Medicine and Health Sciences Commons^™

Effective Connectivity Measured Using Optogenetically Evoked Hemodynamic Signals Exhibits Topography Distinct From Resting State Functional Connectivity In The Mouse, Adam Q Bauer, Andrew W Kraft, Grant A Baxter, Patrick W Wright, Matthew D Reisman, Annie R Bice, Jasmine J Park, Michael R Bruchas, Abraham Z Snyder, Jin-Moo Lee, Joseph P Culver

2010-2019 OA Pubs

Brain connectomics has expanded from histological assessment of axonal projection connectivity (APC) to encompass resting state functional connectivity (RS-FC). RS-FC analyses are efficient for whole-brain mapping, but attempts to explain aspects of RS-FC (e.g., interhemispheric RS-FC) based on APC have been only partially successful. Neuroimaging with hemoglobin alone lacks specificity for determining how activity in a population of cells contributes to RS-FC. Wide-field mapping of optogenetically defined connectivity could provide insights into the brain's structure-function relationship. We combined optogenetics with optical intrinsic signal imaging to create an efficient, optogenetic effective connectivity (Opto-EC) mapping assay. We examined EC patterns of excitatory …

Complete Genome Sequence Of Moraxella Bovis Strain Epp-63 (300), An Etiologic Agent Of Infectious Bovine Keratoconjunctivitis, John Dustin Loy, Aaron M. Dickey, Michael L. Clawson

School of Veterinary and Biomedical Sciences: Faculty Publications

We report here the complete closed genome sequence of Moraxella bovis strain Epp-63 (300) (Epp63). This strain was isolated from an infectious bovine keratoconjunctivitis (IBK) case in 1963. Since then, Epp63 has been used extensively for IBK research. Consequently, the genome sequence of Epp63 should help elucidate IBK host-pathogen interactions.

Non-Naturally Occurring Porcine Reproductive And Respiratory Syndrome Virus (Prrsv) And Methods Of Using, Hiep Lai Xuan Vu, Fernando Osorio, William W. Laegreid, Asit K. Pattnaik, Fangrui Ma

Nebraska Center for Virology: Faculty Publications

A non-naturally occurring porcine reproductive and respiratory syndrome virus (PRRSV) is provided herein, and methods of making and using the non-naturally occurring PRRSV also are provided.

Mcnair Scholars Research Journal 2018, Ryne Dingler, Efret M. Ghirmazion, Paola M. Iracheta, Regan Kubicek, Henry Alvarez, Jazmyn Barajas-Trujillo, Julian Beatty, Enriqueta Calderon, Silvia Chapa, Dominic French, Octavio Miranda, Mariah Ochoa, Susana Pimentel, Elida E. Sorto-Ramos, Andrew Soto-Levins

McNair Scholars Research Journal-Archive

No abstract provided.

Synthetic Investigation Of Natural Products Causing Dopaminergic Neurodegeneration, Michael John Cunningham

Electronic Theses and Dissertations

The terrestrial organisms Streptomyces venezuelae and Rhaponticum repens produce toxic secondary metabolites that likely function as chemical deterrents. The polyketide SV-6 from S. venezuelae and the sesquiterpene lactone repin from R. repens both produce dose-dependent and selective degeneration of dopaminergic neurons. These molecules represent two possible tools that can be used to explore chemotoxic induction of Parkinson’s disease. In the case of SV-6, a newly isolated metabolite, total synthesis was undertaken to confirm its structure and biological activity. The natural product was produced from methacrolein and Roche ester starting materials that were elaborated to their respective fragments, a vinyl iodide …

ผลฉับพลันของการผสมผสานแรงต้านจากฟรีเวทและยางยืดในท่าแบกน้ำหนักกระโดดที่มีต่อพลังสูงสุดและคลื่นไฟฟ้ากล้ามเนื้อ, นภารัตน์ ดวงจันทร์

Chulalongkorn University Theses and Dissertations (Chula ETD)

