Medicine and Health Sciences Commons^™

Adaptation Of A Standardized Handoff System For A Radiology Residency Program, Riti Kanesa-Thasan, Md, Liya Gendler, Md, Megan Margiotta, Md, Kristin Lohr, Md, Grant Turner, Md, Rebecca C. Jaffe, Md, Christopher G. Roth, Md, Suzanne Long, Md

House Staff Quality Improvement and Patient Safety Conference (2016-2019)

Background/Objectives:

• The Joint Commission has linked communication failure as a root cause for a majority of sentinel events.
• The “I-PASS” system is a hand-off mnemonic that has been shown to decrease medical errors, prevent adverse events, and improve communication.
• Multiple Jefferson residency programs have adopted I-PASS training over the last year to standardize sign-outs between treatment teams and departments.
• Radiology residents also participate in hand-offs with other departments, especially in cases of adverse patient reactions that occur within radiology (ie: allergic reaction, seizure, contrast extravasation). In addition, radiology residents also participate in hand offs between daytime and overnight teams, including …

Care For Inmates With Mental Illness: What Can Nurses Do?, Rebecca K. Sakai

Honors Projects

This paper serves to inform nurses of the medical and psychiatric treatment that inmates with mental illness receive and to offer suggestions for treatment interventions. Current practice includes mental health screens, psychotropic medication administration, psychiatric departments, and administrative segregation. The recommended interventions include providing therapy (including Cognitive Behavioral Therapy and Group Therapy), decreasing administrative segregation, implementing reintegration programs, and training and collaborating with correctional officers.

Herpes Zoster Subunit Vaccine For The Prevention Of Herpes Zoster, Melanie Symoniak, Pejman Farrokh, Mona A. Gandhi, Judianne Slish

Pharmacy Faculty/Staff Publications

Purpose Published literature on the efficacy and safety of the herpes zoster (HZ) subunit vaccine (HZ/su vaccine) in reducing the risks of HZ and postherpetic neuralgia (PHN) in adults 50 years of age and older, as well as the vaccine’s properties and efficacy relative to live attenuated vaccine, is reviewed.

Summary HZ/su vaccine (Shingrix, GlaxoSmithKline) is a recently Food and Drug Administration (FDA)–approved vaccine indicated for the prevention of HZ in adults 50 years of age and older. Based on several Phase III trials, the Advisory Committee on Immunization Practices has preferentially recommended HZ/su vaccine over a live attenuated vaccine …

The Causes And Effects Of Attrition From Post-Graduate Residency Programs At The Aga Khan University Hospital, Nairobi., Dennis Wamalwa

Master of Medicine in General Surgery

Background: Resident attrition is a global problem affecting most postgraduate residency training programs. It not only disrupts the educational and workload balance in the program but also results in loss of valuable time invested by the resident who has to leave before completion. AKUHN has similarly been affected with a worrying increase in resident attrition numbers over the last few years. There is however a lack of local studies on resident attrition which would inform measures to address modifiable risk factors for resident attrition and thus prevent future attrition. Objectives: To explore factors attributable to attrition amongst residents in Aga …

Injection Partners, Hcv, And Hiv Status Among Rural Persons Who Inject Drugs In Puerto Rico, Patrick Habecker, Roberto Abadie, Melissa L. Welch-Lazoritz, Juan Carlos Reyes, Bilal Khan, Kirk Dombrowski

Department of Sociology: Faculty Publications

Background—The prevalence of hepatitis C (HCV) and HIV among persons who inject drugs (PWID) and the ability of these diseases to spread through injection networks are well documented in urban areas. However, less is known about injection behaviors in rural areas.

Objectives—This study focuses on the association between the number of self-reported injection partners with the PWID’s self-reported HCV and HIV status. Injection networks provide paths for infection and information to flow, and are important to consider when developing prevention and intervention strategies.

