Medicine and Health Sciences Commons^™

Peroral Endoscopic Myotomy Is Effective And Safe In Non-Achalasia Esophageal Motility Disorders: An International Multicenter Study, Mouen A. Khashab, Pietro Familiari, Peter V. Draganov, Hanaa Dakour Aridi, Joo Young Cho, Michael Ujiki, Ricardo Rio Tinto, Hubert Louis, Pankaj N. Desai, Vic Velanovich, Eduardo Albéniz, Amyn Haji, Jeffrey Marks, Guido Costamagna, Jacques Devière, Yaseen Perbtani, Mason Hedberg, Fermin Estremera, Luis A. Martin Del Campo, Dennis Yang, Majidah Bukhari, Olaya Brewer, Omid Sanaei, Lea Fayad, Amol Agarwal, Vivek Kumbhari, Yen-I Chen

Surgery Faculty Publications

Background and study aims: The efficacy of per oral endoscopic myotomy (POEM) in non-achalasia esophageal motility disorders such as esophagogastric junction outflow obstruction (EGJOO), diffuse esophageal spasm (DES), and jackhammer esophagus (JE) has not been well demonstrated. The aim of this international multicenter study was to assess clinical outcomes of POEM in patients with non-achalasia disorders, namely DES, JE, and EGJOO, in a large cohort of patients.

Patients and methods: This was a retrospective study at 11 centers. Consecutive patients who underwent POEM for EGJOO, DES, or JE between 1/2014 and 9/2016 were included. Rates of technical success (completion of …

Improvement In Existing Chest Wall Irregularities During Breast Reconstruction, Katherine M. Huber, Amanda Zimmerman, Deniz Dayicioglu

Surgery Faculty Publications

Mastectomies for both cancer resection and risk reduction are becoming more common. Existing chest wall irregularities are found in these women presenting for breast reconstruction after mastectomy and can pose reconstructive challenges. Women who desired breast reconstruction after mastectomy were evaluated preoperatively for existing chest wall irregularities. Case reports were selected to highlight common irregularities and methods for improving cosmetic outcome concurrently with breast reconstruction procedures. Muscular anomalies, pectus excavatum, scoliosis, polythelia case reports are discussed. Relevant data from the literature are presented. Chest wall irregularities are occasionally encountered in women who request breast reconstruction. Correction of these deformities is …

Implementation Of An Evidenced-Based Opioid Treatment Program To Improve Maternal-Child Outcomes In Eastern Kentucky, Jordan Rice

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

The Kentucky River Area District Health Department proposes implementation of CHARM-Kentucky, a treatment program for pregnant women with opioid use disorder (OUD), in eastern Kentucky. Over 115 Americans die each day from an opioid overdose, resulting in approximately 42,000 deaths in 2016. In addition to an overall increase in opioid use in recent years, the use of opioids in pregnancy has also increased from 1.19 per 1,000 hospital births in 2000 to 5.63 in 2009. Opioid use during pregnancy results in poor neonatal outcomes including: low birth weight, preterm delivery, small head circumference, increased child maltreatment, and risk for long-term …

The Anorexic's Anorexia: Depictions Of Anorexia In Popular Culture, Samantha L. Tomson

Undergraduate Honors Theses

No abstract provided.

Accountable Care Organization Success Strategies: The Importance Of System Changes, Shelly Pierce

Walden Dissertations and Doctoral Studies

Accountable care organizations (ACOs) are a new health care reform initiative that has been highlighted as one of the most important organizational structures that could lead to quality improvements and cost savings in the United States through shared savings. The inability of health care managers to successfully implement ACOs could result in financial losses, reduced patient access to health care, and poor patient outcomes. Grounded by von Bertanlaffy's general systems theory, the purpose of this multiple case study was to explore the system change strategies health care managers used to implement an ACO to meet ACO quality and cost standards. …

Development Of A Quality Improvement Program To Support Evidence-Based Nursing Practice, Heather Richards

