Medicine and Health Sciences Commons^™

Urinothorax Caused By Xanthogranulomatous Pyelonephritis, Waiel Abusnina, Hazim Bukamur, Zeynep C. Koc

Internal Medicine

Xanthogranulomatous pyelonephritis is a rare form of chronic pyelonephritis that generally afflicts middle-aged women with a history of recurrent urinary tract infections. Its pathogenesis generally involves calculus obstructive uropathy and its histopathology is characterized by replacement of the renal parenchyma with lipid filled macrophages. This often manifests as an enlarged, nonfunctioning kidney that may be complicated by abscess or fistula. This case details the first reported case of xanthogranulomatous pyelonephritis complicated by urinothorax, which resolved on follow-up chest X-ray after robot-assisted nephrectomy.

A Mapping Review Of Randomized Controlled Trials In The Spinal Cord Injury Research Literature, Amanda Mcintyre, Brooke Benton, Shannon Janzen, Jerome Iruthayarajah, Joshua Weiner, Janice J. Eng, Robert Teasell, Spinal Cord Injury Research Evidence Team

Epidemiology and Biostatistics Publications

Study design

Mapping Review.

Objective

The objective of this study was to map out and characterize the quantity and quality of all published spinal cord injury (SCI) randomized controlled trials (RCTs) with respect to number, sample size, and methodological quality between January 1970 and December 2016.

Setting

Not applicable.

Methods

A literature search of multiple research databases was conducted. Studies adhering to the following criteria were included: the research design was an RCT; written in English; participants were >18 years; and the sample was >50% SCI. Data were extracted pertaining to author(s), year of publication, country of origin, initial and …

Economic Evaluation Of Patient Navigation Programs In Colorectal Cancer Care, A Systematic Review., Chloé Gervès-Pinquié, Anne Girault, Serena Phillips, Sarah Raskin, Mandi Pratt-Chapman

Pediatrics Faculty Publications

Patient navigation has expanded as a promising approach to improve cancer care coordination and patient adherence. This paper addresses the need to identify the evidence on the economic impact of patient navigation in colorectal cancer, following the Health Economic Evaluation Publication Guidelines. Articles indexed in Medline, Cochrane, CINAHL, and Web of Science between January 2000 and March 2017 were analyzed. We conducted a systematic review of the literature using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The quality assessment of the included studies was based on the Consolidated Health Economic Evaluation Reporting Standards (CHEERS) checklist. Inclusion criteria …

Trace-Level Identifications Are Not Positives: The Scientifically Correct And Public Relations-Appropriate Approach To Medication Regulation, Clara Fenger, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

No abstract provided.

Craig, Patricia (Fa 1183), Manuscripts & Folklife Archives

Folklife Archives Finding Aids

Finding aid only for Folklife Archives Project 1183. Student paper titled “Folk Remedies” in which Patricia Craig gathers together traditional herbal remedies and folkloric practices as they relate to health and healing. Craig collected information from close relatives, friends, and other residents of Muhlenberg County.

Microgel Core/Shell Architectures As Targeted Agents For Fibrinolysis, Purva Kodlekere, L. Andrew Lyon

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

We demonstrate the utility of microgel core/shell structures conjugated to fibrin-specific peptides as fibrinolytic agents. Poly(N-isopropylmethacrylamide) (pNIPMAm) based microgels conjugated to the peptide GPRPFPAC (GPRP) were observed to bring about fibrin clot erosion, merely through exploitation of the dynamic nature of the clots. These results suggest the potential utility of peptide–microgel hybrids in clot disruption and clotting modulation.

Bridging The Gap: An Innovative Web-Based Approach For Evaluating Ebp Readiness In Direct Care Nurses, Joann D. Long, Stacey L. Spradling, Karen Baggerly, Nikki L. Galaviz, Jamie Roney

Books, Presentations, Posters, Etc.

The provision of universal and equitable access to safe and effective healthcare emphasized in The 2012 World Health Report, 'no health without research': The endpoint needs to go beyond publication outputs, has forwarded the global evidence-based practice (EBP) movement (Zachariah et al., 2011). Notably, Lindeman (1975) identified research utilization and quality improvement as nursing priorities over forty years ago. Yet, current literature suggests research findings may take seventeen years to reach practice integration (Morris et al., 2011). Notably another dilemma added to the challenge is approximately 80% of current nursing practice does not reflect evidence-based nursing decisions (Conner, Dwyer, and …

Apoe And Alzheimer’S Disease: Neuroimaging Of Metabolic And Cerebrovascular Dysfunction, Jason A. Brandon, Brandon C. Farmer, Holden C. Williams, Lance A. Johnson