Methods—Respondent driven sampling was used to conduct 315 interviews with PWID in rural Puerto Rico during 2015. …

Life Satisfaction Among Elderly Patients In Nepal: Associations With Nutritional And Mental Well-Being. Health And Quality Of Life Outcomes, Saruna Ghimire, Binaya Kurmar Baral, Isha Karmacharya, Karen E. Callahan, Shiva Raj Mishra

School of Public Health Faculty Research

Nepal’s demography is aging rapidly, yet few studies to date have examined how this has affected the health and well-being of the elderly, defined as those above 60 years in Nepal’s Senior Citizen Act (2006). Our study, abbreviated NepEldQOLII, aims to assess perceived life satisfaction, and evaluate its relationship with nutritional health and mental well-being among the burgeoning Nepalese elderly population...(See full text for complete abstract)

Complete Blood Count Reference Intervals From A Healthy Adult Urban Population In Kenya, Geoffrey Omuse, Daniel Maina, Jane Mwangi, Caroline Wambua, Kiran Radia, Alice Kanyua, Elizabeth Kagotho, Mariza Hoffman, Peter Ojwang, Zul Premji, Kiyoshi Ichihara, Rajiv Erasmus

Pathology, East Africa

Background: There are racial, ethnic and geographical differences in complete blood count (CBC) reference intervals (RIs) and therefore it is necessary to establish RIs that are population specific. Several studies have been carried out in Africa to derive CBC RIs but many were not conducted with the rigor recommended for RI studies hence limiting the adoption and generalizability of the results.

Method: By use of a Beckman Coulter ACT 5 DIFF CP analyser, we measured CBC parameters in samples collected from 528 healthy black African volunteers in a largely urban population. The latent abnormal values exclusion (LAVE) method was used …

Therapeutic Relationship In Theory And Practice, Jerilyn Callen

Occupational Therapy Collection

No abstract provided.

Structure And Properties Of Dota-Chelated Radiopharmaceuticals Within The 225ac Decay Pathway, Artem R. Khabibullin, Aleksandra Karolak, Mikalai M. Budzevich, Mark L. Mclaughlin, David L. Morse, Lilia M. Woods

Clinical and Translational Science Institute

The successful delivery of toxic cargo directly to tumor cells is of primary importance in targeted (α) particle therapy. Complexes of radioactive atoms with the 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) chelating agent are considered as effective materials for such delivery processes. The DOTA chelator displays high affinity to radioactive metal isotopes and retains this capability after conjugation to tumor targeting moieties. Although the α-decay chains are well defined for many isotopes, the stability of chelations during the decay process and the impact of released energy on their structures remain unknown. The radioactive isotope 225Ac is an α-particle emitter that can be easily …

Epichromatin And Chromomeres: A ‘Fuzzy’ Perspective, Donald E. Olins, Ada L. Olins

Pharmaceutical Sciences Faculty Publications

‘Epichromatin’, the surface of chromatin beneath the interphase nuclear envelope (NE) or at the surface of mitotic chromosomes, was discovered by immunostaining with a specific bivalent mouse monoclonal anti-nucleosome antibody (mAb PL2-6). ‘Chromomeres’, punctate chromatin particles approximately 200–300 nm in diameter, identified throughout the interphase chromatin and along mitotic chromosomes, were observed by immunostaining with the monovalent papain-derived Fab fragments of bivalent PL2-6. The specific target for PL2-6 appears to include the nucleosome acidic patch. Thus, within the epichromatin and chromomeric regions, this epitope is ‘exposed’. Considering that histones possess unstructured ‘tails’ (i.e. intrinsically disordered peptide regions, IDPR), our perception …

The H Syndrome: A Genodermatosis, Sohaib Bhatti, Asma Jamil, Samrah Hasan Siddiqui, Uzair Yaqoob, Luqman Naseer Virk, Areesh Bhatti