การวิจัยนี้มีวัตถุประสงค์เพื่อศึกษาและเปรียบเทียบผลฉับพลันของรูปแบบที่แตกต่างกันของการผสมผสานแรงต้านจากฟรีเวทและยางยืดในท่าแบกน้ำหนักกระโดดที่มีต่อพลังสูงสุดและคลื่นไฟฟ้ากล้ามเนื้อ การวิจัยครั้งนี้ศึกษาใน นิสิตชาย คณะวิทยาศาสตร์การกีฬา จุฬาลงกรณ์มหาวิทยาลัย อายุเฉลี่ย 23.54 ± 1.71 ปี จำนวน 13 คน โดยการเลือกแบบเฉพาะเจาะจง ทำการทดสอบแบกน้ำหนักกระโดดที่ความหนัก 30 เปอร์เซ็นต์ของ 1 อาร์เอ็มจากฟรีเวท ด้วยการผสมผสานแรงต้านจากฟรีเวทและยางยืดที่รูปแบบ 90:10 80:20 70:30 60:40 และ 50:50 โดยทำการกระโดด 6 ครั้ง พักระหว่างครั้ง 20 วินาที การทดสอบแต่ละรูปแบบจะห่างกันไม่น้อยกว่า 48 ชม. และนำข้อมูลที่ได้มาวิเคราะห์ทางสถิติ เพื่อหาค่าเฉลี่ยและส่วนเบี่ยงมาตรฐาน และเปรียบเทียบความแตกต่างโดยใช้สถิติวิเคราะห์ความแปรปรวนทางเดียวชนิดวัดซ้ำ กำหนดความมีนัยสำคัญทางสถิติที่ระดับ .05 ผลการวิจัย 1. รูปแบบแรงต้านของการผสมผสานแรงต้านจากฟรีเวทและยางยืด 50:50 มีค่าเฉลี่ยของพลังสูงสุด มากกว่า รูปแบบแรงต้านของการผสมผสานแรงต้านจากฟรีเวทและยางยืด 90:10 80:20 70:30 และ 60:40 อย่างมีนัยสำคัญทางสถิติที่ระดับ .05 2. รูปแบบแรงต้านของการผสมผสานแรงต้านจากฟรีเวทและยางยืด 90:10 80:20 70:30 60:40 และ 50:50 มีค่าเฉลี่ยของคลื่นไฟฟ้ากล้ามเนื้อ Rectus femoris กล้ามเนื้อ Vastus medialis กล้ามเนื้อ Gastrocnemius medialis และกล้ามเนื้อ Tibialis anterior ไม่แตกต่างกัน สรุปผลการวิจัย การทดสอบแบกน้ำหนักกระโดดที่ความหนัก 30 เปอร์เซ็นต์ของ 1 อาร์เอ็มจากฟรีเวท ด้วยการผสมผสานแรงต้านจากฟรีเวทและยางยืดที่รูปแบบ 50:50 สามารถพัฒนาพลังสูงสุดได้ดีกว่ารูปแบบการผสมผสานแรงต้านจากฟรีเวทและยางยืด 90:10 80:20 70:30 และ 60:40

Effect Of Maternal Blood Heavy Metal Level On Brain-Derived Neurotrophic Factor And Pregnancy Outcomes Among Myanmar Migrants In Samut Sakhon Province, Thailand, Ye Htet Zaw

Chulalongkorn University Theses and Dissertations (Chula ETD)

BACKGROUND: Lead, mercury, cadmium, and arsenic are the priority heavy metals of major public health concern in developing countries. Thailand is a newly industrialized country raising high human workloads of migrant workers form neighbored countries, mostly Myanmar. Exposure to these metals can cause cognitive impairment and depressive disorders through an effect on brain-derived neurotrophic factor (BDNF), which is an important biomarker of pregnancy. Pregnancy outcomes including preeclampsia, preterm birth and low birth weight are major burdens for maternal and child health. Although a number of prior studies have examined the effects of heavy metals on pregnancy, there are few studies …

