Medicine and Health Sciences Commons^™

Cytokine Regulation In Human Cd4 T Cells By The Aryl Hydrocarbon Receptor And Gq-Coupled Receptors, Jeremy P. Mcaleer, Jun Fan, Bryanna Roar, Donald A. Primerano, James Denvir

Clinical and Translational Science Institute

Th17 cells contribute to host defense on mucosal surfaces but also provoke autoimmune diseases when directed against self-antigens. Identifying therapeutic targets that regulate Th17 cell differentiation and/or cytokine production has considerable value. Here, we study the aryl hydrocarbon receptor (AhR)-dependent transcriptome in human CD4 T cells treated with Th17-inducing cytokines. We show that the AhR reciprocally regulates IL-17 and IL-22 production in human CD4 T cells. Global gene expression analysis revealed that AhR ligation decreased IL21 expression, correlating with delayed upregulation of RORC during culture with Th17-inducing cytokines. Several of the AhR-dependent genes have known roles in cellular assembly, organization, …

Clopidogrel And Aspirin In Acute Ischemic Stroke And High-Risk Tia., S. Claiborne Johnston, J. Donald Easton, Mary Farrant, William Barsan, Robin A. Conwit, Jordan J. Elm, Anthony S. Kim, Anne S. Lindbald, Yuko Y. Palesch

Clinical and Translational Science Institute

BACKGROUND—Combination antiplatelet therapy with clopidogrel and aspirin may reduce the rate of recurrent stroke during the first 3 months after a minor ischemic stroke or transient ischemic attack (TIA). A trial of combination antiplatelet therapy in a Chinese population has shown a reduction in the risk of recurrent stroke. We tested this combination in an international population. METHODS—In a randomized trial, we assigned patients with minor ischemic stroke or high-risk TIA to receive either clopidogrel at a loading dose of 600 mg on day 1, followed by 75 mg per day, plus aspirin (at a dose of 50 to 325 …

Select Biomarkers On The Day Of Anterior Cruciate Ligament Reconstruction Predict Poor Patient-Reported Outcomes At 2-Year Follow-Up: A Pilot Study, Christian Lattermann, Caitlin E. -W. Conley, Darren L. Johnson, Emily K. Reinke, Laura J. Huston, Janet L. Huebner, Ching-Heng Chou, Virginia B. Kraus, Kurt P. Spindler, Cale A. Jacobs

Orthopaedic Surgery and Sports Medicine Faculty Publications

Background. The majority of patients develop posttraumatic osteoarthritis within 15 years of anterior cruciate ligament (ACL) injury. Inflammatory and chondrodegenerative biomarkers have been associated with both pain and the progression of osteoarthritis; however, it remains unclear if preoperative biomarkers differ for patients with inferior postoperative outcomes. Hypothesis/Purpose. The purpose of this pilot study was to compare biomarkers collected on the day of ACL reconstruction between patients with "good" or "poor" 2-year postoperative outcomes. We hypothesized that inflammatory cytokines and chondrodegenerative biomarker concentrations would be significantly greater in patients with poorer outcomes. Study Design. Prospective cohort design. Methods. 22 …

Knowledge, Attitudes, And Practices Among Nurses In Pakistan Towards Diabetic Foot, Muhammad Bilal, Abdul Haseeb, Abdur Rehman, Mohammad Hussham Arshad, Aashir Aslam, Sana Godil, Saif N. Husain, Mohammad A. Qamar, Muhammad H. Polani, Araib Ayaz, Altamash S. Ghazanfar, Zaki M. Ghazali, Khurram A. Khoja, Maarij Malik, Hania Ahmad

Medical College Documents

Introduction:
Diabetic foot ulcers are a pressing complication of diabetes mellitus. Wound care requires a significant proportion of healthcare resources. It is imperative, therefore, for healthcare professionals to possess sound knowledge of the disease along with a positive attitude to ensure better clinical practice. Our literature search revealed a scarcity of data pertaining to diabetic foot ulcers. Therefore, this study aims to evaluate the knowledge and attitudes of nurses regarding diabetic foot care.
Methods:
A cross-sectional study design was employed, a pre-validated and pre-tested questionnaire was used to collect data from a sample size of 250 nurses working at two …

To Switch Or Not To Switch: Intentions To Switch To Injectable Prep Among Gay And Bisexual Men With At Least Twelve Months Oral Prep Experience, Kathrine Meyers, Yumeng Wu, Atrina Brill, Theodorus Sandfort, Sarit A. Golub

Publications and Research

Background: Phase III trials of long-acting injectable (LAI) PrEP, currently underway, have great potential for expanding the menu of HIV prevention options. Imagining a future in which multiple PrEP modalities are available to potential users of biomedical HIV prevention, we investigated which factors might help direct a patient-physician shared-decision making process to optimize the choice of biomedical HIV prevention method.