Medical College Documents

H syndrome (histiocytosis lymph adenopathy plus syndrome) is an autosomal recessive disorder caused by mutations in the SLC29A3 gene, encoding the human equilibrative nucleoside transporter (hENT3), characterized by cutaneous hyperpigmentation and hypertrichosis, hepatosplenomegaly, hearing loss, heart anomalies, hypogonadism, low height, hyperglycemia/insulin-dependent diabetes mellitus, and hallux valgus/flexion contractures. Exophthalmos, malabsorption, renal anomalies, flexion contractions of interphalangeal joints and hallux valgus, and lytic bone lesions, as well as osteosclerosis, are also seen. If these are lacking, the constellation of additional findings should raise suspicion for H syndrome. As most of the patients reported to date with H syndrome are from traditional, low-income …

Marcum, Joe (Fa 1161), Manuscripts & Folklife Archives

Folklife Archives Finding Aids

Finding aid only for Folklife Archives Project 1161. Student folk studies project titled “Folklore Collection Project: [Old Recipes and Remedies]” which includes survey sheets with brief descriptions of recipes or remedies in Logan County and Warren County, Kentucky. Sheets may include a recipe, remedy, brief description, informant’s name, address and text classification.

Smith, Jerry W. (Fa 1162), Manuscripts & Folklife Archives

Folklife Archives Finding Aids

Finding aid only for Folklife Archives Project 1162. Student folk studies project titled “Home Remedies of Butler County” which includes survey sheets with brief descriptions of folk remedies in Butler County, Kentucky. Sheets may include a remedy, brief description, informant’s name,

address and text classification.

Endometrial Response To Conceptus-Derived Estrogen And Interleukin-1Β At The Time Of Implantation In Pigs, Hakhyun Ka, Heewon Seo, Yohan Choi, Inkyu Yoo, Jisoo Han

Obstetrics and Gynecology Faculty Publications

The establishment of pregnancy is a complex process that requires a well-coordinated interaction between the implanting conceptus and the maternal uterus. In pigs, the conceptus undergoes dramatic morphological and functional changes at the time of implantation and introduces various factors, including estrogens and cytokines, interleukin-1β2 (IL1B2), interferon-γ (IFNG), and IFN-δ (IFND), into the uterine lumen. In response to ovarian steroid hormones and conceptus-derived factors, the uterine endometrium becomes receptive to the implanting conceptus by changing its expression of cell adhesion molecules, secretory activity, and immune response. Conceptus-derived estrogens act as a signal for maternal recognition of pregnancy by changing the …

Restructuring Data Reported From State Early Hearing Detection And Intervention (Ehdi) Programs: A Pilot Study, Suhana Alam, Tammy O'Hollearn, Jim Beavers, Alyssa K. Rex, Rebekah F. Cunningham, Winnie Chung, Xidong Deng, Thuyquynh N. Do

Journal of Early Hearing Detection and Intervention

Objective: To assess the feasibility, benefits, and challenges surrounding individual-level versus aggregate data reporting by jurisdictional EHDI programs to the Centers for Disease Control and Prevention (CDC).

Methods: Using data reported to CDC by three jurisdictions in 2011, descriptive statistics were used to assess the feasibility of collecting and reporting individual-level data. Comparisons were made on what can be learned from individual-level data as opposed to CDC’s aggregate survey data.

Results: Individual-level data provided a detailed overview of the population served, services received, and variations across jurisdictions in data collection, reporting, and quality monitoring practices. Several challenges and areas needing …

The Past, Present And Future Of Universal Newborn Hearing Screening In Taiwan, Lin Hung-Ching, Hsiu-Wen Chang, Wen-Hui Hsieh

Journal of Early Hearing Detection and Intervention

In Taiwan, the Taipei Mackay Memorial Hospital, in collaboration with the Children’s Hearing Foundation, initiated a free newborn hearing screening program using transient evoked otoacoustic emissions (TEOAE) in 1998. During 2003-2013, there were four major phases of implementation and promotion of universal newborn hearing screening program (UNHS) in Taiwan initiated by the government’s Bureau of Health Promotion. These included (1) establishment of “2004 Taiwan Guidance of Newborn Hearing Screening Program” ; (2) completion of “2008 Taiwan Consensus Statement on Newborn Hearing Screening”; (3) implementation of national government-funded UNHS program in 2012; (4)“2014 Taiwan UNHS revised guidelines”. In summary, in 2016, …