Walden Dissertations and Doctoral Studies

Nurses are expected to perform evidence-based practice (EBP) at the point of care (POC) to promote positive outcomes through the quality and safety of patient care. The struggle for nurses on the surgical digestive unit in a hospital to adopt EBP is the lack of access and knowledge to evidence-based research at the POC. The utilization of information technology is an innovated approach to providing access and knowledge for EBP at the POC to improve patient outcomes. The project was to develop a quality improvement program to improve nursing access and knowledge of EBP resources. The program was to identify …

Jiann-Ping Hsu College Of Public Health Magazine, Georgia Southern University

College of Public Health: News & Publications

• A Message from the Dean
• Leadership
• Center Forges Partnership with EMS
• Perspective
• Faculty-Led Study Abroad Program
• Research Spotlight
• Sustainability at Its Finest
• Student Spotlight
• Alumni Spotlight

Digest Of The Philadelphia College Of Osteopathic Medicine, Philadelphia College Of Osteopathic Medicine

PCOM Digest 2020s

The (2018 No. 2) issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Updates

• Behind the White Coat: Reclaiming Joy in the Art of Healing

• Reclaiming Joy in the Art of Healing: Unfolding Empathy Through Stories

• Reclaiming Joy in the Art of Healing: Building Habits of Positivity

• Class Notes

Digest Of The Philadelphia College Of Osteopathic Medicine, Philadelphia College Of Osteopathic Medicine

PCOM Digest 2020s

The (2018 No. 1) issue of the Digest of the Philadelphia College of Osteopathic Medicine includes the following articles:

• Updates

• Institutional Heritage: Founders’ Day 2018

• Facing Addiction

• Class Notes

Immunization By Radiotherapy: Enhancing An Immune-Mediated Abscopal Effect, Amy Steffen

Biology and Microbiology Graduate Students Plan B Research Projects

Radiotherapy aims to destroy tumors by inducing DNA damage in their cells at the local irradiation site. Its immune-mediated systemic effects, called abscopal effect, has shown to enhance anti-tumor immunity when combined with immune therapies and thus, have gained attention by researchers and clinicians to investigate. Below is a summary of the fundamentals of cancer and the immune system’s response to it, as well as the changes in the phenotype and microenvironment of tumor cells after exposure to radiation. Impacts of the abscopal effect and the induction of effective antitumor immunity with various immune therapy strategies will be outlined. The …

Increasing The Clinical Efficacy Of Radiotherapeutics For Solid Tumors By Inhibition Of Hypoxia Inducible Factor-1a, Austin Levi Walz

Biology and Microbiology Graduate Students Plan B Research Projects

Radiotherapy is commonly used in a variety of tumor types and is effective in control of long term progression and may be curative under certain circumstances. Radiotherapeutics have been shown to be the single most effective therapeutic for cancer and only account for 5% of the total cost. However, treatment of cells with radiation causes the tumor microenvironment to undergo changes and leads to cycles of hypoxia inside the tumor which allows for the cell to undergo angiogenesis, metastasize and may lead to repopulation of the tumor. Current systemic chemotherapeutics typically have an additive toxicity due to the unintended targeting …

A Biological Review Of Mental Illness: An Overview Of Genetics And Pathophysiology Of Schizophrenia, Major Depression, And Addiction, Christopher R. Angerhofer

Biology and Microbiology Graduate Students Plan B Research Projects

Novel approaches in understanding mental illness present solutions to current issues in treatment and diagnosis. With advancements in genetics and neurology, the etiology and pathophysiology of mental illness is slowly unwrapping. In discovering biomarkers for depression, addiction, and schizophrenia, the precision for preventing, diagnosing, and treating these disorders increases. The aim of this paper is to review current research for addiction, major depression, and schizophrenia in genetics and physiology, while also clarifying the need for reclassifying mental illness as diseases with a pathophysiological basis, not syndromal, idiopathic disorders. Mental illness is dynamic in that it encompasses both environmental and biological …

