Medicine and Health Sciences Commons^™

Primary Anaplastic Pleomorphic Xanthoastrocytoma In Adults. Case Report And Review Of Literature, Usama Khalid Choudry, Saad Akhtar Khan, Amjad Qureshi, Muhammad Ehsan Bari

Section of Neurosurgery

Background: Pleomorphic xanthoastrocytoma (PXA) classified as a low Grade (WHO II) astrocytic neoplasm. It is known for its relatively favorable prognosis. It most commonly occurs in young adults. Malignant progression in PXA has been frequently reported since its first description in 1979; however, the presentation of a primary anaplastic PXA tumor with an aggressive clinical course in adults is rare especially in the later age group.
Case description: We present a case of primary anaplastic PXA in a 53 year old male that manifested with an early recurrence pattern at 9 weeks. Treatment performed was surgical excision and external beam …

Cerebral Venous Sinus Thrombosis With Tentorial Haemorrhagic Infarctions In Combined Proteins Deficiency And Hyperhomocysteinemia Treated With Anticoagulation- Limited Evidence With Good Results: A Case Report, Muhammad Waqas, Muhammad Akbar Baig, Shahan Waheed Aga Khan University, Munawar Khursheed

Department of Emergency Medicine

We are presenting a case of a 40-year-old lady who presented with sudden loss of consciousness. Computed Tomography scan of her brain revealed the presence of blood in her sub-arachnoid space on her right hemisphere, cerebral oedema, and cerebral venous sinus thrombosis later magnetic Resonance Imaging revealed extensive cerebral venous sinuses thrombosis formation associated with supra and infra-tentorial haemorrhages. Elevated levels of plasma homocysteine and deficient levels of protein S. Patient was anticoagulated with warfarin and INR was monitored. She recovered successfully with no complication of anticoagulation observed. The use of anticoagulation had a favourable outcome in our …

Small Bowel Ascaris Infestation: A Diagnostic Challenge, Muhammad Waqas Khan, Sanniya Khan Ghauri

Department of Emergency Medicine

Ascariasis is a common infestation in developing countries where there is poor hygiene. A majority of the cases are asymptomatic, with a few cases presenting with mild abdominal pain and nutritional deficiencies in the long term. Here we present a case of a young boy who presented as a diagnostic dilemma, with signs of acute intestinal obstruction without any supporting radiological evidence. A barium study revealed the presence of low-burden Ascaris infestation that was managed medically.

Alzheimer's Disease: Knowledge Of Early Detection, Risk Factors, And Treatment, Anna H. Smith, Katlyn S. Spadino

All Electronic Theses and Dissertations

Alzheimer's disease causes a progressive and irreversible decline in cognitive functioning. There are many people living with this disease, and the prevalence is expected to triple between 2010 and 2050. Many members of society are affected through either a personal diagnosis or the diagnosis of a family member. There have been numerous studies outlining risk factors, signs and symptoms, and treatments for this disease, but it is unknown if this has translated to greater public awareness. This study aims to assess the general adult population's knowledge of Alzheimer's disease. The participants are 35 to 70 years old and live in …

The Determination Of The Needs Of The Families With A Mentally Handicapped Child According To Their Mood, Esat Sanli, Yasar Barut

Khazar Journal of Humanities and Social Sciences

Numerous domain experts who provide service to disabled individuals have focused on only disabled children for many years and the family has not generally dwelled on during this time. But today, it is more clearly seen that meeting the needs of family means meeting the needs of the child. The families may reveal different sensual reactions according to their children’s special condition. In case it is known whether these sensual reactions affect their requirement areas and the intensity of their needs, the quality of the given assistance can be increased.This research was made to determine which requirement areas are affected …

Improved In Vitro Fertilization Via Zona Thinning., Jax Mice Clinical And Research Services

Faculty Research 2016

Mouse in vitro fertilization (IVF) can be used to rapidly expand mouse lines from a few males that carry the desired genotype or to maintain strains with poor breeding efficiency. This guide describes a detailed method using acidified Tyrode solution to open the zona pellucida, and increase the fertilization capacity of frozen mouse sperm. The embryos generated are suitable for transfer into pseudopregnant recipent females, culture or cryopreseration.