Where Do We Go From Here? The Need For Genetic Referrals In Patients Who Are Deaf Or Hard Of Hearing: Findings From A Regional Survey, Tyson S. Barrett, Amanda Wylie, Beth Vogel, Kunal Sanghavi, Melissa Raspa, Kathryn P. Aveni, Kathryn Tullis, Michele Caggana, Karl R. White, Joann Bodurtha

Journal of Early Hearing Detection and Intervention

Purpose: The purpose of this study was to assess primary health care providers’ knowledge and use of genetic services for children whose hearing screening indicates they may be deaf/hard of hearing (D/HH) and identify areas in which health care providers can be supported to increase family education and referral of families for genetic consultation.

Methodology: A survey was developed on current practices, knowledge, and perceived beliefs regarding genetic education and referrals for deafness. The surveys were distributed to pediatricians, family medicine physicians, nurse practitioners, and physician assistants in DC, DE, MD, NJ, NY, PA, VA, and WV.

Results: Among 266 …

Identification Of Oral Clefts As A Risk Factor For Hearing Loss During Newborn Hearing Screening, Patricia L. Purcell, Kathleen Cy Sie, Todd C. Edwards, Debra Lochner Doyle, Karin Neidt

Journal of Early Hearing Detection and Intervention

Objective: This study assessed whether children with oral clefts are appropriately classified as at-risk for hearing loss at the time of newborn hearing screening and describes their screening and diagnostic results.

Design: Birth certificates were used to identify children with cleft lip and palate or isolated cleft palate born in Washington State from 2008–2013. These were cross-referenced with the state’s Early Hearing Detection, Diagnosis and Intervention (EHDDI) database. Multivariate logistic regression was used to examine associations.

Results: Birth records identified 235 children with cleft lip and palate and 116 with isolated cleft palate. Six children were listed as having both …

Pediatric Hearing Device Management: Professional Practices For Monitoring Aided Audibility, Karen F. Munoz, Lauri Nelson, Kacy Herald

Journal of Early Hearing Detection and Intervention

Objective: The purpose of this study was to explore professional practices for monitoring aided audibility for children who are deaf or hard of hearing (DHH).

Design: A cross-sectional survey design was used to identify providers’ self-reported practice patterns for monitoring aided audibility for children who use hearing aids, cochlear implants, and bone-conduction hearing aids. Three surveys were used.

Study Sample: Practicing audiologists, speech-language pathologists, and deaf educators providing services to children birth to six years of age who use hearing technology were recruited to participate. A total of 184 surveys were included in the analysis (96 hearing aid; 47 cochlear …

White Crane Spreads Its Wings And Snow Rabbit Digs The Earth: Kinetograms Of Contrasting Styles Within Chinese Martial And Meditative Arts Of Taijiquan (T’Ai Chi Ch’Uan, 太极拳) And Qigong (Chi Gong, 气功), Keith Mcewing

Journal of Movement Arts Literacy Archive (2013-2019)

Taijiquan is a Chinese martial art that developed in the 17th century from a base of traditional forms from earlier centuries. Now widely practiced internationally, it is promoted as gentle exercise, as self-defense and as movement meditation with significant health benefits. Qigong, consisting of similar movement but intended entirely as a health benefit, has been practiced for considerably longer. This paper discusses the advantages of having Taijiquan sequences or forms recorded with Kinetography Laban/Labanotation over other various memory aids for learning the martial art. It explains the basic principles of Taijiquan and how these can be best captured in the …

A Novel Diabetes Elective Course For Pharmacy Students, Amy M. Egras, Pharmd, Bcps, Bc-Adm

College of Pharmacy Posters

Course Description & Objectives

The Diabetes Immersion elective is a 2-credit hour course offered to pharmacy students in their 3rd year of pharmacy school.

