Medicine and Health Sciences Commons^™

Reduction Of Microhemorrhages In The Spinal Cord Of Symptomatic Als Mice After Intravenous Human Bone Marrow Stem Cell Transplantation Accompanies Repair Of The Blood-Spinal Cord Barrier, David J. Eve, George Steiner, Ajay Mahendrasah, Paul R. Sanberg, Crupa Kurien, Avery Thomson, Cesar V. Borlongan, Svitlana Garbuzova-Davis

Neurosurgery and Brain Repair Faculty Publications

Blood-spinal cord barrier (BSCB) alterations, including capillary rupture, have been demonstrated in animal models of amyotrophic lateral sclerosis (ALS) and ALS patients. To date, treatment to restore BSCB in ALS is underexplored. Here, we evaluated whether intravenous transplantation of human bone marrow CD34⁺ (hBM34⁺) cells into symptomatic ALS mice leads to restoration of capillary integrity in the spinal cord as determined by detection of microhemorrhages. Three different doses of hBM34⁺ cells (5 × 10⁴, 5 × 10⁵ or 1 × 10⁶) or media were intravenously injected into symptomatic G93A SOD1 mice …

Human Umbilical Cord Blood Serum–Derived Α-Secretase: Functional Testing In Alzheimer’S Disease Mouse Models, Ahsan Habib, Huayan Hou, Takashi Mori, Jun Tian, Jin Zeng, Shengnuo Fan, Brian Giunta, Paul R. Sanberg, Darrell Sawmiller, Jun Tan

Neurosurgery and Brain Repair Faculty Publications

Alzheimer’s disease (AD) is an age-related disorder that affects cognition. Our previous studies showed that the neuroprotective fragment of amyloid procurer protein (APP) metabolite, soluble APPα (sAPPα), interferes with β-site APP-cleaving enzyme 1 (BACE1, β-secretase) cleavage and reduces amyloid-β (Aβ) generation. In an attempt to identify approaches to restore sAPPα levels, we found that human cord blood serum (CBS) significantly promotes sAPPα production compared with adult blood serum (ABS) and aged blood serum (AgBS) in Chinese hamster ovary cells stably expressing wild-type human APP. Interestingly, CBS selectively mediated the α-secretase cleavage of human neuron-specific recombinant APP₆₉₅ in a cell-free …

Impact Of Pre-And Postpartum Nutrition On March-Calving Cow And Progeny Productivity, Jacki A. Musgrave, Devin L. Broadhead, L. A. Stalker Stalker, Richard N. Funston

Nebraska Beef Cattle Reports

March-calving cows were fed hay or grazed corn residue prepartum, and then either fed hay or grazed subirrigated meadow postpartum. Combinations of these different feeding strategies impacted body weight (BW) and body condition score (BCS) during the pre-and postpartum period; however, resulted in similar pregnancy rates. Although differences were not observed in cow pregnancy rates, a benefit in pre-weaning growth was observed for calves from the dams in postpartum meadow treatment. A tendency for an improvement in marbling score was observed for steers born to cows fed hay prepartum, perhaps indicating a higher plane of nutrition prepartum may improve quality …

Orbital Skull Base Reconstruction With Temporalis Muscle: The Sphenoid Keyhole Technique, Mofiyinfolu Sokoya, Arash Bahrami, Jason Cohn, Sameep Kadakia, Moustafa Mourad, Yadranko Ducic

Otolaryngology (ENT) Resident Research

The temporalis flap is a common flap used in head and neck reconstruction. In this article, the authors present a new modification of the use of the temporalis muscle flap for orbital skull base reconstruction with the use of a sphenoid keyhole. This technique confers multiple advantages in reducing the arc of rotation and providing a tension-free reconstruction of the orbital skull base.

