Medicine and Health Sciences Commons^™

The Effect Of Urinary Triclosan On Serumthyroxine In Us Population: 2011-2012 Nhanes Data, Katie M. Clark

Master of Public Health Program Student Publications

Background: Triclosan is an antibacterial agent that is added to personal care products to prevent bacterial growth. The FDA banned the use of triclosan in soap in 2016 due to safety concerns. Triclosan is considered an endocrine disruptor and had reported effects on the body, including changes in thyroid function.

Purpose: The purpose of this study was to assess the relationship between urinary triclosan and serum thyroxine in U.S adults. Methods: Data from the 2013-2014 National Health and Nutrition Examination Survey (NHANES) were analyzed (N =1,476). Linear regression analyses were performed to assess the relationship between log transformed triclosan and …

Poor Sleep Health In American Adults: Implications For Screening In Civil Aviation, Melissa E. Gear

Master of Public Health Program Student Publications

Background: Poor sleep health is increasingly prevalent in the United States (US) adult population and contributes to fatigue. Fatigue is a significant safety hazard within civilian aviation, yet data regarding the prevalence of inadequate sleep in this population is sparse. Are there demographic characteristics which put individual at risk of not obtaining adequate sleep which should trigger screening during the medical certification process?

Methods: This cross-sectional study used National Health Interview Survey 2014-2016 data from US adults aged 18 to 65 to observe the relationship of demographic, socioeconomic, health, and behavioral characteristics with reported inadequate sleep duration and quality (trouble …

Chesapeake Bay Nutria Eradication Project: 2017 Update, Margaret Pepper, Kevin Sullivan, Robert Colona, Jonathan Mcknight

United States Department of Agriculture Wildlife Services: Staff Publications

Nutria, a semi-aquatic, South American rodent, was introduced to Maryland during the early 1940s. Originally brought to the area for fur farms, the market never established and animals were released or escaped. Nutria thrived, destroying coastal wetlands which resulted in negative environmental and economic impacts to the Chesapeake Bay region. To preserve and protect valuable wetland resources, the Chesapeake Bay Nutria Eradication Project (CBNEP) was established in 2002 through a partnership between the United States Fish and Wildlife Service, the United States Department of Agriculture’s Wildlife Services, Maryland Department of Natural Resources, and many state agencies and non-governmental organizations. Since …

A Cognitive Model Of Switching Between Reflective And Reactive Decision Making In The Wason Task, Othalia Larue, Alexander Hough, Ion Juvina

Psychology Faculty Publications

Using the Wason card selection task, we model how humansdecide to engage in further deliberation after generating anintuitive response. Central to our model is the Feeling ofRightness which is the fluency with which one makes adecision, and how good one feels about it. The model isimplemented in a cognitive architecture, ACT-R. A core affectmechanism and the Feeling of Rightness component are usedto drive the decision. A training procedure was used to simulateindividual differences in heuristic and analytical behavior.Different degrees of reinforcement were then used to allow themodel to learn logical skills, and acquire differences in FOR,which determined the degree of …

Do We Really Know Where The Molar Teeth Are On The Lateral Headfilm? A Recommendation For A More Precise Way To Locate The Molars On The Lateral Headfilm, Ib Leth Nielsen, Chung-Chen Jane Yao

Taiwanese Journal of Orthodontics

Objective: The aim of this study demonstrates an improved method for determining the exact molar positions on the lateral headfilm. Previously this position was located by visual inspection of the headfilm. We are testing the precision of visual determination compared to using occlusogram measurements. Materials and Methods: In a sample of 34 subjects treated for Class II malocclusion, we examined the pre and post treatment headfilms and compared molar positions determined by visualization with occlusogram measurements. Results: Our data showed that in 15% of the cases there were no differences between the two methods, in 50% the differences were 1 …

Application Of Combined Maxillary Skeletal Expander And Facemask Treatment With An Alternating Rapid Maxillary Expansion And Constriction Protocol In A Female Adolescent With A Class Iii Skeletal Relationship, Li-Fang Hsu, Kai-Wen Yu, Chung-Ji Liu, Jenny Zwei-Chieng Chang

