Medicine and Health Sciences Commons^™

Dynamic Functional Connectivity States Reflecting Psychotic-Like Experiences, A. D. Barber, M. A. Lindquist, P. Derosse, K. H. Karlsgodt

Journal Articles

© 2017 Society of Biological Psychiatry Background: Psychotic-like experiences (PLEs) are associated with lower social and occupational functioning, and lower executive function. Emerging evidence also suggests that PLEs reflect neural dysfunction resembling that of psychotic disorders. Methods: The present study examined dynamic connectivity related to a measure of PLEs derived from the Achenbach Adult Self-Report, in an otherwise-healthy sample of adults from the Human Connectome Project. A total of 76 PLE-endorsing and 153 control participants were included in the final sample. To characterize network dysfunction, dynamic connectivity states were examined across large-scale resting-state networks using dynamic conditional correlation and k-means …

Functional Activation During A Cognitive Control Task In Healthy Youth Specific To Externalizing Or Internalizing Behaviors, K. H. Karlsgodt, A. A. Bato, T. Ikuta, B. D. Peters, P. Derosse, P. R. Szeszko, A. K. Malhotra

Journal Articles

© 2017 Society of Biological Psychiatry Background: Externalizing behaviors are negative behaviors expressed outwardly, including rule breaking, aggression, and risk taking; internalizing behaviors are expressed inwardly, including depression, withdrawal, and anxiety. Such behavior can cause problems in early life and predict difficulties across the lifespan. There is evidence for a relationship between executive function and both externalizing and internalizing. However, although these behaviors occur along a spectrum, there is little neuroimaging research on this relationship in typically developing youth. Methods: We assessed 41 youth (10–19 years of age) using the Multi-Source Interference Task during functional magnetic resonance imaging and related …

Management Of Acute Pancreatitis In The Pediatric Population: A Clinical Report From The North American Society For Pediatric Gastroenterology, Hepatology And Nutrition Pancreas Committee, M. Abu-El-Haija, S. Kumar, J. A. Quiros, K. Balakrishnan, B. Barth, S. Bitton, J. F. Eisses, E. J. Foglio, V. Fox, V. D. Morinville, +14 Additional Authors

Journal Articles

No abstract provided.

Microarray Analysis Of Human Keratinocytes From Different Anatomic Sites Reveals Site-Specific Immune Signaling And Responses To Human Papillomavirus Type 16 Transfection, M. Israr, D. Rosenthal, L. Frejo-Navarro, J. Devoti, C. Meyers, V. R. Bonagura

Journal Articles

No abstract provided.

Delays To Care In Pediatric Lupus Patients: Data From The Childhood Arthritis And Rheumatology Research Alliance Legacy Registry., Tamar B Rubinstein, Wenzhu B Mowrey, Norman T Ilowite, Dawn M Wahezi, L. Abramson, E. Anderson, M. Andrew, N. Battle, J. Chang, B. Gottlieb, +90 Additional Authors

Journal Articles

OBJECTIVE: Prompt treatment for lupus is important to prevent morbidity. A potential barrier to early treatment of pediatric lupus is delayed presentation to a pediatric rheumatologist. To better understand factors contributing to delayed presentation among pediatric lupus patients, we examined differences in demographic and clinical characteristics of lupus patients within the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Legacy Registry with regard to time between symptom onset and presentation to a pediatric rheumatologist.

METHODS: We analyzed data from 598 CARRA Legacy Registry participants for differences between those who presented early (withinonset), between 1-3 months (typical presentation), with moderate delays (3-12 …

Psychopharmacological Treatment In The Raise-Etp Study: Outcomes Of A Manual And Computer Decision Support System Based Intervention, D. G. Robinson, N. R. Schooler, C. U. Correll, M. John, B. T. Kurian, P. Marcy, A. L. Miller, R. Pipes, M. H. Trivedi, J. M. Kane

Journal Articles

No abstract provided.

Exploration Of Treatment Matching Of Problem Drinker Characteristics To Motivational Interviewing And Non-Directive Client-Centered Psychotherapy, A. Kuerbis, J. Houser, S. Levak, S. Shao, J. Morgenstern

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No abstract provided.

Digital Peer-Support Platform (7cups) As An Adjunct Treatment For Women With Postpartum Depression: Feasibility, Acceptability, And Preliminary Efficacy Study, A. Baumel, A. Tinkelman, N. Mathur, J. M. Kane

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No abstract provided.

