Medicine and Health Sciences Commons^™

A Narrative Review On Contrast-Enhanced Ultrasound In Aortic Endograft Endoleak Surveillance., Sriharsha Gummadi, John R. Eisenbrey, Andrej Lyshchik

Department of Radiology Faculty Papers

Endovascular repair of abdominal aortic aneurysms have been performed successfully since 1991. However, 20% to 50% of these patients may develop an endoleak or continued aneurysmal sac expansion or perfusion despite stent graft coverage. Current recommendations suggest lifelong surveillance with computed tomographic angiography (CTA) at least 1 month after intervention and yearly after that. In select patients with a stable aneurysm sac on computed tomography performed 1 year after treatment, future screening could be performed with ultrasonography. However, color Doppler ultrasound can fail to detect as many as 31% of endoleaks. Contrast-enhanced ultrasound (CEUS) provides an alternative approach to excluded …

Protein Tyrosine Phosphatases As Potential Regulators Of Stat3 Signaling, Mihwa Kim, Liza D. Morales, Ik-Soon Jang, Yong-Yeon Cho, Dae Joon Kim

School of Medicine Publications

The signal transducer and activator of transcription 3 (STAT3) protein is a major transcription factor involved in many cellular processes, such as cell growth and proliferation, differentiation, migration, and cell death or cell apoptosis. It is activated in response to a variety of extracellular stimuli including cytokines and growth factors. The aberrant activation of STAT3 contributes to several human diseases, particularly cancer. Consequently, STAT3-mediated signaling continues to be extensively studied in order to identify potential targets for the development of new and more effective clinical therapeutics. STAT3 activation can be regulated, either positively or negatively, by different posttranslational mechanisms including …

Evaluation Of A Competency-Based Health Policy Training Program, Jim P. Stimpson, Kathleen Brandert, Brandon Grimm, Fernando A. Wilson

Reports: Center for Health Policy

No abstract provided.

Economic Implications Of Tobacco Use For The State Of Nebraska Government, Fernando A. Wilson, Nizar K. Wehbi, Ali S. Khan

Reports: Center for Health Policy

We examine smoking-related expenditures for the state Medicaid program and for lost productivity among state government employees. The predicted number of new diagnoses of smoking-related illnesses among government employees ranged from 109 cases of kidney disease to 856 cases of arthritis and related diseases. We estimate over 6,000 lost workdays due to sick leave among currently smoking vs. non-smoking employees. Smoking-related illness is estimated to increase state budgetary expenditures on Medicaid by approximately $114.9 million annually.

Use Of Guedel Airway As A Guide To Insert Nasogastric Tube Under General Anaesthesia: A Simple And Logical Way, Faraz Shafiq, Faruq Hameed, Khalid M Siddiqui

Department of Anaesthesia

No abstract provided.

Bivalirudin Anticoagulation Dosing Protocol For Extracorporeal Membrane Oxygenation: A Retrospective Review., Jared W. Netley Pharmd, Mpa , Bcps, James Roy Pharmd, Joseph Greenlee Iii Md, Shaun Hart Np, Michael Todt Pharmd, Bryan Statz Pharmd

Parkview Pharmacy Department

Anticoagulation with unfractionated heparin during extracorporeal membrane oxygenation (ECMO) is common, but alternative agents are being evaluated for safety and efficacy. The objective of this analysis was to assess if a comprehensive bivalirudin dosing and monitoring protocol effectively guides dose adjustments and monitoring of bivalirudin in patients during ECMO. Our analysis included 11 patients who received bivalirudin during ECMO therapy and had dosing managed using our hospital derived protocol. Patients treated over a 1-year period were included in this retrospective analysis. Clinical characteristics and changes in activated partial thromboplastin time (aPTT) were evaluated from medical records to determine the efficacy …

Pretty Peachy., Li-Anne Lim, Basil K. Williams, Carol L. Shields

Wills Eye Hospital Papers

No abstract provided.