Methods: Participants (n = 105; ages 19–63; 46.7% men of color) were former participants in a PrEP demonstration project and had taken daily oral PrEP for 12 months. Participants were given information about LAI PrEP and asked whether they would …

Provider Perspectives On Demand Creation For Maternal Vaccines In Kenya, Irina Bergenfeld, Stacy W. Nganga, Courtni A. Andrews, Vincent L. Fenimore, Nancy A. Otieno, Sandra S. Chaves, Jennifer R. Verani, Marc-Alain Widdowson, Winnie N. Wairimu, Susan N. Wandera, Raphael O. Atito, Maxwell O. Adero, Paula M. Frew

Environmental & Global Health Faculty Research

Background. Expansion of maternal immunization, which offers some of the most effective protection against morbidity and mortality in pregnant women and neonates, requires broad acceptance by healthcare providers and their patients. We aimed to describe issues surrounding acceptance and demand creation for maternal vaccines in Kenya from a provider perspective. Methods. Nurses and clinical officers were recruited for semi-structured interviews covering resources for vaccine delivery, patient education, knowledge and attitudes surrounding maternal vaccines, and opportunities for demand creation for new vaccines. Interviews were conducted in English and Swahili, transcribed verbatim from audio recordings, and analyzed using codes developed from interview …

Efektivitas Lembar Pemantauan Insulin Terintegrasi Untuk Mengurangi Kejadian Hipoglikemia Pada Pasien Diabetes Mellitus Tipe 2, Dikha Ayu Kurnia, Debie Dahlia

Jurnal Keperawatan Indonesia

The Effectiveness of the Integrated Insulin Monitoring Sheets to Decrease Hypoglycemia Incidence on the Diabetes Mellitus Type 2 Patients. Hypoglycemia is one of the side effects of insulin therapy administration for Type 2 Diabetes Mellitus patients. The study aimed to develop the integrated insulin monitoring sheets and examine its effectiveness in identifying and recording the incidence of hypoglycemia who received analog insulin therapies. The results showed that the integrated insulin monitoring sheet recorded the significantly higher incidence of hypoglycemia during the morning (t (18)= 2.9732; p= 0.0059) and evening (t (18)= 3.0956; p= 0.0043) meals after the administration of rapid-acting …

Different Behavioral Experiences Produce Distinctive Parallel Changes In, And Correlate With, Frontal Cortex And Hippocampal Global Post-Translational Histone Levels., Marissa Sobolewski, Garima Singh, Jay S. Schneider, Deborah A. Cory-Slechta

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

While it is clear that behavioral experience modulates epigenetic profiles, it is less evident how the nature of that experience influences outcomes and whether epigenetic/genetic "biomarkers" could be extracted to classify different types of behavioral experience. To begin to address this question, male and female mice were subjected to either a Fixed Interval (FI) schedule of food reward, or a single episode of forced swim followed by restraint stress, or no explicit behavioral experience after which global expression levels of two activating (H3K9ac and H3K4me3) and two repressive (H3K9me2 and H3k27me3) post-translational histone modifications (PTHMs), were measured in hippocampus (HIPP) …

Medline-Indexed, In Process For Medline, And Non-Indexed Records Added To Pubmed And Pubmed Central, 1990 And 2000-2017, Peace Ossom-Williamson, Christian I.J. Minter

UTA Libraries Datasets - Archive

These files include the underlying data from the PubMed and Scholarly Communication research investigation.

Coping Strategies Among Caregivers Of Children With Autism Spectrum Disorders: A Cluster Analysis, Noor Ismael, Lisa Mische Lawson, Murad Moqbel, Lauren Little

Information Systems Faculty Publications

Introduction/Background: The variability in coping strategies among caregivers of children with ASD may contribute to broader health outcomes; however, it is unclear if specific coping strategies are related to overall strain in this population. Therefore, this study identified groups of caregivers based on coping mechanisms and investigated differences in strain among groups.

