Medicine and Health Sciences Commons^™

Subdermal Ultrasound Contrast Agent Injection For Sentinel Lymph Node Identification: An Analysis Of Safety And Contrast Agent Dose In Healthy Volunteers., Priscilla Machado, Maria Stanczak, Ji-Bin Liu, Jason N. Moore, John R. Eisenbrey, Laurence Needleman, Walter K. Kraft, Flemming Forsberg

Department of Radiology Faculty Papers

Objectives—Mapping of the lymphatic chain for identification of the sentinel lymph node (SLN) is an important aspect of predicting outcomes for breast cancer patients, and it is usually performed as an intraoperative procedure using blue dye and/or radiopharmaceuticals agents. Recently the use of contrast-enhanced ultrasound (CEUS) has been proposed as an alternative imaging technique for this mapping. The objective of this study was to evaluate the use of subdermal administration of the ultrasound contrast agent Sonazoid (GE Healthcare) in terms of patient safety and to select the dose to be used for lymphatic applications in humans.

Methods—This study …

Total Energy Expenditure And Body Composition Of Children With Developmental Disabilities, Michele L. Polfuss, Kathleen J. Sawin, Paula E. Papanek, Linda Bandini, Bethany Forseth, Andrea Moosreiner, Kimberley Zvara, Dale A. Schoeller

Exercise Science Faculty Research and Publications

Background

Obesity prevalence is increased in children with developmental disabilities, specifically in children with spina bifida and Down syndrome. Energy expenditure, a critical aspect of weight management, has been extensively studied in the typically developing population, but not adequately studied in children with developmental disabilities.

Objective

Determine energy expenditure, fat-free mass and body fat percentile and the impact of these findings on recommended caloric intake in children with spina bifida and Down syndrome.

Methods/Measures

This pilot study included 36 children, 18 with spina bifida, 9 with Down syndrome and 9 typically developing children. Half of the children with spina bifida …

The Bulletin: Sidney Kimmel Medical College At Thomas Jefferson University, Volume 67, Issue 2, Spring/Summer 2018

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

This issue includes:

• Exposure: Michael Weinstein, MD '94, had a plan to take his own life; now he is back to living it
• Medical School 2.0: JeffMD - A New Way to Train Physicians
• 25 Years of JeffHOPE Clinics: Student Volunteers Shape Patients' Lives - and Their Own
• Caring for the Most Vulnerable a "Moral, Ethical, Medical Responsibility": Jefferson's Latina Women's Clinic Dispenses Care and Compassion
• The Dean's Column
• Findings: New Look at Eye's Immune Status
• Home at Last: A message from Elizabeth Dale
• Endowed Professorships
• Time Capsule
• On Campus
• Feeling all the Bumps: Jefferson Oncologist Looks at the World …

Other Clinical Applications Of Videolaryngoscopy Besides Intubation, Faisal Shamim, Marium Nafis, Mubasher Ikram

Department of Anaesthesia

No abstract provided.

Obinutuzumab, A Potent Anti-B-Cell Agent, For Rituximab-Unresponsive Igm Anti-Mag Neuropathy., Goran Rakocevic, Ubaldo E. Martinez-Outshoorn, Marinos C. Dalakas

Department of Medical Oncology Faculty Papers

Anti-MAG demyelinating neuropathy is difficult to treat. All immunotherapies have failed except for rituximab, a chimeric B-cell–depleting monoclonal antibody against CD20, that helps up to 40% of patients based on 2 controlled and several uncontrolled series.^1,–,3 Because the majority of these patients are left disabled, stronger anti–B-cell agents might be promising.

We describe clinical response and autoantibody changes after treatment with obinutuzumab (Gazyva), a new generation of humanized anti-CD20 monoclonal antibodies, in 2 patients with anti-MAG neuropathy who continued to worsen despite multiple courses of rituximab. Obinutuzumab, approved for chronic lymphocytic leukemia (CLL), exerts greater peripheral and lymphoid B-cell …

Cold Pressor Pain Response In Children With Cancer, Brooke N. Jenkins, Ryan J. Roemer, Ariana Martinez, Tara K. Torres, Michelle A. Fortier

Psychology Faculty Articles and Research

Objective:

The goal of this study was to examine pain responses in pediatric patients with cancer.

Method:

Children (ages 6 to 18) undergoing treatment for cancer (N=68) completed the cold pressor task.