Twenty-Four Month Results From A Randomized Trial Of Cyanoacrylate Closure Versus Radiofrequency Ablation For The Treatment Of Incompetent Great Saphenous Veins., Kathleen Gibson, Nick Morrison, Raghu Kolluri, Michael Vasquez, Robert Weiss, Daniel Cher, Monte Madsen, Andrew Jones

Surgery Articles

OBJECTIVE: We previously reported 3-month and 12-month occlusion rates after treatment of clinically symptomatic saphenous vein reflux with either cyanoacrylate closure (CAC) using the VenaSeal Closure System (Medtronic, Dublin, Ireland) or radiofrequency ablation (RFA) in a randomized, multicenter, clinical trial, VenaSeal Sapheon Closure System vs Radiofrequency Ablation for Incompetent Great Saphenous Veins (VeClose). Herein we report the 24-month follow-up results of the VeClose trial.

METHODS: There were 222 patients with symptomatic great saphenous vein (GSV) incompetence who were randomly assigned to receive either CAC (n = 108) or RFA (n = 114). Patients were not allowed to receive adjunctive treatment …

Exercise-Induced Pain And Analgesia? Underlying Mechanisms And Clinical Translation, Kathleen A. Sluka, Laura Frey-Law, Marie K. Hoeger Bement

Physical Therapy Faculty Research and Publications

No abstract provided.

Gait Variability And Energy Cost Of Overground Walking In Persons With Multiple Sclerosis: A Cross-Sectional Study, Emerson Sebastião, Rachel E. Bollaert, Elizabeth A. Hubbard, Robert W. Motl

Exercise Science Faculty Research and Publications

Objective: This study examined the associations between gait variability based on common spatiotemporal parameters and energetic cost of walking in persons with multiple sclerosis.

Design: Eighty-six persons with multiple sclerosis underwent the 6-min walk while wearing a portable metabolic unit. The cost of walking was generated by dividing the net steady-state VO₂ (milliliter per kilogram per minute) by walking speed during the 6-min walk. Participants further completed two trials of walking on the GAITRite mat at a self-selected pace for measuring spatiotemporal parameters. Variability of step length, step time, stride length, swing time, stance time, stride velocity, and single- …

Aligning Evidence-Based Practice With Translational Research: Opportunities For Clinical Practice Research, Marianne E. Weiss, Kathleen L. Bobay, Meg Johantgen, Maria Shirey

College of Nursing Faculty Research and Publications

Magnet(R) and other organizations investing resources in evidence-based practice (EBP) are ideal laboratories for translational nursing research. Translational research, the study of implementation of evidence into practice, provides a unique opportunity to leverage local EBP work for maximum impact. Aligning EBP projects with rigorous translational research can efficiently meet both EBP and research requirements for Magnet designation or redesignation, inform clinical practice, and place organizations at the leading edge of practice-based knowledge development for the nursing discipline.

Country-Level Macroeconomic Indicators Predict Early Post-Allogeneic Hematopoietic Cell Transplantation Survival In Acute Lymphoblastic Leukemia: A Cibmtr Analysis., William A. Wood, Ruta Brazauskas, Zhen-Huan Hu, Hisham Abdel-Azim, Ibrahim A. Ahmed, Mahmoud Aljurf, Sherif Badawy, Amer Beitinjaneh, Biju George, David Buchbinder, Jan Cerny, Laurence Dedeken, Miguel Angel Diaz, Cesar O. Freytes, Siddhartha Ganguly, Usama Gergis, David Gomez Almaguer, Ashish Gupta, Gregory Hale, Shahrukh K. Hashmi, Yoshihiro Inamoto, Rammurti T. Kamble, Kehinde Adekola, Tamila Kindwall-Keller, Jennifer Knight, Lalit Kumar, Yachiyo Kuwatsuka, Jason Law, Hillard M. Lazarus, Charles Lemaistre, Richard F. Olsson, Michael A. Pulsipher, Bipin N. Savani, Kirk R. Schultz, Ayman A. Saad, Matthew Seftel, Sachiko Seo, Thomas C. Shea, Amir Steinberg, Keith Sullivan, David Szwajcer, Baldeep Wirk, Jean Yared, Agnes Yong, Jignesh Dalal, Theresa Hahn, Nandita Khera, Carmem Bonfim, Yoshiko Atsuta, Wael Saber