Materials & Methods: This study utilized a secondary data analysis, and included survey responses of 273 caregivers of children with ASD. Measures consisted of the COPE Inventory, and the Caregiver Strain Questionnaire. Data analyses consisted of cluster analysis to group caregiver coping strategies, and Analysis of Variance to …

Transnasal Sphenopalatine Ganglion Block: A Novel Solution For Postdural Puncture Headaches, Kaira Schefter

Nursing Capstones

No abstract provided.

Pediatric Lung Isolation Techniques, Kasey J. Trontvet

Nursing Capstones

No abstract provided.

Smokers' Neurological Responses To Novel And Repeated Health Warning Labels (Hwls) From Cigarette Packages, Johann F. Fridriksson, Chris Rorden, Roger D. Newman-Norlund, Brett Froeliger, Jim Thrasher

Faculty Publications

Graphic health warning labels (HWLs) depicting bodily injury due to smoking are effective for producing changes in affect, cognition and smoking behavior in adult smokers. However, little is known about the effects of repeated presentation of graphic HWL’s on the aforementioned processes. The goal of this study was to examine neural and behavioral responses to graphic HWL’s and evaluate whether the repeated presentation of graphic HWL’s leads to repetition suppression (RS). Smokers (N = 16) performed an event-related HWL cue task while blood oxygen level dependent (BOLD) signal was collected during a functional magnetic resonance imaging (fMRI) experimental session. Consistent …

Homeruns For Health: An Intervention Using Sports To Increase Physical Activity In Kids Attending An After-School Program, Nicholas D. Phalen

Celebration of Learning

This health behavior intervention targets the physical activity of kids (ages 6-14) at the Boys and Girls Club of the Mississippi Valley in Moline, Illinois. This intervention was developed with the application of the Social Cognitive Theory (SCT) during a 10-week long internship at the Boys and Girls Club of the Mississippi Valley’s (BGCMV) facility. A trend of lengthy “screen time” and a lack of emphasis on the importance of physical activity were both noticed during said internship. To address these observations, help was sought out from varsity athletic programs at Augustana College, a private institution in the area. The …

Cerebrovascular Compliance Within The Rigid Confines Of The Skull, Mair Zamir, M. Erin Moir, Stephen A. Klassen, Christopher S. Balestrini, J. Kevin Shoemaker

Bone and Joint Institute

© 2018 Zamir, Moir, Klassen, Balestrini and Shoemaker. Pulsatile blood flow is generally mediated by the compliance of blood vessels whereby they distend locally and momentarily to accommodate the passage of the pressure wave. This freedom of the blood vessels to exercise their compliance may be suppressed within the confines of the rigid skull. The effect of this on the mechanics of pulsatile blood flow within the cerebral circulation is not known, and the situation is compounded by experimental access difficulties. We present an approach which we have developed to overcome these difficulties in a study of the mechanics of …

Antimalarial Proteasome Inhibitor Reveals Collateral Sensitivity From Intersubunit Interactions And Fitness Cost Of Resistance., Laura A. Kirkman, Wenhu Zhan, Joseph Visone, Alexis Dziedziech, Pradeep K. Singh, Hao Fan, Xinran Tong, Igor Bruzual, Ryoma Hara, Masanori Kawasaki, Toshihiro Imaeda, Rei Okamoto, Kenjiro Sato, Mayako Michino, Elena Fernandez Alvaro, Liselle F. Guiang, Laura M. Sanz, Daniel J. Mota, Kavitha Govindasamy, Rong Wang, Yan Ling, Patrick K. Tumwebaze, George Sukenick, Lei Shi, Jeremie Vendome, Purnima Bhanot, Philip J. Rosenthal, Kazuyoshi Aso, Michael A. Foley, Roland A. Cooper, Bjorn Kafsack, J Stone Doggett, Carl F. Nathan, Gang Lin

Natural Sciences and Mathematics | Faculty Scholarship

We describe noncovalent, reversible asparagine ethylenediamine (AsnEDA) inhibitors of the Plasmodium falciparum proteasome (Pf20S) β5 subunit that spare all active subunits of human constitutive and immuno-proteasomes. The compounds are active against erythrocytic, sexual, and liver-stage parasites, against parasites resistant to current antimalarials, and against P. falciparum strains from patients in Africa. The β5 inhibitors synergize with a β2 inhibitor in vitro and in mice and with artemisinin. P. falciparum selected for resistance to an AsnEDA β5 inhibitor surprisingly harbored a point mutation in the noncatalytic β6 subunit. The β6 mutant was resistant to the species-selective Pf20S β5 inhibitor but remained …