Students' Understanding About Clinical Research And Their Willingness To Participate In Clinical Trials, Shashikiran Pathakamudi

Master's Theses and Doctoral Dissertations

Adolescents and young adults remain underrepresented in clinical trials. Knowledge and perceptions related to clinical research usually determine willingness to participate. During the spring of 2016, an in-class paper survey was conducted to determine whether providing a brief introduction to clinical research would affect the willingness of undergraduate students from the College of Arts and Sciences and the College of Technology at Eastern Michigan University to participate in clinical trials. Some participants received information on clinical research through a short paragraph, and some received no new information, which differentiated the “active” group from the “placebo” group. Overall, both groups provided …

How Do Speech-Language Pathologists Perceive Their Influence Over Patient Adherence Regarding Dysphagia Recommendations?, Charlene D. Shin

Master's Theses and Doctoral Dissertations

This qualitative research study explored speech-language pathologists’ (SLP) perceptions regarding their potential to influence patient adherence to dysphagia recommendations. Five SLPs holding the CCC-SLP were interviewed in an open-ended format, and the transcriptions of the interviews were the data for this study. The SLP interviews provided a glimpse into SLP interpretations of patients’ fears, concerns, and comprehension of their dysphagia and the recommendations they were given. The themes identified within the data were SLP education for patient and family, respect for patient decisions, SLP understanding of barriers to patient adherence to dysphagia recommendations, family buy-in and practical support, perpetuation of …

Functional Characterization Of Scaffold Protein Shoc2, Hyein Jang

Theses and Dissertations--Molecular and Cellular Biochemistry

Signaling scaffolds are critical for the correct spatial organization of enzymes within the ERK1/2 signaling pathway and proper transmission of intracellular information. However, mechanisms that control molecular dynamics within scaffolding complexes, as well as biological activities regulated by the specific assemblies, remain unclear.

The scaffold protein Shoc2 is critical for transmission of the ERK1/2 pathway signals. Shoc2 accelerates ERK1/2 signaling by integrating Ras and RAF-1 enzymes into a multi-protein complex. Germ-line mutations in shoc2 cause Noonan-like RASopathy, a disorder with a wide spectrum of developmental deficiencies. However, the physiological role of Shoc2, the nature of ERK1/2 signals transduced through this …

Reversing Opioid Overdoses, Hailey Nestor

Honors Projects

No abstract provided.

Senate Bill 149: Guidelines For Prescribing Opioids, Margaret Buchanan

Honors Projects

No abstract provided.

House Bill 4581: Annual Flu Vaccinations, Hannah Mcdermitt

Honors Projects

No abstract provided.

Impact Of Rapid Meca Polymerase Chain Reaction Rapid Diagnostic Testing For Staphylococcus Aureus In A Pediatric Setting, Emily Drwiega

Undergraduate Honors Thesis Collection

Rapid molecular technology can detect the mecA resistance gene in Staphylococcus aureus (SA), predicting methicillin susceptibility in under one hour. In combination with antimicrobial stewardship program interventions in adults with SA bacteremia, rapid mecA testing decreases time to targeted therapy. This intervention has not yet been shown effective in pediatric patients or in the absence of real-time stewardship interventions. The objective of this study was to determine if time to optimal therapy decreased following implementation of GeneXpert rapid diagnostic testing (RDT) in a pediatric institution without a formal antimicrobial stewardship protocol for response. The primary outcome was time to optimal …

Pilot Data On Responsive Epilepsy Neurostimulation, Measures Of Sleep Apnea And Continuous Glucose Measurements., Katie M Kinnear, Nicole M Warner, Anand Gersappe, Michael J Doherty

Articles, Abstracts, and Reports

Objectives: To match responsive neurostimulator (RNS) and polysomnographic data to determine if RNS detections and stimulations correlate with measurements of sleep disordered breathing and continuous glucose measurements (CGM).

Materials and methods: In a patient with an RNS with detection/stimulation leads implanted bi-temporally detection-stimulation counts were matched by time with coinciding polysomnogram and CGM data.

Results: Temporal dispersion of RNS DSC were independent of measures of sleep apnea, hypopnea or glucose.

Conclusion: Hippocampal nighttime responsive neurostimulation therapies did not appear to worsen measures of normal or abnormal sleep.

