Medicine and Health Sciences Commons^™

Quels Sont Les Facilitateurs Du Maintien En Emploi En Santé Des Travailleurs Seniors Dans Un Milieu D’Éducation Au Québec?, Alessia Negrini, Marc Corbière, Jacques Perron, Julie Hupé, Jessica Dubé, Andrea Gragnano

Rapports de recherche scientifique

Le pourcentage de travailleurs seniors âgés de 45 ans et plus augmente sans cesse sur le marché du travail au Québec. Dans le secteur de l’éducation, une large portion de la main-d’œuvre est âgée de 45 ans et plus (41 %) et un tiers du personnel aura quitté son poste entre 2009 et 2018 (Grenier, 2009). Des statistiques récentes montrent aussi que les lésions tant de nature physique que psychologique des travailleurs québécois du secteur de l’éducation sont souvent associées à une perte de temps indemnisée par la Commission des normes, de l’équité, de la santé et de la sécurité …

Nanoparticle-Mediated Therapeutic Agent Delivery For Treating Metastatic Breast Cancer—Challenges And Opportunities, Yunfei Li, Brock Humphries, Chengfeng Yang, Zhishan Wang

Toxicology and Cancer Biology Faculty Publications

Breast cancer (BC) is the second leading cause of cancer-related death in American women and more than 90% of BC-related death is caused by metastatic BC (MBC). This review stresses the limited success of traditional therapies as well as the use of nanomedicine for treating MBC. Understanding the biological barriers of MBC that nanoparticle in vivo trafficking must overcome could provide valuable new insights for translating nanomedicine from the bench side to the bedside. A view about nanomedicine applied in BC therapy has been summarized with their present status, which is gaining attention in the clinically-applied landscape. The progressions of …

Convergent Roles Of De Novo Mutations And Common Variants In Schizophrenia In Tissue-Specific And Spatiotemporal Co-Expression Network, Peilin Jia, Xiangning Chen, Ayman H. Fanous, Zhongming Zhao

Psychology Faculty Research

Genetic components susceptible to complex disease such as schizophrenia include a wide spectrum of variants, including common variants (CVs) and de novo mutations (DNMs). Although CVs and DNMs differ by origin, it remains elusive whether and how they interact at the gene, pathway, and network levels that leads to the disease. In this work, we characterized the genes harboring schizophrenia-associated CVs (CVgenes) and the genes harboring DNMs (DNMgenes) using measures from network, tissue-specific expression profile, and spatiotemporal brain expression profile. We developed an algorithm to link the DNMgenes and CVgenes in spatiotemporal brain co-expression networks. DNMgenes tended to have central …

Dynamical Properties Of Postural Control In Obese Community-Dwelling Older Adults, Christopher W. Frames, Rahul Soangra, Thurmon Lockhart, John Lach, Dong Sam Ha, Karen A. Roberto, Abraham Lieberman

Physical Therapy Faculty Articles and Research

Postural control is a key aspect in preventing falls. The aim of this study was to determine if obesity affected balance in community-dwelling older adults and serve as an indicator of fall risk. The participants were randomly assigned to receive a comprehensive geriatric assessment followed by a longitudinal assessment of their fall history. The standing postural balance was measured for 98 participants with a Body Mass Index (BMI) ranging from 18 to 63 kg/m2, using a force plate and an inertial measurement unit affixed at the sternum. Participants’ fall history was recorded over 2 years and participants with at least …

Hospital Acquired Pressure Injury Prevention On An Inpatient Unit, Cherilyn Schumacher

Master's Projects and Capstones

Abstract

The aim of the project is to improve the process and delivery of care with established and accepted standards by implementing evidence-based change. The plan is to create a HAPI prevention plan with the main expected outcome to reduce the HAPI occurrences on the unit to zero by July 30, 2018. This will be accomplished by increasing awareness among nursing staff members through education and diligent monitoring of prevention practices and treatments.

The education portion of the plan will include reviewing basic pressure injury education and HAPI prevention and management in the form of visual aids provided by the …

A Curious Researcher's Guide On Successfully Publishing Scientific Manuscripts., Xiao Chi Zhang, Alexander H Tran, Dimitrios Papanagnou

Department of Emergency Medicine Faculty Papers

Publishing a manuscript in an academic journal represents more than just 'promotional currency.' It provides the opportunity to provoke debate, share your experiences, and challenge the status quo on provider practices. Writing a manuscript relies on collaboration and shared responsibility from a research team, which can often challenge mentors as they supervise and guide its development. While there are numerous online resources and peer-reviewed journal articles on 'How to write a scientific article,' we aim to tackle an even larger and overarching theme that transcends specific journal categories, writing styles, and citation formatting. In order to guide new researchers in …

Managing Patient Expectations With Implant Treatment, Daniel B. Kamran, Mark Booth Dds, Eduardo Gonzalez Dds, Ed Shaw Dds

Excellence Day

This patient came to University of the Pacific, Arthur A. Dugoni School of Dentistry to get implants and implant crowns to improve his smile, replacing his upper partial denture. Different approaches were made by the faculty to arrive at best outcomes, which took four years for the patient to receive the treatment he wanted. This abstract will further detail how the treatment was conducted and the results afterwards.

