Medicine and Health Sciences Commons^™

Targeting Neuropeptides To Bone Fractures For Accelerated Healing, Nicholas A. Young, Jeffery J. Nielsen, Philip S. Low

The Summer Undergraduate Research Fellowship (SURF) Symposium

In patients over the age of 65 especially, bone fractures represent a significant disease burden. Non-invasive drug therapies are not available for bone fractures which represents a problem for this population. Vasoactive intestinal peptide (VIP) and Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP), two neuromodulator peptides in the glucagon superfamily, have demonstrated positive regulation of osteoblast proliferation and activity. Using acidic oligopeptides, we have developed ligands that target to and accumulate at fracture sites. These targeting ligands can be synthesized in sequence with bone anabolic peptides to minimize off target effects and increase potency at the fracture site to create safer and …

Targeting Pro-Inflammatory Function Of Microglia Using Small Molecules To Combat Neurodegeneration, Gabrielle C. Williams, Priya Prakash, Gaurav Chopra

The Summer Undergraduate Research Fellowship (SURF) Symposium

Microglia are the brain’s resident immune cells that are responsible for maintaining homeostasis in healthy conditions. During injury or infection, resting microglia get activated and produce pro-inflammatory cytokines such as IL-1b, IL-1a, IL-6, etc. along with reactive oxygen species like nitric oxide (NO) to combat neuroinflammatory diseases such as Alzheimer’s disease (AD). Inflammation is characterized by the activation of resident-immune cells in the brain called microglia that respond to the eat-me signals released by the toxic amyloid beta peptides as well as the dying neurons in the microenvironment. Recent studies have shown that activated microglia induce neuronal death by secreting …

Cost-Effective Paper-Based Diagnostic Using Split Proteins To Detect Yeast Infections, Zachary R. Berglund, Kevin V. Solomon, Mohit S. Verma, Moiz Rasheed, Zachary Hartley, Kevin Fitzgerald, Kok Zhi Lee, Janice Chan, Julianne Dejoie, Makayla Schacht, Alex Zavala

The Summer Undergraduate Research Fellowship (SURF) Symposium

The common yeast infection, vulvovaginal candidiasis, affects three out of four women throughout their lifetime and can be spread to their child in the form of oral candidiasis (thrush). This disease is caused by the fungal pathogen Candida albicans, which is also a major cause of systemic candidiasis, a rarer but deadly disease with up to a 49% lethality rate. Current widely-used diagnostic methods include cell cultures, pH tests, and antibody detection, to assist effective treatment. Despite availability of various diagnostic methods, there is no inexpensive, rapid, and accurate way to detect C. albicans infection. This project aims to …

Polyrotaxane Variants And Their Effects On The Cholesterol Efflux In Patients Suffering From Niemann Pick Type C, Sydney Smith, Zach Struzik, David Thompson

The Summer Undergraduate Research Fellowship (SURF) Symposium

Niemann Pick type C disease (NPC) is a rare lysosomal storage disorder characterized by a progressive accumulation of cholesterol in the late endosomal/lysosomes compartment leading to cellular dysfunction and organ failure. Symptoms include ataxia, dysarthria, cognitive dysfunction, and seizures. Although average life expectancy is below 20, there are no FDA approved treatment available making it a serious unmet medical need. Clinical trials with 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) has shown promise in cholesterol normalization within NPC cells. However, HP-beta-CD treatment has been shown to cause ototoxicity in NPC patients at high dosages. Supramolecular complexes known as polyrotaxanes have been synthesized in hopes of …

Tissue Clearing As A Mechanism To Identify Changes In Fibronectin Structure During Breast Cancer Metastasis, Maryam Nuru, Kelsey Hopkins, Luis Solorio

The Summer Undergraduate Research Fellowship (SURF) Symposium

With metastasis accounting for approximately 90% of breast cancer deaths and an alarming number of over 300,000 new breast cancer cases to be diagnosed by the end of 2018, there is growing need to understand the process of breast cancer. Changes in the extracellular matrix (ECM) of the tumor microenvironment play an essential role in this deadly tumor progression. Specifically, the glycoprotein fibronectin (FN), has been identified to be up-regulated in patients with worse clinical outcomes. During tumor progression fibronectin undergoes conformational changes that aid in metastatic dissemination. In order to analyze the dynamic changes in FN expression and evaluate …

Maternal Programming: Application Of A Developmental Psychopathology Perspective, Laura M. Glynn, Mariann A. Howland, Molly Fox