Microbiome-Gut-Brain Axis: A Pathway For Improving Brainstem Serotonin Homeostasis And Successful Autoresuscitation In Sids-A Novel Hypothesis., Vijayakumar Praveen, Shama Praveen

Articles, Abstracts, and Reports

Sudden infant death syndrome (SIDS) continues to be a major public health issue. Following its major decline since the "Back to Sleep" campaign, the incidence of SIDS has plateaued, with an annual incidence of about 1,500 SIDS-related deaths in the United States and thousands more throughout the world. The etiology of SIDS, the major cause of postneonatal mortality in the western world, is still poorly understood. Although sleeping in prone position is a major risk factor, SIDS continues to occur even in the supine sleeping position. The triple-risk model of Filiano and Kinney emphasizes the interaction between a susceptible infant …

Earle A. Chiles Research Institute 2015 Year In Review, Earle A. Chiles Research Institute

Articles, Abstracts, and Reports

2015 Year in Review highlights translational immunotherapy research from the Earle A. Chiles Research Institute at Providence Cancer Center.

The Earle A. Chiles Research Institute is a world-class research facility located within Providence Cancer Center in Portland, Ore. Home to a team of internationally recognized scientists and physicians, the main area of investigation is cancer immunotherapy.

Modulation Of Gamma And Alpha Spinal Motor Neurons Activity By Trans-Spinal Direct Current Stimulation: Effects On Reflexive Actions And Locomotor Activity, Zaghloul Ahmed

Publications and Research

Spontaneous and evoked spinal activities interact to set the characteristics of emergent motor responses. Gamma motor neurons have feedforward and feedback functions in motor control, which are crucial for transforming motor commands into action. Meanwhile, the intrinsic excitability and functional connectivity of alpha motor neurons determine the accuracy of actions. In this study, we investigated the effects of trans-spinal direct current stimulation (tsDCS) on spontaneous and cortically evoked activity of well-isolated single units of gamma and alpha motor neurons in mice. We also investigated the effects of tsDCS on reflexive and locomotor actions. In general, motor neurons showed increased responses …

Knowledge-Based Tweet Classification For Disease Sentiment Monitoring, Xiang Ji, Soon Ae Chun, James Geller

Publications and Research

Disease monitoring and tracking is of tremendous value, not only for containing the spread of contagious diseases but also for avoiding unnecessary public concerns and even panic. In this chapter, we present a near real-time sentiment analysis service of public health-related tweets. Traditionally, it is impossible for humans to effectively measure the degree of public health concerns due to limited resources and significant time delays. To solve this problem, we have developed a computational intelligence approach for Epidemic Sentiment Monitoring System (ESMOS) to automatically analyze the disease sentiments and gauge the Measure of Concern (MOC) expressed by Twitter users. More …

Peculiarities Of The Super-Folder Gfp Folding In A Crowded Milieu, Olesia V. Stepanenko, Olga V. Stepanenko, Irina M. Kuznetsova, Vladimir N. Uversky, Konstantin K. Turoverov

Molecular Medicine Faculty Publications

The natural cellular milieu is crowded by large quantities of various biological macromolecules. This complex environment is characterized by a limited amount of unoccupied space, limited amounts of free water, and changed solvent properties. Obviously, such a tightly packed cellular environment is poorly mimicked by traditional physiological conditions, where low concentrations of a protein of interest are analyzed in slightly salted aqueous solutions. An alternative is given by the use of a model crowded milieu, where a protein of interest is immersed in a solution containing high concentrations of various polymers that serve as model crowding agents. An expected outcome …

The National Exercise Referral Framework, Catherine B. Woods, Noel Mccaffrey, Brona Furlong, Lorraine Fitzsimons D'Arcy, Maire Murphy, Michael Harrison, Liam Glynn, John O'Riordan, Biddy O'Neill, Sinead Jennings, Caroline Peppard

Reports

A 2013 Review of the HSE funded GP Exercise Referral Programme (GPERP) highlighted the need for a new National Exercise Referral Framework (NERF). The evidence suggests that exercise referral is an effective targeted health intervention for specific patients and with the increasing prevalence of chronic disease it is imperative that we examine, design and progress the implementation of scalable, sustainable evidence-based, interventions, integrated across the health system to improve the health and wellbeing of the population. The development of this proposed National Exercise Referral Framework, commissioned by Health Promotion and Improvement, was led by DCU involving a multi-disciplinary Working Group …

Introduction - Fact Patterns From Anonymous Closed Medical Liability Cases, Steven E. Pegalis J.D., Irwin R. Merkatz M.D.

