Medicine and Health Sciences Commons^™

Anti-Aging Therapy: Can We Age Cancer Cells So They Stop Growing?, Jonathan R. Brody, Phd

Pancreatic Cancer & Related Diseases Patient Symposium

No abstract provided.

Update On Multimodal Therapy For Pancreatic Cancer, Harish Lavu, Md

Pancreatic Cancer & Related Diseases Patient Symposium

No abstract provided.

Precious Data: 2018 Interim Report From The Jefferson Pancreas Tumor Registry, Theresa Yeo, Phd, Mph, Msn, Aocnp

Pancreatic Cancer & Related Diseases Patient Symposium

No abstract provided.

An Update On Personalized Therapy For Pancreatic Cancer, Michael J. Pishvaian, Md, Phd

Pancreatic Cancer & Related Diseases Patient Symposium

No abstract provided.

Advances In Genetic Testing For Pancreatic Cancer, Colette Hyatt, Ms, Lcgc

Pancreatic Cancer & Related Diseases Patient Symposium

Overview

• Background on genetics
• Hereditary risk for pancreatic cancer
• Why do genetic testing?
• How to schedule a clinical genetics appointment at Jefferson

What To Expect From Your Oncology Care Team, Eleanor Vanderklok, Crnp, Aocnp

Pancreatic Cancer & Related Diseases Patient Symposium

No abstract provided.

Welcome And Program Overview, Charles J. Yeo, Md

Pancreatic Cancer & Related Diseases Patient Symposium

No abstract provided.

Breakfast With The Experts, Tbd

Pancreatic Cancer & Related Diseases Patient Symposium

Continental Breakfast, Informational Tables & Scientific Poster Presentations

Population And Fertility By Age And Sex For 195 Countries And Territories, 1950-2017: A Systematic Analysis For The Global Burden Of Disease Study 2017, Gbd 2017 Population And Fertility Collaborators, Paul Evan Kilgore

Department of Pharmacy Practice

Background Population estimates underpin demographic and epidemiological research and are used to track progress on numerous international indicators of health and development. To date, internationally available estimates of population and fertility, although useful, have not been produced with transparent and replicable methods and do not use standardised estimates of mortality. We present single-calendar year and single-year of age estimates of fertility and population by sex with standardised and replicable methods.

Methods We estimated population in 195 locations by single year of age and single calendar year from 1950 to 2017 with standardised and replicable methods. We based the estimates on …

Patient Perceptions Of Their Own Data In Mhealth Technology–Enabled N-Of-1 Trials For Chronic Pain: Qualitative Study, Robin Whitney, Deborah Ward, Maria Marois, Christopher Schmid, Ida Sim, Richard Kravitz

Faculty Publications

Background: N-of-1 (individual comparison) trials are a promising approach for comparing the effectiveness of 2 or more treatments for individual patients; yet, few studies have qualitatively examined how patients use and make sense of their own patient-generated health data (PGHD) in the context of N-of-1 trials. Objective: The objective of our study was to explore chronic pain patients’ perceptions about the PGHD they compiled while comparing 2 chronic pain treatments and tracking their symptoms using a smartphone N-of-1 app in collaboration with their clinicians. Methods: Semistructured interviews were recorded with 33 patients, a consecutive subset of the intervention group in …

Bridging The Gap Of Age And Awkwardness: Improving Geriatric Sex Education, Anne Watson

University Honors Program

Improving geriatric sex education is not a common thought for many Americans, but with a quickly growing population it may soon become a common topic for discussion. Discomfort, awkwardness, and lack of communication often keep health care providers and physicians from discussing sexual health with their elderly patients. These limitations are significantly impairing physicians and health care providers from educating their patients about their sexual health and addressing any concern the patient might have about their sexuality. Sexual health in geriatrics is a growing concern among many health care fields today as the elderly are participating in risky sexual behaviors …

Integrating Facility-Based Surveillance With Healthcare Utilization Surveys To Estimate Enteric Fever Incidence: Methods And Challenges, Jason R. Andrews, Caitlin Barkume, Alexander T. Yu, Samir K. Saha, Farah Qamar, Denise Garrett, Stephen P. Luby

Department of Paediatrics and Child Health

Cohort studies and facility-based sentinel surveillance are common approaches to characterizing infectious disease burden, but present trade-offs; cohort studies are resource-intensive and may alter disease natural history, while sentinel surveillance underestimates incidence in the population. Hybrid surveillance, whereby facility-based surveillance is paired with a community-based healthcare utilization assessment, represents an alternative approach to generating population-based disease incidence estimates with moderate resource investments. Here, we discuss this method in the context of the Surveillance for Enteric Fever in Asia Project (SEAP) study. We describe how data are collected and utilized to adjust enteric fever incidence for blood culture sensitivity, facility-based enrollment, …

Calibration And Analysis Of A Multimodal Micro-Ct And Structured Light Imaging System For The Evaluation Of Excised Breast Tissue., David M. Mcclatchy Iii, Elizabeth J. Rizzo, Jeff Meganck, Josh Kempner, Jared Vicory, Wendy A. Wells, Keith D. Paulsen, Brian W. Pogue

