Medicine and Health Sciences Commons^™

Optimization Of The Split-Spinach Aptamer For Monitoring Contiguous Rna Nanoparticle Assembly, Jack M. O'Hara

Honors Projects

The emerging field of RNA nanotechnology takes advantage of the RNA’s ability to self-assemble into exquisite structures. As nanoparticle design continues to advance and move into increasingly complex biological systems, tools to monitor their assembly and location will be of great importance. Here, a split-aptamer system is used to monitor assembly of a six-membered nanoring based on fluorescence feedback of a fluorophore. First, the split-aptamer is designed into two of the six pieces of the ring. Through mutation and deletion, we optimize the fluorescence feedback established when a six membered nanoparticle assembles, compared to partial assembly. We demonstrate that with …

Prevalence Of Overweight And Obesity Based On The Body Mass Index; A Cross-Sectional Study In Alkharj, Saudi Arabia, Sameer Al-Ghamdi, Mamdouh M. Shubair, Abdulrahman Aldiab, Jamaan M. Al-Zahrani, Khaled K. Aldossari, Mowafa Househ, Shanila Nooruddin, Hira Abdul Razzak, Ashraf El-Metwally

Department of Paediatrics and Child Health

Background: Obesity and overweight are accompanied with several different chronic diseases. Overweight and obesity can be measured by using body mass index (BMI) and is also used widely as an index of relative adiposity among any population. The aim of the study is to evaluate the prevalence of overweight and obesity among general population in Al-Kharj, Saudi Arabia.
Methods: Cross-sectional analysis was undertaken from a representative sample (N = 1019) of the Al Kharj population. Anthropometric measurements including the waist circumference (in centimeters), height (in meters), and weight (in kilograms) of the subjects were undertaken by means of standard apparatus. …

Mother Nature, Breanna M. Glynn

Akesis

Mother Nature is our greatest teacher in the lesson of patience and new growth. She makes us wait for the sweet moments, but when they come how lucky we are to bear witness to her beauty. She renews life, and breaths fresh air into the dead leaves that winter has plastered onto the ground. She reminds us that with death, comes more vibrant and boisterous life. We just need to sit back, relax, and enjoy the show.

Boompa, Breanna M. Glynn

Akesis

My Boompa was my mother's father, and my beloved grandfather. He passed away this April just after his 85th birthday. He, and the rest of the family, thought he would make it to at least 100. Boompa was one of the greatest people I will ever meet. Yea, sure, a lot of people say that, but I really mean it. He was the most kind, genuine, empathetic, hardworking man, always taking care of others first. This photo is a picture of the eucalyptus and pussy willows that were in the floral arrangement that laid over his coffin during his services. …

A Love Song, Jack Williams Phd, Med

Akesis

For us to truly succeed in our chosen work of helping and healing, we must succeed in listening deeply to ourselves and to others--listening to the voices of our hearts. Without this wholeness, we become shells of ourselves and cannot be fully present for others in their healing. I wrote this poem in celebration of my best friend and partner, Beth. During our 43 years together, our oneness has given me the courage and creativity needed to work in the service of others far beyond what I could have ever achieved alone. She has helped me to laugh and to …

Ada News - 06/04/2018, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Adult Vaccination Rates In The Severely Mentally Ill Population: An Improvement Project In An Outpatient Setting In Utah, Nathalia H. Williams, Leslie Miles, Beth Luthy, Lacey Eden

Student Works

Background: Adults who suffer with severe and persistent mental illness (SPMI) rarely access medical care to address basic medical needs, so they are subsequently less likely to receive preventive vaccines. The aim of this project was to increase the rate of vaccines among the SPMI population. This project started in 2011 and still is ongoing. It took place in an outpatient community mental health center (CMHC) which serves about 4,200 SPMI clients. Personnel managing the project included registered nurses from the local health department, staff from the CMHC, and volunteer nursing students.

Methods: A review of the literature identified a …

The Effects Of Habits On Motor Skill Learning, Nicola J. Popp, Atsushi Yokoi, Paul L. Gribble, Jörn Diedrichsen

BrainsCAN Publications

Skill learning involves the formation of stable motor patterns. In musical and athletic 3 training, however, these stable patterns can also impede the attainment of higher levels 4 of performance, and hence constitute a motor habit. We developed an experimental 5 paradigm to induce a specific motor pattern in a sequence production task and 6 investigated how it affected subsequent optimization over a 3-week training period. 7 Participants initially practiced small segments of 2 to 3 finger movements, which were 8 then combined to form longer sequences. This initial training induced a persistent 9 chunking behavior, with shorter inter-press-intervals within …

What's Happening: June 4, 2018, Maine Medical Center

What's Happening

No abstract provided.

