Medicine and Health Sciences Commons^™

Slaying Little Dragons: The Impact Of The Guinea Worm Eradication Program On Dracunculiasis Disability Averted From 1990 To 2016, Elizabeth A. Cromwell, Sharon Roy, Dieudonne P. Sankara, Adam Weiss, Jeffrey Stanaway, Ellen Goldberg, David M. Pigott, Heidi Larson, Stein Emil Vollset, Zulfiqar Ahmed Bhutta

Department of Paediatrics and Child Health

Background: The objective of this study was to document the worldwide decline of dracunculiasis (Guinea worm disease, GWD) burden, expressed as disability-adjusted life years (DALYs), from 1990 to 2016, as estimated in the Global Burden of Disease study 2016 (GBD 2016). While the annual number of cases of GWD have been consistently reported by WHO since the 1990s, the burden of disability due to GWD has not previously been quantified in GBD.
Methods: The incidence of GWD was modeled for each endemic country using annual national case reports. A literature search was conducted to characterize the presentation of GWD, translate …

Mhealth Technology Use And Implications In Historically Underserved And Minority Populations In The United States: Systematic Literature Review, Charkarra Anderson-Lewis, Gabrielle Darville, Rebeccah Eve Mercado, Savannah Howell, Samantha Di Maggio

Faculty Publications

Background: The proportion of people in the United States who are members of at least two ethnic groups is projected to increase to 10% by the year 2050. This makes addressing health disparities and health inequities in minority populations increasingly more difficult. Minority populations, including those who classify themselves as African American and Hispanic, are using mobile phones to access health information via the internet more frequently than those who classify themselves as white, providing unique opportunities for those in public health and health education to reach these traditionally underserved populations using mobile health (mHealth) interventions.

Objective: The objective of …

Dominique Gummelt, Dominique Gummelt

Summer 2018

It is so easy to live or work alongside someone for many years and not really know them. I have always been inspired by the energy, passion and cheerfulness of our director of University Health & Wellness, Dominique Gummelt, but I have never spent time getting to know her. This week I decided it was time to change that reality. I am glad I did. As she shared her story with me, I discovered some interesting facts. Dominique came to the United States as an exchange student at age 16 and has lived here since that time. Life had been …

Distribution And Localization Of Novel Iodine Nanoparticles In The Human Glioma 1242 Growing In The Brains Of Mice, Benjamin Billings

Honors Scholar Theses

Observing and designing the in vivo distribution and localization of therapeutic nanoparticles is an essential aspect of developing and understanding novel nanoparticle- based medical treatments. This study investigates novel PEGylated Iodine-based nanoparticles (INPs), an alternate composition to the more widely researched gold nanoparticles (AuNPs), which may help avoid adverse effects associated with AuNPs, such as potential toxicity and skin discoloration, when used in similar applications. Determining the localization of the novel INPs within murine brains containing human glioma U-1242MG cells is critical in assisting the development of radiation dose enhancement therapy for this aggressive cancer. Radiation dose enhancement utilizes the …

Looking Beyond Patient Satisfaction: Experiences Of Spanish-Speaking Patients Seeking Non-Urgent Care In An Emergency Department, Seiichi Villalona

USF Tampa Graduate Theses and Dissertations

This exploratory mixed-methods study examines the experiences of Spanish-speaking patients seeking non-urgent care in an emergency department setting. Emphasis is placed on understanding variables that influence patient satisfaction among this particular special patient population. This study draws from the explanatory models of illness and perspectives of clinically applied anthropology in contributing to the limited body of scholarly work that utilizes ethnographic approaches in clinical spaces to investigate how patients experience seeking emergency care services. Health-related deservingness, social determinants of health, and health literacy are used as complementary frameworks in understanding the unique experiences of these patients. The combination of methodological …

Medical School Watercooler Newsletter - June 17, 2018, Lindsey Lyle

Watercooler Newsletter

This is the June 17, 2018 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Register Now - Conquering the Crisis: Fighting Substance Misuse in Alabama
• Class of 2020 Cloaked With White Coats at Annual Ceremony
• USA Health Hosts Appreciation Social for Providers
• USA College of Medicine Welcomes Back Dr. Antonio Pacheco
• USA Welcomes New Physician-Scientist

Anti-Proliferation Effect Of Theasaponin E₁ On The Aldh-Positive Ovarian Cancer Stem-Like Cells, Ling-Yan Jia, Hui-Long Xia, Zhi-Da Chen, Casey Compton, Heather Bucur, Devendra A. Sawant, Gary O. Rankin, Bo Li, You-Ying Tu, Yi Charlie Chen