Psychology Faculty Articles and Research

The fetal phase of life has long been recognized as a sensitive period of development. Here we posit that pregnancy represents a simultaneous sensitive period for the adult female with broad and persisting consequences for her health and development, including risk for psychopathology. In this review, we examine the transition to motherhood through the lens of developmental psychopathology. Specifically, we summarize the typical and atypical changes in brain and behavior that characterize the perinatal period. We highlight how the exceptional neuroplasticity exhibited by women during this life phase may account for increased vulnerability for psychopathology. Further, we discuss several modes …

Pubh 4134 A & B – Research Methods And Evaluation (Crn A=86030, B = 87523), Helen W. Bland

College of Public Health: Faculty Syllabi (2014-2021)

This course introduces the student to research methods used in health education and promotion. In addition, this course examines the rationale and procedure to evaluate health education/promotion programs. The course focuses on several topics including: research design, methods of program evaluation, planning research and evaluation, the politics and ethics of evaluation, measurement, sampling logistics, data analysis, and the development, in conjunction with Program Planning I (PUBH 4132), of a student project. 3 credits (3-0-3).

An Eqtl Landscape Of Kidney Tissue In Human Nephrotic Syndrome., Christopher E. Gillies, Rosemary Putler, Rajasree Menon, Edgar Otto, Kalyn Yasutake, Viji Nair, Paul Hoover, David Lieb, Shuqiang Li, Sean Eddy, Damian Fermin, Michelle T. Mcnulty, Nephrotic Syndrome Study Network (Neptune), Nir Hacohen, Krzysztof Kiryluk, Matthias Kretzler, Xiaoquan Wen, Matthew G. Sampson, Tarak Srivastava

Manuscripts, Articles, Book Chapters and Other Papers

Expression quantitative trait loci (eQTL) studies illuminate the genetics of gene expression and, in disease research, can be particularly illuminating when using the tissues directly impacted by the condition. In nephrology, there is a paucity of eQTL studies of human kidney. Here, we used whole-genome sequencing (WGS) and microdissected glomerular (GLOM) and tubulointerstitial (TI) transcriptomes from 187 individuals with nephrotic syndrome (NS) to describe the eQTL landscape in these functionally distinct kidney structures. Using MatrixEQTL, we performed cis-eQTL analysis on GLOM (n = 136) and TI (n = 166). We used the Bayesian "Deterministic Approximation of Posteriors" (DAP) to fine-map …

Left Ventricular Pseudoaneurysm: An Overview Of Diagnosis And Management., Faisal Inayat, Ali Raza Ghani, Iqra Riaz, Nouman Safdar Ali, Usman Sarwar, Raphael Bonita, Hafeez Ul Hassan Virk

Abington Jefferson Health Papers

Left ventricular pseudoaneurysm is a rare but life-threatening disorder that is frequently reported secondary to myocardial infarction or cardiac surgery. In this article, we chronicle the case of a patient with no prior risk factors who presented with a 2-week history of nonexertional atypical left chest pain. Apical 2-chamber transthoracic echocardiography revealed an unexpected outpouching of basal inferoseptal wall of the left ventricle, which had a narrow neck and relatively wide apex. The patient was diagnosed with left ventricular pseudoaneurysm and medical therapy was initiated. He refused to undergo the surgical intervention and subsequently, he was discharged from the hospital …

Retinitis Pigmentosa, Amanda Moore

Nursing Student Class Projects (Formerly MSN)

This poster contains information on the pathophysiology of Retinitis Pigmentosa (RP). Main points of the poster include a description of the disease, the pathophysiology of RP, diagnostics, signs and symptoms, nursing implications, and the resources used to obtain the information. This topic was chosen based on my father in law, who is currently living with retinitis pigmentosa. The purpose of this was to educate myself about RP, and to recognize any signs and symptoms in the case that my husband and/or son develop the genetic disease

Leadership: Self-Awareness Of Leadership Styles In Occupational Therapy, Katrina Greathouse, Joseph Gritter, Alexandra Imhoff

Work

Successful organizations and professions depend on quality leadership. However, the literature on leadership in the field of occupational therapy, particularly understanding the effects of self-awareness, is limited. The qualitative, hermeneutic, phenomenological methodology combined with grounded theory analysis utilized in this study, examines the perceived effects of self-awareness of leadership styles on occupational therapy leaders’ decision making. Data was collected through semi-structured interviews, four weeks after the completion of two self-awareness assessments. There were a total of four participants. All participants were occupational therapists and currently held a formal leadership title in the Midwest United States. The data was transcribed verbatim …

Implementation Of A Screening Protocol To Improve Provider Assessment Of Depression In Patients With Psoriasis, Marlee Bryant