Anonymous Closed Medical Liability Cases

Introduction to the anonymous closed medical liability cases. New York Law School's Patient Safety Project was granted special permission by the New York State Office of Court Administration to obtain and make available these closes cases for the purpose of stimulating "diligent conversations" about the fact patterns so that the discussions can positively impact the safety processes and reduce the future incidence of patient injury.

Ada News Convention Daily - 2016 Day 3, American Dental Association, Publishing Division

ADA News

The ADA News Daily (also called the ADA News Convention Daily) is a special edition of the ADA News published each day during American Dental Association Annual Sessions.

Towards 3d In Vitro Models For The Study Of Cardiovascular Tissues And Disease, Claire M. Brougham, Alan J. Ryan, Carolina D. Garciarena, Steve W. Kerrigan, Fergal J. O'Brien

Articles

The field of tissue engineering is developing biomimetic biomaterial scaffolds which are showing increasing therapeutic potential for the repair of cardiovascular tissues. However, a major opportunity exists to use them as 3D in vitro models for the study of cardiovascular tissues and disease in addition to drug development and testing. These in vitro models can span the gap between 2D culture and in vivo testing thus reducing cost, time and the ethical burden of current approaches. This review outlines the progress to date and requirements for the development of ideal in vitro 3D models for blood vessels, heart valves and …

Harmful Or Helpful? Direct To Consumer Advertising, Sally A. Kiss

The Graduate Review

Policy change in 1997 by the Food and Drug Administration made the United States only one of two countries to allow direct-to-consumer advertising (DTCA). DTCA refers to the promotion of prescription medications through media directly to consumers as opposed to distribution of information only medical professionals. Supporters argue that DTCA educates consumers and helps them to make more informed decisions about their health care. On the other side, opponents argue that it leads to otherwise healthy people believing they are sick, thereby increasing profits for pharmaceutical companies. After reviewing the history of DTCA and literature demonstrating the pros and cons …

Veterans Treatment Courts: Pure Pretextualism Or A Venue For Veterans' Needs?, John William Erickson Jr.

School of Criminal Justice Theses and Dissertations

The intended goals of Veterans Treatment Courts (VTCs) are consistent with what drove the establishment of Drug Courts and Mental Health Courts in the ‘90s. That is, a recognition that the traditional criminal justice system is geared toward punitive court dispositions; not the unique characteristics of addicts and/or mental health defendants (G. Lerner-Wren, personal communication, January 12, 2015). For example, In Dade County, Florida, a former U.S. Attorney, then the Dade County State Attorney, recognized that reform was necessary to avoid the criminalization of drug addiction; given the high prevalence of cocaine abuse. Today, U.S. Military Veterans returning from Iraq …

Il-15 Mediates Mitochondrial Activity Through A Ppar𝛿-Dependent-Ppar𝛼-Independent Mechanism In Skeletal Muscle Cells, Shantaé M. Thornton, James E. Krolopp, Marcia J. Abbott

Health Sciences and Kinesiology Faculty Articles

Molecular mediators of metabolic processes, to increase energy expenditure, have become a focus for therapies of obesity. The discovery of cytokines secreted from the skeletal muscle (SKM), termed “myokines,” has garnered attention due to their positive effects on metabolic processes. Interleukin-15 (IL-15) is a myokine that has numerous positive metabolic effects and is linked to the PPAR family of mitochondrial regulators. Here, we aimed to determine the importance of PPAR𝛼 and/or PPAR𝛿 as targets of IL-15 signaling. C2C12 SKM cells were differentiated for 6 days and treated every other day with IL-15 (100 ng/mL), a PPAR𝛼 inhibitor (GW-6471), a PPAR𝛿 …