Rapid Placement And Anatomical Sculpting Of Hardened Posterior Composite, Patrick Roetzer, Mahek Pipalia, Krunali Kapadia

Excellence Day

Posterior composites have long had a reputation for being difficult and time consuming in clinical practice. In addition to this reputation, it has been noted that recurrent caries and in general failure of these restorations prematurely has been a problem. Relative to amalgams, posterior composites have vexed even good clinical dentist. This video presentation illustrates techniques that not only save time but also create more predictable high-quality restorations.

A Modified “Wound Healing” And Hypoxia Model In Vitro, Schuyler G. Tang, Isabel Kwon, Marie M. Tolarova, Mirek Tolar

Excellence Day

Closing a wound may resemble some aspects of fusion of embryonic processes during development of face. In addition, both are sensitive to oxygen supply.

Effect Of Folate On Endoplasmic Reticulum Stress Caused By Hypoxia, Paul Kim, Shub Dhillon, Mahsa Mortazavi, Marie M. Tolarova, Mirek Tolar

Excellence Day

Endoplasmic reticulum (ER) stress is involved in the pathogenesis of congenital cardiac defects, intrauterine growth restriction, craniofacial anomalies, and many common diseases. The purpose of this study was to test if folic acid (FA) can mitigate ER stress or improve recovery of cells from ER stress.

Integrating Interprofessional Education Through Service-Learning: Continued Multidisciplinary Collaboration For Student-Led Volunteer Healthcare Event, Sunny Jisun Lee, Heather Leo, Sachan Bhatia, Byron Chou, Christine E. Miller

Excellence Day

SCOPE (Student Community Outreach for Public Education) at University of the Pacific (UOP), Arthur A. Dugoni School of Dentistry sponsored the 25th Annual Senior Smiles Health & Wellness Fair in its clinic, located in San Francisco on April 21^th, 2018. More than 105 San Francisco’s senior citizens with limited access to health care attended this event. As a continuation of last year’s Senior Smiles & Wellness which pioneered the launch of Interprofessional education (IPE) activities, SCOPE provided various health screenings to the senior attendees in partnership with Dugoni’s sister schools UOP Audiology and Physical Therapy program as well …

Biomarkers Of Orthodontic Tooth Movement, Ellie Schwartz, Shubdeep Kaur, Mahsa Mortazavi, Marie M. Tolarova, Mirek Tolar

Excellence Day

Orthodontic tooth movement is made possible by remodeling of the alveolar bone process. Bone remodeling is carried out by cellular activities of osteoclasts, osteoblasts, and osteocytes. This in turn is regulated by a number of extracellular factors including growth factors, cytokines, chemokines, hormones and biomechanical force. This review is focused on chemical biomarkers characterizing orthodontic tooth movement.

Geometric Morphometric Shape Assessment Of Juvenile Mandibles, Tiffany Tran, Vicki Lo, Hee Soo Oh, Gary D. Richards

Excellence Day

OBJECTIVES: We explore three-dimensional data to delineate idiosyncratic and progressive growth variation in 6.0-8.0 year old mandibles (n=45).

Variation In And Assessment Of Inferior Alveolar Nerve Block Landmarks In Children And Adolescents, Soi Park, Younjin Lee, Younyoung Lee, Tiffany Tran, Gary D. Richards

Excellence Day

OBJECTIVES: In earlier work (Lambert et al., 2017) we demonstrated the efficacy of new landmarks for inferior alveolar nerve (IAN) block injections. While the latter study focused on adult morphology, the landmarks were shown to be effective in cases where the M³/₃ were present but unerupted. Based on these result a question arose as to their applicability of the landmarks to children and adolescents, given the known changes in mandibular foramen position during growth. Here we quantify the position of the mandibular foramen relative to standard landmarks during growth and assess the new landmarks applicability for IAN …

Shear Bond Strength Of Nine Dual Cured Build-Up Materials And A Light-Curing Adhesive System On Dentin, Deepali Malla, Karen Schulze, Patrick Roetzer

Excellence Day

The purpose of this study was to measure the shear bond strength of nine different commercially available dual cured core build-up materials on human dentin in conjunction with a light curing adhesive system. The null hypothesis was that there is no statistical significant difference among the core build-up systems.