Clinical and Translational Science Institute

Ovarian cancer has the highest mortality rate of all gynecological malignancies and the five-year death rate of patients has remained high in the past five decades. Recently, with the rise of cancer stem cells (CSCs) theory, an increasing amount of research has suggested that CSCs give rise to tumor recurrence and metastasis. Theasaponin E1 (TSE1), which was isolated from green tea (Camellia sinensis) seeds, has been proposed to be an effective compound for tumor treatment. However, studies on whether TSE1 takes effect through CSCs have rarely been reported. In this paper, ALDH-positive (ALDH+) ovarian cancer stem-like cells from two platinum-resistant …

Reversal Of Fixed Pulmonary Hypertension With Transcatheter Valve Replacement For Aortic Insufficiency On Ventricular Assist Device Support, Faraz S. Ahmad, Mark J. Ricciardi, Laura J. Davidson, Allen S. Anderson, Kambiz Ghafourian, Ike Okwuosa, Esther Vorovich, Jane E. Wilcox, Daniel D. Holloway, Duc T. Pham, Jonathan D. Rich

The VAD Journal

We present a 43-year-old woman with a nonischemic cardiomyopathy implanted with a ventricular assist device (VAD) as bridge to transplant due to severe, “fixed” pulmonary hypertension (PH). Within three months of VAD implant, her “fixed” PH had resolved entirely. Nearly two years later, still supported with a VAD because of severe HLA allosensitization, she developed dyspnea and “moderate” aortic insufficiency (AI) by standard criteria. Invasive hemodynamics revealed recurrence of severe PH in the setting of elevated left-sided filling pressures. We concluded the AI was indeed severe and the cause of her symptoms and recurrent PH. Despite her minimally calcified aortic …

An Adaptation Of Grounded Theory Using A Modified Convergent Interviewing Technique, Elica Safari Mehr, Peter Carswell, Karen Day

The Qualitative Report

Grounded Theory (GT) researchers have been using adaptations of this methodology to serve theory building purposes, following different theoretical frameworks. However, there is a lack of enough information on the variation of GT used, or their epistemological assumptions in some studies. The purpose of this paper is to provide our experience in a GT study using a modified convergent interviewing technique to help guide other researchers on using this method and build their own research design. We have combined a decision-making technique, called Delphi, with convergent interviewing and provided a clear explanation of the steps required to apply this method …

Agenda (Pdf), Department Of Orthopaedic Surgery

Dept. of Orthopaedics: Robert D. D’Ambrosia Lectureship & Research Day

No abstract provided.

Multimodal Pain Management For Older Adults In Primary Care, Bina Solanky

DNP Qualifying Manuscripts

Persistent pain affects 50% to 75% of adults of the age of 65 and it is often underreported and undertreated in primary care. This manuscript discusses how nurse practitioners and other primary care providers can manage persistent pain in older adults utilizing nonpharmacological methods in addition to standard pharmacological treatments.

The Role Of Communities In Mental Health Care In Low- And Middle-Income Countries: A Meta-Review Of Components And Competencies., Brandon A Kohrt, Laura Asher, Anvita Bhardwaj, Mina Fazel, Mark J D Jordans, Byamah B Mutamba, Abhijit Nadkarni, Gloria A Pedersen, Daisy R Singla, Vikram Patel

Psychiatry and Behavioral Sciences Faculty Publications

Abstract

Community-based mental health services are emphasized in the World Health Organization’s Mental Health Action Plan, the World Bank’s Disease Control Priorities, and the Action Plan of the World Psychiatric Association. There is increasing evidence for effectiveness of mental health interventions delivered by non-specialists in community platforms in low- and middle-income countries (LMIC). However, the role of community components has yet to be summarized. Our objective was to map community interventions in LMIC, identify competencies for community-based providers, and highlight research gaps. Using a review-of-reviews strategy, we identified 23 reviews for the narrative synthesis. Motivations to employ community …

Ophthalmic Artery Aneurysm In A Cadaver: Case Report., Dominic Dalip, Joe Iwanaga, Marios Loukas, Rod J Oskouian, R Shane Tubbs