Mild Traumatic Brain Injuries And Cte: A Review Highlighting The Connection Between The Two, Leandre Kennedy

Biology and Microbiology Graduate Students Plan B Research Projects

Chronic Traumatic Encephalopathy (CTE) is a traumatic brain injury based disease that is garnering a lot of attention in the United States. The purpose of this paper is to conduct an extensive review of the information available about the condition. Recently there has been a limited amount of published information and treatment opportunities are rare since the only way of diagnosing has come post mortem. Various literary reviews and experiments were analyzed for appropriate information regarding CTE’s pathology and treatments and only peer reviewed published works were allowed in this paper. This resulted in promising information about the disease and …

Autophagosome-Based Strategy To Monitor Apparent Tumor-Specific Cd8 T Cells In Patients With Prostate Cancer., Rieneke Van De Ven, Traci L Hilton, Hong-Ming Hu, Christopher J Dubay, Daniel Haley, Christopher Paustian, Sachin Puri, Walter Urba, Brendan Curti, Sandra Aung, Bernard A Fox

Articles, Abstracts, and Reports

The immune system plays an essential role in eradicating cancer in concert with various treatment modalities. In the absence of autologous tumor material, no standardized method exists to assess T cell responses against the many antigens that may serve as cancer rejection antigens. Thus, development of methods to screen for therapy-induced anti-tumor responses is a high priority that could help tailor therapy. Here we tested whether a tumor-derived antigen source called DRibbles®, which contain a pool of defective ribosomal products (DRiPs), long-lived and short-lived proteins (SLiPs) and danger-associated molecular patterns (DAMPs), can be used to identify tumor-associated antigen (TAA)-specific responses …

City Of Faith Vertical File Finding Aid, Holy Spirit Research Center, Oral Roberts University

City of Faith

A finding aid for the City of Faith file in the Holy Spirit Vertical File located in the Holy Spirit Research Center at Oral Roberts University.

Two Patients With Daptomycin Induced Eosinophilic Pneumonia With Different Presentations And Treatment, Yonas Raru, Fuad Zeid, Shannon L. Browning, Elizabeth Saunders

Pulmonology

We present two cases of daptomycin-induced eosinophilic pneumonia with characteristic chest x ray, CT scan and bronchoalveolar lavage (BAL) findings. It is not a commonly seen complication of Daptomycin but when it happens, it could cause a diagnostic and treatment dilemma. Patients could present acutely with hypoxic respiratory failure or a less dramatic chronic presentation is also possible. Our two patients presented with acute hypoxic respiratory failure and presentation resembles that of an infectious etiology. Diagnosis is confirmed by bronchoscopy with BAL in one of them and the other was treated empirically as the clinical and radiologic presentation was typical. …

Hypoxic Respiratory Failure Due To Hyperammonemic Encephalopathy Induced By Concurrent Use Of Valproic Acid And Topiramate, A Case Report And Review Of The Literature, Yonas Raru, Fuad Zeid

Pulmonology

Valproic acid (VPA) is widely used for the treatment of epilepsy, migraine, and a variety of psychiatric symptoms, including bipolar disorder, borderline personality disorder, and alcohol withdrawal. Valproate is associated with severe idiosyncratic adverse effects, the most notable being valproate-induced hyperammonemic encephalopathy (VHE). Topiramate is also a broad-spectrum anticonvulsant that is also extensively used for migraine prophylaxis, as a mood stabilizer, and for alcohol dependency. There is increased occurrence of VHE when valproate is used with other medications like phenytoin, phenobarbital, and topiramate. Our case report is on a young patient who was on valproic acid and topiramate and developed …

Risk In Privacy Breach Determination: The Application Of Prospect Theory To Healthcare Privacy Officers, Amanda Walden

Electronic Theses and Dissertations

A significant concern in healthcare is that of patient privacy and how organizations protect against unauthorized access to protected health information. The federal government has responded by instituting policies and guidelines on requirements for protection. However, the policy language leaves areas open to interpretation by those following the guidelines. Reporting to the Office for Civil Rights and/or the patient can open an organization to risk of financial and possible criminal penalties. There is a risk of harm to their reputation which could impact patient visits and market share. Therefore, Privacy Officers might view risk in different ways and therefore handle …

Graduate Bulletin, 2018-2019, Minnesota State University Moorhead

Graduate Bulletins (Catalogs)

No abstract provided.