Dartmouth Scholarship

A multimodal micro-computed tomography (CT) and multi-spectral structured light imaging (SLI) system is introduced and systematically analyzed to test its feasibility to aid in margin delineation during breast conserving surgery (BCS). Phantom analysis of the micro-CT yielded a signal-to-noise ratio of 34, a contrast of 1.64, and a minimum detectable resolution of 240 ?m for a 1.2?min scan. The SLI system, spanning wavelengths 490?nm to 800?nm and spatial frequencies up to 1.37 , was evaluated with aqueous tissue simulating phantoms having variations in particle size distribution, scatter density, and blood volume fraction. The reduced scattering coefficient, and phase function …

Pvsripo Effect On Cancer, Vishal Jindal, Matthew Lee, Darshan Rola, Mir Saleem

Biology Faculty Articles

PVSRIPO, a variant of the poliovirus, is a revolutionary virus that demonstrates key characteristics for oncolytic virotherapy due to its ability to attack glioblastomas. The first criteria that PVSRIPO demonstrates is tumor-targeting tropism. PVSRIPO binds to nectin-like molecule 5 (Necl-5), a poliovirus receptor (PVR), found on different types of cancers such as lung cancer, colorectal cancer, and glioblastomas. This allows the virus to have a high binding affinity to tumor cells. Secondly, after modifying the poliovirus by substituting its internal ribosome entry site (IRES) with the Human Rhinovirus 2's (HRV2) IRES, the poliovirus becomes PVSRIPO, an attenuated version of the …

An Atypical Presentation Of Mycobacterium Abscessus Soft Tissue Infection Leading To A Protracted Disease Course, Joseph Moran Do, Joseph Scurozo Do, Brian Friel Do

Department of Medicine

No abstract provided.

Chemo-Coronaries: A Rare Form Of Coronary Vasospasm Following 5-Fu Infusion, George Prousi Md, Joseph Moran Do, Ross Biggs Do, John Mannisi Md

Department of Medicine

No abstract provided.

Phase I Of The Surveillance For Enteric Fever In Asia Project (Seap): An Overview And Lessons Learned, Caitlin Barkume, Kashmira Date, Samir K. Saha, Farah Qamar, Dipika Sur, Jason R. Andrews, Stephen P. Luby, M Imran Khan, Alex Freeman, Mohammad Tahir Yousafzai, Denise Garret

Department of Paediatrics and Child Health

Objective: The objective of Phase I of the Surveillance for Enteric Fever in Asia Project (SEAP), a multiphase surveillance study characterizing the burden of disease in South Asia, was to inform data collection for prospective surveillance and to capture clinical aspects of disease.
Methods: Through a retrospective record review conducted at hospitals in Bangladesh, India, Nepal, and Pakistan, we examined laboratory and clinical records to assess the culture positivity rate for Salmonella Typhi and Salmonella Paratyphi, age and sex distribution, and antimicrobial susceptability in each country.
Results: Of all blood cultures performed in Bangladesh, India, Nepal, and Pakistan, 1.5%, 0.43%, …

A Retrospective Study Of Laboratory-Based Enteric Fever Surveillance, Pakistan, 2012-2014, Farah Naz Qamar, Mohammad Tahir Yousafzai, Shazia Sultana, Attaullah Baig, Sadia Shakoor, Farzeen Hirani, Abdul Wassay, Sehrish Khushboo, Junaid Mehmood, Alexander Freeman

Department of Paediatrics and Child Health

Introduction: The Surveillance for Enteric Fever in Asia Project (SEAP) is a multisite surveillance study designed to capture morbidity and mortality burden of enteric fever (typhoid and paratyphoid) in Bangladesh, Nepal, and Pakistan. We aim to describe enteric fever disease burden, severity of illness, and antimicrobial resistance trends in Pakistan.
Methods: In this retrospective, cross-sectional study, laboratory records of hospitalized patients who received a blood culture in any of 3 Aga Khan University hospitals in Karachi and Hyderabad, Pakistan, from 2012 to 2014 were reviewed. A case was defined as having a positive blood culture for Salmonella Typhi (S. Typhi) …

Between A Rock And A Hard Place: Thrombotic Thrombocytopenic Purpura Induced St-Elevation Myocardial Infarction, Sagar Vadhar Do, Damon Mcenroe Md, Shivtaj Mann Do

Department of Medicine

No abstract provided.

Sapho: A Challenging Diagnosis In A Young Woman With Recurrent Osteomyelitis, Kourtney Erickson Do, Grace Berlin Do, Yehia Y. Mishriki Md

Department of Medicine

No abstract provided.

An Atypical Adverse Drug Event: Bactrim Induced Autoimmune Hemolytic Anemia, Joseph Scurozo Do, George Prousi Md, Grace Chong Do, Brian J. Costello Do

Department of Medicine

No abstract provided.