Taiwanese Journal of Orthodontics

A 13-year-old female patient presented with a chief complaint of anterior crossbite and chin prognathism. She had a skeletal Class III relationship with a brachyfacial vertical pattern. Anterior crossbite exhibited maximum intercuspation–centric relation shift, leading to an edge to-edge incisal position. On the basis of this patient’s chronological age, it was too late to perform conventional early treatment of Class III cases, which includes rapid palatal expansion combined with facemask or chincap therapy. After discussing treatment options with the patient and her parents, we decided to try combined maxillary skeletal expander and facemask treatment with an alternating rapid maxillary expansion …

Correction Of 2 Impacted Dilacerated Maxillary Central Incisors With Collaborative Surgical And Orthodontic Treatment, Yi-Hsin Chang, Jung-Hsuan Cheng

Taiwanese Journal of Orthodontics

Impaction in maxillary central incisor is not as common in comparison with maxillary canine, whereas it causes more occlusal and esthetic impact due to its visible location. This case reported a combined surgical and orthodontic treatment on two horizontally impacted maxillary central incisors with dilacerated roots. The treatment included 2 stages. In the first stage, the dental space was regained and surgical exposure with closed eruption technique was applied. In the second stage, excisional gingivectomy combined with orthodontic traction were used to reposition both teeth into alignment. During orthodontic treatment, transpalatal arch (TPA) was applied for intraoral anchorage. The maxillary …

A Pilot Experimental Study Of Adding The Copm To The Occupational Therapy Evaluation Process In The Swing-Bed Division Of A Rural Hospital Setting, Sarah T. Durbin Ms.

Occupational Therapy Doctorate Capstone Projects

Background: Extensive evidence is available on the efficacy of occupation-based practice for improving patient outcomes in hospital settings. There were no studies that took place specifically in the swing-bed division of rural hospital settings regarding occupation-based practice prior to the implementation of this study. Purpose: This study sought to determine whether the addition of the COPM would increase occupational performance and patient satisfaction for individuals treated in the swing-bed division of a rural hospital setting. Theoretical Framework: The Canadian Model of Occupational Performance and Engagement is the primary theory supporting this study, due to the emphasis placed on client-centeredness, spirituality, …

The Impact Of Interactive Education On Caregivers Caring For Individuals With Dementia, Lisa K. Hong

Occupational Therapy Doctorate Capstone Projects

Background: Alzheimer’s disease and related dementias are becoming more prevalent and individuals with the disease requiring much physically and emotionally from caregivers. As caregivers are often thrust unprepared into their roles, the need for quality education becomes increasingly important.

Purpose: The purpose of this study was to identify changes in caregiver perception after participation in an interactive educational program. The following research questions were used: 1) What is the perception of both professional and family caregivers about their ability to provide care following an interactive education program for dementia care? 2) Does an education program change the caregiver’s general knowledge …

Life In Hampton Roads Survey Press Release #4: Health, Health Care, And Other Health Related Issues, Social Science Research Center, Old Dominion University

Life in Hampton Roads Survey Report

[Introductory paragraph]

This report examines regional and sub-regional measures of health and health related issues from the 2018 Life In Hampton Roads survey (LIHR 2018) conducted by the Old Dominion University Social Science Research Center. Data from prior years is also provided when available to show comparisons in responses over time. Responses were weighted by city population, race, age, gender, and phone usage (cell versus land-line) to be representative of the Hampton Roads region. For additional information on survey methodology, and analyses of other issues, please see the SSRC website at www.odu.edu/ssrc. The health of Hampton Roads residents is …

Expression Of The Microrna-143/145 Cluster Is Decreased In Hepatitis B Virus-Associated Hepatocellular Carcinoma And May Serve As A Biomarker For Tumorigenesis In Patients With Chronic Hepatitis B, Qi Zhao, Xiangfei Sun, Chao Liu, Tao Li, Juan Cui, Chengyong Qin