1. Demonstrate empathy regarding the impact of diabetes on everyday life.
2. Demonstrate the ability to monitor blood glucose, count carbohydrates, inject “insulin”, and adjust insulin dose based on daily experiences.
3. Discuss the impact of mental health and sociobehavioral/cultural aspects on diabetes.
4. Develop and provide diabetes education to the community.

Increased Reactive Oxygen Species And Cell Cycle Defects Contribute To Anemia In The Rasa3 Mutant Mouse Model S, Emily S Hartman, Elena C Brindley, Julien Papoin, Steven L. Ciciotte, Yue Zhao, Luanne L. Peters, Lionel Blanc

Faculty Research 2018

RASA3 is a Ras GTPase activating protein that plays a critical role in blood formation. The autosomal recessive mouse model scat (severe combined anemia and thrombocytopenia) carries a missense mutation in Rasa3. Homozygotes present with a phenotype characteristic of bone marrow failure that is accompanied by alternating episodes of crisis and remission. The mechanism leading to impaired erythropoiesis and peripheral cell destruction as evidenced by membrane fragmentation in scat is unclear, although we previously reported that the mislocalization of RASA3 to the cytosol of reticulocytes and mature red cells plays a role in the disease. In this study, we …

Oocyte Stage-Specific Effects Of Mtor Determine Granulosa Cell Fate And Oocyte Quality In Mice., Jing Guo, Teng Zhang, Yueshuai Guo, Tao Sun, Hui Li, Xiaoyun Zhang, Hong Yin, Guangyi Cao, Yaoxue Yin, Hao Wang, Lanying Shi, Xuejiang Guo, Jiahao Sha, John J. Eppig, You-Qiang Su

Faculty Research 2018

MTOR (mechanistic target of rapamycin) is a widely recognized integrator of signals and pathways key for cellular metabolism, proliferation, and differentiation. Here we show that conditional knockout (cKO) of Mtor in either primordial or growing oocytes caused infertility but differentially affected oocyte quality, granulosa cell fate, and follicular development. cKO of Mtor in nongrowing primordial oocytes caused defective follicular development leading to progressive degeneration of oocytes and loss of granulosa cell identity coincident with the acquisition of immature Sertoli cell-like characteristics. Although Mtor was deleted at the primordial oocyte stage, DNA damage accumulated in oocytes during their later growth, and …

A Comprehensive Review Of The Fabella Bone., Dominic Dalip, Joe Iwanaga, Rod J Oskouian, R Shane Tubbs

Articles, Abstracts, and Reports

The fabella is a sesamoid bone that is embedded in the lateral head of the gastrocnemius muscle and often articulates directly with the lateral femoral condyle. It is present in 10-30% of the general population with a higher incidence in Asians. The fabella can lead to various pathologies such as fabella pain syndrome and common fibular nerve palsy. Conservative treatment involves physical therapy or injecting local anesthetics or steroids around this bone. However, if symptoms persist, then a fabellectomy can be performed. Physicians should be aware of the fabella bone and the multiple pathologies associated with it in order to …

Effect Of Manual Over Scoring On Automated Analysis Of Level 3 Home Sleep Testing (Hst) Results, Theodora Fynn, Ritu Grewal, Karl Doghramji, Prakash Vasudevan, Tingting Zhan

Department of Sleep Medicine Posters

No abstract provided.

Novel Genotype-Phenotype Correlations In Five Chinese Families With Von Hippel-Lindau Disease., Qiuli Liu, Gang Yuan, Dali Tong, Gaolei Liu, Yuting Yi, Jun Zhang, Yao Zhang, Lin-Ang Wang, Luofu Wang, Dianzheng Zhang, Rongrong Chen, Yanfang Guan, Xin Yi, Weihua Lan, Jun Jiang

PCOM Scholarly Works

CONTEXT: Von Hippel-Lindau (VHL) disease manifests as a variety of benign and malignant neoplasms. Previous studies of VHL disease have documented several genotype-phenotype correlations; however, many such correlations are still unknown. Increased identification of new mutations and patients with previously described mutations will allow us to better understand how VHL mutations influence disease phenotypes.