Using The Literature To Identify Confounders, Scott Malec

Dissertations and Theses (Open Access)

Prior work in causal modeling has focused primarily on learning graph structures and parameters to model data generating processes from observational or experimental data, while the focus of the literature-based discovery paradigm was to identify novel therapeutic hypotheses in publicly available knowledge. The critical contribution of this dissertation is to refashion the literature-based discovery paradigm as a means to populate causal models with relevant covariates to abet causal inference. In particular, this dissertation describes a generalizable framework for mapping from causal propositions in the literature to subgraphs populated by instantiated variables that reflect observational data. The observational data are those …

Examination Of Resistance Settings Based On Body Weight For The 3-Minute All-Out Critical Power Test, Marlene J. Schulte, Jody L. Clasey, Bradley S. Fleenor, Haley C. Bergstrom

Kinesiology and Health Promotion Faculty Publications

There are conflicting suggestions regarding the most valid resistance (3-5% of body weight) to use for the critical power (CP) 3-min all-out (CP_3min) test to estimate CP and anaerobic work capacity (AWC). The purpose of this study was to determine if the CP and AWC estimates from the CP_3min test were affected by the percentage of body weight used to set the resistance on a Monark cycle ergometer. Ten recreationally trained participants (mean ± SD: Age: 22.2 ± 2.2 yrs.) completed the CP_3min test at resistances of 4.5% (CP_4.5%) and 3% (CP_3%) …

Effects Of Very Short-Term Dynamic Constant External Resistance Exercise On Strength And Barbell Velocity In Untrained Individuals, M. Travis Byrd, Haley C. Bergstrom

Kinesiology and Health Promotion Faculty Publications

This study examined the effect of an upper body dynamic constant external resistance (DCER) exercise (barbell bench press [BP]), using the very short-term training (VST) model on strength and barbell velocity. Ten (5 females, 5 males) subjects (mean ± SD age: 21.4 ± 2.8 yrs; height: 1.75 ± 0.12 m; body mass: 83 ± 8.8 kg) completed two pre-test visits (pre-test 1 and pre-test 2) to serve as the within subjects control, three training visits, and one post-test visit. The subject’s 1 repetition maximum (1RM) for the BP as well as the mean (BP_MV) and peak (BP_{PV …}

Modeling The Expected Cost-Effectiveness And Impact Of Oral Pre-Exposure Prophylaxis In Uganda And Swaziland, Project Soar

HIV and AIDS

Clinical trials have shown that oral antiretrovirals (ARVs) containing tenofovir/emtricitabine used by HIV-negative individuals to prevent HIV acquisition, called oral pre-exposure prophylaxis (PrEP), are safe and effective in several populations. Prior modeling work has demonstrated that oral PrEP is most cost effective when targeted to populations at very high risk of infection, with risk dependent on a combination of individual behavior and epidemic contexts. This brief describes a study Project SOAR is conducting to assist Uganda and Swaziland in making critical decisions about oral PrEP introduction and scale up by modeling the expected cost effectiveness and impact of oral PrEP …

Effectiveness Of Practicum Supervision As Perceived By Hispanic Undergraduate Rehabilitation Services Students, Roy K. Chen, Kim L. Nguyen-Finn, Jinhee Park

School of Rehabilitation Services & Counseling Faculty Publications

Practica are integral to the culmination of systematic learning in higher education, particularly in fields such as health sciences and human services. For undergraduate rehabilitation services students, these placements typically mark the first-time students apply textbook knowledge to real life situations. Therefore, effective site supervision is an important part of the undergraduate field experience. The purpose of the present study was to examine the perceived effectiveness of undergraduate rehabilitation services practicum site supervision. The sample consisted of 154 Hispanic undergraduate rehabilitation services students. The findings show that students were satisfied with the supervision they received. Students also rated the competency …

Wv Senate Bill 61, Rowan Jalso

Honors Projects

No abstract provided.

Proposed Metrics To Measure Quality: Overview, Anrudh K. Jain, John Townsend, Saumya Ramarao

Reproductive Health

The first quality-of-care framework in family planning was articulated over 25 years ago and a considerable amount of work has been done since then to measure quality in the context of routine service delivery, yet, we do not have agreed-upon indicators to measure quality that can be applied uniformly across different health systems and social contexts. This paper takes a slightly different approach and uses a common definition of quality from the outset. Indicators of quality are required for describing the nature of family planning services and quality of care offered by a health service delivery program, and for improving …

Social Networks, Social Relationships, And Their Effects On The Aging Mind And Brain, Sato Ashida, Ellen J. Schafer

Public and Population Health Faculty Publications and Presentations

Key Points

• Increasing evidence shows the behavioral, perceptual, and biological pathways by which social relationships and social networks positively impact health outcomes, including those for the aging mind and brain.