Manuscripts, Articles, Book Chapters and Other Papers

For patients with acute lymphoblastic leukemia (ALL), allogeneic hematopoietic cell transplantation (alloHCT) offers a potential cure. Life-threatening complications can arise from alloHCT that require the application of sophisticated health care delivery. The impact of country-level economic conditions on post-transplantation outcomes is not known. Our objective was to assess whether these variables were associated with outcomes for patients transplanted for ALL. Using data from the Center for Blood and Marrow Transplant Research, we included 11,261 patients who received a first alloHCT for ALL from 303 centers across 38 countries between the years of 2005 and 2013. Cox regression models were constructed …

Profiles And Predictors Of Risk For Developmental Delay: Insights Gained From A Community-Based Universal Screening Program, Jing Chen, Gwenden Dueker, Candace Cowling

Open Access Publishing Support Funded Articles

No abstract provided.

Management Of Cervical Root Fracture Injury In A Patient With Epilepsy: Case Report With 5-Year Follow-Up, Elif Ataol, Gizem Erbaş Ünverdi, H. Cem Güngör

School of Dentistry Faculty Research and Publications

The difficulty in providing stability to the coronal segment makes cervical root fracture one of the most challenging dental traumatic injury. This type of injury is less frequent in children. However, due to their serious consequences and poor prognosis, tooth loss may occur. This report presents the management of a case of cervical root fracture in an 11-year-old patient with epilepsy. The stabilization of the root-fractured tooth with a splint failed due to the recurrent seizures the patient had. Coronal fragment was removed and vital root submergence was performed in order to support the alveolar growth. The natural tooth crown …

Monitoring Il-13 Expression In Relation To Mirna-155 And Mirna-133 Changes Following Intra-Tracheal Administration Of Mesenchymal Stem Cells And Conditioned Media In Ovalbuminsensitized Rats, Mahdi Ahmadi, Reza Rahbarghazi, Amir-Ali Shahbazfar, Rana Keyhanmanesh

The Thai Journal of Veterinary Medicine

The overall goal of the current study was to show possibly mechanisms by which mesenchymal stem cells (MSCs) or conditioned media (CM) exert immune-modulatory properties for amelioration of asthmatic changes. Male rats were classified into healthy (C) and ovalbumin-sensitized groups (S), which further were divided into three subgroups (n=6); rats given intratracheally PBS (CPT and SPT groups), CM (CST and SST groups) and MSCs (CCT and SCT groups). Two weeks post treatment, IL-13, miRNA- 133 and miRNA-155 transcripts, pathological injuries and the homing of MSCs into the lung parenchyma were evaluated. The local administration of CM and notably MSCs blunted …

Prevalence And Risk Factors For Canine Cognitive Dysfunction Syndrome In Thailand, Chutamas Benjanirut, Chanakarn Wongsangchan, Piyathip Setthawong, Wittanee Pradidtan, Suphanuch Daechawattanakul, Kris Angkanaporn

The Thai Journal of Veterinary Medicine

Canine cognitive dysfunction syndrome (CDS) is a disease similar to Alzheimer’s in humans. This progressive neurodegenerative disease affects senior dogs, causes many behavioral changes and decreases welfare in both the dog and owner. Even with its high impact, many studies have shown CDS is underdiagnosed. The aims of this study were to investigate the prevalence of CDS in Thailand and to identify its risk factors. In this study, 622 senior dogs (seven years old and older) were randomly recruited. After an initial interview, 389 dogs were excluded from the study due to clinical and/or sensory impairment. Owners of the remaining …

Curriculum For Neurogastroenterology And Motility Training: A Report From The Joint Anms-Esnm Task Force., C P Gyawali, E Savarino, A Lazarescu, S Bor, A Patel, R Dickman, A Pressman, A M Drewes, John Rosen, V Drug, M Saps, L Novais, M Vazquez-Roque, D Pohl, M A L Van Tilburg, A Smout, S Yoon, J Pandolfino, G Farrugia, G Barbara, S Roman