Root Analogue Implant Creation: Establishing Procedures For The General Dentist, Alicia Hazdovac, Sarah Osborne, Gary D. Richards

Excellence Day

The possibility of replacing damaged teeth with custom-made root analogue implants was initially suggested around 1969 and reintroduced by Lungren et al. in 1992. The latter authors created custom implants in titanium and reported good osteointegration and aesthetic results. Following this effort there has been an increasing focus on custom root analogue implants as a replacement for ‘screw-type’ implants. Given the availability of software to manipulate 3D image data and the rapid rise of 3D printing technology, the question arises as to whether a general dentist can produce their own implants. Here we test the feasibility of practitioners producing custom …

The Role Of Aryl Hydrocarbon Receptor (Ahr) Signaling Pathway In Oral Squamous Cell Carcinoma (Oscc): Preliminary Results., Renee Lee, Cui Xu, Leticia Ferreira, Ana Carolina Morandini, Erivan Ramos-Junior

Excellence Day

OBJECTIVES: A large number of experimental and clinical studies suggest that the origin of oral squamous cell carcinoma (OSCC) is linked to environmental carcinogenesis (tobacco, alcohol). Among these environmental factors, cigarette smoking is the most studied and has been associated with increased susceptibility to OSCC by activating signaling pathways responsible for cancer initiation and progression. Besides nicotine, cigarette smoke also contains aryl hydrocarbon receptor (AhR) agonists, such as dioxin and benzo(a)pyrene. Aberrant AhR expression and AhR pathway activation are involved in several types of cancer. However, the relationship between AhR pathway activation and oral cancer progression is still unclear.

Genes Associated With Mandibular Prognathism In The Chinese Population, Jacqueline Payne, Marie Tolarova M.D., Ph.D., D.Sc.

Excellence Day

Mandibular prognathism (MP) is the relationship of the mandible anteriorly positioned in relation to the cranial base. The prevalence of MP in Asians is estimated to be 15%, whereas American and European descent exhibit a 5% prevalence. Orthodontic treatment is lengthy and challenging, and severe cases require surgical intervention. However, when a treatment is planned well, the outcomes are predominantly successful. It has been known that genetics are involved in the etiology of prognathism and that greater genetic contribution corresponds to greater challenges to treatment. Thus, there is a desire to determine genes involved in the etiology of prognathism.

Socio-Economic Factors That May Contribute To Etiology Of Orofacial Clefts., Shubdeep Kaur, Mahsa Mortazavi, Geethapriya Kumar, Marie M. Tolarova

Excellence Day

Association of socio-economic status (SES) with congenital anomalies and diseases has been studied for many years. Under the umbrella of SES are several factors and they vary in different parts of the world due to differences in climate, ethnicity, and culture.

The purpose of this systematic review was to determine associations between various risk factors related to SES and prevalence of orofacial clefts (OFC).

Orofacial Clefts In The Middle Eastern Countries – A Systematic Review, Mahsa Mortazavi, Marie M. Tolarova

Excellence Day

The purpose of this study was to determine the prevalence of orofacial clefts (OFC) in the Middle East. Recent studies of etiology of OFC in populations of different countries characterized by a specific cultural, religious, or socioeconomic status revealed that different environmental and genetic factors may participate in their etiology.

Distribution Of Malocclusions In Middle East Countries: A Systematic Review., Mahsa Mortazavi, Marie M. Tolarova

Excellence Day

High prevalence, multifactorial etiology and the effect on the esthetic, function and quality of life, make the malocclusions as a subject of debate for many years. Regarding the important role of malocclusion in treatment approaches, policy making in health organizations and understanding the etiology factors, this literature review was performed with the purpose of determining the prevalence and distribution of malocclusion in region of the Middle East.

Case Report: Use Of Non-Ridgid Connector, Veniamin Dronov

Excellence Day

Long span bridges have a tendency to experience harmful stress due to the increased surface area and of the restoration. These stresses can cause several problems including failure of the restoration or cause significant discomfort to the patient.

Treatment Planning: Facially Generated, Digitally Guided, Manually Fabricated Smile Design, Neal Atul Patel

Excellence Day

A clinical case presentation of a smile design that consists of 10 units of minimally invasive indirect restorations.