Results:

Average pain tolerance was 118.22 seconds (SD=101.18) and 40% of the children kept their hand in the water the entire 4-minute ceiling. On a 0 to 10 numeric rating scale, children reported a pain severity of 5.07 (SD=3.47) at their first report of pain, a pain severity of 5.94 (SD=3.54) at their maximum report of pain, and a pain severity of 5.33 (SD=3.72) at the time they …

Patterns Of Bronchial Challenge Testing In Canada, Rémi Thériault, Amir Raz

Psychology Faculty Articles and Research

Background: Bronchial challenge testing (BCT) measures airway hyperresponsiveness; asthma guidelines recommend using BCT when symptoms manifest despite normal spirometry. Improper application of these guidelines commonly results in the misdiagnosis of asthma. Yet, statistics concerning BCT remain largely obscure. The current paper addresses this gap and explores how various health variables may elucidate adherence to asthma guidelines and patterns of BCT across Canadian provinces.

Methods: Using the Access to Information Act, medical financial claims for BCT (or equivalent procedures) were requested from each of the Canadian provinces and territories. Based on the available information (from provinces only), correlations between …

Assessment Of Knowledge And Attitude Regarding Organ Donation, Blessy Anderson Ms

Manipal Journal of Nursing and Health Sciences

Introduction: Fast advancing medical technology has made organ donation and transplantation possible. With an alarming increase in non-communicable diseases, organ transplantation is undoubtedly a boon to humanity, which is possible only with organ donation. There is always an ever-increasing demand for organs globally. Adolescents who possess adequate knowledge and attitude on organ donation are more likely to discuss with their families about the willingness to donate their organs. The study was undertaken to assess the knowledge and attitude regarding organ donation among college students. Objectives: The objectives of the study were to assess the knowledge on organ donation, to assess …

Effect Of Structured Enlightenment Program On Knowledge And Attitude Regarding Organ Donation Among College Students, Lekshmi Vijayan Ms, Deepa P Ms

Manipal Journal of Nursing and Health Sciences

Introduction: According to the report of World Health Organization (WHO) on the state of international organ trade (2017), the donation rate in India is 0.5 per million populations, very low compared with other countries. There is a need for improving the knowledge and attitude of the community to attract more people towards organ donation. Objectives: The objectives were to evaluate the effect of structured enlightenment program on knowledge and attitude and to determine the correlation between them among college students. Methods: In phase I, a descriptive cross-sectional design and in Phase II a quasi-experimental one group pre-test post-test designs were …

A Comparative Study To Assess The Risk Of Varicose Vein Among Critical Care Nurses And Nurses Working In Other Nursing Units Of Selected Hospital, Guwahati, Assam, Rony Bosco Shadap Mr, Manashi Sengupta Ms, Rikupar Iawin Ms

Manipal Journal of Nursing and Health Sciences

Background: Varicose veins is increasing worldwide, since the nurses especially the critical care nurses spend most of the time standing, they are prone to get lower limb symptoms like itchiness, cramps, burning sensation, and pain especially when standing which result in superficial swollen veins and later develop to varicose veins. Objective: The main objective of the study is to assess the risk of varicose vein among critical care nurses and nurses working in other general units of selected hospital. Method: A non-experimental descriptive research design was adopted for the study. In this study 100 staff nurses working in Guwahati Neurological …

Knowledge, Attitude, And Barriers Of Nursing Research Among Bsc Nursing Students, In Selected Nursing College Of Malappuram District, Hanibernia S Ms

Manipal Journal of Nursing and Health Sciences

Introduction: Nursing research is the systematic pursuit of knowledge involving the understanding and formulation of a problem, the collection of information through observation or any other method. This study aimed to assess the knowledge on nursing research and attitude towards it and also identify the barriers to conduct nursing research. Objectives: The objectives of the study were to assess the knowledge and attitude on nursing research among BSc nursing students, to find out the barrier of nursing research among BSc nursing students, and to find out the association between the knowledge and attitude score with selected demographic variables. Methods: A …

Registered Nurses’ Knowledge On Comprehensive Neuro Assessment: A Pre- Experimental Design, Divya K. Y Ms, R Ponchitra Ms