Doctoral Dissertations and Scholarly Projects

Patients with psoriasis are at an increased risk for depression. Despite this risk, many dermatology care providers do not screen for depression in practice, including providers at the target practice for this project. This evidence-based practice pilot project was purposed to increase dermatology providers’ assessment of depression in patients with psoriasis. This project involved implementing a depression screening protocol at one private dermatology practice and educating providers on the use of the protocol including the embedded depression screening tool, the Patient Health Questionnaire-9. The project leader used a quasi-experimental design and collected data utilizing retrospective chart reviews completed pre- and …

Increasing Advance Care Planning In The Primary Care Setting, Nicole Marie Coffey

Doctoral Dissertations and Scholarly Projects

Evidence shows the many benefits of advance care planning (ACP) discussions, including; giving patients peace of mind, decreasing healthcare costs, increasing quality of care, and decreasing distress at the end of life. Due to the many proven benefits of ACP, the United States Department of Health and Human Services as well as many leading national health organizations are promoting ACP, even tying it to reimbursement. The best setting and time to initiate ACP is in the primary care setting as early as possible, before patients have any cognitive decline. In this context, patients have an established relationship with their provider, …

Madness And Lived Experience: An Analysis Of The Icarus Project, Alyson Young

Social Justice and Community Engagement

Psychiatric frameworks are used as the primary lens in the Western world to understand, define, describe, and categorize the experience of mental distress in individuals. The Icarus Project is a community mental health organization that has a focus on intersectionality and uses a social justice lens to look at experiences of mental distress. Members of The Icarus Project believe that they possess knowledge about the potential benefits that exist in the space between brilliance and madness as a community of individuals with lived experience of mental distress. Members believe that, through this knowledge, they can instill a sense of hope …

A Qualitative Analysis Of The Role Of Emotions In Different Patterns Of Long-Term Weight Loss, John Spencer Ingels, Sam Zizzi

Clinical and Translational Science Institute

Objective—To explore participant perspectives of the impact emotions have on weight loss. Design—A qualitative design gathered data through semi-structured interviews with participants in a weight management programme. The interview addresses the following research questions: (1) how do individuals working to lose weight perceive the impact emotions have on their longterm success, and (2) what strategies do more or less successful participants use to regulate their emotions? Researchers conducted and transcribed the interviews then completed content analysis to create and organise themes. Results—Two broad themes emerged through the interviews with 21 participants: emotional impact and emotional regulation. Further subthemes captured emotions …

A Retrospective Study To Assess The Prevalence, Determinants And Outcome Of Sepsis In A Tertiary Care Hospital, Udupi District., Drago Melba Bazel

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A retrospective study to assess the prevalence, determinants and outcome of sepsis among ICU patients in a selected tertiary care hospital, Udupi District was conducted in partial fulfilment of the requirement for the award of Master of Science in Nursing at Manipal College of Nursing Manipal, Manipal Academy of Higher Education Manipal.

The study objectives were to measure the prevalence, determinants and outcome of sepsis and to find the association between determinants and outcome of sepsis among ICU patients. The research variables were prevalence, determinants and outcome of sepsis. The demographic variables were age, gender, diagnosis, history of smoking …

A Study To Assess The Knowledge On Stroke And Health Seeking Behaviour Among Hypertensive Patients In Selected Tertiary Care Hospital, Udupi District, Karnataka., Divya Davis

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT “A study to assess the knowledge on stroke and health seeking behaviour among hypertensive patients in a selected tertiary care hospital, Udupi district, Karnataka” was carried out by Ms Divya Davis in partial fulfilment of the requirement for the degree of Master of Science in Nursing at Manipal College of Nursing, Manipal Academy of Higher Education, Manipal, Karnataka. The objectives of the study were to assess the knowledge on stroke among hypertensive patients attending Medicine OPD, to assess the health seeking behavior among hypertensive patients, to find the association between the knowledge on stroke and selected socio-demographic variables and …

A Study To Assess The Pain Level Of The Critically Ill Patients Admitted In Icus And The Nurse’S Perception On Pain Of Critically Ill Patients In Selected Tertiary Care Hospital, Udupi District., Chhanda Chakraborty

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A study to assess the pain level of the critically ill patients who are unable to communicate and the perception of the nurses regarding the pain of the critically ill patients admitted in tertiary care hospital of Udupi district, Karnataka was conducted by Ms. Chhanda Chakraborty in partial fulfillment of the requirements for the award of Master of Science in Nursing at Manipal College of Nursing Manipal, MAHE.