Diagnostic Performance Of The Faas Stroke Screening Tool Faas Stroke Screening Tool In Patients Who Presented To The Emergency Room With Neurological Symptoms, Warongporn Phuenpathom

Chulalongkorn University Theses and Dissertations (Chula ETD)

Background: Rapid screening and intervention are the keys to successful early treatment of stroke. In Thailand, the conventional FAST stroke screening tool has generally been used by triage nurses to promptly detect acute stroke. However, the FAST score has a limitation in detecting posterior circulation stroke. Previous studies showed that adding ataxia could increase the sensitivity of posterior circulation stroke detection. Therefore, we studied the performance of a new stroke screening tool, the FAAS score, among acute ischemic stroke patients. Objectives: To evaluate the diagnostic performance of the FAAS score and compare the diagnostic performance between FAAS and the conventional …

Surveillance Of South Dakota Mosquito Abundance, Infection Rate, And Insecticide Susceptibility, Geoffrey P. Vincent

Electronic Theses and Dissertations

The aim of this dissertation was to survey and evaluate the abundance, infection rate, and insecticide susceptibility of mosquito fauna present in South Dakota. Mosquito surveillance has been conducted across South Dakota to record and track potential West Nile virus (WNV) vectors from 2004 to 2017. The nuisance mosquito Aedes vexans was found to be the most abundant species overall in the state and most abundant in many of the regions. The WNV vector, Culex tarsalis, was found to be the second most abundant mosquito and the most abundant vector mosquito across the state. However, geospatial variation did exist between …

Daily Pork Consumption As A Part Of The Dietary Approaches To Stop Hypertension Diet Influences Body Composition And Preserves Muscle Mass In Older Adults Consuming Controlled Intakes, Alyssa Anne Kauffman

Electronic Theses and Dissertations

The purpose of this study was to test the hypothesis that muscular fitness is preserved in older adults who consumed pork daily as a part of the DASH dietary pattern. A controlled feeding pilot study was used to test this. Eight healthy older men and women were randomly assigned to consume either 3 ounces or 6 ounces of pork daily as a part of the DASH diet for a total of 12 weeks. Indicators of muscle mass, strength, and function were assessed at five time points (weeks 0, 3, 6, 9, 12) throughout the 12 weeks. A seven day cyclical …

A Longitudinal Examination Of Eating Disorders And Associated Risk Factors In Division I Student-Athletes, Nicole Court-Menendez

Electronic Theses and Dissertations

CONTEXT: Eating disorders represent a significant concern across multiple populations including collegiate athletes. Risk factors for eating disorders may be amplified in athletes because of internal and external performance and image expectations. Little is known about how these risk factors change over time in collegiate student-athletes.
OBJECTIVE: To longitudinally examine select eating disorder risk factors in National Collegiate Athletic Association (NCAA) Division I student-athletes.
DESIGN: Descriptive longitudinal study.
SETTING: NCAA Division I collegiate athletics.
PARTICIPANTS: Retired Division I collegiate athletes (n=204), ages 18-22, who competed in football, women’s soccer, women’s volleyball, baseball, men’s and women’s track and field, men’s and …

The Role Of Brand Name Fluency: A Pharmaceutical Marketing Perspective, David Wamble

Electronic Theses and Dissertations

Background: consumers are exposed to thousands of advertisements, most all of which are designed to promote a particular brand and accompanying brand name. The selection of a brand name is a critical strategic decision and is an important means to building brand equity. The importance of branding elements, specifically brand names, has led pharmaceutical manufacturers to become more creative and open the possibilities of language in brand name development. Given the complexities associated with brand name development in the U.S. pharmaceutical industry and the trends observed in recent pharmaceutical brand names, advancing the understanding of how brand name selection can …

Data Note: State Intellectual And Developmental Disability Agencies’ Service Trends, Agnes Zalewska, Jean Winsor, Thinkwork! At The Institute For Community Inclusion At Umass Boston

ThinkWork! Publications

In FY2016, an estimated 638,568 individuals received day or employment supports from state IDD program agencies. This number grew from 455,824 in FY1999. The estimated number of individuals in integrated employment services increased from 108,227 in FY1999 to 120,244 in FY2016. Despite the trend to terminate facility-based services in some states, the overall state investment continues to emphasize non-work services, rather than integrated employment services. Figure 1 shows the trends in the percentage of people served in integrated employment and facility-based and non-work settings between FY2008 and FY2016.