Reframing Sports Psychology: A Phenomenological Perspective On Mental Imagery, Motivation, Emotions And Teamwork, Daniel Mcloughlin, Rachel Sowinski

Psychology Department Student Scholarship

The majority of research in the field of sports psychology focuses on quantifiable, evidence-based, universally applicable theory. Current evidence-based programs of intervention are heavily based on symptomatology and often ignore the lived experiences of athletes; an unspoken assumption seems to exist that events, dialogue, and emotions will elicit identical responses from all athletes. Many clinicians find a large portion of their work focused on the subfields of mental imagery, motivation, emotions, and teamwork. Each topic has a dominating theory, which is typically derived from the concepts of Cognitive-Behavioral Therapy. While CBT certainly has its benefits, its shortcomings are evident in …

Vital Signs, Winter 2018, Boonshoft School Of Medicine

Vital Signs

A thirty-six page newsletter created by the Boonshoft School of Medicine to document the current affairs of the school. This issue includes a variety of feature articles, alumni profiles, class notes, and more.

Wellbeing Begins With Employees: Exploring Associations Of Physical Health In A Head Start Organization, Kristin Snyder, Madelyn Hill

Master of Public Health Program Student Publications

The purpose of this research was to describe self-reported physical health status, behaviors, and wellbeing interests of teachers and other staff within a Head Start agency. Information on overall health, behaviors, demographics, and interests in wellbeing programs was collected through a 58-item questionnaire (N = 312). A majority of participants were white (66.8%), female (93.7%), and half were teachers (49.4%). Bivariate analyses and an ordinal logistic regression were performed to test the association of physical health with independent variables, health behaviors, and demographics. Associations with “very good/excellent” physical health displayed by the regression model include mental health, chronic conditions, vegetable …

Hope Center For Families: Addressing Health Needs Through A Two Generation Model, Brianna Burlock

Master of Public Health Program Student Publications

This project’s objective is to explore how the Two Generation Model of the Hope Center for Families can address the health needs of the zip code 45406 community in order to combat negative health outcomes for impoverished families. The investigator researched studies regarding the Two Generation Model and previous organizational applications of the model. Interviews were held with the partners of Hope Center for Families and with an organization that uses the Two Generation Model. The interviews were analyzed for recurring themes after listening to each of them several times and then transcribed. A logic model for the Hope Center …

Impact Of Perioperative Surgical Home On First Cases Delayed On Day Of Surgery In Colorectal Patients, Maria Sparaco

Master of Public Health Program Student Publications

Perioperative Surgical Homes (PSH) are evolving patient-centered medical home models that coordinate stream-lined care among all providers in the care process. The PSH model can serve as a solution to improve quality assurance, patient satisfaction, and reduce errors that lead to poor outcomes, many of which are preventable and can lead to higher costs. This model has many benefits, but it can be a challenge to execute in a hospital system. TriHealth chose to adopt a PSH model, the TriHealth Surgical Optimization Center (TSOC) in March 2017. It implemented a pilot program for its colorectal patients. Metrics of primary interest …

Oral Health 2020: Recommendations To Help Ohio Meet Healthy People 2020 Goals Based On States’ Oral Health Plans, Mackenzie Hunter

Master of Public Health Program Student Publications

Dental caries remains one of the largest untreated diseases in children and is one of the leading causes of poor oral health in the United States. Many states have joined forces with the Centers for Disease Control and Prevention and Medicaid to formulate a state oral health action plan that targets the Healthy People 2020 Goals for Oral Health to improve the overall oral health of children in the state. Through this plan, in connection with state oral health plans many states are comprehensively addressing these Healthy People 2020 goals. Ohio, on the other hand, has not met a number …

Conduct Disorder In Times Of Crisis In The Eastern Mediterranean Region, Ruaa A. Al-Juboori

Master of Public Health Program Student Publications

Background: The Eastern Mediterranean Region (EMR), comprising of 22 countries, has a high burden of conduct disorder (CD) and has the largest burden of displaced populations. Violence and displacement increase the need for mental health services.

