Medicine and Health Sciences Commons^™

Representation Of South Asian Countries In Five High-Impact Anesthesia Journals, Mohammad Irfan Akhtar, Karima Karam Khan, F. Khan

Department of Anaesthesia

Context: The South Asian region is comprised of eight countries, i.e., Pakistan, India, Bangladesh, Sri Lanka, Afghanistan, Bhutan, Nepal, and Maldives. There is dearth of literature documenting anesthesia research in this region.
Aim: The aim of this audit was to look at research productivity in the region by examining the volume and the type of anesthesia publication in five high-index anesthesia journals.
Settings and Design: The study design was a survey of literature in the top five high-impact anesthesiology journals carried out at a tertiary care hospital.
Materials and Methods: The journal citation report 2016 was accessed to identify the …

In Wound Repair Vimentin Mediates The Transition Of Mesenchymal Leader Cells To A Myofibroblast Phenotype., J. L. Walker, B. M. Bleaken, A. R. Romisher, A. A. Alnwibit, A. S. Menko

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Following injury, mesenchymal repair cells are activated to function as leader cells that modulate wound healing. These cells have the potential to differentiate to myofibroblasts, resulting in fibrosis and scarring. The signals underlying these differing pathways are complex and incompletely understood. The ex vivo mock cataract surgery cultures are an attractive model with which to address this question. With this model we study, concurrently, the mechanisms that control mesenchymal leader cell function in injury repair within their native microenvironment and the signals that induce this same cell population to acquire a myofibroblast phenotype when these cells encounter the environment of …

Assessment Of Health Literacy Level In 18-30 Year-Old Adults, An Iranian Experience, Masoumeh Ansari, Fatemeh Mohammad-Moradi, Mehrdad Khaledian, Maryam Shekofteh, Ali Valinejadi

Library Philosophy and Practice (e-journal)

Objective: Health literacy is knowledge for comprehension, assessment and achievement of health and benefit of it in life finally to health promotion. People, who have little health literacy, have less knowledge about their health condition therefore they don’t take sufficient preventive services instead they receive more hospital and emergency units' services. Identification and promotion of health literacy level is one of the best solutions to increase social health and play important role in making healthy social in future, too.

Design and setting: This descriptive study, about 170 people (ranging from18-30 year-old) who referred to Shemiranat health network in end of …

Pregnancies Complicated By Maternal Osteogenesis Imperfecta Type Iii: A Case Report And Review Of Literature., Tetsuya Kawakita, Melissa Fries, Jasbir Singh, Huda B. Al-Kouatly

Department of Obstetrics and Gynecology Faculty Papers

The restrictive lung disease can be exacerbated by growing fundus in women with osteogenesis imperfecta type III. Regional anesthesia can be performed in these women. Mode of delivery for women with osteogenesis imperfecta type III is generally cesarean delivery. Neonatal outcomes are complicated due to indicated preterm deliveries.

Inference And Analysis Of Multilayered Mirna-Mediated Networks In Cancer, Duc Do

Dissertations (1934 -)

MicroRNAs (miRNAs) are small noncoding transcripts that can regulate gene expression, thereby controlling diverse biological processes. Aberrant disruptions of miRNA expression and their interactions with other biological agents (e.g., coding and noncoding transcripts) have been associated with several types of cancer. The goal of this dissertation is to use multidimensional genomic data to model two different gene regulation mechanisms by miRNAs in cancer. This dissertation results from two research projects. The first project investigates a miRNA-mediated gene regulation mechanism called competing endogenous RNA (ceRNA) interactions, which suggests that some transcripts can indirectly regulate one another's activity through their interactions with …

Understanding Relationships Between Early Life Toxic Stress, Childhood Socioeconomic Disadvantage, And Allostatic Load In Adolescence, Amanda King

Dissertations (1934 -)

Chronic disease prevalence among children and adolescents is rising, which is thought to result in part from elevations in allostatic load (AL). AL is the cumulative physiological dysregulation that results from exposure to biological, social and environmental stressors over time. Socioeconomic disparities in chronic disease and AL have been well-documented in adult populations, including links between childhood socioeconomic disadvantage (CSD) and AL, yet little is known as to whether CSD may begin to impact AL earlier in life. Differential exposure and vulnerability to stress among racial/ethnic minorities may increase risk for elevated AL among those experiencing CSD. Framed by the …