Physiology Faculty Publications

Apolipoprotein E4 (ApoE4) is the strongest genetic risk factor for late onset Alzheimer’s Disease (AD), and is associated with impairments in cerebral metabolism and cerebrovascular function. A substantial body of literature now points to E4 as a driver of multiple impairments seen in AD, including blunted brain insulin signaling, mismanagement of brain cholesterol and fatty acids, reductions in blood brain barrier (BBB) integrity, and decreased cerebral glucose uptake. Various neuroimaging techniques, in particular positron emission topography (PET) and magnetic resonance imaging (MRI), have been instrumental in characterizing these metabolic and vascular deficits associated with this important AD risk factor. In …

Identifying An Early Treatment Window For Predicting Breast Cancer Response To Neoadjuvant Chemotherapy Using Immunohistopathology And Hemoglobin Parameters, Quing Zhu, Susan Tannenbaum, Scott H. Kurtzman, Patricia Defusco, Andrew Ricci Jr., Hamed Vavadi, Feifei Zhou, Chen Xu, Alex Merkulov, Poornima Hegde, Mark Kane, Liqun Wang, Kert Sabbath

Publications and Research

Background

Breast cancer pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) varies with tumor subtype. The purpose of this study was to identify an early treatment window for predicting pCR based on tumor subtype, pretreatment total hemoglobin (tHb) level, and early changes in tHb following NAC.

Methods

Twenty-two patients (mean age 56 years, range 34–74 years) were assessed using a near-infrared imager coupled with an Ultrasound system prior to treatment, 7 days after the first treatment, at the end of each of the first three cycles, and before their definitive surgery. Pathologic responses were dichotomized by the Miller-Payne system. Tumor …

Clinical Effectiveness Of Family Therapeutic Interventions In The Prevention And Treatment Of Perinatal Depression: A Systematic Review And Meta-Analysis, Fallon Cluxton-Keller, Martha L. Bruce

Dartmouth Scholarship

Background:

Family therapy is a potential strategy to increase family support for those suffering from perinatal depression. Family therapeutic interventions for this population typically target depressed women and their adult family members to improve family functioning and reduce depressive symptoms.

Objective:

This systematic review and meta-analysis is a synthesis of the current evidence on the usefulness of family therapy interventions in the prevention and treatment of perinatal depression and impacts on maternal depressive symptoms and family functioning.

Methods:

This study used the Cochrane Collaboration guidelines for systematic reviews and meta-analyses. Six electronic databases were searched for randomized controlled trials and …

Altered Expression Of Genes Involved In Ganglioside Biosynthesis In Substantia Nigra Neurons In Parkinson's Disease., Jay S. Schneider

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Reduced expression of GM1 and other major brain gangliosides GD1a, GD1b and GT1b have been reported in Parkinson's disease (PD) brain. Mechanisms underlying these changes are unclear but may be due to a deficit in the ganglioside biosynthetic process. The present study examined the extent to which deficits in gene expression of key biosynthetic enzymes involved in synthesis of GM1 and GD1b (B3galt4) and GD1a and GT1b (St3gal2) exist in neuromelanin-containing neurons in the PD substantia nigra (SN). In situ hybridization histochemistry was used to examine gene expression of B3GALT4 and ST3GAL2 in neuromelanin-containing neurons in the SN in 8 …

Genomic Dissection Of Bipolar Disorder And Schizophrenia, Including 28 Subphenotypes, Douglas M. Ruderfer, Stephan Ripke, Andrew Mcquillin, James Boocock, Ney Alliey Rodriguez

School of Medicine Publications

Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology. Understanding the genetic factors contributing to the shared and disorder-specific symptoms will be crucial for improving diagnosis and treatment. In genetic data consisting of 53,555 cases (20,129 bipolar disorder [BD], 33,426 schizophrenia [SCZ]) and 54,065 controls, we identified 114 genome-wide significant loci implicating synaptic and neuronal pathways shared between disorders. Comparing SCZ to BD (23,585 SCZ, 15,270 BD) identified four genomic regions including one with disorder-independent causal variants and potassium ion response genes as contributing to differences in biology between the disorders. Polygenic risk score (PRS) analyses identified several …

Feeding The World With Die Rolls: Potential Applications Of Quantum Computing

Dartmouth Undergraduate Journal of Science

No abstract provided.

The Mouhefanggai And Cavalieri's Principle

Dartmouth Undergraduate Journal of Science

No abstract provided.

Ethical Regulation Of Medical Experiments On Humans, Nick Awertschenko

Dartmouth Undergraduate Journal of Science

No abstract provided.