Week Of July 17, 2018, New York Medical College

InTouch

• Center Of Excellence In Precision Responses to Bioterrorism and Disasters is Awarded $750,000 by New York State
• Two SHSP Students Win Prestigious Healthcare Leaders Awards
• Department of Pharmacology Hosts Talk by Regeneron Executive
• TouroCDM Class of 2020 Kicks Off Their Clinical Training

Health Data And Privacy In The Digital Era, Lawrence O. Gostin, Sam F. Halabi, Kumanan Wilson

Georgetown Law Faculty Publications and Other Works

In 2010, the social networking site Facebook launched a platform allowing private companies to request users’ permission to access personal data. Few users were aware of the platform, which was integrated into Facebook’s terms of service. In 2014, Cambridge Analytica, a UK-based political consulting firm, developed a data-harvesting app. That app prompted Facebook users to provide psychological profiles, including responses such as “I get upset easily” and “I have frequent mood-swings” as part of a “research project.”

The Facebook platform allowed users to share their friends’ data as well, enabling Cambridge Analytica to access tens of millions of personal profiles, …

Using Mobile Augmented Reality To Enhance Health Professional Practice Education, Bernie M. Garrett, Joseph Anthony, Cathryn Jackson

Current Issues in Emerging eLearning

The use of augmented reality (AR) as a new multimedia networking technology is increasing. An investigation was made of the value of using AR as a tool to support the teaching of clinical practice skills. A series of mobile AR resources were created for use on tablet computers and smartphones to supplement clinical skills teaching in the laboratory (using image recognition), and clinical practice (using geolocation). Undergraduate students in nursing, physiotherapy, and occupational therapy tested these resources in lab sessions, a location-based campus exercise, and during clinical practice experiences. Following this, a post-exposure web survey and focus group interviews were …

Jörg Langowski: His Scientific Legacy And The Future It Promises, Giuseppe Chirico, Alexander Gansen, Sanford H. Leuba, Ada L. Olins, Donald E. Olins, Jeremy C. Smith, Katalin Tóth

Pharmaceutical Sciences Faculty Publications

Background: With the passing of Jörg Langowski 6 May 2017 in a sailplane accident, the scientific community was deprived of a strident and effective voice for DNA and chromatin molecular and computational biophysics, for open access publishing and for the creation of effective scientific research networks. Methods: Here, after reviewing some of Jörg’s key research contributions and ideas, we offer through the personal remembrance of his closest collaborators, a deep analysis of the major results of his research and the future directions they have engendered. Conclusions: The legacy of Jörg Langowski has been to propel a way of viewing biological …

What's Happening: July 16, 2018, Maine Medical Center

What's Happening

No abstract provided.

Recruitment Maneuvers And Positive End Expiratory Pressure For Obese Patients Undergoing Laparoscopic Procedures, Nathan Mcgee

Nursing Capstones

No abstract provided.

A V-To-F Substitution In Sk2 Channels Causes Ca2+ Hypersensitivity And Improves Locomotion In A C. Elegans Als Model, Young-Woo Nam, Sabia N. Baskoylu, Dimitris Gazgalis, Razan Orfali, Meng Cui, Anne C. Hart, Miao Zhang

Pharmacy Faculty Articles and Research

Small-conductance Ca2+-activated K+ (SK) channels mediate medium afterhyperpolarization in the neurons and play a key role in the regulation of neuronal excitability. SK channels are potential drug targets for ataxia and Amyotrophic Lateral Sclerosis (ALS). SK channels are activated exclusively by the Ca2+-bound calmodulin. Previously, we identified an intrinsically disordered fragment that is essential for the mechanical coupling between Ca2+/calmodulin binding and channel opening. Here, we report that substitution of a valine to phenylalanine (V407F) in the intrinsically disordered fragment caused a ~6 fold increase in the Ca2+ sensitivity of SK2-a channels. This substitution resulted in a novel interaction between …

08-13-2018 Notice Of Hsc Committee Mtg, Patrice Martin

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

College Of Health Professions News, Georgia Southern University

College of Health Professions: News & Publications (2012-2023)

• Students Study Abroad in Italy

Dexmedetomidine For Prevention Of Emergence Delirium In Pediatric Anesthesia, Kayla B. Henneberg

Nursing Capstones

No abstract provided.