A Simulations Approach For Meta-Analysis Of Genetic Association Studies Based On Additive Genetic Model, M. John, T. Lencz, A. K. Malhotra, C. U. Correll, J. P. Zhang

Journal Articles

© 2018 Elsevier B.V. Meta-analysis of genetic association studies is being increasingly used to assess phenotypic differences between genotype groups. When the underlying genetic model is assumed to be dominant or recessive, assessing the phenotype differences based on summary statistics, reported for individual studies in a meta-analysis, is a valid strategy. However, when the genetic model is additive, a similar strategy based on summary statistics will lead to biased results. This fact about the additive model is one of the things that we establish in this paper, using simulations. The main goal of this paper is to present an alternate …

Comparing Daily Drivers Of Problem Drinking Among Older And Younger Adults: An Electronic Daily Diary Study Using Smartphones, A. Kuerbis, H. Treloar Padovano, S. Shao, J. Houser, F. J. Muench, J. Morgenstern

Journal Articles

© 2018 Elsevier B.V. Background: By 2030, numbers and proportions of older adults with substance-use problems are expected to increase. While risk factors for problem drinking in late life have been identified, it remains unknown whether these factors drive daily drinking among older problem drinkers. This study examined the daily drivers of drinking among problem drinkers, moderated by age, utilizing ecological momentary assessment (EMA). Method: Participants (N = 139), ages 20–73, received daily EMA online surveys completed via a smartphone prior to initiation of treatment. Multilevel modeling tested the moderating impact of age on within- and between-person relationships between drinking …

Dopamine Modulates Striatal Response To Reward And Punishment In Patients With Parkinson's Disease: A Pharmacological Challenge Fmri Study, M. Argyelan, M. Herzallah, W. Sako, I. Delucia, D. Sarpal, V. An, T. Fitzpatrick, A. A. Moustafa, D. Eidelberg, M. Gluck

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No abstract provided.

Dimensional Symptom Severity And Global Cognitive Function Predict Subjective Quality Of Life In Patients With Schizophrenia And Healthy Adults, P. Derosse, G. C. Nitzburg, M. Blair, A. K. Malhotra

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No abstract provided.

Study Of 300,486 Individuals Identifies 148 Independent Genetic Loci Influencing General Cognitive Function, G. Davies, M. Lam, S. E. Harris, J. W. Trampush, M. Luciano, P. Derosse, J. Yu, A. Malhotra, T. Lencz, I. J. Deary, +211 Additional Authors

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No abstract provided.

Association Between Psychosis In Elderly Patients With Alzheimer Disease And Impaired Social Cognition, J. Koppel, A. Sousa, M. L. Gordon, L. Giliberto, E. Christen, P. Davies

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No abstract provided.

Summary Of Key Issues Raised In The Technology For Early Awareness Of Addiction And Mental Illness (Teaam-I) Meeting, A. Baumel, J. Baker, M. L. Birnbaum, H. Christensen, M. De Choudhury, D. C. Mohr, F. Muench, D. Schlosser, N. Titov, J. M. Kane

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No abstract provided.

Computational Linguistic Analysis Applied To A Semantic Fluency Task To Measure Derailment And Tangentiality In Schizophrenia, L. Pauselli, B. Halpern, S. D. Cleary, B. Ku, M. A. Covington, M. T. Compton

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No abstract provided.

Genome-Wide Association Meta-Analysis In 269,867 Individuals Identifies New Genetic And Functional Links To Intelligence, J. E. Savage, P. R. Jansen, S. Stringer, K. Watanabe, J. W. Trampush, P. Derosse, T. Lencz, A. K. Malhotra, J. Yu, D. Posthuma, +107 Additional Authors

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No abstract provided.

The Age-Related Perfusion Pattern Measured With Arterial Spin Labeling Mri In Healthy Subjects, N. Zhang, M. L. Gordon, Y. Ma, B. Chi, J. J. Gomar, S. Peng, P. B. Kingsley, D. Eidelberg, T. E. Goldberg

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No abstract provided.