The objectives of the study were to assess the critically ill patients’ level of pain during positioning, and endotracheal suctioning procedures as measured by the BPS, the perception of the staff …

A Descriptive Study To Assess The Symptoms And Risk Factors Of Carpal Tunnel Syndrome Among The Computer Users In Selected Workplaces Of Udupi District, Karnataka, Keerthi Naik

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A descriptive study to assess the symptoms and risk factors of carpal tunnel syndrome among the computer users in selected workplaces of Udupi district, Karnataka was conducted by Ms. Keerthi Naik in partial fulfilment of the requirement for the award of Master of Science in Medical Surgical Nursing at Manipal College of Nursing Manipal, Manipal Academy of Higher Education, Manipal. The objectives of the study aimed to assess the symptoms of carpal tunnel syndrome, identify the risk factors of carpal tunnel syndrome, to find the association between demographic variables and symptoms of carpal tunnel syndrome and to find the …

A Study To Assess The Effectiveness Of Mindfulness Meditation On Anxiety And Sleeping Pattern Among The Nursing Students In Selected Nursing Colleges Of Udupi District", Uma Lamichaney

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A research study titled “A study to assess the effectiveness of mindfulness meditation on anxiety and sleeping pattern among the nursing students of selected nursing colleges of Udupi district” was conducted by Uma Lamichaney, as partial fulfilment of the requirement for the degree of Master of Science at Manipal College of Nursing, Manipal. The objectives of the study were to determine the level of anxiety, assess the sleeping pattern, and measure the effectiveness of mindfulness meditation in terms of reduction of anxiety and improvement in the sleeping pattern. The conceptual framework for the study was based on CIPP model. …

A Study To Assess The Peer Influence And The Behavior Among Adolescents Of Pre-University Colleges Of Udupi Taluk, Jisha Mary Alexander

Manipal College of Nursing, Manipal Theses and Dissertations

Abstract Background: Adolescence is a transitional phase which begins at the end of childhood and lasts till the beginning of adulthood- and characterised by the physical and mental improvement. Peer influence, development of attitudes and behavioural changes are some of the impacts that happen in this phase. Objective: The objective of the study was to assess the peer influence among the adolescents and their behaviour and to find out the association between peer influence and behaviour. Method: A survey design was used in the study and total of 355 adolescents were selected randomly from five pre university colleges. Result: The …

A Correlative Study On Social Media Addiction And Self-Esteem Among Students Of Selected Degree Colleges Of Udupi Taluk, Karnataka., Sriparna Sarkar

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A research study titled “A correlative study on social media addiction and self-esteem among students of selected degree colleges of Udupi Taluk, Karnataka” was conducted by Sriparna Sarkar, as a partial fulfilment of the requirement for the degree of Master of Science in Nursing at Manipal College of Nursing, MAHE, Manipal. The objectives of the study were to assess the social media addiction and determine the self-esteem of the students, find the relationship between social media addiction and self-esteem among students and to find the association between social media addiction and selected socio-demographic variables. The conceptual framework of the …

A Study To Assess The Effectiveness Of Motivational Enhancement Therapy On Relapse Prevention Among Adults With Alcohol Dependence Syndrome In Selected Hospitals Of Udupi District, Karnataka, Prathima Sherigarthy

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A research study to effectiveness of Motivational Enhancement Therapy on relapse prevention among adults with Alcohol Dependence Syndrome in selected hospitals of Udupi District, Karnataka was carried out at Manipal Academy of Higher Education (MAHE), Manipal. The objectives of the study were to assess the level of motivation among adults with Alcohol Dependence Syndrome in selected hospitals of Udupi District, to find the effectiveness of Motivational Enhancement Therapy on relapse prevention among adults with Alcohol Dependence Syndrome in selected hospitals of Udupi District in terms of increase in motivation scores measured by using URICA scale and decrease in warning …

A Correlational Study On Physical Activity, Energy Expenditure And Body Weight Among Secondary School Children In Selected Schools Of Udupi District, Karnataka., Kalyani Biswas

Manipal College of Nursing, Manipal Theses and Dissertations

Abstract Manipal College of Nursing Manipal iv ABSTRACT A research study titled “A correlational study on physical activity, energy expenditure and body weight among secondary school children in selected schools of Udupi district, Karnataka” was conducted by Ms. Kalyani Biswas, as a partial fulfilment of the requirement for the degree of Master of Science in Nursing at Manipal College of Nursing, MAHE, Manipal. The objectives of the study were to determine the physical activity and energy expenditure of secondary school children and to find the relationship between physical activity, body weight and energy expenditure among secondary school children. The conceptual …

A Study To Assess The Effectiveness Of An Educational Intervention On Knowledge And Practice Of Staff Nurses On Prevention Of Ventilator Associated Pneumonia (Vap) In Neonates Of A Selected Neonatal Intensive Care Unit Of A Tertiary Care Hospital., Dipanjali Roy

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A research study “Effectiveness of an educational intervention on knowledge and practice of staff nurses on prevention of Ventilator Associated Pneumonia (VAP) in neonates of a selected Neonatal Intensive Care Unit of a tertiary care hospital” was carried out at Manipal Academy of Higher Education (MAHE), Manipal, by Dipanjali Roy for the award of Master of Science in Nursing as a partial fulfilment of the course.