Treatment Of Obstructive Sleep Apnea With Maxillo-Mandibular Advancement Surgery: Evaluation And Predictors Of Success, Daniel Taub, Dmd, Md, Michael Courtney, Dmd, Md, Karl Doghramji, Md

Department of Oral and Maxillofacial Surgery Posters

Obstructive sleep apnea (OSA) is a well-recognized disease entity affecting approximately 2% to 4% of the population. Maxillomandibular advancement (MMA) surgery is a highly successful surgical alternative to poorly tolerated CPAP therapy and achieves a success rate of 89% in the current literature. Our present study evaluates the effectiveness of MMA surgery in the treatment of patients with moderate to severe OSA based on Shers criteria of 50% reduction in AHI and AHI < 20. Radiographic and clinical treatment variables were evaluated in determining predictors of success for MMA in individuals with OSA.

Does Transition From Cpap To Bipap Improve Symptoms Of Aerophagia?, Kathy Tran, Do, Karl Doghramji, Md

Department of Sleep Medicine Posters

Introduction

Adherence to continuous positive airway pressure (CPAP) therapy has been an ongoing dilemma in obstructive sleep apnea patients and up to 83% of patients are noncompliant. It is believed that mask discomfort or pressure intolerance are the major causes. Aerophagia, or “air swallowing” may be an under-recognized and insidious cause for CPAP nonadherence. Patients generally complain of belching, bloating, abdominal pain and distention. Some studies have reported worsening gastrointestinal reflux symptoms from PAP-induced aerophagia. Although bi-level positive airway pressure (BIPAP) is often utilized in such circumstances, this practice had not been examined. We hypothesized that transitioning patients from CPAP …

Plasmodium Falciparum Gametocyte Dynamics After Pyronaridine-Artesunate Or Artemether-Lumefantrine Treatment Nct02411994 Nct, Johanna M. Roth, Patrick Sawa, George Omweri, Victor Osoti, Nicodemus Makio, John Bradley, Teun Bousema, Henk D.F.H. Schallig, Pètra F. Mens

All Peer-Reviewed Publications

Background: Artemisinin-based combinations differ in their impact on gametocyte prevalence and density. This study assessed female and male gametocyte dynamics after treating children with uncomplicated Plasmodium falciparum malaria with either pyronaridine-artesunate (PA) or artemether-lumefantrine (AL). Methods: Kenyan children with uncomplicated Plasmodium falciparum malaria were included and randomly assigned to PA or AL treatment. Filter paper blood samples were collected as a source of RNA for quantitative reverse-transcription PCR (qRT-PCR) and nucleic acid sequence based amplification (QT-NASBA) to detect female gametocytes (targeting Pfs25 mRNA). Male gametocytes were detected by qRT-PCR (targeting PfMGET mRNA). Duration of gametocyte carriage, the female and male …

A Bibliometric Analysis Of The Top 100 Cited Articles On Hepatic Magnetic Resonance Imaging., Waqas Ullah, Hafez Mohammad A. Abdullah, Ejaz Ahmad, Mamoon Ur Rashid, Muhammad Bashir, Asad Ur Rahman, Asrar Ahmad, Abu Hurairah

Abington Jefferson Health Papers

The purpose of this study is to guide the readers to the impact of the articles published on hepatic magnetic resonance imaging (MRI). We searched Scopus using 10 different search terms for hepatic MRI. The selected studies were thoroughly reviewed by two independent authors and any disagreement was sorted out by mutual consensus. The list of articles and journals was downloaded into an excel spreadsheet. Only the top 100 cited articles were selected by mutual consensus among all the authors. These articles were further read in the full-text form and were further categorized into subgroups. Three authors independently reviewed the …

Design, Construction, And Characterization Of The University Of South Florida Wind Tunnel, Jason S. Garcia

USF Tampa Graduate Theses and Dissertations

Much of the aerosol research completed at the University of South Florida has revolved around evaluating industrial hygiene equipment and instrumentation in environmental chambers. Data collected during these studies has provided valuable baseline data on equipment and instrument performance under calm air conditions. A newly constructed wind tunnel now allows researchers to evaluate industrial hygiene instruments under moving air conditions. Because the wind tunnel is capable of producing wind velocities that a worker could encounter in the occupational setting, researchers may gain insight into instrument performance under simulated field conditions. Because aerosols can be introduced into the new wind tunnel …

Medical School Watercooler Newsletter - June 3, 2018, Lindsey Lyle

Watercooler Newsletter

This is the June 3, 2018 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Family Medicine Moves to Strada Patient Care Center
• USA Physicians Group Hosts First Aid Tent at 2018 Grandman Triathlon
• Mark Your Calendar: 3rd Annual Project TIPP Autism Conference
• Stacy Wagner Named Director of Operations for Obstetrics and Gynecology

Burden Of Depression Among Working-Age Adults With Rheumatoid Arthritis, Arijita Deb, Nilanjana Dwibedi, Traci Lemasters, Jo Ann Hornsby, Wenhui Wei, Usha Sambamoorthi

Clinical and Translational Science Institute

Objective. Tis study estimated the excess clinical, humanistic, and economic burden associated with depression among workingage adults with Rheumatoid Arthritis (RA). Methods. A retrospective cross-sectional study was conducted among working-age (18 to 64 years) RA patients with depression (� = 647) and without depression (�=2,015) using data from the nationally representative Medical Expenditure Panel Survey for the years 2009, 2011, 2013, and 2015. Results. Overall, 25.8% had depression. In adjusted analyses, adults with RA and depression compared to those without depression were signifcantly more likely to have pain interference with normal work (severe pain: AOR = 2.22; 95% CI = …

Cohort Profile: The Maternal And Infant Nutrition Interventions In Matlab (Minimat) Cohort In Bangladesh, Shams El Arifeen, Eva-Charlotte Ekström, Edward A. Frongillo Jr., Jena Hamadani, Ashraful I. Khan, Ruchira T. Naved, Anisur Rahman, Rubhana Raqib, Kathleen M. Rasmussen, Katarina Ekholm Selling, Yukiko Wagatsuma, Lars Åke Persson

Faculty Publications

No abstract provided.

