Medicine and Health Sciences Commons^™

Distinct Role Of Il-27 In Immature And Lps-Induced Mature Dendritic Cell-Mediated Development Of Cd4, Fang Zhou, Guang-Xian Zhang, A. M. Rostami

Department of Neurology Faculty Papers

Interleukin-27 (IL-27) plays an important role in regulation of anti-inflammatory responses and autoimmunity; however, the molecular mechanisms of IL-27 in modulation of immune tolerance and autoimmunity have not been fully elucidated. Dendritic cells (DCs) play a central role in regulating immune responses mediated by innate and adaptive immune systems, but regulatory mechanisms of DCs in CD4⁺ T cell-mediated immune responses have not yet been elucidated. Here we show that IL-27 treated mature DCs induced by LPS inhibit immune tolerance mediated by LPS-stimulated DCs. IL-27 treatment facilitates development of the CD4⁺ CD127⁺3G11⁺ regulatory T cell subset …

Treating Comorbid Ptsd And Bpd: A Dialectical Approach, Meredith Pescatello

Intuition: The BYU Undergraduate Journal of Psychology

According to the Biosocial Developmental Model for Borderline Personality Disorder (BPD), individuals with a biological vulnerability (i.e., heightened emotional sensitivity and impulsive tendencies), plus an invalidating environment may develop BPD (Crowell, Beauchaine, & Linehan, 2009). Individuals with BPD are especially difficult to treat, because of their “extreme emotional, behavioral, and cognitive dysregulation” (Crowell, Beauchaine, & Linehan, 2009). Though challenging to treat, BPD can be successfully treated using Dialectical Behavior Therapy (DBT) (Linehan, 1993; Linehan 2015). Similarly, Posttraumatic Stress Disorder (PTSD) is complex and often burnout inducing to treat, because of the intensity of the emotional content related to traumatic events …

Healthy Habits To Reduce Sleep Deprivation In College Students, Jenna L. Bair

Intuition: The BYU Undergraduate Journal of Psychology

Abstract

Sleep can affect many regular functions in the body. Consequently, the physiological and psychological effects of sleep deprivation have many ramifications, including long-term health issues, depression, and eating disorders (Alhola & Polo-Kantola, 2007; Beiter et al., 2015; Jarcho, Slavich, Tylova-Stein, Wolkowitz, & Burke, 2013; Ozsoy, Besirli, Unal, Abdulrezzak, & Orhan, 2015). Despite the importance of sleep for regulative processes, studies indicate that the general population does not receive adequate sleep quality or length (Watson et al., 2017). College students represent a large demographic and often do not obtain enough sleep (Gaultney, 2010). Thus, it is proposed that collegiate institutions …

What's Happening: November 12, 2018, Maine Medical Center

What's Happening

No abstract provided.

Lestaurtinib Is A Potent Inhibitor Of Anaplastic Thyroid Cancer Cell Line Models, Nicole Pinto, Stephenie D. Prokopec, Frederick Vizeacoumar, Karlee Searle, Matthew Lowerison, Kara M. Ruicci, John Yoo, Kevin Fung, Danielle Macneil, Jim C. Lacefield, Hon S. Leong, Joe S. Mymryk, John W. Barrett, Alessandro Datti, Paul C. Boutros, Anthony C. Nichols

Anatomy and Cell Biology Publications

Anaplastic thyroid cancer (ATC) is a rare and lethal human malignancy with no known effective therapies in the majority of cases. Despite the use of conventional treatments such as chemotherapy, radiation and surgical resection, this disease remains almost universally fatal. In the present study, we identified the JAK2 inhibitor Lestaurtinib as a potent compound when testing against 13 ATC cell lines. Lestaurtinib demonstrated a potent antiproliferative effect in vitro at nanomolar concentrations. Furthermore, Lestaurtinib impeded cell migration and the ability to form colonies from single cells using scratch-wound and colony formation assays, respectively. Flow cytometry was used for cell cycle …

Who Did It?: A Review On The Possible Causes Of Multiple Sclerosis, Mia Difrancesco