Articles, Abstracts, and Reports

The ophthalmic artery arises from the supraclinoid segment of the internal carotid artery (ICA) and enters the orbit through the optic canal. It perfuses the orbit and the orbit apparatus. Ophthalmic artery aneurysms (OAA) account for 0.5% to 11% of all intracerebral aneurysms. Patients are usually asymptomatic but, in some cases, patients can present with ophthalmoplegia and total blindness if these aneurysms rupture. Aneurysms are usually diagnosed using computed tomography (CT) angiography but can also be seen on magnetic resonance imaging (MRI) and four-vessel digital subtraction angiography. Treatment of OAA entails either surgical or endovascular approaches with the mortality rate …

Trends And Factors Associated With Early Initiation Of Breastfeeding In Namibia: Analysis Of The Demographic And Health Surveys 2000–2013, M. N. Ndirangu, Samwel Gatimu, H. M. Mwinyi, D. C. Kibiwott

School of Nursing & Midwifery, East Africa

Background: Early initiation of breastfeeding (EIBF) lowers the risk for all-cause mortality in babies, including those with low birth weight. However, rates of neonatal mortality and delayed initiation of breastfeeding remain high in most low- and middle-income countries. This study aimed to assess the trends and factors associated with EIBF in Namibia from 2000 to 2013.

Methods: An analysis of EIBF trends was conducted using data from three Namibia Demographic Health Surveys. The present sample included singleton children younger than 2-years from 2000 (n = 1655), 2006–2007 (n = 2152) and 2013 (n = 2062) surveys. Descriptive statistics were used …

Emerging Cellular And Molecular Strategies For Enhancing Central Nervous System (Cns) Remyelination., Mohammad Abu-Rub, Robert H Miller

Anatomy and Regenerative Biology Faculty Publications

Myelination is critical for the normal functioning of the central nervous system (CNS) in vertebrates. Conditions in which the development of myelin is perturbed result in severely compromised individuals often with shorter lifespans, while loss of myelin in the adult results in a variety of functional deficits. Although some form of spontaneous remyelination often takes place, the repair process as a whole often fails. Several lines of evidence suggest it is feasible to develop strategies that enhance the capacity of the CNS to undergo remyelination and potentially reverse functional deficits. Such strategies include cellular therapies using either neural or mesenchymal …

Linking Molar Organizational Climate And Strategic Implementation Climate To Clinicians’ Use Of Evidence-Based Psychotherapy Techniques: Cross-Sectional And Lagged Analyses From A 2-Year Observational Study, Nathaniel J. Williams, Mark G. Ehrhart, Gregory A. Aarons, Steven C. Marcus, Rinad S. Beidas

Social Work Faculty Publications and Presentations

Background: Behavioral health organizations are characterized by multiple organizational climates, including molar climate, which encompasses clinicians’ shared perceptions of how the work environment impacts their personal well-being, and strategic implementation climate, which includes clinicians’ shared perceptions of the extent to which evidence-based practice implementation is expected, supported, and rewarded by the organization. Theory suggests these climates have joint, cross-level effects on clinicians’ implementation of evidence-based practice and that these effects may be long term (i.e., up to 2 years); however, no empirical studies have tested these relationships. We hypothesize that molar climate moderates implementation climate’s concurrent and long-term relationships with …

Effects Of 8-Week Sensory Electrical Stimulation Combined With Motor Training On Eeg-Emg Coherence And Motor Function In Individuals With Stroke, Li-Ling Hope Pan, Wen-Wen Yang, Mei-Wun Tsai, Shun-Hwa Wei, Felipe Fregni, Vincent Chiun-Fan Chen, Li-Wei Chou

Engineering Science Faculty Publications

The peripheral sensory system is critical to regulating motor plasticity and motor recovery. Peripheral electrical stimulation (ES) can generate constant and adequate sensory input to influence the excitability of the motor cortex. The aim of this proof of concept study was to assess whether ES prior to each hand function training session for eight weeks can better improve neuromuscular control and hand function in chronic stroke individuals and change electroencephalography-electromyography (EEG-EMG) coherence, as compared to the control (sham ES). We recruited twelve subjects and randomly assigned them into ES and control groups. Both groups received 20-minute hand function training twice …

Effects Of 8-Week Sensory Electrical Stimulation Combined With Motor Training On Eeg-Emg Coherence And Motor Function In Individuals With Stroke, Li-Ling Hope Pan, Wen-Wen Yang, Chung-Lan Kao, Mei-Wun Tsai, Shun-Hwa Wei, Felipe Fregni, Vincent Chiun-Fan Chen, Li-Wei Chou