Pre-Death Grief, Resourcefulness And Perceived Stress Among Care Givers Of Partners With Young Onset Dementia, Karie Kobiske

Dissertations (1934 -)

Over 200,000 Americans are diagnosed with young onset dementia (YOD). YOD is the dementia diagnosed prior to the age of 65. Most persons of YOD are cared for by their partners. Caregiving for a partner diagnosed with YOD has unique challenges including multiple losses resulting from the functional, cognitive, and behavioral declines which can be demanding and stressful. These losses experienced by the caregiver of a partner diagnosed with YOD have been termed pre-death grief. Caregivers of partners with YOD often report high levels of burden and stress resulting in depression, anxiety, hopelessness, as well as increase morbidity and mortality. …

Change In Bone Mineral Density Among High Frequency Apheresis Blood Donors, Walter Bialkowski

Dissertations (1934 -)

Exposure to citrate anticoagulant during apheresis blood donation induces significant decreases in serum ionized calcium with subsequent perturbations to parathyroid hormone, vitamin D, and markers of bone remodeling. Cross-sectional studies of bone mineral density (BMD) among apheresis donors exhibit conflicting results. Resolving the potential impact of the highest apheresis donation frequency represents a significant knowledge gap in ensuring adequate protections for volunteer apheresis blood donors. ALTRUYST (NCT02655055) was a randomized, longitudinal, controlled clinical trial designed to determine if repeated exposure to citrate through apheresis donation reduces BMD. Male donors, 18-65 years of age with no more than five previous apheresis …

Body Dissatisfaction And Suicidal Ideation Among Psychiatric Inpatients With Eating Disorders, Katrina A Rufino, Humsini Viswanath, Rebecca Wagner, Michelle A Patriquin

Staff and Researcher Publications

The current study the relationship between eating disorders (EDs) and suicidal ideation and suicide attempt in adult inpatients. In particular, the present study investigated one potential mechanism, body dissatisfaction (BD), which may contribute to increased risk for suicide in adult ED patients. A sample of 432 psychiatric inpatients ranging from 18 to 65 years of age participated in the current study. Findings indicated that patients who have higher levels of BD also had higher levels of passive and active suicidal ideation and previous suicide attempts. Higher levels of BD were also related to increased suicidal ideation after controlling for depression …

Predictors And Outcomes Of Nurses’ Use Of Smartphones For Work Purposes, John Robert Bautista, Sonny Rosenthal, Trisha T.C. Lin, Yin Leng Theng

Research Collection College of Integrative Studies

Recent studies have indicated that nurses use their smartphones for work purposes to enhance productivity. However, few theory-driven quantitative studies have examined factors associated with such use. This study aims to address this research gap by developing and testing a model based on the theory of planned behavior, organizational support theory, and IT consumerization theory. Hypothesis testing used structural equation modeling of survey data from 517 staff nurses employed in 19 tertiary-level general hospitals in the Philippines. Results showed that injunctive norm, descriptive norm, and perceived behavioral control were positively associated with intention to use smartphones for work purposes. Moreover, …

How Do You Define ‘Professional Demeanor’?, Michael G. Maihofer Dds

The Journal of the Michigan Dental Association

Regular column featuring ethical guidance and consideration for practicing dentists.

J Mich Dent Assoc Jul 2018

The Journal of the Michigan Dental Association

Archival issues of the Journal of the Michigan Dental Association may include reports on the activities of the association and its members, clinical articles, information on legal and ethical practice considerations, and perspectives of interest to MDA members and those in the oral health profession.

Detecting, Quantifying, And Discriminating The Mechanism Of Mosaic Chromosomal Aneuploidies Using Mad-Seq, Yu Kong, Esther R. Berko, Anthony Marcketta, Shahina B. Maqbool, Claudia A. Simoes-Pires, David F. Kronn, John M. Greally

NYMC Faculty Publications

Current approaches to detect and characterize mosaic chromosomal aneuploidy are limited by sensitivity, efficiency, cost, or the need to culture cells. We describe the mosaic aneuploidy detection by massively parallel sequencing (MAD-seq) capture assay and the MADSEQ analytical approach that allow low (

Testing The Efficacy Of Transcranial Magnetic Stimulation (Tms) In Treating Depression In Patients With Cognitive Impairment, Daniel Robert Schaffer