D.U.Quark

Multiple Sclerosis (MS) is an incurable autoimmune disorder that attacks the myelin sheath surrounding nerve cells. Steady demyelination of these cells over time results in painful inflammation and reduced mobility. Genetic abnormalities could be responsible for the onset of this disease. Chromosomal mutations found in MS patients as well as environmental factors influencing the expression of certain genes will be analyzed in this review. Moreover, treatments regulating gene expression in MS patients will be discussed. Further genetic research would not only provide scientists and medical professionals with a deeper understanding of MS and other autoimmune disorders, but also lead to …

Implanted Hemodynamic Monitoring In Management Of Significant Right Heart Failure Before And After Lvad Implantation: Creation And Maintenance Of Fontan Physiology In Severe Rv Dysfunction, Kevin Yei, Casey Kaisi, Rajeev Mohan, Ajay Srivastava, J Thomas Heywood

The VAD Journal

In the left ventricular assist device (LVAD) population, right ventricular (RV) failure represents a significant cause of morbidity and mortality. It is unclear whether hemodynamic monitoring with the implantable CardioMEMS system can improve outcomes within this population. This case report highlights two patients in our clinic who had CardioMEMS implanted after LVAD, enabling us to modify their medical regimens remotely and more frequently in the management of their RV failure.

Week Of November 12, 2018, New York Medical College

InTouch

• GSBMS Launches New M.S. in Clinical Laboratory Sciences Program
• NYMC Takes Hard Hat Tour of Ellis Island
• HSL Hosts Special Presentation on "The Art of Observation"

Étude Comparative Des Banques De Données De Mesures D’Exposition Imis (Osha) Et Lims (Irsst), Philippe Sarazin, France Labrèche, Jacques Lesage, Jérôme Lavoué

Rapports de recherche scientifique

Une bonne connaissance des niveaux d’exposition des travailleurs aux contaminants chimiques est fondamentale dans un programme de maîtrise, de prévention et de gestion des risques associés à ces substances. Au Québec, l’Institut de recherche Robert-Sauvé en santé et en sécurité du travail (IRSST) administre un système de gestion de l’information du laboratoire (LIMS – Laboratory Information Management System). Cette banque de données électronique contient l’ensemble des résultats d’analyse liés à l’évaluation de l’exposition telle que mesurée par les équipes de santé au travail depuis 1985. Les données du LIMS sont intéressantes pour établir des portraits d’exposition. Cependant, leur interprétation est …

Il-24 Promotes Apoptosis Through Camp-Dependent Pka Pathways In Human Breast Cancer Cells, Leah Persaud, Jason Mighty, Xuelin Zhong, Ashleigh Francis, Marifer Mendez, Hilal Muharam, Stephen M. Redenti, Dibash Das, Bertal Huseyin Aktas, Moira Sauane

Publications and Research

Interleukin 24 (IL-24) is a tumor-suppressing protein, which inhibits angiogenesis and induces cancer cell-specific apoptosis. We have shown that IL-24 regulates apoptosis through phosphorylated eukaryotic initiation factor 2 alpha (eIF2α) during endoplasmic reticulum (ER) stress in cancer. Although multiple stresses converge on eIF2α phosphorylation, the cellular outcome is not always the same. In particular, ER stress-induced apoptosis is primarily regulated through the extent of eIF2α phosphorylation and activating transcription factor 4 (ATF4) action. Our studies show for the first time that cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) activation is required for IL-24-induced cell death in a variety of …

Transcranial Direct Current Stimulation For Online Gamers: A Prospective Single-Arm Feasibility Study, Sang Hoon Lee, Jooyeon Jamie Im, Jin Kyoung Oh, Eun Kyoung Choi, Sujing Yoon, Marom Bikson, In-Uk Song, Hyeonseok Jeong, Yong-An Chung

Publications and Research

Aim: Excessive use of online games can have negative influences on mental health and daily functioning. Although the effects of transcranial direct current stimulation (tDCS) have been investigated for the treatment of addiction, it has not been evaluated for excessive online game use. This study aimed to investigate the feasibility and tolerability of tDCS over the dorsolateral prefrontal cortex (DLPFC) in online gamers. Methods: A total of 15 online gamers received 12 active tDCS sessions over the DLPFC (anodal left/cathodal right, 2 mA for 30 min, 3 times per week for 4 weeks). Before and after tDCS sessions, all …

