Medicine and Health Sciences Commons^™

Uncovering The Wisdom Hidden Between The Lines: The Collaborative Reflexive Deliberative Approach., Benjamin F. Crabtree Phd, William L. Miller Md, Ma, Jane M. Gunn Mbbs, Phd Fracgp, William E. Hogg Md, Cathie M. Scott Phd, Jean-Frédéric Levesque Md, Phd, Frcp, Mark F. Harris Mbbs, Md, Sabrina M. Chase Phd, Jenny R. Advocat Phd, Lisa M. Halma Ma, Grant M. Russell Mbbs, Phd, Fracgp

Department of Family Medicine

Background: Meta-analysis and meta-synthesis have been developed to synthesize results across published studies; however, they are still largely grounded in what is already published, missing the tacit 'between the lines' knowledge generated during many research projects that are not intrinsic to the main objectives of studies.

Objective: To develop a novel approach to expand and deepen meta-syntheses using researchers' experience, tacit knowledge and relevant unpublished materials.

Methods: We established new collaborations among primary health care researchers from different contexts based on common interests in reforming primary care service delivery and a diversity of perspectives. Over 2 years, the team met …

Determining Success Or Failure After Foot And Ankle Surgery Using Patient Acceptable Symptom State (Pass) And Patient Reported Outcome Information System (Promis), Michael R. Anderson, Judith F. Baumhauer, Benedict F. Digiovanni, Sam Flemister, John P. Ketz, Irvin Oh, Jeff Houck

Faculty Publications - College of Physical Therapy

Background: As the role of generic patient-reported outcomes (PROs) expands, important questions remain about their interpretation. In particular, how the Patient Reported Outcome Measurement Instrumentation System (PROMIS) t score values correlate with the patients’ perception of success or failure (S/F) of their surgery is unknown. The purposes of this study were to characterize the association of PROMIS t scores, the patients’ perception of their symptoms (patient acceptable symptom state [PASS]), and determination of S/F after surgery.

Methods: This retrospective cohort study contacted patients after the 4 most common foot and ankle surgeries at a tertiary academic medical center (n = …

Fungal Endophytes In A Seed-Free Host: New Species That Demonstrate Unique Community Dynamics, Brett Steven Younginger

Dissertations and Theses

Fungal endophytes are highly diverse, cryptic plant endosymbionts that form asymptomatic infections within host tissue. They represent a large fraction of the millions of undescribed fungal taxa on our planet with some demonstrating mutualistic benefits to their hosts including herbivore and pathogen defense and abiotic stress tolerance. Other endophytes are latent saprotrophs or pathogens, awaiting host plant senescence to begin alternative stages of their life cycles. Most, however, are likely plant commensals with no observable benefits to their hosts while under study. Yet, when considering the context-dependence that may determine plant resistance to pathogen attack, the consortium of endophytes present …

Exploring The Association Of Victimization And Alcohol And Marijuana Use Among American Indian Youth Living On Or Near Reservations: A Mixed Methods Study, Lindsay Nicole Merritt

Dissertations and Theses

Adolescent substance use research has yet to consider victimization as a potential risk factor contributing to alcohol and marijuana use among American Indian youth living on or near reservations, despite the presence of traumatic experiences, childhood adverse events, racism, and discrimination. Contribution to this lack of attention may be due to little being known about American Indian youth victimization. Even less is known about its association with alcohol and marijuana use in general and for those youth living on or near reservations in particular.

This study utilizes mixed methods with a nationally representative sample of American Indian youth living on …

Cordycepin Induces Apoptosis Of Human Ovarian Cancer Cells By Inhibiting Ccl5-Mediated Akt/Nf-Κb Signaling Pathway, Zhen Yang Cui, Soo Jung Park, Eunbi Jo, In-Hu Hwang, Kyung-Bok Lee, Sung-Woo Kim, Dae Joon Kim, Jong Chun Joo, Seok Hoon Hong, Min-Goo Lee, Ik-Soon Jang

School of Medicine Publications

The chemokine, CCL5, is a key mediator for the recruitment of immune cells into tumors and tissues. Akt/NF-κB signaling is significantly activated by CCL5. However, the role of NF-κB inactivation in apoptosis induced by negative regulation of CCL5 remains unclear. Here, we analyzed the effect of cordycepin on NF-κB activity in SKOV-3 cells and found that cordycepin-mediated inhibition of NF-κB signaling induced apoptosis in SKOV-3 cells via the serial activation of caspases. In addition, immune-blotting analysis showed that CCL5 is highly expressed in SKOV-3 cells. In addition to activating caspases, we show that, cordycepin prevents TNF-α-induced increase in CCL5, Akt, …

A Metabolomic Approach To Diagnosing Prosthetic Joint Infection, Victor Borza, Christian A. Rees, Douglas W. Van Citters, Jane E. Hill

Wetterhahn Science Symposium Posters 2018

No abstract provided.