Engineering Science Faculty Publications

The peripheral sensory system is critical to regulating motor plasticity and motor recovery. Peripheral electrical stimulation (ES) can generate constant and adequate sensory input to influence the excitability of the motor cortex. The aim of this proof of concept study was to assess whether ES prior to each hand function training session for eight weeks can better improve neuromuscular control and hand function in chronic stroke individuals and change electroencephalography-electromyography (EEG-EMG) coherence, as compared to the control (sham ES). We recruited twelve subjects and randomly assigned them into ES and control groups. Both groups received 20-minute hand function training twice …

Three Years In--Changing Plan Features In The U.S. Health Insurance Marketplace, Caitlin N. Mckillop, Teresa M. Waters, Cameron M. Kaplan, Erin K. Kaplan, Michael P. Thompson, Ilana Graetz

Health Management and Policy Faculty Publications

Background: A central objective of recent U.S. healthcare policy reform, most notably the Affordable Care Act's (ACA) Health Insurance Marketplace, has been to increase access to stable, affordable health insurance. However, changing market dynamics (rising premiums, changes in issuer participation and plan availability) raise significant concerns about the marketplaces' ability to provide a stable source of healthcare for Americans that rely on them. By looking at the effect of instability on changes in the consumer choice set, we can analyze potential incentives to switch plans among price-sensitive enrollees, which can then be used to inform policy going forward.

Methods: Data …

An Unusual Back Muscle Identified Bilaterally: Case Report., Juan J Altafulla, Mayank Patel, R Shane Tubbs, Joe Iwanaga, Zachary Litvack

Articles, Abstracts, and Reports

Most muscular structures in the human body are named based on their function, origin/insertion, or shape. During routine dissection of the back, an unusual muscle was found deep to the rhomboid muscles. The details of this case and a review of the extant literature are provided.

Chronic Lymphocytic Leukemia-Derived Il-10 Suppresses Antitumor Immunity., Sara S Alhakeem, Mary K Mckenna, Karine Z Oben, Sunil K Noothi, Jacqueline R Rivas, Gerhard C Hildebrandt, Roger A Fleischman, Vivek M Rangnekar, Natarajan Muthusamy, Subbarao Bondada

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Chronic lymphocytic leukemia (CLL) patients progressively develop an immunosuppressive state. CLL patients have more plasma IL-10, an anti-inflammatory cytokine, than healthy controls. In vitro human CLL cells produce IL-10 in response to BCR cross-linking. We used the transgenic Eμ-T cell leukemia oncogene-1 (

Dextran Hydrogels Incorporated With Bioactive Glass-Ceramic: Nanocomposite Scaffolds For Bone Tissue Engineering, Parisa Nikpour, Hamed Salimi-Kenari, Farahnaz Fahimipour, Sayed Mahmood Rabiee, Mohammad Imani, Erfan Dashtimoghadam, Lobat Tayebi

School of Dentistry Faculty Research and Publications

A series of nanocomposite scaffolds comprised of dextran (Dex) and sol–gel derived bioactive glass ceramic nanoparticles (nBGC: 0–16 (wt%)) were fabricated as bioactive scaffolds for bone tissue engineering. Scanning electron microscopy showed Dex/nBGC scaffolds were consisting of a porous 3D microstructure with an average pore size of 240 μm. Energy-dispersive x-ray spectroscopy illustrated nBGC nanoparticles were homogenously distributed within the Dex matrix at low nBGC content (2 wt%), while agglomeration was observed at higher nBGC contents. It was found that the osmotic pressure and nBGC agglomeration at higher nBGC contents leads to increased water uptake, then reduction of the compressive …

What Insights Do Patients And Caregivers Have On Acute Kidney Injury And Posthospitalization Care? A Single-Centre Qualitative Study From Toronto, Canada, Samuel A. Silver, Marianne Saragosa, Neill K. Adhikari, Chaim M. Bell, Ziv Harel, Andrea Harvey, Abhijat Kitchlu, Javier A. Neyra, Ron Wald, Lianne Jeffs

Internal Medicine Faculty Publications

Objectives Hospitalisation with acute kidney injury (AKI) is associated with short-term and long-term adverse events, but patient and caregiver experiences with AKI are not well described. We sought to better understand patient and caregiver perspectives after a hospitalisation with AKI to inform discharge strategies that may improve outcomes for this high-risk population.

Design Qualitative study with semistructured interviews.

Setting Tertiary care hospital in Toronto, Ontario, Canada.

