสตร์ของมหาวิทยาลัยนเรศวร, รุ่งรัตน์ ฉันทพานิช, รัชนี ชนะสงค์, เทวรัตน์ คุ้มจันทึก, พงษ์พิทักษ์ ภูติวัตร์, ณัฐธิยา สกุลศักดิ์

Chulalongkorn Medical Journal

เหตุผลของการทำวิจัย : หน่วยรับบริจาคร่างกาย ภาควิชากายวิภาคศาสตร์ คณะวิทยาศาสตร์การแพทย์ มหาวิทยาลัยนเรศวร มีหน้าที่รับผิดชอบเกี่ยวกับการบริหารจัดการร่างอาจารย์ใหญ่เพื่อสนับสนุนการเรียนมหกายวิภาคศาสตร์วัตถุประสงค์ : เพื่อให้ได้ข้อมูลที่นำไปสู่การวางแผนให้มีร่างอาจารย์ใหญ่ที่เพียงพอต่อการจัดการเรียนการสอนล่วงหน้าอย่างน้อยอีก 5 ปีวิธีการทำวิจัย : คณะผู้วิจัยได้ทำการรวบรวมและวิเคราะห์ข้อมูลย้อนหลังในระยะ 15 ปี(พ.ศ. 2544 - 2558) โดยเก็บข้อมูลแบบรายปีและสะสมของจำนวนผู้บริจาคร่างกาย จำนวนอาจารย์ใหญ่ที่เสียชีวิตจริงและจำนวนอาจารย์ใหญ่ที่นำมาใช้ในการเรียนการสอนจริง ทำการวิเคราะห์ข้อมูลทางสถิติแบบร้อยละและวิเคราะห์การถดถอยผลการศึกษา : ผลการศึกษาพบว่าในช่วง 15 ปีย้อนหลัง มีจำนวนผู้บริจาคร่างกายทั้งสิ้น 24,476 ราย ในจำนวนนี้ส่วนมากเป็นเพศหญิง คิดเป็นร้อยละ 60.88และร้อยละ 50.7 มีอายุในช่วง 41 - 60 ปี โดยจำนวนผู้บริจาคร่างกายมีแนวโน้มเพิ่มขึ้นทุกปี ซึ่งมีค่าเพิ่มขึ้นคิดเป็น 37.5 เท่าในระยะเวลา15 ปี อย่างไรก็ตามจำนวนอาจารย์ใหญ่ที่เสียชีวิตจริงมีจำนวน 1,174 รายโดยในจำนวนนี้ ร้อยละ 52.2 เสียชีวิตในช่วงอายุ 61 - 80 ปี ซึ่งคิดเป็นอัตราการเสียชีวิตโดยเฉลี่ยร้อยละ 2 - 6 ต่อปี เมื่อคำนวณสัดส่วนค่าเฉลี่ยสะสมของจำนวนผู้บริจาคร่างกาย : จำนวนอาจารย์ใหญ่ที่เสียชีวิตจริง : จำนวนอาจารย์ใหญ่ที่นำมาใช้ในการเรียนการสอนจริงมีค่าเท่ากับ 30.6 : 1.2 : 1 ราย จากสัดส่วนนี้ สามารถคาดการณ์ได้ว่าในอนาคตช่วงปี พ.ศ. 2559 -2563 จะมีร่างอาจารย์ใหญ่ที่คาดว่าจะเสียชีวิตทั้งสิ้น จำนวน 956 ราย และคาดว่าจะใช้ในการเรียนการสอนจริงจำนวน 275 ราย (55 รายต่อปี) หรือคิดเป็นร้อยละ 28.77 และคาดว่าจะมีร่างอาจารย์ใหญ่สำรองอยู่ประมาณ 681 รายสรุป : ดังนั้นการศึกษาครั้งนี้ทำให้ทราบว่าในอนาคตอีก 5 ปี หน่วยรับบริจาคร่างกายจะมีจำนวนร่างอาจารย์ใหญ่ที่เพียงพอต่อการจัดการเรียนสอนทางมหกายวิภาคศาสตร์ตามปกติอย่างแน่นอน อีกทั้งยังมีจำนวนที่เพียงพอสำหรับรองรับการเรียนการสอนที่อาจเพิ่มมากขึ้นในอนาคต.

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