Identifying A Test To Monitor Weightlifting Performance In Competitive Male And Female Weightlifters, S. Kyle Travis, Jacob R. Goodin, George K. Beckham, Caleb D. Bazyler

ETSU Faculty Works

Monitoring tests are commonly used to assess weightlifter’s preparedness for competition. Although various monitoring tests have been used, it is not clear which test is the strongest indicator of weightlifting performance. Therefore, the purpose of this study was to (1) determine the relationships between vertical jump, isometric mid-thigh pull (IMTP) and weightlifting performance; and (2) compare vertical jumps to IMTP as monitoring tests of weightlifting performance in a large cohort of male and female weightlifters. Methods: Fifty-two competitive weightlifters (31 males, 21 females) participated in squat and countermovement jump testing (SJ, CMJ), and IMTP testing performed on force plates. All …

Visualizing Mutation-Specific Differences In The Trafficking-Deficient Phenotype Of Kv11.1 Proteins Linked To Long Qt Syndrome Type 2, Allison R. Hall, Corey L. Anderson, Jennifer L. Smith, Tooraj Mirshahi, Samy-Claude Elayi, Craig T. January, Brian P. Delisle

Physiology Faculty Publications

KCNH2 encodes the Kv11.1 α-subunit that underlies the rapidly activating delayed-rectifier K⁺ current in the heart. Loss-of-function KCNH2 mutations cause long QT syndrome type 2 (LQT2), and most LQT2-linked missense mutations inhibit the trafficking of Kv11.1 channel protein to the cell surface membrane. Several trafficking-deficient LQT2 mutations (e.g., G601S) generate Kv11.1 proteins that are sequestered in a microtubule-dependent quality control (QC) compartment in the transitional endoplasmic reticulum (ER). We tested the hypothesis that the QC mechanisms that regulate LQT2-linked Kv11.1 protein trafficking are mutation-specific. Confocal imaging analyses of HEK293 cells stably expressing the trafficking-deficient LQT2 mutation F805C showed that, …

Understanding The Factors Influencing The Perception Of Organizational Sustainability Among Healthcare Professionals (Hcps) Post The Patient Protection And Affordable Care Act, Funso A. Olufade

Seton Hall University Dissertations and Theses (ETDs)

Background and Purpose of the Study: Healthcare costs in the United States has continued to increase annually, and new policy's attempt at protocol changes in healthcare practices does not ensure quality care delivery. An example of these policies include provisions and new guidelines under the 2010 healthcare legislation, - The Patient Protection and Affordable Care Act (ACA). The premise with the Affordable Care Act (ACA) is increased healthcare access for patients. However, not responsibly balancing the increased demand with the escalating cost of care creates an unsustainable system (Department of Health & Human Services, 2015). Healthcare organizations, including hospitals …

Oxygen Consumption In Sepsis, Julie Graham

Dissertations

Background: Sepsis is a life-threatening condition that can lead to septic shock and death. With over 300,000 annual cases (AHRQ, 2011) costing a staggering $1.5 billion (Health Care Utilization Project Brief #185), the importance of sepsis is becoming clear. However, some basic biological mechanisms are poorly understood. Study Purpose: This study investigated the relationships between select demographics, resting energy expenditure (REE), serum lactate, SOFA score mortality index, oxygen consumption [by way of measuring net oxygen consumed, (V02) and net carbon dioxide produced (VC02)], and sepsis. Specific Aims: Aims were to describe 1) patient demographics, serum lactate, SOFA score mortality index, …

Admission Eeg Findings In Diverse Paediatric Cerebral Malaria Populations Predict Outcomes., Douglas G Postels, Xiaoting Wu, Chenxi Li, Peter W Kaplan, Karl B Seydel, Terrie E Taylor, Youssef A Kousa, Richard Idro, Robert Opoka, Chandy C John, Gretchen L Birbeck

Pediatrics Faculty Publications

BACKGROUND: Electroencephalography at hospital presentation may offer important insights regarding prognosis that can inform understanding of cerebral malaria (CM) pathophysiology and potentially guide patient selection and risk stratification for future clinical trials. Electroencephalogram (EEG) findings in children with CM in Uganda and Malawi were compared and associations between admission EEG findings and outcome across this diverse population were assessed. Demographic, clinical and admission EEG data from Ugandan and Malawian children admitted from 2009 to 2012 with CM were gathered, and survivors assessed for neurological abnormalities at discharge.