Neurosyphilis: A Simulation Case For Emergency Medicine Residents., Chana Rich, Dimitrios Papanagnou, David Curley, Xiao Chi Zhang

Department of Emergency Medicine Faculty Papers

Neurosyphilis is a dangerous and increasingly more prevalent sexually transmitted infection of the central nervous system caused by the bacterium Treponemapallidum that can present during the advanced stages of the disease (tertiary syphilis). Health care providers must remain vigilant in screening for syphilis in patients with high-risk behaviors as a delay in diagnosis and treatment may lead to symptom progression and debilitating sequelae years later. To date, there have been no published simulation case studies on neurosyphilis. This simulation case, based on a real patient encounter, is written for emergency medicine residents to diagnose and manage a patient …

Hyperthermia Induces Therapeutic Effectiveness And Potentiates Adjuvant Therapy With Nontargeted And Targeted Drugs In An In Vitro Model Of Human Malignant Melanoma, T. Mantso, S. Vasileiadis, I. Anestopoulos, G. P. Voulgaridou, E. Lampri, S. Botaitis, E. N. Kontomanolis, C. Simopoulos, G. Goussetis, R. Franco, K. Chlichlia, A. Pappa, M. I. Panayiotidis

School of Veterinary and Biomedical Sciences: Faculty Publications

In the present study, we have aimed to characterize the intrinsic, extrinsic and ER-mediated apoptotic induction by hyperthermia in an in vitro model of human malignant melanoma and furthermore, to evaluate its therapeutic effectiveness in an adjuvant therapeutic setting characterized by combinational treatments with non-targeted (Dacarbazine & Temozolomide) and targeted (Dabrafenib & Vemurafenib) drugs. Overall, our data showed that both low (43 °C) and high (45 °C) hyperthermic exposures were capable of inducing cell death by activating all apoptotic pathways but in a rather distinct manner. More specifically, low hyperthermia induced extrinsic and intrinsic apoptotic pathways both of which activated …

Fasudil In Combination With Bone Marrow Stromal Cells (Bmscs) Attenuates Alzheimer's Disease-Related Changes Through The Regulation Of The Peripheral Immune System., Jiezhong Yu, Yuqing Yan, Qingfang Gu, Gajendra Kumar, Hongqiang Yu, Yijin Zhao, Chunyun Liu, Ye Gao, Zhi Chai, Jasleen Chumber, Bao-Guo Xiao, Guang-Xian Zhang, Han-Ting Zhang, Yuqiang Jiang, Cun-Gen Ma

Department of Neurology Faculty Papers

Alzheimer's disease (AD) is a chronic progressive neurodegenerative disease. Its mechanism is still not clear. Majority of research focused on the central nervous system (CNS) changes, while few studies emphasize on peripheral immune system modulation. Our study aimed to investigate the regulation of the peripheral immune system and its relationship to the severity of the disease after treatment in an AD model of APPswe/PSEN1dE9 transgenic (APP/PS1 Tg) mice. APP/PS1 Tg mice (8 months old) were treated with the ROCK-II inhibitor 1-(5-isoquinolinesulfonyl)-homo-piperazine (Fasudil) (intraperitoneal (i.p.) injections, 25 mg/kg/day), bone marrow stromal cells (BMSCs; caudal vein injections, 1 × 10

Advantages Of Percutaneous Endoscopic Gastrostomy Tube Placement In Patients With Head And Neck Cancer Who Receive Radiation As Part Of Their Treatment, Nevin Thul

Speech and Hearing Sciences ETDs

The use of percutaneous endoscopic gastrostomy tubes as an intervention strategy in head and neck cancer was investigated in this retrospective chart review. Twenty-five veterans met the inclusion criteria and were categorized into two groups – use of prophylactic percutaneous endoscopic gastrostomy and absence of percutaneous endoscopic gastrostomy tube placement. Medical charts were reviewed and data extracted included weight, swallow function, swallow exercise compliance, and physical and social quality of life for 2 years post-treatment. Month-to-month data were compared across the two groups with respect to weight, swallow function, swallow exercise compliance, and physical and social quality of life scores. …