Psychology Theses & Dissertations

The purpose of this study is to (1) examine the efficacy of Transcranial Magnetic Stimulation (TMS) in treating depression among individuals with cognitive impairment and (2) to examine if TMS is capable of facilitating cognitive improvements independent of mood improvements. Mild cognitive impairment (MCI) is often seen as a pre-clinical stage to dementia, and depressive disorders are highly prevalent among both MCI and dementia. There is a large body of research that has linked depressive disorders as a prodromal symptom of MCI and the later development of dementia. While some researchers debate whether or not this link between depression and …

Developmental Steps For A Functional Three-Dimensional Cell Culture System For The Study Of Asymmetrical Division Of Neural Stem Cells, Martina Zamponi

Biomedical Engineering Theses & Dissertations

Stem cells are a cell type present during and following development, which possess self- renewal properties, as well as the ability to differentiate into specific cells. Asymmetrical division is the cellular process that allows stem cells to produce one differentiated and one un-differentiated daughter cell during the same mitotic event. Insights in the molecular mechanisms of such process are minimal, due to the absence of effective methods for its targeted study. Currently, traditional methods of investigation include monolayer cell culture and animal models. The first poses structural limitations to the accurate representation of human tissue and cell structures, while animal …

The Relationship Between Childhood Adversity And Adult Relationship Health For Economically Marginalized, Racially And Ethnically Diverse Individuals, Sandy-Ann M. Griffith

Counseling & Human Services Theses & Dissertations

Childhood adversity is prevalent and significantly influences an individual’s life. Adverse Childhood Experiences (ACEs) are linked to chronic physical and mental health issues, as well as maladaptive and abusive patterns of behavior in adult relationships such as unhealthy problem-solving strategies, poor ability at conflict resolution, and intimate partner violence (IPV). The current study explored the relationship between ACEs and adult relationship health outcomes. Controlling for the effect of average individual yearly income on adult relationship health, the extent to which demographic factors (i.e., gender, race and ethnicity, and children status) moderate the relationship between ACEs and adult relationship health and …

Mgmt Inhibition In Er Positive Breast Cancer Leads To Cdc2, Top2a, Aur, Cdc20, Kiff20a, Cyclin A2, Cyclin B2, Cyclin D1, Erα And Survivin Inhibition And Enhances Response To Temozolomide, George Bobustuc, Amin Kassam, Richard Rovin, Sheila Jeudy, Joshua S. Smith, Beth Isley, Maharaj Singh, Nathan David Sassoon, Kalkunte S. Srivenugopal, Santhi Konduri

College of Nursing Faculty Research and Publications

The DNA damage repair enzyme, O⁶-methylguanine DNA methyltransferase (MGMT) is overexpressed in breast cancer, correlating directly with estrogen receptor (ER) expression and function. In ER negative breast cancer the MGMT promoter is frequently methylated. In ER positive breast cancer MGMT is upregulated and modulates ER function. Here, we evaluate MGMT’s role in control of other clinically relevant targets involved in cell cycle regulation during breast cancer oncogenesis. We show that O⁶-benzylguanine (BG), an MGMT inhibitor decreases CDC2, CDC20, TOP2A, AURKB, KIF20A, cyclin B2, A2, D1, ERα and survivin and induces c-PARP and p21 and sensitizes ER …

Inhibition Of Ferrochelatase Impairs Vascular Enos/No And Sgc/Cgmp Signaling, Bin Zhang, Norah Alruwaili, Sharath Kandhi, Wensheng Deng, An Huang, Michael S. Wolin, Dong Sun

NYMC Faculty Publications

Ferrochelatase (FECH) is an enzyme necessary for heme synthesis, which is essential for maintaining normal functions of endothelial nitric oxide synthase (eNOS) and soluble guanylyl cyclase (sGC). We tested the hypothesis that inhibition of vascular FECH to attenuate heme synthesis downregulates eNOS and sGC expression, resulting in impaired NO/cGMP-dependent relaxation. To this end, isolated bovine coronary arteries (BCAs) were in vitro incubated without (as controls) or with N-methyl protoporphyrin (NMPP; 10-5-10-7M; a selective FECH antagonist) for 24 and 72 hours respectively. Tissue FECH activity, heme, nitrite/NO and superoxide levels were sequentially measured. Protein expression of FECH, eNOS and sGC was …