PATIENTS AND DESIGN: A total of 45 individuals from five unrelated families were evaluated, of which 21 patients were either diagnosed with VHL disease or showed strong evidence related to this disease. We compared the patients' gene sequencing results with their medical records including computed tomography …

Using Mhealth To Increase Treatment Utilization Among Recently Incarcerated Homeless Adults (Link2care): Protocol For A Randomized Controlled Trial, Jennifer M. Reingle Gonzalez, Michael S. Businelle, Darla Kendzor, Michele Staton, Carol S. North, Michael Swartz

Behavioral Science Faculty Publications

Background: There is a significant revolving door of incarceration among homeless adults. Homeless adults who receive professional coordination of individualized care (ie, case management) during the period following their release from jail experience fewer mental health and substance use problems, are more likely to obtain stable housing, and are less likely to be reincarcerated. This is because case managers work to meet the various needs of their clients by helping them to overcome barriers to needed services (eg, food, clothing, housing, job training, substance abuse and mental health treatment, medical care, medication, social support, proof of identification, and legal aid). …

Alcohol Consumption Promotes Colorectal Carcinoma Metastasis Via A Ccl5-Induced And Ampk-Pathway-Mediated Activation Of Autophagy, Haodong Zhao, Danlei Chen, Rui Cao, Shiqing Wang, Dandan Yu, Yakun Liu, Yu Jiang, Mei Xu, Jia Luo, Siying Wang

Pharmacology and Nutritional Sciences Faculty Publications

There is a definite relationship between alcohol consumption and colorectal cancer (CRC) development. We investigated effect of alcohol consumption on CRC patients’ progression and prognosis by utilizing epidemiological data and found patients with alcohol consumption increased risks of tumor-node-metastasis (TNM), organ metastasis and poorer prognosis. Because their tumor tissues displayed increased expression of C-C chemokine ligand 5 (CCL5), we hypothesized CCL5 might participate in cancer progression in such patients. Ethanol increased the secretion of CCL5 in two CRC cell lines, HT29 and DLD-1. Treatment with CCL5 directly increased migratory ability of these cells, whereas neutralization or knockdown of CCL5 can …

Codon Usage Revisited: Lack Of Correlation Between Codon Usage And The Number Of Trna Genes In Enterobacteria, Joaquín Rojas, Gabriel Castillo, Lorenzo Eugenio Leiva, Sara Elgamal, Omar Orellana, Michael Ibba, Assaf Katz

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

It is widely believed that if a high number of genes are found for any tRNA in a rapidly replicating bacteria, then the cytoplasmic levels of that tRNA will be high and an open reading frame containing a higher frequency of the complementary codon will be translated faster. This idea is based on correlations between the number of tRNA genes, tRNA concentration and the frequency of codon usage observed in a limited number of strains as well as from the fact that artificially changing the number of tRNA genes alters translation efficiency and consequently the amount of properly folded protein …

The Assessment Of Isometric, Dynamic, And Sports-Specific Upper-Body Strength In Male And Female Competitive Surfers, Joanna Parsonage, Josh Secomb, Rebecca Dowse, Brendon Ferrier, Jeremy Sheppard, Sophia Nimphius

Research outputs 2014 to 2021

The primary purpose of this study was to investigate gender differences in the dynamic strength index (DSI): an assessment of upper-body dynamic strength relative to maximal isometric strength. The secondary purpose was to investigate gender differences in the dynamic skill deficit (DSD): an assessment of sports-specific dynamic strength relative to maximal isometric strength, and its association with a sports-specific performance measure in surfers. Nine male (age = 30.3 ± 7.3 yrs) and eight female (age = 25.5 ± 5.2 yrs) surfers undertook three upper-body assessments: isometric push-up, dynamic push-up, and a force plate pop-up to determine the DSI and DSD. …