Honoring Veterans Means Funding Suicide Prevention, Brendan Cushing-Daniels, Christopher R. Fee

Economics Faculty Publications

Many Americans may not know that it was Dwight D. Eisenhower who in 1954 issued the official proclamation celebrating the service of all veterans by designating Nov. 11, formerly known as Armistice Day, in honor of our vets. Eisenhower, of course, was supreme commander of Allied Forces in Europe during World War II and commander in chief as the 34th president of the United States.

In Ike’s words, “on that day let us solemnly remember the sacrifices of all those who fought so valiantly, on the seas, in the air, and on foreign shores, to preserve our heritage of freedom, …

Development Of A Diagnostic Marker For Phlebotomus Papatasi To Initiate A Potential Vector Surveillance Program In North America, Austin Merchant, Tian Yu, Jizhe Shi, Xuguo Zhou

Entomology Faculty Publications

Phlebotomus papatasi, an Old World sand fly species, is primarily responsible for the transmission of leishmaniasis, a highly infectious and potentially lethal disease. International travel, especially military rotations, between domestic locations and P. papatasi-prevalent regions in the Middle East poses an imminent threat to the public health of US citizens. Because of its small size and cryptic morphology, identification of P. papatasi is challenging and labor-intensive. Here, we developed a ribosomal DNA-polymerase chain reaction (PCR)-based diagnostic assay that is capable of detecting P. papatasi genomic DNA from mixed samples containing multiple sand flies native to the Americas. Serial …

10-09-18 Hsc Commmittee Meeting Minutes, Hsc Committee

HSC Committee (A subcommittee of the UNM Board of Regents)

No abstract provided.

Functional Brain Activation Changes Associated With Practice In Delaying Smoking Among Moderate To Heavy Smokers: Study Protocol And Rationale Of A Randomized Trial (Cope)., Andrew T. Fox, Delwyn Catley, Kimber P. Richter, Edward F. Ellerbeck, Morgan G. Brucks, Vlad B. Papa, Laura E. Martin

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Most smokers struggle to overcome tobacco addiction. Neuroscientific models of addiction emphasize the importance of brain regions associated with cognitive control and reward to understand the cycle of addiction and relapse. During an attempt at abstinence, the cognitive control system appears to be underpowered to override the heightened reward system of the addicted brain. Thus, one neural target for treatment is to strengthen the cognitive control system. It may be possible to improve the functioning of the cognitive control system via deliberate practice.

METHODS/DESIGN: This study will determine the effects of practicing delaying smoking on brain and behavioral measures …

Modulation Of Auxin And Cytokinin Responses By Early Steps Of The Phenylpropanoid Pathway, Jasmina Kurepa, Timothy E. Shull, Sumudu S. Karunadasa, Jan A. Smalle

Plant and Soil Sciences Faculty Publications

Background: The phenylpropanoid pathway is responsible for the synthesis of numerous compounds important for plant growth and responses to the environment. In the first committed step of phenylpropanoid biosynthesis, the enzyme phenylalanine ammonia-lyase (PAL) deaminates L-phenylalanine into trans-cinnamic acid that is then converted into p-coumaric acid by cinnamate-4-hydroxylase (C4H). Recent studies showed that the Kelch repeat F-box (KFB) protein family of ubiquitin ligases control phenylpropanoid biosynthesis by promoting the proteolysis of PAL. However, this ubiquitin ligase family, alternatively named Kiss Me Deadly (KMD), was also implicated in cytokinin signaling as it was shown to promote the degradation of …

No Evidence For Kin Protection In The Expression Of Sickness Behaviors In House Mice, Patricia C. Lopes, Per Block, Alice Pontiggia, Anna K. Lindholm, Barbara König