Learning While Doing: Program Evaluation Of The Medical Library Association Systematic Review Project, Catherine Boden, Marie T. Ascher, Jonathan Eldredge

NYMC Faculty Publications

Objectives: The Medical Library Association (MLA) Systematic Review Project aims to conduct systematic reviews to identify the state of knowledge and research gaps for fifteen top-ranked questions in the profession. In 2013, fifteen volunteer-driven teams were recruited to conduct the systematic reviews. The authors investigated the experiences of participants in this large-scale, volunteer-driven approach to answering priority research questions and fostering professional growth among health sciences librarians. Methods: A program evaluation was conducted by inviting MLA Systematic Review Project team members to complete an eleven-item online survey. Multiple-choice and short-answer questions elicited experiences about outputs, successes and challenges, lessons learned, …

Drug-Induced Dermatomyositis After Lacosamide: A Case Report., Rebecca G. Gaffney, Meera Tarazi, Victoria P. Werth

Student Papers, Posters & Projects

Here we describe a caseof a woman who had DM after treatment withlacosamide. To our knowledge, drug-induced DMfrom lacosamide has not been reported previously.

Noninvasive Hemodynamic Monitoring In Emergency Trauma Patients, Ryan Boyd

Nurse Anesthesia MSNA Student Capstones

Noninvasive hemodynamic monitoring has evolved steadily over the past few decades in response to healthcare providers' preference for less invasive monitoring methods for their patients. Invasive monitoring has its place in the critically ill patient population as witnessed in intensive care units throughout the country. Even in this environment, providers are opting less for the pulmonary artery catheter which has been the gold standard for invasive cardiac output monitoring in the past. Providers are now utilizing less invasive monitoring techniques which offer fewer potential complications to the patient while providing rapid access to critically important hemodynamic data. Examination of different …

The Utilization Of Laryngeal Mask Airways Vs. Endotracheal Tubes In Pediatrics With Upper Respiratory Tract Infection In Reducing Airway Complications, Ruby Foster

Nurse Anesthesia MSNA Student Capstones

According to Tait & Malviya, (2005) children typically experience six to eight upper respiratory infections (URIs) per year with ninety-five percent being viral in etiology (Tait & Malvia, 2005). URIs commonly occur in the pediatric population (Bernando-Ocampo, 2012). An issue surrounding the debate on whether a child with upper respiratory infection (URI) should proceed with surgery or cancel surgery is a debate that has been ongoing for several years (Tait el al. 2005). This review examines whether children who have an URI scheduled for surgery are at an increased risk for adverse respiratory complications when the laryngeal mask airway (LMA) …

American Thyroid Association Statement On Postoperative Hypoparathyroidism: Diagnosis, Prevention, And Management In Adults, Lisa A. Orloff, Sam M. Wiseman, Victor J. Bernet., Thomas J. Fahey Iii, Ashok R. Shaha, Maisie L. Shindo, Samuel K. Snyder, Brendan C. Stack Jr., John B. Sunwoo, Marilene B. Wang

School of Medicine Publications

Background: Hypoparathyroidism (hypoPT) is the most common complication following bilateral thyroid operations. Thyroid surgeons must employ strategies for minimizing and preventing post-thyroidectomy hypoPT. The objective of this American Thyroid Association Surgical Affairs Committee Statement is to provide an overview of its diagnosis, prevention, and treatment.

Summary: HypoPT occurs when a low intact parathyroid hormone (PTH) level is accompanied by hypocalcemia. Risk factors for post-thyroidectomy hypoPT include bilateral thyroid operations, autoimmune thyroid disease, central neck dissection, substernal goiter, surgeon inexperience, and malabsorptive conditions. Medical and surgical strategies to minimize perioperative hypoPT include optimizing vitamin D levels, preserving parathyroid blood supply, and …

Investigating Sports Drinks. Are They Worth The Money?, Ross Winter, Jamie Burnell

The International Student Science Fair 2018

Investigating Sports Drinks. Are they worth the money?