The Science Behind Memory: Hippocampal Neural Cell Assemblies, Nishi Jain

Dartmouth Undergraduate Journal of Science

No abstract provided.

The Immunity Of The Many: Ethical Considerations Of Vaccinations In Light Of Herd Immunity, Sophia Koval

Dartmouth Undergraduate Journal of Science

No abstract provided.

Frontiers In Dna Synthesis: Click Chemistry

Dartmouth Undergraduate Journal of Science

No abstract provided.

Cilia And Flagella: From Discovery To Disease, Dylan J. Cahill

Dartmouth Undergraduate Journal of Science

No abstract provided.

Letter From The Editor

Dartmouth Undergraduate Journal of Science

No abstract provided.

Traditional And Systems Biology Based Drug Discovery For The Rare Tumor Syndrome Neurofibromatosis Type 2, R. Allaway, S. P. Angus, R. L. Beauchamp, J. O. Blakely, M. Bott, S. S. Burns, A. Carlstedt, L-S Chang, X. Chen, D. W. Wade Clapp, P. A. Desouza, S. Erdin, C. Fernandez-Valle, J. Guinney, J. F. Gusella, S. J. Haggarty, G. L. Johnson, S. La Rosa, H. Morrison, A. M. Petrilli, S. R. Plotkin, A. Pratap, V. Ramesh, N. Sciaky, A. Temmer-Rachamimov, T. J. Stuhlmiller, M. E. Talkowski, D. B. Welling, C. W. Yates, J. S. Zawistowski, W-N Zhao

Pharmaceutical Sciences

No abstract provided.

Jnk2 Deficiency Increases The Rate Of Glaucomatous Neurodegeneration In Ocular Hypertensive Dba/2j Mice., Jeffrey M. Harder, Pete A. Williams, Ileana Soto, Nicole E Foxworth, Kimberly A Fernandes, Nelson F Freeburg, Richard T Libby, Simon W M John

Faculty Research 2018

The cJun N-terminal kinases (JNKs; JNK1, JNK2, and JNK3) promote degenerative processes after neuronal injury and in disease. JNK2 and JNK3 have been shown to promote retinal ganglion cell (RGC) death after optic nerve injury. In their absence, long-term survival of RGC somas is significantly increased after mechanical optic nerve injury. In glaucoma, because optic nerve damage is thought to be a major cause of RGC death, JNKs are an important potential target for therapeutic intervention. To assess the role of JNK2 and JNK3 in an ocular hypertensive model of glaucoma, null alleles of Jnk2 and Jnk3 were backcrossed into …

In Memoriam: Herbert L. Needleman (1927-2017), Aldemaro Romero Jr.

Publications and Research

On July 18, 2017, Dr. Herbert L. Needleman, of Squirrel Hill, Pittsburgh, a pediatrician and a child psychiatrist who greatly contributed to improve environmental health worldwide by demonstrating in the late 1970s that children exposed to even small amounts of lead could suffer intellectual and behavioral disorders, passed away. He was living at Weinberg Village, an assisted living home in Glen Hazel, neighbor in Pittsburgh, Pa., where he had spent the last two years while suffering from Alzheimer's disease. Dr. Needleman's work prompted regulations that limited or banned the metal in a range of common products, like gasoline and paint, …

Exposure To Household Air Pollution From Biomass-Burning Cookstoves And Hba1c And Diabetic Status Among Honduran Women, S. Rajkumar, M. L. Clark, B. N. Young, Megan L. Benka-Coker, A. M. Bachand, R. D. Brook, T. L. Nelson, J. Volckens, S. J. Reynolds, C. L'Orange, N. Good, K. Koehler, S. Africano, A. B. Osorto Pinel, J. L. Peel

Health Sciences Faculty Publications

Household air pollution from biomass cookstoves is estimated to be responsible for more than two and a half million premature deaths annually, primarily in low and middle‐income countries where cardiometabolic disorders, such as Type II Diabetes, are increasing. Growing evidence supports a link between ambient air pollution and diabetes, but evidence for household air pollution is limited. This cross‐sectional study of 142 women (72 with traditional stoves and 70 with cleaner‐burning Justa stoves) in rural Honduras evaluated the association of exposure to household air pollution (stove type, 24‐hour average kitchen and personal fine particulate matter [PM2.5] mass and black carbon) …

Mir126-5p Downregulation Facilitates Axon Degeneration And Nmj Disruption Via A Non-Cell-Autonomous Mechanism In Als., Roy Maimon, Ariel Ionescu, Avichai Bonnie, Sahar Sweetat, Shane Wald-Altman, Shani Inbar, Tal Gradus, Davide Trotti, Miguel Weil, Oded Behar, Eran Perlson