Manipal Journal of Nursing and Health Sciences

Background: A thorough clinical assessment is the initial step to be done by the the nurses in order to provide quality care. The more precise the assessment, the more accurate the interventions are going to be. Objectives: The aim of this study was to assess the effect of a structured training program on comprehensive neuro system assessment among registered nurses. Materials and methods: This pre-test post-test research design was carried out among a convenient sample of 83 registered nurses. Data was collected before and after the training program, using a semi structured questionnaire prepared by the researcher assessing knowledge on …

Effect Of Health Promotion Program Among Patients With Newly Diagnosed Diabetes Mellitus Regarding Lifestyle Modification, G Jhansi Rani Ms

Manipal Journal of Nursing and Health Sciences

Introduction: Diabetes Mellitus (DM) is a metabolic disorder. A change in lifestyle helps to control diabetes. Objectives: To find the knowledge and attitude on lifestyle modification among patients with newly diagnosed diabetes and effectiveness of health promotion program. Material and methods: Pre-experimental one group pretest, post-test designs are adopted and purposive sampling techniques are used to select 30 newly diagnosed diabetic patients. The knowledge and attitude on lifestyle modification among diabetic patient was assessed by using structured questionnaire. Then the health promotion program was given after pre-test and post-test was carried out after two weeks (during next follow up). Results …

Prevalence Of Depression Among Post-Stroke Survivors In South Asian Region: A Narrative Review, Roseminu Varghese Ms, Laveena Anitha Barboza Ms

Manipal Journal of Nursing and Health Sciences

Stroke is the third biggest reason for mortality and has a massive emotional effect on clients and the members of their family. Depression is a debilitative complication of stroke, with repeated occurrences of depressive ailments after the stroke. Prevalence of post-stroke depression (PSD) has always remained unknown and is a disabling entity among the stroke survivors. Objective: The aim of this narrative review is to determine the prevalence of depression among post-stroke survivors. Methods: A comprehensive literature search was made in the following databases such as the Web of Science, PubMed-Medline, CINAHL, Scopus, J gate, and IndMED for studies between …

Jellyfish Sting: A Case Report, Binu E. Margaret Ms, Suneel C. Mundkur Dr, Shrikiran A. Hebbar Dr

Manipal Journal of Nursing and Health Sciences

Jellyfish stings are frequently reported marine animal envenomation worldwide. Jellyfish stings in the coastal regions of India are a major public health hazard. Jellyfish stings are known to produce mild to severe toxic effect based on the type of species. There is no specific data from India, but very few cases are reported from the coastal regions. The investigators report a case of jellyfish sting to a nine-year-old child from the coastal area of Udupi district, Karnataka.

Northeast Iowa Medical Foundation Clinical Study Of Type Two Diabetes, Thomas Blake

Undergraduate Student Work

The purpose of the study is to see the difference in quality between Sotagliflozin and Glimepiride and to see which one will lower patients' blook flucose levels more effectively.

Fms Squat Assessment And 2d Video Motion Analysis As Screening Indicators Of Low Back Pain: A Cross Sectional Case- Study, Tracy Donlon, Britanny Franklin, Courtney Machamer, Christina Mogelnicki, Jeffrey Verneus, Christopher Taber

Exercise Science Faculty Publications

Aim: Low back pain (LBP) is a disabling condition to individuals in the United States and physical therapy (PT) has been proven to be a beneficial treatment by analyzing their movement patterns. The main objective of this study was to analyze the deep squat component of the Functional Movement Screen (FMS) as an indicator of LBP while simultaneously using 2-D analysis. Method: This cross-sectional case study included 36 participants that completed a total of six deep squats. Three raters scored the FMS score of each participant. Results: The association between FMS score and the presence of LBP showed to be …

Risk Factors For Microvascular Complications Of Diabetes In A High-Risk Middle East Population, Sohaila Cheema, Patrick Maisonneuve, Mahmoud Zirie, Amin Jayyousi, Hekmat Alrouh, Albert B. Lowenfels, Ravinder Mamtani

NYMC Faculty Publications

Aims: Much of the diabetes burden is caused by its complications. This cross-sectional study aimed to determine the prevalence and risk factors for diabetic microvascular complications (retinopathy, nephropathy, and neuropathy) in a high-risk population. Methods: We collected information via a structured questionnaire and directly from the patient's record on 1034 adult type 2 diabetic patients who were attending outpatient clinics in Qatar. Results: The mean age of the patients was 55 +/- 10 years, and the mean duration of diabetes was 12.4 +/- 8.9 years. Forty-five percent had one or more microvascular complications. Shared risk factors for multiplicity and for …