Functionality And Role Of Different Fatty Alcohols In Topical O/W Cream Formulation, Supriya Bhide

Electronic Theses and Dissertations

Fatty alcohols are excipients that are abundantly used in various pharmaceutical formulations. The objective of the present study was to evaluate the impact of incorporating different fatty alcohols on microstructural and formulation characteristics of topical o/w clotrimazole cream formulation. The formulations containing different fatty alcohols as Kolliwax® CSA 50 (CSA 50), Kolliwax® CSA 70 (CSA 70), Kolliwax® MA (MA), Kolliwax® CA (CA), Kolliwax® SA (SA) were prepared by selecting suitable RPM and homogenization time. The M.P. of API and fatty alcohols were determined using DSC technique. The prepared cream formulations were evaluated for their phase separation. The various tests like …

Polymer Based Delivery Of Doxycycline Hyclate For The Prevention Of Peri-Implant Mucositis Infection, Sagar Deepak Sawant

Electronic Theses and Dissertations

Peri-implant mucositis is a silent inflammatory condition that is destructive in nature affecting only the soft tissues in the vicinity of dental implants. The current line of treatment includes the use of systemic antibiotics, mechanical debridement using LASER decontamination, the use of mouthwash or oral rinsing with chlorhexidine, maintenance and improvement of oral hygiene, mechanical debridement with or without systemic antibiotic treatment, mechanical debridement with or without the use of local drug delivery systems. However, these treatments do not solve the problem of implant rejection as peri-mucositis progresses to per-implantitis which causes severe bone loss and ultimately leading to implant …

Silver/Bismuth/Nafion Modified Pencil Graphite Electrode For Trace Heavy Metal Determination, Shirley Tiong Palisoc, Michelle Natividad, Marissa Noel

Angelo King Institute for Economic and Business Studies (AKI)

Frequent exposure to heavy metals can cause various health problems (Nagles Arancibia, Rojas, & Segura, 2012; Keawkim, Chuanuwatanakul, Chailapakul, & Motomizu, 2013; Xiao et al., 2014). Among the heavy metals, cadmium and lead have a great impact on biota. Cadmium can cause nephrotoxicity, and even lung cancer, when the amount of exposure to the said metal exceeds 26 µg/kg body mass on a monthly basis (Li et al., 2011; Chen et al., 2014; Aragay & Meroçi, 2012). Lead can greatly affect the nervous system (encephalopathy) and the hormones, and it can trigger some cancers at more than 0.02-3 μg/kg for …

Vitamin Fortification Of Milled Rice: A New Approach To Address Micronutrient Malnutrition, Drexel H. Camacho

Angelo King Institute for Economic and Business Studies (AKI)

To address micronutrient deficiencies in the susceptible sector of society, it is recommended to fortify the commercial milled rice with vitamins using the new technique of fortification. The simple approach, which involves rice surface modification and vitamin absorption, is deemed economical compared to traditional fortification processes. Moreover, the susceptibility of losing vitamins due to washing processes is resolved in this improved grain fortification as ~90% of the vitamins are retained. The results shown in this study indicate the successful fortification of vitamins on rice and that fortification is more pronounced when the grain undergoes sonication process. As the staple food …

Interferon Gamma And Interleukin 8 Gene Polymorphisms In Patients With Hepatitis C Virus Related Oral Lichen Planus, Enji Ahmed Mahmoud, Noha Adel Azab, Lobna Abdelsalam, Marwa Elsharkawy, Aisha Elsharkawy, Shahira Elashiry