School of Computing: Faculty Publications

The aims of the present study were to identify the expression profile of microRNA (miR)‑143/145 in hepatitis B virus (HBV)‑associated hepatocellular carcinoma (HCC), explore its association with prognosis and investigate whether the serum miR‑143/145 expression levels may serve as a diagnostic indicator of HBV‑associated HCC. The microRNA (miRNA) chromatin immunoprecipitation dataset was obtained from The Cancer Genome Atlas (TCGA) and the Gene Expression Omnibus databases, and analyzed using the Wilcoxon signed‑rank test. It was observed that the expression of miR‑143 and miR‑145 was decreased 1.5‑fold in HBV‑associated HCC samples compared with non‑tumor tissue in the TCGA and the GSE22058 datasets …

Critically Appraised Paper For “Adaptive Vs. Non-Adaptive Cognitive Training By Means Of A Personalized App: A Randomized Trial In People With Multiple Sclerosis.”, Kevin Ng, Jeffrey Kou, Patricia Lyons, Yvonne Lam, America Ortega, Kitsum Li

Occupational Therapy | Critically Appraised Papers Series

Multiple sclerosis (MS) is a condition that causes cognitive and physical fatigue, which can slow cognitive processing speed (CPS). Slow CPS affects occupational engagement. Evidence suggests that physical activity can be used as an intervention to address and manage slowed CPS in MS. This Level I randomized controlled trial (RCT) examined the impact of a physical-activity behavioral intervention on CPS and walking performance among people with mild to moderate MS.

Seventy-six participants with mild to moderate MS participated in the study for 6 months. The participants were split into two groups, the intervention group and the wait-list control group. In …

Rest Upregulates Gremlin To Modulate Diffuse Intrinsic Pontine Glioma Vasculature, Shavali Shaik, Bridget Kennis, Shinji Maegawa, Keri Schadler, Yang Yanwen, Javad Nazarian, +Several Additional Authors

Genomics and Precision Medicine Faculty Publications

Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive glial tumor that occurs in children. The extremely poor median and 5-year survival in children afflicted with DIPG highlights the need for novel biology-driven therapeutics. Here, we have implicated the chromatin remodeler and regulator of brain development called RE1 Silencing Transcription Factor (REST), in DIPG pathology. We show that REST protein is aberrantly elevated in at least 21% of DIPG tumors compared to normal controls. Its knockdown in DIPG cell lines diminished cell growth and decreased their tumorigenicity in mouse intracranial models. DIPGs are vascularized tumors and interestingly, REST loss in …

Clozapine-Induced Myocarditis, Tanuka Datta, Allen J. Solomon

Medicine Faculty Publications

Approved in 1989 for the management of treatment-resistant schizophrenia, Clozapine is a last-line atypical antipsychotic drug used with increasing frequency. In addition to its well-known side effect of agranulocytosis, this drug also carries with it rare but serious adverse cardiovascular risk of myocarditis. We present a patient on Clozapine who was admitted to the cardiology service with chest pain, ST segment elevations and elevated troponin concerning for acute myocardial infarction. Evaluation with imaging revealed decreased left ventricular function, however, no coronary artery disease was present on catheterization; findings consistent with a diagnosis of myocarditis. Subsequent discontinuation of the patient’s Clozapine …

Percutaneous Management Of Ostial Stenosis Of The Left Internal Mammary Artery Graft, Tanuka Datta, Mohammed Gibreal, Ramesh Mazhari, Allen J. Solomon

Medicine Faculty Publications

A 61-year-old man, who had undergone coronary artery bypass surgery 10 years earlier, presented with a non-ST segment elevation myocardial infarction. He was treated with medical therapy and taken to the Cardiac Catheterization Laboratory. A left heart catheterization demonstrated an ostial stenosis in the left internal mammary artery graft, which was felt to be the culprit lesion. This was successfully repaired with a drug eluting stent. This case is presented as an unusual location for a de novo coronary stenosis. The pathophysiology of these lesions is not well understood.