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

When infected, animals change their behaviors in several ways, including by decreasing their activity, their food and water intake, and their interest in social interactions. These behavioral alterations are collectively called sickness behaviors and, for several decades, the main hypotheses put forward to explain this phenomenon were that engaging in sickness behaviors facilitated the fever response and improved the likelihood of host survival. However, a new hypothesis was recently proposed suggesting that engaging in sickness behaviors may serve to protect kin. We tested this kin protection hypothesis by combining a field and a laboratory experiment in house mice. In both …

Impact Of Biobanks On Research Outcomes In Rare Diseases: A Systematic Review, Monique Garcia, Jenny Downs, Alyce Russell, Wei Wang

Research outputs 2014 to 2021

BACKGROUND: Alleviating the burden of rare diseases requires research into new diagnostic and therapeutic strategies. We undertook a systematic review to identify and compare the impact of stand-alone registries, registries with biobanks, and rare disease biobanks on research outcomes in rare diseases.

METHODS: A systematic review and meta-aggregation was conducted using the preferred reporting items for systematic reviews and meta-analyses (the PRISMA statement). English language publications were sourced from PubMed, Medline, Scopus, and Web of Science. Original research papers that reported clinical, epidemiological, basic or translational research findings derived from data contained in stand-alone registries, registries with biobanks, …

The Role Of Migration-Related Stress In Depression Among Haitian Immigrants In Florida: A Mixed Method Sequential Explanatory Approach, Dany Amanda C. Fanfan

USF Tampa Graduate Theses and Dissertations

Recognizing, appropriately treating depression, and meeting the mental health needs of the growing number of Haitian immigrants in the United States (US), continue to pose a challenge because of differences in culture, beliefs, idiom of distress, expression of depression as well as specific stressors associated with the migration process. Previous studies, while limited, document high levels of depression among Haitian migrants, and postulated that migration-related stress (MRS) may play a significant role. Aspects of the migration process, more specifically stressors endured during settlement in the US may negatively precipitate the development of depression.

This study used a mixed method sequential …

Impact Of Maternally Derived Pertussis Antibody Titers On Infant Whole-Cell Pertussis Vaccine Response In A Low Income Setting, Romesa Ibrahim, Syed Asad Ali, Abdul Momin Kazi, Arjumand Rizvi, L. Beryl Guterman, Robert A. Bednarczyk, Ellie Kim, Sohee Park, Simon Paulos, Amilia Jeyachandran

Department of Paediatrics and Child Health

Background: Maternal vaccines against pertussis are not yet recommended in the developing world. Besides unclear burden estimates, another concern is that transplacental transfer of maternal pertussis antibodies could result in attenuation of the immune response to whole cell pertussis (DTwP) primary vaccination series in infants. This study was taken up to determine whether higher levels of maternal pertussis antibodies attenuate immune response of infants to DTwP vaccination series given at 6-10-14 weeks of age.
Methodology: A total of 261 pregnant women and their infants from four low-income settlements in Karachi, Pakistan were enrolled in this study. The study endpoints were …

Expanding Magnetic Resonance Imaging Access For Patients With Cardiovascular Implantable Electronic Devices, Rosalie Geronimo

DNP Qualifying Manuscripts

There are over two million patients in the United States that have cardiovascular implantable electronic devices (CIEDs). In 2017, the Heart Rhythm Society (HRS) provided a consensus statement with guidelines and recommendations for device management of patients with magnetic resonance (MR) conditional as well as MR non-conditional CIEDs (Indik et al. 2017). In January 2018, the Centers for Medicare and Medicaid Services (CMS) proposed that a qualified physician, nurse practitioner (NP), or physician assistant (PA) with expertise in implanted permanent pacemakers (PM), implantable cardioverter defibrillator (ICD), cardiac resynchronization therapy pacemakers (CRT-P), or cardiac resynchronization therapy defibrillators (CRT-D) must directly supervise …

Medical School Watercooler Newsletter - November 11, 2018, Lindsey Lyle

Watercooler Newsletter

This is the November 11, 2018 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• USA Health Employees Well Represented on US-A Team, Christie Miree Awards
• USA Chapter Receives 2018 Pediatric Interest Group of the Year Award
• Dr. Om Jha Recognized For Faculty Innovation
• Patient Discusses Benefits of Collaborative Care at USA Health in Facebook Live Video
• USA College of Medicine Annual Report Now Online
• USA Health Hosts Meet & Greet for Dr. Michael Chang
• Dr. Pack-Mabien Receives 2018 Outstanding Regional Nurse Practitioner Award