A New Benchmarking Methodology To Monitor Industry's Investment In Community-Based Obesity Prevention And Food Access Initiatives: Gaps And Opportunities, Olivia Barata Cavalcanti

Dissertations and Theses

Background:

Despite increased public health efforts and investment in obesity prevention, obesity continues to be a growing problem in the United States.¹ Excess weight increases the risk for a series of correlated diseases, such as type 2 diabetes, hyperinsulinemia, hypertension, dyslipidemia, joint abnormalities, polycystic ovarian syndrome, nonalcoholic fatty liver disease, sleep disturbances and a decreased life span.^2–9

Traditional interventions to improve nutrition or decrease obesity have not achieved the desired success so far because obesity is a complex problem, involving a vast number of factors, sectors and actors that influence individuals’ energy balance.^10,11 To achieve change in …

Mobile Alcohol Primary Prevention: Feasibility With Urban Communter College Students, Janice Chisholm

Dissertations and Theses

The first year and possibly as early as the first two to six weeks of college are marked with personal and social transitions that may help to define academic and other behavior for new college students, including alcohol use patterns.1 Evidence suggests that alcohol use by college students negatively affects learning, retention, and graduation,2,3 and is associated with alcohol related unintentional injury, deaths, sexual violence, suicide and other problems.4 Young adults entering college have been found to increase their usage during the transition from high school, particularly for students with certain social characteristics (male sex, history of conduct issues, peer …

Inertial Sensor-Based Variables Are Indicators Of Frailty And Adverse Post-Operative Outcomes In Cardiovascular Disease Patients, Rahul Soangra, Thurmon E. Lockhart

Physical Therapy Faculty Articles and Research

Cardiovascular disease (CVD) patients with intrinsic cardiac cause for falling have been found to be frail and submissive to morbidity and mortality as post-operative outcomes. In these older CVD patients, gait speed is conjectured by the Society of Thoracic Surgeons (STS) as an independent predictor of post-operative morbidity and mortality. However, this guideline by STS has not been studied adequately with a large sample size; rather it is based largely on expert opinions of cardiac surgeons and researchers. Although one’s gait speed is not completely associated with one’s risk of falls, gait speed is a quick robust measure to classify …

A Mathematical Model Of The Immune System Response To Leishmania Parasite, Ephraim Agyingi

Biology and Medicine Through Mathematics Conference

No abstract provided.

Regulation Of Cellular Patterning Through The Extracellular Matrix, Lewis Scott, Lauren Griggs, Vani Narayanan, Daniel Conway Phd, Seth H. Weinberg Phd, Christopher Lemmon Phd

Biology and Medicine Through Mathematics Conference

No abstract provided.

Optimal Control Applied To A Visceral Leishmaniasis Model, Buddhi Pantha

Biology and Medicine Through Mathematics Conference

No abstract provided.

Stochastic Averaging For Multiple Cooperative And Antagonistic Molecular Motors, Joe Klobusicky

Biology and Medicine Through Mathematics Conference

No abstract provided.

Modeling The Influenza Virus Infection In A Host: Consideration Of Semi-Infectious Particles, Alex P. Farrell, Ruian Ke

Biology and Medicine Through Mathematics Conference

No abstract provided.

Effects Of Configuration On Ensemble Dynamics In A Network Of Wilson-Cowan Nodes, Anca R. Radulescu

Biology and Medicine Through Mathematics Conference

No abstract provided.

Neural Phase Oscillators Incorporating Noise And Correlated Sources Of Heterogeneity, Kyle Wendling

Biology and Medicine Through Mathematics Conference

No abstract provided.

Deriving Ode Approximations For Spatial Networks: Modeling Environmentally Transmitted Infections, Kale J. Davies, Cristina Lanzas, Suzanne Lenhart, Judy D. Day

Biology and Medicine Through Mathematics Conference

No abstract provided.

Mathematical Modeling Of Nutrient Signaling And Growth In Saccharomyces Cerevisiae, Amogh P. Jalihal, Pavel Kraikivski, T.M. Murali, John J. Tyson

Biology and Medicine Through Mathematics Conference

No abstract provided.

The Dynamic Nature Of Functional Brain Networks Of Emotional Regulation, Sherli Koshy Chenthittayil, Reinhard C. Laubenbacher, Paola Vera-Licona, Michael Stevens, Andrew Poppe

Biology and Medicine Through Mathematics Conference

No abstract provided.