Methods: Using descriptive study design, 2015 global CD burden (disability-adjusted life years DALYs per 100,000 populations) was compared to the EMR burden. Across 25 years (1990-2015) trend of CD in 22 EMR countries was graphed and compared with the global CD burden. Association of CD with a) Corruption Perception Index; b) Global Peace Index; c) Human Development Index was assessed using correlation analysis. CD …

Does Self-Efficacy Mediate The Relationship Between Parenting Style And Adolescent Fruit And Vegetable Consumption?, Sumayyah S. Shermadou

Master of Public Health Program Student Publications

Background: Inadequate fruit and vegetable (FV) consumption is a serious public health issue in children and adolescents that is influenced by the type of parenting style and one’s self-efficacy.

Purpose: The purpose of the study was to determine the association between parenting style and adolescent FV consumption and whether adolescent self-efficacy mediates this relationship.

Methods: Data retrieved from the Family, Life, Activity, Sun, Health, and Eating (FLASHE) study were used to perform statistical analyses on 1,382 parent – adolescent dyads. A mediation analysis using the causal steps approach was used to determine whether adolescent self-efficacy mediated the effect of parenting …

Benzodiazepines Ii: Waking Up On Sedatives: Providing Optimal Care When Inheriting Benzodiazepine Prescriptions In Transfer Patients, Jeffrey Guina, Brian Merrill

Psychiatry Faculty Publications

This review discusses risks, benefits, and alternatives in patients already taking benzodiazepines when care transfers to a new clinician. Prescribers have the decision—sometimes mutually agreed-upon and sometimes unilateral—to continue, discontinue, or change treatment. This decision should be made based on evidence-based indications (conditions and timeframes), comorbidities, potential drug-drug interactions, and evidence of adverse effects, misuse, abuse, dependence, or diversion. We discuss management tools involved in continuation (e.g., monitoring symptoms, laboratory testing, prescribing contracts, state prescription databases, stages of change) and discontinuation (e.g., tapering, psychotherapeutic interventions, education, handouts, reassurance, medications to assist with discontinuation, and alternative treatments).

A Program Evaluation Of A Colon Cancer Screening Program Using At-Home Fecal Immunochemical Tests With Certified Patient Navigators, Candace E. H. Brunk

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Colorectal cancer is the second leading cause of cancer-related death in this country, but 33% of these deaths could be prevented by screening. While colonoscopy is an effective screening tool, it is expensive, invasive, and prone to encounter considerable patient resistance. An alternative is to first screen those at-risk using at-home fecal immunochemical test (FIT) kits. This study determined factors associated with the return of these kits distributed by Kentucky CancerLink, a non-profit organization, and its affiliates to participants in a colon cancer prevention program.

Objectives: To identify factors associated with: completing a FIT kit, completing the kit with minimal …

Epidemiology Of Young Adult Renal Cell Carcinoma In Kentucky: Incidence, Clinicopathologic Features, And Cancer-Specific Survival, Jason R. Bylund

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Introduction:

Renal cell carcinoma (RCC) is an important cause of morbidity and mortality in our country. Previously reported data suggest that the overall incidence of RCC continues to rise and may be accelerating even faster among younger adult patients.

Methods:

Data for analysis included the combined NPCR-SEER USCS public use database and the Kentucky Cancer Registry dataset. Incidence rates and trends by age group and location were calculated and tested. Clinicopathologic features of disease among Kentucky cases were analyzed by age group. Cancer-specific survival (CSS) analysis was performed, along with Cox proportional hazards regression to test for association of younger …