Digital Trajectories To Care In First-Episode Psychosis., M. L. Birnbaum, A. F. Rizvi, K. Faber, J. Addington, C. U. Correll, C. Gerber, A. C. Lahti, R. L. Loewy, D. H. Mathalon, J. M. Kane, +4 Additional Authors

Journal Articles

OBJECTIVE::The emphasis on reducing the duration of untreated psychosis (DUP) has highlighted complex barriers to accessing appropriate services. Internet and social media use by individuals with first-episode psychosis (FEP) was examined to explore how these platforms might be used to facilitate treatment initiation. METHODS::Participants ages 15-35 were interviewed with the Pathways to Care for Psychosis Questionnaire, an 81-item instrument designed to explore online activity during symptom emergence. RESULTS::Of 112 participants, 90% used the Internet and social media daily. The Internet was listed as the most used resource (62%) for information while symptoms were emerging. A minority (19%) shared concerns via …

Healthy Adolescent Performance With Standardized Scoring Tables For The Matrics Consensus Cognitive Battery: A Multisite Study., R. E. Smelror, K. N. Jørgensen, V. Lonning, I. Kelleher, M. Cannon, P. Derosse, A. K. Malhotra, K. H. Karlsgodt, O. A. Andreassen, I. Agartz, +6 Additional Authors

Journal Articles

The aim of this study was to develop standardized scores and scoring tables for test performance in healthy adolescents for the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Consensus Cognitive Battery (MCCB) for each year from 11 to 19 years of age, by sex, with T scores and percentile ranks.A total of 502 healthy participants (aged 11-19 years) from 7 cohorts from Ireland, Norway, Sweden, and United States, were included in this multisite study. Regression-predicted means for the MCCB tests, except the social cognition subtest, were calculated using the MCCB test scores as outcome variables and age, …

The Role Of Genetics In Advancing Precision Medicine For Alzheimer's Disease-A Narrative Review., Y. Freudenberg-Hua, W. Li, P. Davies

Journal Articles

Alzheimer's disease (AD) is the most common type of dementia, which has a substantial genetic component. AD affects predominantly older people. Accordingly, the prevalence of dementia has been rising as the population ages. To date, there are no effective interventions that can cure or halt the progression of AD. The only available treatments are the management of certain symptoms and consequences of dementia. The current state-of-the-art medical care for AD comprises three simple principles: prevent the preventable, achieve early diagnosis, and manage the manageable symptoms. This review provides a summary of the current state of knowledge of risk factors for …

Cytogenomic Identification And Long-Read Single Molecule Real-Time (Smrt) Sequencing Of A Bardet-Biedl Syndrome 9 (Bbs9) Deletion, J. Reiner, L. Pisani, W. Qiao, R. Singh, Y. Yang, L. Shi, W. A. Khan, R. Sebra, N. Cohen, S. A. Scott, +3 Additional Authors

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No abstract provided.

Pleural Effusion In A 7-Year-Old Child - With Unique Cells, N. Gupta, K. Das

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No abstract provided.

Cold-Inducible Rna-Binding Protein Activates Splenic T Cells During Sepsis In A Tlr4-Dependent Manner, A. C. Bolognese, A. Sharma, W. Yang, J. Nicastro, G. F. Coppa, P. Wang

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No abstract provided.

A Cold-Inducible Rna-Binding Protein (Cirp)-Derived Peptide Attenuates Inflammation And Organ Injury In Septic Mice, F. Zhang, M. Brenner, W. Yang, P. Wang

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No abstract provided.

Bleeding Risk And Thromboprophylaxis In Neurosurgical Patients After Emergency Procedures, J. Cagliani, G. Ritter, C. Nelson, D. Knobel, K. Hopkins, E. P. Molmenti, J. Nicastro, G. Coppa, R. Barrera

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No abstract provided.

Cirp Increases Icam-1(+) Phenotype Of Neutrophils Exhibiting Elevated Inos And Nets In Sepsis, Y. Ode, M. Aziz, P. Wang

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No abstract provided.

Activation Of Invariant Natural Killer T Cells Redirects The Inflammatory Response In Neonatal Sepsis, A. C. Bolognese, W. Yang, L. W. Hansen, A. Sharma, J. M. Nicastro, G. F. Coppa, P. Wang

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No abstract provided.

Neonatal Intestinal Dysbiosis In Necrotizing Enterocolitis, N. Denning, J. M. Prince

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No abstract provided.

Age And Other Risk Factors Influencing Long-Term Mortality In Patients With Traumatic Cervical Spine Fracture., M. Bank, K. Gibbs, C. Sison, N. Kutub, A. Paptheodorou, S. Lee, A. Stein, O. Bloom

Journal Articles

To identify clinical or demographic variables that influence long-term mortality, as well as in-hospital mortality, with a particular focus on the effects of age.Cervical spine fractures with or without spinal cord injury (SCI) disproportionately impact the elderly who constitute an increasing percentage of the US population.We analyzed data collected for 10 years at a state-designated level I trauma center to identify variables that influenced in-hospital and long-term mortality among elderly patients with traumatic cervical spine fracture with or without SCI. Acute in-hospital mortality was determined from hospital records and long-term mortality within the study period (2003-2013) was determined from the …