RESULTS: 281 children were enrolled (Uganda n = 122, Malawi n = 159). …

A Small Molecule P53 Activator Attenuates Fanconi Anemia Leukemic Stem Cell Proliferation, Wei Du, Xiaoli Li, Andrew F. Wilson, Qishen Pang

Clinical and Translational Science Institute

Although p53 mutations are common in solid tumors, such mutations are found at a lower frequency in hematologic malignancies. In the genetic disorder Fanconi anemia (FA), p53 has been proposed as an important pathophysiological factor for two important hematologic hallmarks of the disease: bone marrow failure and leukemogenesis. Here we show that low levels of the p53 protein enhance the capacity of leukemic stem cells from FA patients to repopulate immunodeficient mice. Furthermore, boosting p53 protein levels with the use of the small molecule Nutlin-3 reduced leukemia burden in recipient mice. These results demonstrate that the level of p53 protein …

Method Overtness, Forensic Autopsy, And The Evidentiary Suicide Note: A Multilevel National Violent Death Reporting System Analysis, Ian R. H. Rockett, Eric D. Caine, Steven Stack, Hilary S. Connery, Kurt B. Nolte, Christa L. Lilly, Ted R. Miller, Lewis S. Nelson, Sandra L. Putnam, Paul S. Nestadt, Haomiao Jia

Clinical and Translational Science Institute

Objective Higher prevalence of suicide notes could signify more conservatism in accounting and greater proneness to undercounting of suicide by method. We tested two hypotheses: (1) an evidentiary suicide note is more likely to accompany suicides by drug-intoxication and by other poisoning, as less violent and less forensically overt methods, than suicides by firearm and hanging/suffocation; and (2) performance of a forensic autopsy attenuates any observed association between overtness of method and the reported presence of a note. Methods This multilevel (individual/county), multivariable analysis employed a generalized linear mixed model (GLMM). Representing the 17 states participating in the United States …

Cross-Cultural E-Learning Between Cypriot And American Occupational Therapy Students: A Pilot Study, Kayla Collins, Pavlina Psychoili, Mary Zadnik

Occupational Therapy Collection

Rationale: Culturally competent practice is necessary for occupational therapists (OT) working with clients from different backgrounds, values, and beliefs. Developing sustainable methods for providing students with cross-cultural experiences reinforces a global understanding of the profession and broadens students’ views of clinical practice.

Objectives: Investigate potential benefits of cross-cultural collaborations for student learning. Identify facilitators and barriers of cross-cultural educational collaborations for development of curriculums that give students opportunities to evaluate cultural variations in occupation.

Approach: This pilot study will be implemented in phases, the first of which has been completed. OT students from the European University of Cyprus and the …

Integrating A Behavioral Activation Approach Within Occupation-Based Intervention To Reduce Depression In Older Adults With Low Vision, Tracey Vause-Earland, Phd, Otr/L, Catherine Verrier Piersol, Phd, Otr/L, Faota

Department of Occupational Therapy Posters and Presentations

No abstract provided.

A Rare Case Of Diffuse Alveolar Hemorrhage Secondary To Dabigatran Successfully Treated With Extracorporeal Membrane Oxygenation, C. Hutchinson, F. M. West, H. Hirose

Department of Medicine Posters

Introduction

Dabigatran, a direct thrombin inhibitor, is used for stroke risk reduction in non-valvular atrial fibrillation and for treatment and prevention of venous thromboembolism. Minor side effects include indigestion and stomach pain. Major life threatening bleeding occurs in up to 2% of patients and is largely attributed to gastrointestinal hemorrhage. Here, we describe a case of a dabigatran related diffuse alveolar hemorrhage (DAH) treated successfully with extracorporeal membrane oxygenation.

Novel Tnf Receptor-1 Inhibitors Identified As Potential Therapeutic Candidates For Traumatic Brain Injury, Rachel K. Rowe, Jordan L. Harrison, Hongtao Zhang, Adam D. Bachstetter, David P. Hesson, Bruce F. O'Hara, Mark I. Greene, Jonathan Lifshitz

Sanders-Brown Center on Aging Faculty Publications

Background: Traumatic brain injury (TBI) begins with the application of mechanical force to the head or brain, which initiates systemic and cellular processes that are hallmarks of the disease. The pathological cascade of secondary injury processes, including inflammation, can exacerbate brain injury-induced morbidities and thus represents a plausible target for pharmaceutical therapies. We have pioneered research on post-traumatic sleep, identifying that injury-induced sleep lasting for 6 h in brain-injured mice coincides with increased cortical levels of inflammatory cytokines, including tumor necrosis factor (TNF). Here, we apply post-traumatic sleep as a physiological bio-indicator of inflammation. We hypothesized the efficacy of novel …