•The facilitation of healthy aging, in turn, has been shown to increase social participation among older adults through community-based interventions and contributes to societal well-being.

D-Cycloserine-Augmented One-Session Treatment Of Specific Phobias In Children And Adolescents, Lara J. Farrell, Allison M. Waters, Ella L. Oar, Evelin Tiralongo, Vinay Garbharran, Clair Alston-Knox, Harry Mcconnell, Nigel Collings, Melanie Zimmer-Gembeck, Caroline L. Donovan, Chris Testa, Eric A. Storch, Thomas H. Ollendick

Pediatrics Faculty Publications

Background: D-Cycloserine has potential to enhance exposure therapy outcomes. The current study presents a preliminary randomized, placebo-controlled double-blind pilot trial of DCS-augmented one-session treatment (OST) for youth (7–14 years) with specific phobia. A secondary aim of this pilot study was to explore the effects of youth age and within-session fear reduction as potential moderators of DCS outcomes in order to generate hypotheses for a larger trial. It was hypothesized that DCS would be associated with greater improvements than placebo, that children (7–10 years) would have greater benefits than adolescents (11–14 years), and that DCS effects would be stronger for participants …

Two Unrelated Patients With Autosomal Dominant Omodysplasia And Frizzled2 Mutations, Hannah E. Warren, Raymond J. Louie, Michael J. Friez, Jaime L. Frías, Jules G. Leroy, Jürgen W. Spranger, Steven A. Skinner, Neena L. Champaigne

Pediatrics Faculty Publications

No abstract provided.

Distribution And Community Reception Of Medication Disposal Pouches Compared With Distribution Of Unintentional Overdose-Related Deaths In Montgomery County, Ohio, Parvaneh K. Nouri

Master of Public Health Program Student Publications

Introduction: Substance misuse is a significant problem nationally, where Ohio ranks within the top five states contributing to this burden. Montgomery County experiences the most deaths in the state. While illicit fentanyl and analogs are increasingly responsible for overdose-related deaths, prescription misuse is a significant risk factor for progression to illicit substance use. Methods: Survey data from a pilot medication safety campaign utilizing medication disposal pouches were evaluated by descriptive analysis and qualitative analysis. Survey findings were compared to data of all unintentional overdose-related deaths in Montgomery County from January to October, 2017. Secondary analysis of death data was performed …

Demographic Trends In Prescription Pain Reliever Misuse And Treatment-Seeking For Addiction, Megan C. Smith

Master of Public Health Program Student Publications

Opioid addiction in the United Sates has reached epidemic proportions in recent years, demanding targeted efforts in both clinical medicine and public health. This analysis outlined a demographic profile of recent prescription pain reliever (PPR) misusers and compared those characteristics to the population of individuals currently enrolled in addiction treatment. To explain the difference in numbers between these two populations, reported reasons for non-treatment seeking are analyzed by demographic characteristic. This discussion reviews existing literature profiling PPR misusers and treatment-seekers, as well as research exploring barriers to addiction treatment. A secondary analysis was performed using data from the National Survey …

Marijuana Use Among Pregnant Women In A High-Risk Population, Shanice A. Akoto

Master of Public Health Program Student Publications

Background: Marijuana is the most commonly used illicit substance in pregnancy, often used concurrently with tobacco, increasing the risk for prematurity and low birth weight. Programs such as Healthy Start and CenteringPregnancy® provide resources and prenatal care to women in underserved communities in hopes of improving birth outcomes.