Longitudinal Cephalometric Study Of Untreated Subjects With Different Facial Types, Divya Vadlamudi, Shalaka Desai, Ambika Arun, Bhuvaneshwari Tatikonda, Shreya Penukonda, Apurva Dabak, Cindy Kim, Mai Nguyen, Heesoo Oh

Excellence Day

To examine the craniofacial morphological characteristics of different facial types based on vertical dysplasia in untreated subjects from the ages of 8 to 18.

Changes In Airway Volume In Adult Patients Following Orthodontic Treatment With Premolar Extractions Versus Non-Extraction, Sunny Jisun Lee, Allison Kawata, Hayoung Michael Shin, David Chambers, Joorok Park, Heesoo Oh

Excellence Day

Recent concerns about the prevalence of obstructive sleep apnea (OSA) and its negative sequelae have led to investigations of how manipulation of the dentofacial complex may affect airway problems. CBCT can be used to measure airway dimensions of patients. Extraction of premolars is indicated as part of orthodontic treatment for patients who have severe crowding or protrusion of incisors. Some have suggested that the reduction in arch circumference after premolar extraction would lead to decreased airway volume, which may predispose a patient for sleep disordered breathing (SDB). The purpose of this study was to determine whether there is a significant …

Changes In Cephalometric Measurements In Adult Patients Following Orthodontic Treatment With Premolar Extractions Versus Non-Extraction, Byron Chou, David Dang, Adrienne Joy, David Chambers, Joorok Park, Heesoo Oh

Excellence Day

Extraction of premolars is indicated as part of orthodontic treatment for patients who have severe crowding or protrusion of incisors. CBCT can be used to locate cephalometric landmarks in 3D. The purpose of this study was to determine whether there are differences in sagittal, transverse, and vertical skeletal and dental dimensions for adult patients who were treated with premolar extractions in conjunction with orthodontic treatment compared to those who received orthodontic treatment without extractions.

Condylar Degeneration In Patients With Dental Open Bite Versus Skeletal Open Bite Utilizing Cbct, Alex Rauchle, Alston Trinh, Linda Phi, Brad Albertson, Joorok Park, Heesoo Oh

Excellence Day

Idiopathic condylar resorption (ICR) is a condition in which either one or both condyles undergo degeneration. Bilateral TMJ involvement presents as a clockwise rotation of the mandible in the posterior-inferior direction, resulting in an anterior open bite. The purpose of the study was to assess TMJ condylar degeneration in dental open bites compared to skeletal open bites.

Impact Of Diffuse Large B-Cell Lymphoma On Visits To Different Provider Specialties Among Elderly Medicare Beneficiaries: Challenges For Care Coordination, Rahul Garg, Usha Sambamoorthi, Xi Tan, Soumit K. Basu, Treah Haggerty, Kimberly M. Kelly

Clinical and Translational Science Institute

Newly diagnosed diffuse large B-cell lymphoma (DLBCL) can pose significant challenges to care coordination. We utilized a social-ecological model to understand the impact of DLBCL diagnosis on visits to primary care providers (PCPs) and specialists, a key component of care coordination, over a 3-year period of cancer diagnosis and treatment. We used hurdle models and multivariable logistic regression with the Surveillance Epidemiology and End Result-Medicare linked dataset to analyze visits to PCPs and specialists by DLBCL patients (n = 5,455) compared with noncancer patients (n = 14,770). DLBCL patients were more likely to visit PCPs (adjusted odds ratio, AOR [95% …

Next-Generation Novel Noninvasive Cancer Molecular Diagnostics Platforms Beyond Tissues, Xiaoliang Wu, Lin Zhu, Patrick C. Ma

Clinical and Translational Science Institute

No abstract provided.

Dimensions And Intensity Of Inter-Professional Teamwork In Primary Care: Evidence From Five International Jurisdictions., Jean-Frédéric Levesque Md, Phd, Frcp, Mark F. Harris Mbbs, Md, Cathie M. Scott Phd, Benjamin F. Crabtree Phd, William L. Miller Md, Ma, Lisa M. Halma Ma, William E. Hogg Md, Jan-Willem Weenink, Jenny R. Advocat Phd, Jane M. Gunn Mbbs, Phd Fracgp, Grant M. Russell Mbbs, Phd, Fracgp

Department of Family Medicine

Background: Inter-professional teamwork in primary care settings offers potential benefits for responding to the increasing complexity of patients' needs. While it is a central element in many reforms to primary care delivery, implementing inter-professional teamwork has proven to be more challenging than anticipated.

Objective: The objective of this study was to better understand the dimensions and intensity of teamwork and the developmental process involved in creating fully integrated teams.

Methods: Secondary analyses of qualitative and quantitative data from completed studies conducted in Australia, Canada and USA. Case studies and matrices were used, along with face-to-face group retreats, using a Collaborative …