Sodium Bicarbonate Cotransporter Nbce2 Gene Variants Increase Sodium And Bicarbonate Transport In Human Renal Proximal Tubule Cells., John J Gildea, Peng Xu, Brandon A Kemp, Julia M Carlson, Hanh T Tran, Dora Bigler Wang, Christophe J Langouët-Astrié, Helen E Mcgrath, Robert M Carey, Pedro A Jose, Robin A Felder

Medicine Faculty Publications

RATIONALE: Salt sensitivity of blood pressure affects >30% of the hypertensive and >15% of the normotensive population. Variants of the electrogenic sodium bicarbonate cotransporter NBCe2 gene, SLC4A5, are associated with increased blood pressure in several ethnic groups. SLC4A5 variants are also highly associated with salt sensitivity, independent of hypertension. However, little is known about how NBCe2 contributes to salt sensitivity, although NBCe2 regulates renal tubular sodium bicarbonate transport. We hypothesized that SLC4A5 rs10177833 and rs7571842 increase NBCe2 expression and human renal proximal tubule cell (hRPTC) sodium transport and may be a cause of salt sensitivity of blood pressure.

OBJECTIVE: To …

Pediatric Rheumatology: Addressing The Transition To Adult-Orientated Health Care., Sara Sabbagh, Tova Ronis, Patience H White

Medicine Faculty Publications

The transition from pediatric to adult health care is often a challenging process due to multiple interwoven complexities, especially for children with chronic medical conditions. Health care transition (HCT) is a process of moving from a pediatric to an adult model of health care with or without a transfer to a new clinician. This paper focuses on what is known about HCT for youth and young adults (Y/YA) with rheumatic diseases within a larger context of HCT recommendations. HCT barriers for youth, families, and providers and current evidence for a structured HCT processes are reviewed. Practical advice is offered on …

Gut Microbiota And Cardiovascular Uremic Toxicities, Manuel T. Velasquez, Patricia Centron, Ian Barrows, Rama Dwivedi, Dominic S. Raj

Medicine Faculty Publications

Cardiovascular disease (CVD) remains a major cause of high morbidity and mortality in patients with chronic kidney disease (CKD). Numerous CVD risk factors in CKD patients have been described, but these do not fully explain the high pervasiveness of CVD or increased mortality rates in CKD patients. In CKD the loss of urinary excretory function results in the retention of various substances referred to as “uremic retention solutes”. Many of these molecules have been found to exert toxicity on virtually all organ systems of the human body, leading to the clinical syndrome of uremia. In recent years, an increasing body …

A Case Of Eosinophilic Annular Erythema As A Presenting Sign For Autoimmune Hepatitis, Olabola Awosika, Kristin Totoraitis, Misty Eleryan, Monica Rengifo-Pardo, Alison Ehrlich

Dermatology Faculty Publications

Eosinophilic annular erythema (EAE) is a relatively new entity, clinically presenting as a figurate erythema. The cause of EAE remains obscure, but it has been associated with several chronic conditions and malignancies. We describe an unusual case of EAE developing before the onset of autoimmune hepatitis.

Profile Of Dupilumab And Its Potential In The Treatment Of Inadequately Controlled Moderate-To-Severe Atopic Dermatitis., Olabola Awosika, Lori Kim, Momina Mazhar, Monica Rengifo-Pardo, Alison Ehrlich

Dermatology Faculty Publications

Atopic dermatitis (AD) is a common inflammatory skin disorder that manifests as eczematous lesions, often associated with allergic rhinitis and asthma. Historically, moderate-to-severe disease has been managed with systemic immunosuppression, such as oral corticosteroids, which result in relapse and limiting side effects. Due to recent advancements in the identification of interleukin (IL)-4 and IL-13 as key mediators in AD, new biological agents have been developed for treatment. Dupilumab is a recently approved monoclonal antibody that targets the alpha subunit of the IL-4 receptor and, thus, downregulates activity of IL-4 and IL-13. This review discusses the profile of dupilumab and its …

Association Of Two Foxp3 Polymorphisms With Breast Cancer In Chinese Han Women, Wenge Zhu, +Several Additional Authors

Biochemistry and Molecular Medicine Faculty Publications

Background

Forkhead box P3 (FOXP3) is a key gene in the immune system which also plays a role in tumor development. This study aims to explore the association of two FOXP3 polymorphisms (rs3761548 and rs3761549) with susceptibility to breast cancer (BC).