Farber Institute for Neuroscience Faculty Papers

Axon degeneration and disruption of neuromuscular junctions (NMJs) are key events in amyotrophic lateral sclerosis (ALS) pathology. Although the disease's etiology is not fully understood, it is thought to involve a non-cell-autonomous mechanism and alterations in RNA metabolism. Here, we identified reduced levels of miR126-5p in presymptomatic ALS male mice models, and an increase in its targets: axon destabilizing Type 3 Semaphorins and their coreceptor Neuropilins. Using compartmentalized

Can Capture Be Used To Identify Undiagnosed Patients With Mild-To-Moderate Copd Likely To Benefit From Treatment?, Nancy K. Leidy, Fernando J. Martinez, Karen G. Malley, David M. Mannino, Meilan K. Han, Elizabeth D. Bacci, Randall W. Brown, Julia F. Houfek, Wassim W. Labaki, Barry J. Make, Catherine A. Meldrum, Wilson Quezada, Stephen Rennard, Byron Thomashow, Barbara P. Yawn

Preventive Medicine and Environmental Health Faculty Publications

Background: COPD Assessment in Primary Care To Identify Undiagnosed Respiratory Disease and Exacerbation Risk (CAPTURE™) uses five questions and peak expiratory flow (PEF) thresholds (males ≤350 L/min; females ≤250 L/min) to identify patients with a forced expiratory volume in 1 second (FEV₁)/forced vital capacity (FVC)11 60%–80% predicted) who may also benefit from diagnosis and treatment.

Methods: Data from the CAPTURE development study were used to test its sensitivity (SN) and specificity (SP) differentiating mild-to-moderate COPD (n=73) from no COPD (n=87). SN and SP for differentiating all COPD cases (mild to severe; n=259) from those without COPD (n=87) were …

Use Of Lightboard Video Technology To Address Medical Dosimetry Concepts: Field Notes, Julia Vandermolen, Kristen Vu, Justin Melick

Current Issues in Emerging eLearning

Focusing on Lightboard video technology to create online videos as a resource for Medical Dosimetry students, this field note shares perspectives and student voices on Lightboard videos that can be useful in understanding the concepts pertaining to Medical Dosimetry such as brachytherapy equations. Through the study, the instructors wanted to know students’ perceptions of how video use increased their interest and understanding of brachytherapy equations. A SurveyMonkey questionnaire collected responses from eight students and revealed that these students perceived the use of Lightboard videos provided a solid learning platform to master the concept of brachytherapy prior to performing the homework. …

Anti-Tumor Activity Of Phenoxybenzamine And Its Inhibition Of Histone Deacetylases, Mario A. Inchiosa

NYMC Faculty Publications

The principal finding from this study was the recognition that the α-adrenergic antagonist, phenoxybenzamine, possesses histone deacetylase inhibitory activity. Phenoxybenzamine is approved by the United States Food and Drug Administration for the treatment of hypertensive crises associated with tumors of the adrenal medulla, pheochromocytomas. It has several "off label" indications relative to its capacity to relax vascular smooth muscle and smooth muscle of the urogenital tract. The drug also has a long history of apparent efficacy in ameliorating, and perhaps reversing, the severe symptoms of neuropathic pain syndromes. Our interest in this feature of the drug relates to the fact …

Well-Being And Readiness To Change Among Career Firefighters, Elizabeth R. Feinauer

Morehead State Theses and Dissertations

A thesis presented to the faculty of the College of Science, Morehead State University in partial fulfillment of the requirements for the Degree Master of Arts by Elizabeth R. Feinauer on June 12, 2018.

Sources And Fates Of Carbamyl Phosphate: A Labile Energy-Rich Molecule With Multiple Facets., Dashuang Shi, Ljubica Caldovic, Mendel Tuchman

Genomics and Precision Medicine Faculty Publications

Carbamyl phosphate (CP) is well-known as an essential intermediate of pyrimidine and arginine/urea biosynthesis. Chemically, CP can be easily synthesized from dihydrogen phosphate and cyanate. Enzymatically, CP can be synthesized using three different classes of enzymes: (1) ATP-grasp fold protein based carbamyl phosphate synthetase (CPS); (2) Amino-acid kinase fold carbamate kinase (CK)-like CPS (anabolic CK or aCK); and (3) Catabolic transcarbamylase. The first class of CPS can be further divided into three different types of CPS as CPS I, CPS II, and CPS III depending on the usage of ammonium or glutamine as its nitrogen source, and whether