Dentistry

Objectives: This study aimed to determine the association of rs2430561 and rs4073 polymorphisms in the Interferon gamma (IFN-ɤ) and Interleukin 8 (IL-8) genes, respectively, with hepatitis C virus-related oral lichen planus and disease severity. Design: This is a case-control study. 60 subjects were equally divided into patients with and without oral lichen planus. They were further subdivided into hepatitis C virus seropositive and seronegative patients. All patients were genotyped for IFN-γ rs2430561 thymine to adenine (T > A) and IL-8 rs4073 adenine to thymine (A > T) polymorphisms. All patients with oral lichen planus had their lesions measured and documented using the …

Short Length Versus Conventional Implants In Rehabilitation Of Completely Edentulous Mandible, Fardos N. Rizk, Engy Tallat, Mahmoud Elhomossany, Ahmed Lasheen Dr., Hebatalla Mahmoud

Dentistry

Various bone augmentation strategies have been proposed to overcome the anatomic and physiologic limitations of implant placement in patients with atrophic edentulous ridges. The use of short implants may provide an alternative treatment to avoid complications associated with alveolar bone augmentation. However, the clinical effectiveness of short implants versus long implants was not thoroughly investigated. Marginal bone height changes around short and conventional implants were evaluated in this study Methods: Fourteen completely edentulous male patients were selected and divided into two equal groups. Group (I) Patients received conventional complete maxillary dentures opposed by mandibular overdentures supported and retained by two …

Book Review: Surrogacy: A Human Rights Violation By Renate Klein, Kate Rose

Dignity: A Journal of Analysis of Exploitation and Violence

No abstract provided.

Electrotransfer Of Different Control Plasmids Elicits Different Antitumor Effectiveness In B16.F10 Melanoma, Masa Bosnjak, Tanjo Jesenko, Urska Kamensek, Gregor Sersa, Jaka Lavrencak, Loree Heller, Maja Cemazar

Bioelectrics Publications

Several studies have shown that different control plasmids may cause antitumor action in different murine tumor models after gene electrotransfer (GET). Due to the differences in GET protocols, plasmid vectors, and experimental models, the observed antitumor effects were incomparable. Therefore, the current study was conducted comparing antitumor effectiveness of three different control plasmids using the same GET parameters. We followed cytotoxicity in vitro and the antitumor effect in vivo after GET of control plasmids pControl, pENTR/U6 scr and pVAX1 in B16.F10 murine melanoma cells and tumors. Types of cell death and upregulation of selected cytosolic DNA sensors and cytokines were …

Does The Start Of Dialysis Initiate A Period Of Increased Risk Of Ulceration Or Amputation?, Lawrence A. Lavery, David C. Lavery, Nathan A. Hunt, Javier La Fontaine, Ryan D. Lavery

School of Podiatric Medicine Publications

Background: Dialysis therapy is associated with an increased incidence of lower-extremity wounds and amputations. We compared the incidence of foot ulcers and amputations before and after the start of dialysis.

Methods: We evaluated 150 consecutive diabetic patients receiving dialysis and compared the incidence of foot complications 30 months before and after initiation of hemodialysis. We used claims data for diabetes, ulceration, and dialysis and abstracted medical records to verify diagnoses and dates of ulcers and amputations. We compared initial and cumulative ulcer/amputation incidence to account for multiple events in the same person over time. We used the same formula to …

Novel Applications Of Hot-Melt Extrusion Technology, Ajinkya Moreshwar Bhagurkar

Electronic Theses and Dissertations

Hot-melt extrusion, an adaptable technology, has established its position in a wide spectrum of manufacturing operations like amorphous solid dispersions, immediate and controlled oral formulations, implants, and taste masked products. In recent years the industrial focus has shifted towards continuous manufacturing, thus melt extrusion is being explored for new applications. The aim of this research work was to investigate the novel applications of hot-melt extrusion by carrying out an in depth study to understand the interplay between the process and the product. The conventional techniques used for the preparation of ointments and nanostructured lipid carriers are multi-step and time consuming …