Continue, Adjust, Or Stop Antipsychotic Medication: Developing And User Testing An Encounter Decision Aid For People With First-Episode And Long-Term Psychosis, Yaara Zisman-Ilani, David Shern, Patricia Deegan, Julie Kreyenbuhl, Lisa Dixon, Robert Drake, William Torrey, Manish Mishra, Ksenia Gorbenko, Glyn Elwyn

Dartmouth Scholarship

Background:

People with psychosis struggle with decisions about their use of antipsychotics. They often want to reduce the dose or stop, while facing uncertainty regarding the effects these decisions will have on their treatment and recovery. They may also fear raising this issue with clinicians. The purpose of this study was to develop and test a shared decision making (SDM) tool to support patients and clinicians in making decisions about antipsychotics.

Methods:

A diverse editorial research team developed an Encounter Decision Aid (EDA) for patients and clinicians to use as part of the psychiatric consultation. The EDA was tested using …

Temporal Arteritis Presenting As An Isolated Bilateral Abducens Nerve Palsy: A Rare Case Of A 65-Year-Old Male, Abhishek Lunagariya, Chintan Rupareliya, Pradeep C. Bollu, Zabeen Mahuwala

Neurology Faculty Publications

Giant cell arteritis (GCA) or temporal arteritis (TA) is a granulomatous inflammation of medium to large-sized arteries. It may have a diverse presentation. The most common presenting symptoms of GCA are fever, malaise, unilateral headache, jaw claudication, polymyalgia rheumatica (PMR) and ophthalmoplegia. Most severe sequelae of GCA could be blindness. We report a case of a 65-year-old Caucasian male who presented for the third time with recurrent episodes of diplopia. Neurologic exam showed bilateral cranial nerve (CN) VI palsy, slightly worse on the right than the left side. Other focal neurological deficits were absent. GCA was considered and biopsy of …

Protozoal Coinfection In Horses With Equine Protozoal Myeloencephalitis In The Eastern United States, Sarah Schale, Daniel Howe, Michelle Yeargan, Jennifer K. Morrow, Amy Graves, Amy L. Johnson

Maxwell H. Gluck Equine Research Center Faculty Publications

Background: Infection by 2 or more protozoa is linked with increased severity of disease in marine mammals with protozoan encephalitis.

Hypothesis/Objectives: To assess whether horses with equine protozoal myeloencephalitis (EPM) caused by Sarcocystis neurona also have evidence of infection with Neospora hughesi or Toxoplasma gondii. We hypothesized that horses with EPM would be more likely than horses with cervical vertebral stenotic myelopathy (CVSM) to be positive for antibodies to multiple protozoan parasites.

Animals: One hundred one horses with neurologic disease: 49 with EPM and 52 with CVSM.

Methods: Case review. Archived serum and cerebrospinal fluid (CSF) from 101 horses …

Trpv4 Mediates Hypotonic Inhibition Of Central Osmosensory Neurons Via Taurine Gliotransmission, Sorana Ciura, Masha Prager-Khoutorsky, Zahra S. Thirouin, Joshua C. Wyrosdic, James E. Olson, Wolfgang Liedtke, Charles W. Bourque

Emergency Medicine Faculty Publications

The maintenance of hydromineral homeostasis requires bidirectional detection of changes in extracellular fluid osmolality by primary osmosensory neurons (ONs) in the organum vasculosum laminae terminalis (OVLT). Hypertonicity excites ONs in part through the mechanical activation of a variant transient receptor potential vanilloid-1 channel (dn-Trpv1). However, the mechanism by which local hypotonicity inhibits ONs in the OVLT remains unknown. Here, we show that hypotonicity can reduce the basal activity of dn-Trpv1 channels and hyperpolarize acutely isolated ONs. Surprisingly, we found that mice lacking dn-Trpv1 maintain normal inhibitory responses to hypotonicity when tested in situ. In the intact setting, hypotonicity inhibits ONs …

Week Of May 22, 2018, New York Medical College

InTouch

• Students Delve into an Array of Public Health Issues at SHSP Research Day
• Department of Family and Community Medicine Hosts Sixth Annual Research Day
• Eighth Annual Paul K. Woolf, M.D., Pediatric Trainee Research Symposium Highlights New and Innovative Biomedical Research
• Would You Like to Interview Applicants to the School of Medicine?
• SOM P2P Committee Recognizes Role Models at NYMC