Chronic Low Back And Pelvic Girdle Pain 10 Months Post-Partum: A Case Study, Heidi Hansen

Physical Therapy Scholarly Projects

Background and Purpose

Due to the increase in relaxin hormone during pregnancy women often experience increases in joint and ligament laxity. The result of this increase in laxity during or after pregnancy can lead to problems with postural and/or gait abnormalities, diastasis recti (separation between left and right side of rectus abdominus muscle) and pain, specifically, low back and pelvic girdle pain. Activities of daily living are often impacted because of these problems. The purpose of this case study is to highlight some of the principal issues and therapeutic options for postpartum women as presented through the case of one …

A Case Report: Cerebrovascular Accident, Kayla Andreasen

Physical Therapy Scholarly Projects

Background: Cerebrovascular accidents (CVAs) are one of the leading disabilities in America resulting in mild to severe functional limitations. These functional limitations can be addressed in physical therapy (PT).

Purpose: The purpose of this case report is to review background, treatments, physical therapy interventions and outcomes of a patient with a sub-acute stroke, treated in an inpatient setting.

Case Description: The patient was a 70 year old male with a severe ischemic CVA following surgery to repair an abdominal aortic aneurysm. The patient was transferred to a nursing home to recover and returned to the hospital 5 …

Timed Up And Go (Tug) Test And Its Effectiveness In Fall Risk Screening And Assessing The Success Of The Stepping On Program In Fall Prevention, Eric Estes

Physical Therapy Scholarly Projects

Background: The Timed Up and Go (TUG) test is a functional assessment that has been proven effective at identifying individuals at a risk for falls. The Stepping On program aims toward fall prevention through education, exercise, and shared experiences among participants. With previous evidence displaying positive, significant results for Stepping On and the TUG, a utilization of this assessment to track participants' progress in the course is indicated.

Objective: The purpose of this study was 1) to determine if the Stepping On program displays a decrease in fall risk through the application of the TUG and 2) if …

An Athlete And Patellar Tendinosis: A Case Study, Lisa Monson

Physical Therapy Scholarly Projects

Background and Purpose: Patellar tendinosis is a pathology among young athletes with research being conducted about it every year. This single patient case study goes through the examination and evaluation leading to a diagnosis along with the treatment, outcomes, and discussion of this patient and patients recorded in other research studies.

Case Description: This case report was conducted on a 15 year old male presenting with left patellar tendinosis. Treatment lasted eight weeks with emphasis on eccentric quadriceps exercises and return to sport activities.

Outcomes: The results of conservative treatment for this young athlete were successful. The …

The Trials Of Transverse Myelitis: A Case Study, Catherine Heggie

Physical Therapy Scholarly Projects

Background and Purpose: Idiopathic acute transverse myelitis (ATM) is an inflammation in the spinal cord that develops suddenly. In the span of a day, an individual can lose all motor control. Most of the time the motor impairment is not permanent and strength can return as the inflammation dies down. However the physical rehabilitation component of recovery is remarkably unstudied.

Case Description: This case report details the hospital stay of a young man with ATM from the perspective of his physical therapists. When evaluated, the patient had only trace (1/5) muscle strength in some of his extremities.

Intervention …

A Case Report: Paraplegia Secondary To A Failed Lumbar Fusion, Nicole Jefferson

Physical Therapy Scholarly Projects

Background and Purpose: Low back pain is one of the most common symptoms that individuals experience around the world. The total cost for low back pain in the United States are over a billion dollars per year. Although an ample amount of research has been done looking into the epidemiology and treatment of back pain, many people are still suffering from lack of effective treatments.

Case Description: The purpose of this case report was to describe a patient who was post lumbar surgery to evaluate and examine the benefits of physical therapy. The patient in this case report was …

Evaluating The Effectiveness Of Therapy Interventions On A Patient Who Underwent A Spinal Thoracic Abscess Removal: A Case Report, Natalie Gleason

Physical Therapy Scholarly Projects

Background and Purpose: An epidural abscess comes from an infection of the central nervous system. In this patient's case he had a spinal thoracic abscess removed that was pushing against his spinal cord. The purpose of this case report is to assess the patient's outcome after therapy implementation. The goal was to see how effective the interventions were for the patient.