Immune Related Adverse Events: Isolated Acth Deficiency With Nivolumab/ Ipilimumab Combination Therapy, Joseph Scurozo Do, Angela Magdaleno Do, Sharmila C. Koshy Md

Department of Medicine

No abstract provided.

Are Dietary Factors And Exercise Levels Related To Fertility Status?, Britt Fugmann, Rachel Tinius

Posters-at-the-Capitol

BACKGROUND: Infertility is a major public health concern as it affects up to 25% of couples in Western Countries. While there is some evidence that diet and exercise may be linked to fertility, there is no official dietary or exercise guidance for couples when trying to conceive. Additional information regarding the relationship between diet, exercise, and fertility is needed to better inform the development of guidelines for couples trying to conceive.

PURPOSE: To examine the relationships between diet, exercise, and fertility among women.

METHODS: Participants were selected from on ongoing pregnancy study (N=33). All participants went on to have healthy …

Scientia: Fall 2018

Scientia

Gerald Koocher Steps Down as Dean; Calculus, Conquered; Math Magic; New Programs: We've Got a Degree in That; Lab Notes; To Croatia, With Curiosity; Human Nature Inextricable from Scientific Advances; The Scientists of Summer

Steve & Anita, Steve, Anita, Tsos

TSOS Interview Gallery

Steve and Anita Canfield helped the Church of Jesus Christ of Latter-day Saints in Turkey. They helped send blankets, coats, and washing machines to Syrian refugees. They were assigned to Frankfurt to assess refugee camps, soup kitchens, warehouses, and immigrant communities. The couple visited refugee camps and soup kitchens all over Europe to determine what was needed most by refugees.

The Canfields established the Friendship Center in Rome. The center offers classes in Italian, English, Italian, and a Red Cross course. It also has a gospel choir, a popular activity for primarily African refugees. The LDS Church has plans to …

Oral Pathobiont Activates Anti-Apoptotic Pathway, Promoting Both Immune Suppression And Oncogenic Cell Proliferation., Pachiappan Arjunan, Mohamed M Meghil, Wenhu Pi, Jinxian Xu, Liwei Lang, Ahmed El-Awady, William Sullivan, Mythilypriya Rajendran, Mariana Sousa Rabelo, Tong Wang, Omnia K Tawfik, Govindarajan Kunde-Ramamoorthy, Nagendra Singh, Thangaraju Muthusamy, Cristiano Susin, Yong Teng, Roger M Arce, Christopher W Cutler

Faculty Research 2018

Chronic periodontitis (CP) is a microbial dysbiotic disease linked to increased risk of oral squamous cell carcinomas (OSCCs). To address the underlying mechanisms, mouse and human cell infection models and human biopsy samples were employed. We show that the 'keystone' pathogen Porphyromonas gingivalis, disrupts immune surveillance by generating myeloid-derived dendritic suppressor cells (MDDSCs) from monocytes. MDDSCs inhibit CTLs and induce FOXP3 + T

"They Destroy The Reproductive System": Exploring The Belief That Modern Contraceptive Use Causes Infertility, Erica Sedlander, Jeffrey B. Bingenheimer, Mary Thiongo, Peter Gichangi, Rajiv N. Rimal, Mark Edberg, Wolfgang Munar

Prevention and Community Health Faculty Publications

No abstract provided.

Roche Announces First Sites For Key Huntington’S Disease Observational Study, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Demonstration Of Monolithic-Silicon Carbide (Sic) Neural Devices, Evans K. Bernardin

USF Tampa Graduate Theses and Dissertations

Brain Machine Interfaces (BMI) provide a communication pathway between the electrical conducting units of the brain (neurons) and external devices. BMI technology may provide improved neurological and physiological functions to patients suffering from disabilities due to damaged nervous systems. Unfortunately, microelectrodes used in Intracortical Neural Interfaces (INI), a subset of the BMI device family, have yet to demonstrate long-term in vivo performance due to material, mechanical and electrical failures. Many state-of-the-art INI devices are constructed using stacks of multiple materials, such as silicon (Si), titanium (Ti), platinum (Pt), parylene C, and polyimide. Not only must each material tolerate the biological …

Associations Of Demographic Factors And Tobacco Use With Progesterone And Estradiol During Pregnancy, Kristin Ashford, Emily Rayens, Amanda T. Wiggins, Mary Kay Rayens, Molly Malany Sayre, John O'Brien

Perinatal Research and Wellness Center Faculty Publications

Objective: To evaluate the association of biochemically validated prenatal tobacco use with serum progesterone and estradiol in the second trimester of pregnancy, controlling for demographic and personal factors.

Study design: This secondary analysis of a multicenter longitudinal study included 114 women with singleton pregnancies. Multiple regression analysis assessed whether prenatal tobacco use was related to hormone levels during the second trimester, controlling for covariates (age, body mass index, and race or ethnicity, with gestational age added to subsequent models).

Result: In the initial regressions, tobacco users had significantly lower progesterone level compared with nonsmokers (p = .037), while estradiol …