Method

A case–control study was conducted, involving 560 patients and 583 healthy individuals from the Chinese Han population. The genotypes of FOXP3 polymorphisms were detected using the Sequenom MassARRAY method. The association between FOXP3 polymorphisms and BC risk was evaluated using a χ2 test with an odds ratio (OR) and 95% confidence intervals (95% CIs) under six …

Aberrant Brain Functional Connectivity In Newborns With Congenital Heart Disease Before Cardiac Surgery, Josepheen De Asis-Cruz, Mary T. Donofrio, Gilbert Vezina, Catherine Limperopoulos

Pediatrics Faculty Publications

Newborns with congenital heart disease (CHD) requiring open heart surgery are at increased risk for neurodevelopmental disabilities. Recent quantitative MRI studies have reported disrupted growth, microstructure, and metabolism in fetuses and newborns with complex CHD. To date, no study has examined whether functional brain connectivity is altered in this high-risk population after birth, before surgery. Our objective was to compare whole-brain functional connectivity of resting state networks in healthy, term newborns (n = 82) and in term neonates with CHD before surgery (n = 30) using graph theory and network-based statistics. We report for the first time intact global network …

Comparison Between Different Strategies Of Rheumatic Heart Disease Echocardiographic Screening In Brazil: Data From The Provar (Rheumatic Valve Disease Screening Program) Study, B Nascimento, Craig A. Sable, M Nunes, A Diamantino, K Oliveira, Andrea Z. Beaton, +Several Additional Authors

Pediatrics Faculty Publications

Background-—Considering the limited accuracy of clinical examination for early diagnosis of rheumatic heart disease (RHD), echocardiography has emerged as an important epidemiological tool. The ideal setting for screening is yet to be defined. We aimed to evaluate the prevalence and pattern of latent RHD in schoolchildren (aged 5–18 years) and to compare effectiveness of screening between public schools, private schools, and primary care centers in Minas Gerais, Brazil.

Methods and Results-—The PROVAR (Rheumatic Valve Disease Screening Program) study uses nonexperts and portable and handheld devices for RHD echocardiographic screening, with remote interpretation by telemedicine, according to the 2012 World Heart …

Treatment Challenges In An Atypical Presentation Of Tubulointerstitial Nephritis And Uveitis (Tinu), S Caplash, S Gangaputra, S Kodati, Shamir Tuchman, Hemalatha Srinivasalu, H Sen

Pediatrics Faculty Publications

Purpose: To describe an atypical presentation of Tubulointerstitial Nephritis and Uveitis (TINU), with challenges in treatment course. Observations: A 12-year-old Hispanic female presented to the National Eye Institute's Uveitis clinic with bilateral blurred vision, red eyes and photophobia, not responsive to topical steroids. On exam, she had bilateral severe panuveitis with areas of subretinal fluid. During her evaluation, she was noted to have elevated serum creatinine. A kidney biopsy confirmed the presence of severe tubulointerstitial nephritis and interstitial fibrosis. She was treated with oral steroids with excellent resolution of symptoms and subretinal fluid. She continued to have anterior segment flares …

The Neurodevelopmental Perspective Of Surgical Necrotizing Enterocolitis: The Role Of The Gut-Brain Axis., Chariton Moschopoulos, Panagiotis Kratimenos, Ioannis Koutroulis, Bhairav V Shah, Anja Mowes, Vineet Bhandari

Pediatrics Faculty Publications

This state-of-the-art review article aims to highlight the most recent evidence about the therapeutic options of surgical necrotizing enterocolitis, focusing on the molecular basis of the gut-brain axis in relevance to the neurodevelopmental outcomes of primary peritoneal drainage and primary laparotomy. Current evidence favors primary laparotomy over primary peritoneal drainage as regards neurodevelopment in the surgical treatment of necrotizing enterocolitis. The added exposure to inhalational anesthesia in infants undergoing primary laparotomy is an additional confounding variable but requires further study. The concept of the gut-brain axis suggests that bowel injury initiates systemic inflammation potentially affecting the developing central nervous system. …