Manuscripts, Articles, Book Chapters and Other Papers

Although neurogastroenterology and motility (NGM) disorders are some of the most frequent disorders encountered by practicing gastroenterologists, a structured competency-based training curriculum developed by NGM experts is lacking. The American Neurogastroenterology and Motility Society (ANMS) and the European Society of Neurogastroenterology and Motility (ESNM) jointly evaluated the components of NGM training in North America and Europe. Eleven training domains were identified within NGM, consisting of functional gastrointestinal disorders, visceral hypersensitivity and pain pathways, motor disorders within anatomic areas (esophagus, stomach, small bowel and colon, anorectum), mucosal disorders (gastro-esophageal reflux disease, other mucosal disorders), consequences of systemic disease, consequences of therapy …

It's About Communities: The Commitment To Promoting A Culturally Competent Environmental Health Workforce, Clint Pinion Jr., Leslie D. Mitchell, Jason W. Marion

EKU Faculty and Staff Scholarship

Environmental health and public health are profoundly local. The Association of Environmental Health Academic Programs (AEHAP) firmly agrees and for this reason, it is important to have local environmental health experts who know the pulse of their communities. AEHAP believes in supporting the advanced scientific education of environmental health in these communities through people from these communities. Accordingly, AEHAP has sought to promote and support accredited environmental health programs among a diverse cross-section of the U.S. higher education landscape. AEHAP’s students are diverse in many ways, including socioeconomically, racially, ethnically, and culturally. The value of this approach enhances the overall …

Chemoradiation And The Role Of Adjuvant Chemotherapy In Lymph Nodal-Metastatic Cervical Cancer, Nasir Ali, Azmina Tajdin Valimohammad, Ahmed Nadeem Abbasi, Muhammad Atif Mansha, Asim Hafiz, Bilal Mazhar Qureshi

Department of Radiation Oncology

Purpose: To report the long-term outcome in lymph nodal-metastatic cervical squamous cell cancer after chemoradiation followed by adjuvant chemotherapy.
Patients and Methods: Between 2010 and 2013, five patients were diagnosed with advanced cervical cancer with clinically involved para-aortic lymph nodes (ie, International Federation of Gynecology and Obstetrics stage IVB). These patients were treated with concurrent chemoradiation therapy followed by adjuvant chemotherapy. Concurrent chemoradiation consisted of cisplatin given once per week concomitantly with extended-field radiation therapy followed by high-dose-rate brachytherapy. Adjuvant chemotherapy comprised four courses of carboplatin and paclitaxel given every three weeks. The primary outcomes were local and distant failures. …

Evaluation Of Quality Of Warfarin Therapy By Assessing Patient's Time In Therapeutic Range At A Tertiary Care Hospital In Pakistan, Haris Hakeem, Ammar Zaman Khan, Kashif Aziz, Ayesha Abbasi, Anam Haider, Bushra Moiz, Mohammad Wasay

Section of Neurology

Objective: To assess the time in therapeutic range in patients on warfarin anti-coagulation therapy.

Methods: The retrospective chart review was conducted at Aga Khan University Hospital, Karachi, and comprised data of patients having undergone anti-coagulation with warfarin from January 2013 to April 2015. To determine the mean time in therapeutic range, Rosendaal method was used. Association of time in therapeutic range with the composite outcome, bleeding and thromboembolic events was also assessed. Percentage of patients with time in therapeutic range <60% was calculated.

Results: There were 92 patients whose median time in therapeutic range was 34.9% (interquartile range: 20.0- 55.7). Overall, 71(77.2%) …

Impact Of Airborne Pollutants On Stroke, Adeel Khoja, Fizzah Kazim

Section of Neurology

No abstract provided.