Case Description: The patient was a 63-year-old male who underwent surgery to remove a thoracic epidural abscess that was causing paraplegia. He was coming to outpatient physical therapy 2 months before I started my clinical treating him. …

The Activities-Specific Balance Confidence Scale And Its Use In Assessing Confidence In Elderly Community-Dwellers Attending The Stepping On Program, Sierra Heeren

Physical Therapy Scholarly Projects

Introduction: Stepping On is a 7-week comprehensive fall program aimed at reducing falls for the community-dwelling elderly. Participants are educated on balance and strengthening exercises, and the influence medications, visions, inclement weather, etc. has on safety and falls.

Purpose: The main purpose of this study is to utilize the Activities-specific Balance Confidence scale (ABC) and survey results to determine if attendance of Stepping On improves balance confidence. Secondly, this research sought out to discover if increased balance confidence relates to decreased fall risk.

Methods: Participants of this were included 13 individuals initially (with one participant joining the …

Effectiveness Of Cognitive Timed Up And Go Test In Assessing Fall Risk In The Older Adult, Cory Sailer

Physical Therapy Scholarly Projects

Introduction: Falls are a common and devastating injury for the older adult. Fall programs, such as the Stepping On program, are used to educate, strengthen, and sequentially reduce the number of falls its participant's endure. The Stepping On program is a multifactorial fall prevention program that addresses: balance and strength exercises, visual impairments, home modifications, pharmacologic effects, and even assistive devices. One aspect that has been found to be influential on fall risk is cognition, in particular executive functioning during ambulation.

Purpose: The purpose of this study was to screen participants of the Stepping On program for unknown …

Evaluation Of Fall Risk, Functional Mobility And Quality Of Life Changes Of Community-Dwelling Older Adults With Parkinson's Disease Participating In A Community Exercise Program, Gabrielle Dahl, Elizabeth Hermanson, Laura Nelson, Kayla Selinger

Physical Therapy Scholarly Projects

Purpose/Hypothesis: Falls are evident in the older population and are a common and disabling feature of Parkinson Disease (PO). The benefits of activity are well known to decrease balance deficits and increase overall quality of life in the older adult population. In addition highly challenging exercises have been suggested to increase neuroplasticity in individuals with PD. The effect of challenging exercises on clinical outcomes in a structured Physical Therapy setting is documented in literature; however, the effect of a community based program is not well documented. Our pilot study examined the effect of a community exercise program on improving …

Effectiveness Of The 30 Second Chair Stand Test In Reducing The Fall Risk Of Community Dwelling Older Adults Participating In The Stepping On Program, Corissa Kruse

Physical Therapy Scholarly Projects

Stepping On is a seven week fall prevention program that utilizes education and exercise. The purpose of this study is to see if the participants of Stepping On can show a decrease in fall risk through the use of the 30 Second Chair Stand Test (30sCST), a functional assessment tool used to assess fall risk. This study looked at a group of 14 females (M=87 y/o) at an assisted living facility, who met the program's qualifications (community dwelling individuals and ≥ 65 y/o) and attended the Stepping On program. Only eight participants were tested using the 30sCST at Week 1 …

Cobalt Use And Regulation In Horseracing: A Review, K. Brewer, G. Maylin, C. K. Fenger, Thomas Tobin

Veterinary Science Faculty Publications

Cobalt, atomic weight 58.9, is a metallic element and environmental substance found in the animal in microgram quantities, predominantly as vitamin B12, but is also a component of at least one mammalian enzyme unassociated with B12. Cobalt is a required trace mineral and has long been administered as a dietary supplement to humans and animals. Cobalt deficiency outside of its requirement in vitamin B12 has not been reported in humans. The administration of cobalt salts was once standard treatment for anaemia in humans, owing to its ability to stimulate red blood cell synthesis. Elemental cobalt acts by stabilising hypoxia inducible …