The Pathology Workforce And Clinical Licensure, Robin Lorenz, Donald S. Karcher, Michael Gautreaux, Melvin Limson, Dani Zander

Pathology Faculty Publications

There has been a recent recognition of the need to prepare PhD-trained scientists for increasingly diverse careers in academia, industry, and health care. The PhD Data Task Force was formed to better understand the current state of PhD scientists in the clinical laboratory workforce and collect up-to-date information on the training and certification of these laboratorians. In this report, we summarize the findings of the PhD Data Task Force and discuss the relevance of the data collected to the future supply of and demand for PhD clinical laboratory scientists. It is clear that there are multiple career opportunities for PhD …

Pd-L1 Checkpoint Inhibition And Anti-Ctla-4 Whole Tumor Cell Vaccination Counter Adaptive Immune Resistance: A Mouse Neuroblastoma Model That Mimics Human Disease., Priya Srinivasan, Xiaofang Wu, Mousumi Basu, Christopher Rossi, Anthony D Sandler

Pathology Faculty Publications

BACKGROUND: Adaptive immune resistance induces an immunosuppressive tumor environment that enables immune evasion. This phenomenon results in tumor escape with progression and metastasis. Programmed cell death-ligand 1 (PD-L1) expressed on tumors is thought to inhibit tumor-infiltrating lymphocytes (TILs) through programmed cell death 1 (PD1), enabling adaptive immune resistance. This study investigates the role of PD-L1 in both mouse and human neuroblastoma immunity. The consequence of PD-L1 inhibition is characterized in the context of an established whole tumor cell vaccine.

METHODS AND FINDINGS: A mouse model of neuroblastoma was investigated using an Id2 knockdown whole cell vaccine in combination with checkpoint …

How Household Healthcare Expenditures Redistribute Disposable Income? An Analysis Using Bangladesh Household Income And Expenditure Survey, 2010., Azahar Molla Md, Phd, Mph, Msc, Chunhuei Chi Mph, Sc.D.

Faculty & Staff Research and Creative Activity

Essential healthcare is a civil right. Payments toward healthcare is a moral compulsion, and no less strong than legal compulsion like income tax. Healthcare payments can redistribute disposable income. Redistribution may be vertical (from rich to poor or opposite) and horizontal (from men to women or from households without children to households with children). Health planners are interested in degrees to which redistribution occurs. In this paper, we aim to analyze how well different forms of healthcare payments in Bangladesh redistribute disposable income. Our data comes from Bangladesh Household Income and Expenditure Survey, 2010. Using the methods developed by Aronson …

Dental Student Skills In Matching Radiographs For Forensic Identification And In Forensic Knowledge, Mona Sivaneri, R Constance Wiener, Alcinda K. Trickett-Shockey, Christopher Waters

Faculty & Staff Scholarship

Purpose and Objectives. Dental and dental hygiene curricula must meet the core competencies established by the American Dental Association Commission on Dental Accreditation. As a result, there is limited time to expose students to the research and knowledge associated with additional important topics, such as dental forensics. The purpose of this research is to assess dental forensic knowledge and dental forensic radiographic skills of dental students. Methods. Ten radiographs of extracted permanent maxillary molars were exposed. One of the teeth was heat-altered to 600°F (315.6°C) for 15 minutes and then was radiographed. The 11 radiographs were presented to 152 dental …

Clinical Oral Health Recommended Care And Oral Health Self-Report, Nhanes, 2013-2014, R Constance Wiener, Nilanjana Dwibedi, Chan Shen, Patricia A. Findley, Usha Sambamoorthi

Faculty & Staff Scholarship

Purpose. The purpose of this study was to determine the concordance of self-reported responses to oral health questions versus clinically evaluated recommended need for oral healthcare by calibrated dentists to determine usefulness of the questions for epidemiological studies. We additionally examined other factors associated with concordant self-reports versus clinical evaluations. Materials and Methods. We used a cross-sectional study design with 4,205 participants, ages 30 years and above, who had complete oral health self-perception data and dental referral data in the NHANES 2013-14. Calibrated dentists completed clinical oral healthcare assessments. The assessments were dichotomized to (1) recommendation for immediate care and …