Effect Of Centric Interference On Canine Tooth Wear, Andrey Gaiduchik

Loma Linda University Electronic Theses, Dissertations & Projects

Purpose: The aim of this study was to determine the long term effect of a centric interference on canine tooth wear (CTW) and on centric occlusion (CO) and maximal intercuspation (MIP) variance. Materials and Methods: Thirty subjects, 11 males and 19 females, were selected based on inclusion and exclusion criteria. Changes in enamel volume were studied between the end of orthodontic treatment (T2) and at least seven years post treatment (T4). All models were scanned using a high resolution desktop scanner, (OrthoInsight 3D Scanner™, MotionView LLC). T4 models were articulated using a Panadent® Articulator and evaluated for dental interferences and …

The Relationship Between Psychotherapist Personality And Therapeutic Alliance, Michael Finlay

Loma Linda University Electronic Theses, Dissertations & Projects

Time-limited effective psychotherapy is a topic that is frequently addressed in clinical therapy research. Though a wide range of therapeutic factors, expectancy effects, techniques, and extratherapeutic have all been demonstrated to be related to outcome, researchers have consistently identified the therapeutic alliance as one of the strongest factors in predicting psychotherapy outcomes. Researchers are beginning to measure the effectiveness of therapy by evaluating improvements in outcome measures, and client reported therapeutic alliance. Researchers have recently began investigating the common personality profiles among psychotherapists, and have hypothesized that there is a relationship between psychotherapist personality and therapeutic alliance. The goal of …

Estimating Root Volumes By Limited Segmentation: A Volumetric Analysis Of Cbct And Micro-Ct Data, Theresa C. Baldwin

Loma Linda University Electronic Theses, Dissertations & Projects

Introduction: The increased dimensional accuracy of images provided by cone beam computed tomography (CBCT) scans allows for more in-depth diagnosis and treatment planning. Expedient interpolation of segmented data that provides clinically acceptable results will encourage clinicians to frequently use CBCT images for clinical/radiographic evaluation. Some of these applications include, quantification of root resorption, determination of force required for specific tooth movements, and customized appliances. Purpose: The study had two purposes. The first was to compare the accuracy of digital tooth volumes acquired from CBCT to the gold standard, micro-computed tomography (micro-CT). The second was to determine the effect of axial …

Investigation Into Toxin And Slime Genes In Staphylococci Isolated From Goat Milk And Goat Cheese In Southern Turkey, Sevda Pehlivanlar Onen, Zafer Cantekin, Faiza Mebkhout, Osman Aygun, Yasar Ergun

The Thai Journal of Veterinary Medicine

The aim of this study was to investigate the presence of Staphylococcus aureus and coagulase-negative staphylococci (CNS) isolated from goat milk and cheese, as well as their toxin genes and slime genes. S. aureus and CNS isolates were subjected to polymerase chain reaction (PCR) analyses to determine the prevalence of enterotoxin (sea, seb, sec, sed, see), toxic shock syndrome (TSS) toxin (tst), exfoliative toxin (eta and etb) and slime genes (icaA and icaD). sec, sed and tst genes together were detected in 4 (33.3%), sec + tst genes in 2 (16.7%) and tst gene in 1 (8.3%) of the 12 …

Therapeutic Use Of Sulfadimethoxine-Ormetoprim For Control Of Streptococcus Agalactiae Infection In Nile Tilapia (Oreochromis Niloticus) Fry, Nion Vinarukwong, Mintra Lukkana, Jan O. Berntsen, Janenuj Wongtavatchai

The Thai Journal of Veterinary Medicine

The therapeutic efficacy of sulfadimethoxine-ormetoprim (SDMX-OMP) against Streptococcus agalactiae (S. agalactiae) infection in tilapia (Oreochromis niloticus) was examined in tilapia fry. Fish (3+0.44 g) underwent 3-hour immersion challenge with 50% infective dose (2.58 x 106 CFU/ml) of S. agalactiae and were treated at 24 hours post challenge with daily dosages of 30 and 50 mg SDMX-OMP/kg body weight (BW) feeding medication for 7 days. The administration of medicated feed increased the survival of the infected tilapia fry. The survival rate of the challenged, non-medicated group was 51.25+4.79%. The fish which were challenged with S. agalactiae and received the 30 and …