The objectives of the study were to assess the knowledge of staff nurses working in NICU regarding prevention of VAP among neonates as measured by a structured knowledge questionnaire, to identify the practices …

A Study To Assess The Effectiveness Of Nutritional Enhancement Programme On Knowledge And Micronutrient Deficiency Assessment Skills Among Mothers Of Anganwadi Children And Dietary Intake Of Micronutrients Of Anganwadi Children In Selected Anganwadi Centres Of Udupi District, Karnataka., Shraddha S Kanchan

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT “A study to assess the effectiveness of nutritional enhancement programme on knowledge and micronutrient deficiency assessment skills among mothers of anganwadi children and dietary intake of micronutrients of anganwadi children in selected anganwadi centres of Udupi district, Karnataka” was conducted by Ms. Shraddha S Kanchan in partial fulfilment of the requirement for the degree of Master of Science in Nursing at Manipal College of Nursing, MAHE, Manipal. The objectives of the study were: to assess the knowledge of mothers regarding micronutrients, find out the assessment skills of mothers of anganwadi children regarding micronutrient deficiency, assess the dietary intake of …

A Study To Assess The Perceived Stress And Eating Behaviour Among Undergraduate Students In Selected Professional And Non-Professional Colleges Of Udupi District., Rintu Thomas

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A research study titled “A study to assess the perceived stress and eating behavior among undergraduate students in selected professional and non-professional colleges of Udupi district” was conducted by Ms Rintu Thomas in partial fulfilment of the requirement for the degree of Masters of Science in Nursing at Manipal College of Nursing, Manipal, Manipal Academy of Higher Education, Karnataka. The objectives of the study were to determine level of perceived stress among the undergraduate students, to find out the factors influencing stress among undergraduates, to assess the eating behavior of undergraduate students, to compare the perceived stress of professional …

A Study To Assess The Effectiveness Of An Educational Intervention On Knowledge And Practice Of Peripheral Intravenous Catheterization By Healthcare Professionals (Nurses) Among Neonates Of Nicu’S In Selected Hospitals Of Udupi District, Karnataka., Jiji Mathew

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A research study titled “A study to assess the effectiveness of an educational intervention on knowledge and practice of peripheral intravenous catheterization by healthcare professionals (Nurses) among neonates of NICU’s in selected hospitals of Udupi district, Karnataka”, was conducted by Ms. Jiji Mathew in partial fulfilment of the requirement for the award of Master of Science in Nursing at Manipal College of Nursing, Manipal, MAHE. The objectives of the study were to assess the knowledge and practice of healthcare professionals (Nurses) regarding peripheral intravenous catheterization as measured by structured knowledge questionnaire and observational checklist and to evaluate the effectiveness …

A Study To Compare The Quality Of Life, Child Adjustment And Social Support Of Only Child And Child With Siblings In Selected Schools Of Udupi District., Arline Tency Dsouza

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A research study entitled, “A study to compare the quality of life, child adjustment and social support of ‘only child’ and ‘child with siblings’ in selected schools of Udupi district” was conducted by Ms Arline Tency D’ Souza, as partial fulfillment of the requirement for the degree of Master of Science in Nursing at Manipal College of Nursing, Manipal Academy of Higher Education, Manipal, Karnataka. The purposes of the study were, to identify and compare the differences as well as the similarities on quality of life, child adjustment and social support among children belonging to eighth, ninth and tenth …

A Case Control Study To Compare The Factors Influencing Early Onset Of Menarche Among School Children In Selected Schools Of Udupi District., Jesna Joseph

Manipal College of Nursing, Manipal Theses and Dissertations

ABSTRACT A study titled “A case- control study to compare the factors influencing early onset of menarche among school children in selected schools of Udupi District” was conducted by Mrs. Jesna Joseph in partial fulfillment of the requirement of the award of Master of Science in Nursing at Manipal College of Nursing, MAHE, Manipal, Karnataka. The present study was an attempt to assess the mean age at onset of menarche and to assess the factors influencing it, thereby health awareness can be given to the public. The objectives of the study were to determine the mean age at onset of …