Improving Communication To Reduce Patient Falls In A 48-Bed Medical-Surgical Unit, Christian Gella

Nursing and Health Professions Faculty Research and Publications

Abstract

Problem: Patient falls has been associated with increased morbidity, mortality and decreased quality of life. The increase in total patient falls for 2018 relative to 2017, and a spike of 10 patient falls for the month of June 2018 from a baseline of 5.3 falls per month has gained greater attention to reduce patient harm from falls while hospitalized. Prevention of falls minimizes patient exposure to the possibility of being injured. Despite efforts to curtail patient falls, improvement in communication is essential to address the safety issues surrounding improving quality of care practices, and consequentially reduce un-reimbursable hospital costs …

Early Speech Deterioration In Amyotrophic Lateral Sclerosis: A Case Study Of Newscaster Donna Britt, Emily Watkins

LSU Master's Theses

Abstract

Purpose: The aim of this study is to detect and track speech changes using acoustic and perceptual measures in an individual (a local newscaster) with amyotrophic lateral sclerosis (ALS) using data from before her diagnosis, around the time of her diagnosis, and after her diagnosis.

Methods: Six time points, ranging from 37 months around her diagnosis, were analyzed from one speaker with ALS. Three acoustic parameters were measured: articulation rate, acoustic vowel space, and the slope of the second formant. Additionally, two experts with more than 10 years of experience perceptually analyzed the speech samples on 17 characteristics using …

Patient Experiences And Satisfaction With Homeopathic Treatment In Pune, India, Asmita R. Mhaskar

USF Tampa Graduate Theses and Dissertations

Introduction: Global populations are increasingly pursuing Complementary and Alternative Medicines (CAM) as safe, holistic options to attain health and wellness. Homeopathy is one such system of medicine whose demand is growing across the world, with maximum users in India. Yet, patient satisfaction and experiences with Homeopathy have not been addressed comprehensively in India.

Methods: A two-phase, mixed-methods study was designed to assess patient satisfaction and patient experiences with Homeopathic medicines and clinics in Pune, India. Phase I included the design and validation of a survey on Homeopathy specific experiences in English and Marathi for collecting data. Phase II employed a …

Ketamine: The Potential For Treatment Resistant Depression, Rachel A. Sauter

Nursing Capstones

No abstract provided.

Anaplastic Pleomorphic Xanthoastrocytoma Presenting With Musical Hallucination., Oreoluwa Oladiran, Ifeanyi Nwosu, Steve Obanor, Chinyere Ogbonna-Nwosu, Brian Le

Reading Hospital Internal Medicine Residency

Musical hallucinations are a relatively rare form of auditory hallucination characterized by hearing of music in the absence of any external stimuli. This phenomenon has been linked to both psychiatric and structural lesions. We present the case of a previously healthy young male whose presentation with musical hallucinations led to the diagnosis of a rare tumour, anaplastic pleomorphic xanthoastrocytoma.

When Minimal Becomes Multiple: An Adult With Multiple Flares Of Minimal Change Disease, Kyle Kreitman Do, Nathan Brewster Do, Kaitlyn Musco Md

Department of Medicine

No abstract provided.

Survivorship And The Skcc Cancer Support And Welcome Center, Shawnna Cannaday, Rn, Msn, Fnp-Bc, Gregory Garber, Msw, Lcsw, Rebecca Cammy, Msw, Lcsw, Lisa Capparella, Mss, Lcsw, Osw-C

Pancreatic Cancer & Related Diseases Patient Symposium

No abstract provided.

Scientific Collaborations In Pancreatic Cancer And What's On The Horizon For Research/Clinical Trials, Jonathan R. Brody, Phd, Elda Grabocka, Phd, Michael J. Pishvaian, Md, Phd, James A. Poser, Iii, Md

Pancreatic Cancer & Related Diseases Patient Symposium

No abstract provided.