Decreasing Duration Of Androgenic Hormone Feeding Supplement For Production Of Male Monosex In Tilapia (Oreochromis Spp.) Fry, Nion Vinarukwong, Mintra Lukkana, Janenuj Wongtavatchai

The Thai Journal of Veterinary Medicine

The effects of an exogenous androgenic hormone on sex differentiation were examined in Nile tilapia (Oreochromis niloticus) and red tilapia (Oreochromis spp.) fry. Tilapia aquaculture in Thailand commonly applies methyltestosterone at the dose of 80 mg/kg diet on the first feeding of fish fry for 21-28 days to achieve male-monosex crop. In this study, male sex reversal was induced with an alternative androgenic hormone, 17α- methyldihydrotestosterone (MDHT), at a dose of 80 mg/kg diet for shorter periods; 5, 10, 15, or 20 days. Microscopic examination of fish gonad stained with aceto-carmine was used to determine male and female fish fry …

Novel Methods To Diagnose Pulmonary Hypertension In Dogs Assessed By Thoracic Radiography, Kawinthip Chanroon, Thanat Tuntipas, Promsin Sukpanich, Pawit Punyarit, Sirilak Disatian Surachetpong

The Thai Journal of Veterinary Medicine

The objective of this retrospective study was to distinguish between dogs with pulmonary hypertension (PH) and non-PH by using parameters obtained from thoracic radiographs. Data of 72 dogs of small breeds aged more than 1 year old and weighing less than 10 kg were retrieved. Echocardiography was used as a gold standard to diagnose PH and separate the dogs into two groups: PH (n=15) and non-PH (n=57). Seven formulae were created from measurements on right lateral and ventrodorsal radiographic views. Five formulae from the ventrodorsal view provided an outcome that could differentiate PH and non-PH dogs. Two formulae are recommended …

Current Situation Of Neospora Caninum And Toxoplasma Gondii Infection Among Beef Cattle In Kanchanaburi, Ratchaburi And Nakhon Patom Provinces, Thailand, Ruenruetai Udonsom, Yaowalark Sukthana, Yoshifumi Nishikawa, Ragab M. Fereig, Charoonluk Jirapattharasate

The Thai Journal of Veterinary Medicine

Toxoplasmosis and neosporosis are parasitic diseases of livestock globally. In this study, we investigate the presence of Neospora caninum and Toxoplasma gondii in 250 beef cattle from Kanchanaburi, Ratchaburi and Nakhon Patom provinces, Thailand comparing with the results from 5 years earlier. The serological diagnosis for toxoplasmosis and neosporosis were performed by indirect ELISA technique using recombinant antigens TgGRA7 and NcSAG1, respectively. Furthermore, risk factors at the animal- and herd-levels were also evaluated. Seroprevalence of T. gondii, N. caninum and co-infections were 15.2%, 20.8% and 27.2%, respectively. In comparison to the results from 5 years earlier, seropositivity of N. caninum …

Long-Term Effects Of Repeated Oral Dose Of Ivabradine On Heart Rate Variability In Dogs With Asymptomatic Degenerative Mitral Valve Disease, Prapawadee Pirintr, Nakkawee Saengklub, Vudhiporn Limprasutr, Anusak Kijtawornrat

The Thai Journal of Veterinary Medicine

Degenerative mitral valve disease (DMVD) is the most common acquired cardiac disease in geriatric dogs leading to impaired cardiac autonomic activity and functions. This study aimed to evaluate the heart rate (HR), blood pressure (BP), myocardial oxygen consumption (MVO2) and heart rate variability (HRV) of dogs with DMVD stage B2 in response to long-term treatment with ivabradine, orally. Four beagles with naturally occurring DMVD stage B2 were instrumented with a 24-h Holter recorder to obtain electrocardiography and HRV, an oscillometric device to acquire blood pressure (BP), HR and myocardial oxygen consumption (MVO2) as assessed by rate-pressure product (RPP = HR …