The sports drinks industry is a huge global business which shows no signs of slowing down. The inspiration to conduct this investigation came from an observation that there is an increasing consumption of sports and energy drinks within our community, particularly amongst children. The message from the advertisers is clear- athletes should replace lost body fluid with drinks that contain electrolytes, such as sports drinks. However, there are conflicting suggestions from conducting literature reviews; that, not only are these drinks unhealthy in terms of the high sugar content, but instead water …

Classification Of Intensity-Modulated Proton Therapy Plans, Alice Liu

The International Student Science Fair 2018

Abstract

Title: Classification of IMPT Plans

Purpose:

Create a method to aid physicists and dosimetrists in the classification of Intensity Modulated Proton Therapy treatment plans.

Method:

A Python program was developed to read structure sets and dose grids from radiation treatment plans. The program outputs field-specific histograms of the number of voxels within the planning target volume that received dose and normalizes each histogram to the percent volume of the target that received each field’s contribution of the total dose. It then determines the number of Gaussian distributions in each histogram, which serves as an initial classification metric, and calculates …

The Effect Of Hyperthermia On Liver Cell Viability, Jada Grant

The International Student Science Fair 2018

Hyperthermia is a treatment for liver cancer where the tumor is exposed to a relatively high heat temperature. This process is designed to make the tumor more susceptible to chemotherapy. My thought process was that if hyperthermia can kill cancerous cells, then there will be negative long term effects on the noncancerous cells surrounding the tumor. The project experimented on Kidney cells because the Kidney and Liver both go through the process of filtration. This means that the Kidney cells should give similar results that Liver cells would. Kidney cells were heated at 40 degrees Celsius for time amounts of …

The Effect Of The Oxytocin Hormone In Cocaine Addicted Rats Suffering From Abstinence Syndrome, Juan Padilla

The International Student Science Fair 2018

Rehabilitation from a history of drug abuse is a very difficult and life changing process. Abstinence syndrome forces the rehabilitating patient to go through anxiety like symptoms. The Oxytocin hormone has been believed to be a potential facilitator in the rehabilitation process. This hormone is very present during interactions of affection (hugs) and birth, it foments trust while it associates to a feeling of calmness. Oxytocin would theoretically be a calming agent to the anxiety like symptoms such as craving. The experiment aimed to test the calming effects of the hormone, consisted of a five-day systemic cocaine injections treatment schedule …

The Effect Of Kalanchoe Pinnata On The Cell Migration Of Astrocytomas, Jorge Rosa

The International Student Science Fair 2018

Astrocytomas, from cell line 1321N1,are cancerous astrocytes. These are a type of glial cell in the brain which is responsible for maintaining synaptic contact and the signaling capacities among neurons. They also represent a fundamental element in controlling blood flow and defining brain micro structure. Due to the fact that this variant is cancerous, a condition commonly described as an abnormal cell cycle and uncontrolled reproduction of cells, they have the ability to metastasize.

In the metastatic process of cancer cells the initial phase is know as tumor invasion. This stage consists mainly of the cells migrating away from the …

Cloning Of An Overexpression Vector For The Rare And Uncharacterized Kras Mutant R164l, Julliane Jeanne Negre

The International Student Science Fair 2018

Mutations in the coding DNA of KRAS, which encodes for an active protein in the Ras signaling pathway regulating cell proliferation and growth, may be critical in the development of lung and colorectal cancer in humans. Clinical tests and therapies for cancer specifically target mutations, some of which may cause erroneous prognosis and prescription of cancer therapy posing more danger for patients with unique mutations. Therefore, characterization of non-hotspot mutations is becoming more important, where, KRAS R164L is an existing uncharacterized mutation identified through the Catalogue of Somatic Mutations in Cancer (COSMIC). The project aimed to clone a pTarget overexpression …

A Humanized Hypertrophic Cardiomyopathy Model To Elucidate Molecular Mechanism In Disease Pathology, Ragavi Vijayakumar, Maxine Hong

The International Student Science Fair 2018

Hypertrophic cardiomyopathy (HCM), that clinically manifests as an enlarged heart is a highly prevalent cardiac disorder with propensity towards arrhythmia-induced sudden cardiac death. The mechanism of HCM remains poorly defined, necessitating further understanding of the disease for improved therapeutic strategies. As it is challenging to obtain cardiac biopsies from human subjects, using induced pluripotent stem cells technology, we generated cardiomyocytes (CMs) in a dish from HCM patients. These HCM-CMs presented the clinical manifestation in that they were significantly larger in size in comparison to control (healthy)-CMs. Furthermore, gene expression profiling of cardiac ion channels revealed increased transcripts encoding for calcium …