Participants Adult patients (n=15) who survived a hospitalisation with Kidney Disease Improving Global Outcomes stage 2 or 3 AKI from May to December 2016. We also interviewed five patient caregivers. We required patients to …

Habitual Heat Exposure And Acclimatization Associated With Athletic Performance In The Multistage Marathon Des Sables, Leonidas G. Ioannou, Lydia Tsoutsoubi, Lars Nybo, Georgios I. Tsianos, Andreas D. Flouris

Journal of Human Performance in Extreme Environments

Introduction

The aim of this study was to investigate the impact of heat acclimatization on athletic performance during the 7-day Marathon des Sables (MdS) which takes place in the Sahara Desert.

Methods

Anonymous data for nationality and average running speed (km/h) of all runners who ran the MdS during the period 2000–2015 were collected from the official website of the race and other related websites. Average maximum temperature for each runner’s country during the month preceding the MdS was collected from www.weatherbase.com. Athletes were divided into two Torigin groups as follows: 25 to 15°C (i.e., cold countries) and 15 to …

Cadaveric Simulation For Improving Surgical Training In Dermatology., Ezra Hazan, Richard Torbeck, Deirdre Connolly, Jordan V. Wang, Thomas Griffin, Matthew Keller, Joshua Trufant

Department of Dermatology and Cutaneous Biology Faculty Papers

Simulation models are rapidly changing medical education, especially the training of dermatology residents. Various models are available, including cadaveric simulations. Our study evaluates the impact of a cadaveric simulation on the training of dermatology residents. Over a period of three years, cadaveric simulation was shown to increase the surgical knowledge of residents. Residents were more confident in their knowledge of surgical anatomy and also surgical skills. Cadaveric simulation may offer a positive impact on resident training in dermatology.

June 2018, Randy Curry, Cindy Brooks

RURAL ROCKS

Rural Rocks, the Rural Health Network newsletter by the SWOSU College of Pharmacy

Precision Oncology Decision Support: Current Approaches And Strategies For The Future, Katherine C Kurnit, Ecaterina E Ileana Dumbrava, Beate Litzenburger, Yekaterina B Khotskaya, Amber M Johnson, Timothy A Yap, Jordi Rodon, Jia Zeng, Md Abu Shufean, Ann M Bailey, Nora S Sánchez, Vijaykumar Holla, John Mendelsohn, Kenna Mills Shaw, Elmer V Bernstam, Gordon B Mills, Funda Meric-Bernstam

Faculty, Staff and Student Publications

With the increasing availability of genomics, routine analysis of advanced cancers is now feasible. Treatment selection is frequently guided by the molecular characteristics of a patient's tumor, and an increasing number of trials are genomically selected. Furthermore, multiple studies have demonstrated the benefit of therapies that are chosen based upon the molecular profile of a tumor. However, the rapid evolution of genomic testing platforms and emergence of new technologies make interpreting molecular testing reports more challenging. More sophisticated precision oncology decision support services are essential. This review outlines existing tools available for health care providers and precision oncology teams and …

Women’S Healthcare In Cuba, Hannah M. Van Curen

Student Works

Cuba’s healthcare system has been an important discussion since it became socialized in 1965. The seemingly prestigious and highly criticized system has had global impact: from the break of tradition from conservative Latin American countries, to the almost idyllic approach Cuba has taken proving socialism can exist. This paper explores the major differences between Cuba’s and America’s approach to women’s healthcare. This paper examines different aspects of women's health care through interviews of locals and observation of different clinics around the island. The topics include maternity leave, child care, abortions, and sex education. While there is varying discussion on how …

Aerosol Sampling In A Hospital Emergency Room Setting: A Complementary Surveillance Method For The Detection Of Respiratory Viruses, J. Y. Choi, J. Zemke, S. E. Philo, E. S. Bailey, M. Yondon, G. C. Gray

Public Health

No abstract provided.

Tgf-Β Sustains Tumor Progression Through Biochemical And Mechanical Signal Transduction., Robert L Furler, Douglas F Nixon, Christine A Brantner, Anastas Popratiloff, Christel H Uittenbogaart

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Transforming growth factor β (TGF-β) signaling transduces immunosuppressive biochemical and mechanical signals in the tumor microenvironment. In addition to canonical SMAD transcription factor signaling, TGF-β can promote tumor growth and survival by inhibiting proinflammatory signaling and extracellular matrix (ECM) remodeling. In this article, we review how TGF-β activated kinase 1 (TAK1) activation lies at the intersection of proinflammatory signaling by immune receptors and anti-inflammatory signaling by TGF-β receptors. Additionally, we discuss the role of TGF-β in the mechanobiology of cancer. Understanding how TGF-β dampens proinflammatory responses and induces pro-survival mechanical signals throughout cancer development is critical for designing therapeutics that …