Patient-Specific Multiscale Computational Fluid Dynamics Assessment Of Embolization Rates In The Hybrid Norwood: Effects Of Size And Placement Of The Reverse Blalock–Taussig Shunt, Ray Prather, John Seligson, Marcus Ni, Eduardo Divo, Alain J. Kassab, William Decampli

Publications

The hybrid Norwood operation is performed to treat hypoplastic left heart syndrome. Distal arch obstruction may compromise flow to the brain. In a variant of this procedure, a synthetic graft (reverse Blalock–Taussig shunt) is placed between the pulmonary trunk and innominate artery to improve upper torso blood flow. Thrombi originating in the graft may embolize to the brain. In this study, we used computational fluid dynamics and particle tracking to investigate the patterns of particle embolization as a function of the anatomic position of the reverse Blalock–Taussig shunt. The degree of distal arch obstruction and position of particle origin influence …

Internet And Social Media Access Among Youth Experiencing Homelessness: Mixed-Methods Study., Lauren A. Houdek Vonholtz, Rosemary Frasso, Jesse M. Golinkoff, Alicia J. Lozano, Alexandra Hanlon, Nadia Dowshen

College of Population Health Faculty Papers

BACKGROUND: Youth experiencing homelessness are at a risk for a variety of adverse outcomes. Given the widespread use of the internet and social media, these new technologies may be used to address their needs and for outreach purposes. However, little is known about how this group uses these resources.

OBJECTIVE: This study investigated how homeless adolescents use these technologies for general and health-related purposes, whether the scope of their use changes with housing status, and their interest in a website dedicated to youth experiencing homelessness.

METHODS: A convenience sample of youth aged 18 to 21 years was recruited from a …

Prison Rehabilitation: The Sociological, Physiological, And Psychological Effects Of Animal-Assisted Interventions, Daisy Corleto

Themis: Research Journal of Justice Studies and Forensic Science

This paper examines animal-assisted interventions as a new form of rehabilitation in the prison setting. It focuses specifically on the multiple benefits that this form of therapy/intervention can bring to inmates, such as the reduction in recidivism and the acquirement of new skills. Additionally, this paper considers the reasons for which rehabilitation in general is necessary in order to truly transform an individual. The first section provides a brief history of AAI in the prison environment and its effects on the prisoners. The paper then transitions to an account of analyzing the sociological, physiological, and psychological effects of AAI on …

Ada News - 05/21/2018, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

The Victimization Of The Misconceived: The Mentally Ill In The Criminal Justice System, Margarita Trejo

Themis: Research Journal of Justice Studies and Forensic Science

It is unfortunate to say that the number of people who suffer from a serious mental illness has been drastically increasing in the criminal justice system since the late 1960s. This drastic change has captivated the minds of the public, forced them to develop a fallacious stereotype, and labeled the mentally ill population as wrongdoers. This image, however, is inaccurate. In reality, these people are the victims of a broken system. This paper establishes the victimization that a person with a serious mental illness experiences as they are processed through the criminal justice system. The following elaborates how victimization is …

What's Happening: May 21, 2018, Maine Medical Center

What's Happening

No abstract provided.

A Systematic Review Of The Effect Of Habitual Breakfast For Adolescents Aged 11-19 Years On Academic Performance, Lena Yaslam Babaeer, Darren Wraith

Journal of Adolescent and Family Health

Background: Breakfast consumption plays an important role for growth, energy, BMI, and lifestyle. Studies show that it has positive influences on cognitive and academic outcomes. Despite this benefits of consuming breakfast on school grades, there has been no systematic review of literature focusing habitual breakfast consumption on scholastic achievement among adolescent students aged 11-19. Objective: The objective of this systematic review was to evaluate the existing evidence on habitual breakfast consumption and academic performance in adolescents aged 11-19 years. Methods: A systematic review of studies was conducted through three electronic databases which were searched for relevant articles published between 1990 …

Therapeutic Theatre With Adolescents At-Risk Of School Dropout, Dan Summer

Expressive Therapies Dissertations

The aim of this study was to assess the effects of therapeutic theatre, a method of drama therapy, on resilience among adolescents at risk of high school dropout. A mixed method approach was employed to qualitatively examine participant perspectives on resilience and quantitatively measure change in resilience. Participants engaged in weekly after-school drama therapy groups to collaborate on developing themes and a script for a performance to be witnessed by an audience of family and community members. Qualitative and quantitative findings were triangulated and embedded to examine relationships. The Behavioral Assessment System for Children Second Edition (BASC-2) and Resilience Scale …