Quality Of Life After Functional Endoscopic Sinus Surgery In Patients With Chronic Rhinosinusitis, Sadaf Qadeer, Shabbir Akhtar, Montasir Junaid, Muhammad Sohail Halim

Section of Otolaryngology, Head & Neck Surgery

Chronic Rhinosinusitis (CRS) is a group of disorders characterized by the inflammation of mucosa of the nasal passages and paranasal sinuses. It includes chronic rhinosinusitis with polyps, CRS without polyps and Allergic Fungal Sinusitis (AFS). This debilitating disease causes negative impact on quality of life (QOL) of patients. Functional endoscopic sinus surgery (FESS) is the mainstay of surgical treatment for patients and improves QOL of patients. This subjective assessment of QOL can be measured by disease specific questionnaires. SNOT-22 questionnaire is widely used and validated questionnaire for this purpose. Prospective study was done on 54 patients. Data were collected using …

Relationship Between Shift Hours Worked (12 Versus 8), Workload, And Nurses' Burnout: A Study Across Acute Care Units In A Community Hospital, Liliane Nyamuziga

Doctor of Nursing Practice Projects

Nurses are expected to provide quality care to patients, and work demands in the health care system are increasing. An increased turnover in nursing staff was observed in a southwest Michigan community hospital, and the possibility of burnout contributing to this turnout was proposed. The purpose of this scholarly project was to evaluate the significance and level of perceived burnout in nurses who work the 12-hour shift compared to those who work the eight-hour shift, to investigate the relationship between nurse-to-patient ratios and burnout, and to compare burnout levels between nurses working day versus night shifts. This project utilized a …

Whole Genome Sequencing Of 91 Multiplex Schizophrenia Families Reveals Increased Burden Of Rare, Exonic Copy Number Variation In Schizophrenia Probands And Genetic Heterogeneity, Fayeza F. Khan, Phillip E. Melton, Nina S. Mccarthy, Bharti Morar, John Blangero, Eric K. Moses, Assen Jablensky

School of Medicine Publications

The importance of genomic copy number variants (CNVs) has long been recognized in the etiology of neurodevelopmental diseases. We report here the results from the CNV analysis of whole-genome sequences from 91 multiplex schizophrenia families. Employing four algorithms (CNVnator, Cn.mops, DELLY and LUMPY) to identify CNVs, we find 1231 rare deletions and 287 rare duplications in 300 individuals (77 with schizophrenia (SZ), 32 with schizoaffective disorder (SAD), 82 with another neuropsychiatric diagnosis and 109 unaffected). The size of the CNVs ranges from a few hundred base-pairs to about 1.3Mb. The total burden of CNVs does not differ significantly between affected …

Visual Cycle Proteins: Structure, Function, And Roles In Human Retinal Disease, Andrew T C Tsin, Brandi Betts-Obregon, Jeffery Grigsby

School of Medicine Publications

Here, we seek to summarize the current understanding of the biochemical and molecular events mediated by visual cycle molecules in the eye. The structures and functions of selected visual cycle proteins and their roles in human retinal diseases are also highlighted. Genetic mutations and malfunctions of these proteins provide etiological evidence that many ocular diseases arise from anomalies of retinoid (vitamin A) metabolism and related visual processes. Genetic retinal disorders such as retinitis pigmentosa, Leber's congenital amaurosis, and Stargardt's disease are linked to structural changes in visual cycle proteins. Moreover, recent reports suggest that visual cycle proteins may also play …

Sexual Violence Victimization, Mental Health, And University-Based Health Service Use Among College Females, Julie E. Stoner

Health Services Research Dissertations

Females between the ages of 18 and 24 consistently experience higher rates of sexual violence compared to females in any other age group (Sinozich & Langton, 2014). Approximately one in five college women experience sexual violence victimization (SVV; Krebs, Lindquist, Berzofsky, Shook-Sa & Peterson, 2016) during the academic year. Among undergraduate female students, 23.1% are victims of sexual violence due to physical force, violence or incapacitation (Cantor et al., 2015). Sexual victimization has been associated with several short- and long-term psychological health consequences, accounting for enhanced symptoms of depression, anxiety, PTSD, and suicide risk (Basile, Smith, Breiding, Black & Mahendra, …

A Word From The Writing Team (July 2018), Jennifer Wilson, Ms, Els, Pam Walter, Mfa