Objective: Evaluate marijuana use in pregnant women living in Montgomery County, Ohio in the highest risk zip codes (45402, 45403, 45405, 45414, 45416, 45417, 45426) and determine if use at delivery is lower in women enrolled in CenteringPregnancy® compared to women who were not. Methods: A secondary analysis of previously collected de-identified …

The Association Of Perfluoroalkyl Substances Exposure And Metabolic Syndrome In U.S. Adults, David B. Leary

Master of Public Health Program Student Publications

Background: Perfluoroalkyl substances (PFASs) are persistent synthetic compounds that have been environmental contaminants since the 1950s. Exposure in the general population can be through food and water ingestion, use of non-stick cookware, and dust from stain-resistant carpet. Studies have suggested PFASs act as endocrine disrupters and to affect liver and immune function, as well as cause increases in serum lipid levels.

Objective: To explore the association between six common detectable PFASs and the metabolic syndrome (MetS) in United States (U.S.) adults. Methods: Data from 739 participants aged 20 years and older from the 2013-2014 National Health and Nutrition Examination Survey …

Preclinical Pharmacokinetic Evaluation To Facilitate Repurposing Of Tyrosine Kinase Inhibitors Nilotinib And Imatinib As Antiviral Agents, Hari Krishna Ananthula, Scott Parker, Erin Touchette, R. Mark Buller, Gopi Patel, Daniel Kalman, Johanna S. Salzer, Nadia Gallardo-Romero, Victoria Olson, Inger K. Damon, Tessa Moir-Savitz, Larry Sallans, Milton H. Werner, Catherine M.T. Sherwin, Pankaj B. Dasai

Pediatrics Faculty Publications

Background

Several tyrosine kinase inhibitors (TKIs) developed as anti-cancer drugs, also have anti-viral activity due to their ability to disrupt productive replication and dissemination in infected cells. Consequently, such drugs are attractive candidates for “repurposing” as anti-viral agents. However, clinical evaluation of therapeutics against infectious agents associated with high mortality, but low or infrequent incidence, is often unfeasible. The United States Food and Drug Administration formulated the “Animal Rule” to facilitate use of validated animal models for conducting anti-viral efficacy studies.

Methods

To enable such efficacy studies of two clinically approved TKIs, nilotinib, and imatinib, we first conducted comprehensive pharmacokinetic …

A Closer Look At The Items Within Three Measures Of Evolution Acceptance: Analysis Of The Mate, I-Sea, And Gaene As A Single Corpus Of Items, William L. Romine, Amber Todd, Emily M. Walter

Biological Sciences Faculty Publications

Background

Current direct Likert measures for evolution acceptance include the MATE, GAENE, and I-SEA. Pros and cons of each of these instruments have been debated, and yet there is a dearth of research teasing out their similarities and differences when they are used together in a single context beyond the fact that their measures tend to be highly correlated. We administered these to 452 college students in non-major biology classes at two research-intensive universities from the Midwestern and Western United States to investigate the measurement properties of the items within these instruments when combined as a single corpus.

Results

Factor …

Changes In Water Quality Of Grand Lake St. Marys Watershed Following Implementation Of A Distressed Watershed Rules Package, Stephen J. Jacquemin, Laura T. Johnson, Theresa A. Dirksen, Gregory J. Mcglinch

Biological Sciences Faculty Publications

Grand Lake St. Marys watershed has drawn attention over the past decade as water quality issues resulting from nutrient loading have come to the forefront of public opinion, political concern, and scientific study. The objective of this study was to assess long-term changes in water quality (nutrient and sediment concentrations) following the distressed watershed rules package instituted in 2011. Since that time, a variety of rules (e.g., winter manure ban) and best management practices (cover crops, manure storage or transfers, buffers, etc.) have been implemented. We used a general linear model to assess variation in total suspended solids, particulate phosphorus, …

Food For Thought: Eating Habits Of College Freshmen Examined Through The Socio-Ecological Model, Malia T. Morris Ms.

Undergraduate Theses, Professional Papers, and Capstone Artifacts

The purpose of this project is to assess the dietary habits of college freshmen living in on-campus housing. A review of the literature regarding college student eating behavior is completed and examined through the socio-ecological model in order to identify key determinants affecting students’ meal choices. The second component of this project develops potential intervention plans specifically designed for UM students to improve eating habits campus wide.