Central Hypoventilation: A Rare Complication Of Wallenberg Syndrome, Keithan Sivakumar Md, Mba, Manveer Garcha, Dev Mehta, Megan Leary Md, Hussam A. Yacoub Md

Department of Medicine

Central alveolar hypoventilation disorders denote conditions resulting from underlying neurologic disorders affecting the sensors, the central controller, or the integration of those signals leading to insufficient ventilation and reduction in partial pressures of oxygen. We report a patient who presented with a left lateral medullary ischemic stroke after aneurysm repair who subsequently developed a rare complication of CAH. Increased awareness of this condition’s clinical manifestations is crucial to make an accurate diagnosis and understand its complications and prognosis.

Just Another Fever And Rash? A Broad Differential Leading To A Relatively Uncommon Condition In Adult Still's Disease., Nathan Brewster Do, Jaimin Patel Do, Rachel Kinney Do

Department of Medicine

No abstract provided.

What Does The Fos Say? Using Fos-Based Approaches To Understand The Contribution Of Stress To Substance Use Disorders, Jayme R. Mcreynolds, John P. Christianson, Jordan M. Blacktop, John Mantsch

Biomedical Sciences Faculty Research and Publications

Despite extensive research efforts, drug addiction persists as a largely unmet medical need. Perhaps the biggest challenge for treating addiction is the high rate of recidivism. While many factors can promote relapse in abstinent drug users, the contribution of stress is particularly problematic, as stress is uncontrollable and pervasive in the lives of those struggling with addiction. Thus, understanding the neurocircuitry that underlies the influence of stress on drug seeking is critical for guiding treatment. Preclinical research aimed at defining this neurocircuitry has, in part, relied upon the use of experimental approaches that allow visualization of cellular and circuit activity …

The Opiod Epidemic: Clinical Dental Update, Matthew Hearing

Biomedical Sciences Faculty Research and Publications

No abstract provided.

Black Males, Trauma, And Mental Health Service Use: A Systematic Review., Robert Motley, Andrae Banks

Brown School Faculty Publications

Objective: To systematically review the evidence of and synthesize results from relevant studies that have examined barriers and facilitators to professional mental health service use for Black male trauma survivors ages 18 and older.

Methods: A thorough search of selected databases that included EBSCO, ProQuest, and Web of Science Core Collection and careful consideration of inclusion and exclusion criteria yielded a final six studies for detailed review.

Results: Black male trauma survivors were significantly less likely to be utilizing mental health services than other sex-ethnic groups. High levels of daily crises, a lack of knowledge of steps to …

Changing Attitudes: The Impact Of A Disability Awareness Class, Christine Ann Masci

Honors Theses and Capstones

Attitudes towards people with disabilities can be either positive or negative. A undergraduate college course about disability awareness followed a structure focusing on awareness, interaction with PWD, and education in order to make a positive impact on attitudes. The study compared the disability awareness class to a general education humanities class. While results indicated that there was not a significant change in pre and post scores when comparing the classes, there was a significant change in the disability awareness class upon further analysis of data. There are additional suggestions to further the impact of the class within the disability awareness …

The Impact Of Academic Self-Efficacy On The Occupation Of Education In College Athletes Who Experience Concussion, Samantha Colaw

Honors Theses and Capstones

An emerging area of inquiry for occupational therapists (OT) is consideration of the impact of concussion on a person’s ability to engage in and perform meaningful everyday activity. The perspective of student-athletes (SA) living with post-concussion symptoms has received limited attention in research and there is a lack of focused attention regarding the role of being a student. This research adds to the growing body of literature regarding the implications of concussion on academics, specifically academic self-efficacy (ASE) and their self-perceived roles. The purpose of this study is to investigate the differences in ASE between college athletes with and without …