A Word From the Writing Team (Newsletter)

This issue includes:

• From Thesis to Journal Article
• Open All Summer
• Sign Up for Our Fall Writing Retreat
• Writing Café

Distribution Of Chromosomal Abnormalities Commonly Observed In Adult Acute Myeloid Leukemia In Pakistan As Predictors Of Prognosis, Muhammad Shariq Shaikh, Zeeshan Ansar Ahmed, Mohammad Usman Shaikh, Salman Naseem Adil, Mohammad Khurshid, Tariq Moatter, Anila Rashid, Farheen Karim, Ahmed Raheem, Natasha Ali

Department of Pathology and Laboratory Medicine

Objectives: The heterogenous response to treatment in acute myeloid leukemia (AML) can be attributed largely to the difference in cytogenetic features identified in between cases. Cytogenetic analysis in acute leukemia is now routinely used to assist patient management, particularly in terms of diagnosis, disease monitoring, prognosis and risk stratification. Knowing about cytogenetic profile at the time of diagnosis is important in order to take critical decisions in management of these patients. The study was conducted to determine the distribution of cytogenetic abnormalities in Pakistani adult patients with AML in order to have insights regarding behavior of the disease.
Methods: A …

Clinicopathological Prognostic Factors Of Oral Squamous Cell Carcinoma: An Experience Of A Tertiary Care Hospital, Muhammad Usman Shaikh, Ahmed Raheem Baksh, Sayed Akbar Abbas, Javeria Saeed, Salman Hashmi

Department of Pathology and Laboratory Medicine

Locoregional recurrence accounts for majority of the treatment failures in oral cancer patients. Current study aimed to determine the predictors of recurrence and survival in patients with biopsy proven Squamous Cell Carcinoma (SCC) of the oral cavity. This study included 88 patients of squamous cell carcinoma treated at our institution from 2007 till 2013. Primary intervention was surgery in all patients with radiation and chemotherapy in selected patients. Primary end point was locoregional recurrence, distant metastasis and death. Out of 88 patients, 23 (26.1%) patients developed locoregional recurrence and 6 (6.8%) patients developed distant metastasis. Overall survival rate was 77.3%. …

Environment, Pollution And Stroke, Maria Khan, Mohammad Wasay

Section of Neurology

No abstract provided.

Synovial Sarcoma Of Cervicodorsal Spine: A Case Report, Wali Umer Shah, Syeda Dania Shujaat, Naseeb Ullah, Salman Mansoor

Section of Neurology

Synovial sarcoma is a soft-tissue sarcoma. Its involvement of the spine is extremely rare. We report a 40 year old male who presented with shoulder pain and progressive weakness in all four limbs for six months with a visible, slowly growing bulge in his upper back. On examination he had quadriparesis and diffuse sensory deficit. MRI of the cervical spine showed a large soft tissue mass, iso to hypointense, extending into the neural canal, compressing the cord. The mass had a few internal areas of contrast enhancement with extension into the right paraspinal regions involving the vertebral bodies. Sub-periosteal spine …

Adult Experts' Perceptions Of Telemental Health For Youth: A Delphi Study., Abigail Howard, Mindy Flanagan, Michelle Drouin, Maria D. Carpenter, Elizabeth Chen, Catherine Duchovic, Tammy Toscos

Health Services and Informatics Research

OBJECTIVES: Our objectives were to measure experts' opinions and develop consensus via the Delphi process on the barriers, applications, and concerns associated with telemental health (TMH) for youth.

MATERIALS AND METHODS: We delivered 3 online surveys over 2 months in Summer, 2016-2025 adult experts, including adults who experienced youth depression or suicidality, parents of youth with lived experience, and professionals (ie youth mental health researchers, clinicians/staff, or educators). We used the Delphi method to construct Likert and open-ended questions, developing expert consensus over 3 iterative surveys on the barriers and benefits of TMH for youth.

RESULTS: Adult experts identified stigma …

July 2018, Swosu Bulldog Wellness Committee

SWOSU BULLDOG WELLNESS

SWOSU Rural Health Center will be offering the National Diabetes Prevention Program (NDPP) again for those with prediabetes or at high risk for type 2 diabetes starting in September. The program has proven to cut the risk for type 2 diabetes in half. Please complete the following questionnaire to see if you qualify! https://swosu.formstack.com/forms/prescreening_questionnaire_dpp