Medicine and Health Sciences Commons^™

Analysis Of Slot Height Accuracy And Precision Of Stainless Steel Orthodontic Brackets Manufactured By Metal Injection Molding And Computer Numerical Control Milling Using Stereomicroscopy, Mark D. Angeloni

MUSC Theses and Dissertations

Objective: It is the objective of this study to determine the dimensional accuracy and precision that is achievable by two manufacturing methods of stainless steel orthodontic brackets, CNC milling and metal-injection molding. To determine this, we propose the following specific aims: 1) to determine the actual dimensions of the slots in both milled and MIMed orthodontic bracket and standard deviations. 2) Using mathematical models to determine if the dimensional difference, if one exists, between milled and MIMed brackets will result in a difference in third order tooth movement (torque) realization (effective torque vs nominal torque). The actual bracket slot dimensions …

Social Disparities In Exposure To Point-Of-Sale Cigarette Marketing, Mohammad Siahpush, Evi A. Farazi, Jungyoon Kim, Tzeyu L. Michaud, Aaron Yoder, Ghada Soliman, Melissa Tibbits, Minh N. Nguyen, Raees A. Shaikh

Journal Articles: Epidemiology

While most ecological studies have shown that higher levels of point-of-sale (POS) cigarette marketing are associated with larger proportions of residents from lower socioeconomic and minority backgrounds in neighborhoods, there are no studies that examine individual-level social disparities in exposure to POS cigarette marketing among smokers in the United States. Our aim was to examine these disparities in a Midwestern metropolitan area in the United States. We conducted a telephone survey to collect data on 999 smokers. Cigarette marketing was measured by asking respondents three questions about noticing advertisements, promotions, and displays of cigarettes within their respective neighborhoods. The questions …

Angiotensin Ii-Induced Hypertension Is Attenuated By Overexpressing Copper/Zinc Superoxide Dismutase In The Brain Organum Vasculosum Of The Lamina Terminalis., John P. Collister, Heather Taylor-Smith, Donna Drebes, David Nahey, Jun Tian, Matthew C. Zimmerman

Journal Articles: Cellular & Integrative Physiology

Angiotensin II (AngII) can access the brain via circumventricular organs (CVOs), including the subfornical organ (SFO) and organum vasculosum of the lamina terminalis (OVLT), to modulate blood pressure. Previous studies have demonstrated a role for both the SFO and OVLT in the hypertensive response to chronic AngII, yet it is unclear which intracellular signaling pathways are involved in this response. Overexpression of copper/zinc superoxide dismutase (CuZnSOD) in the SFO has been shown to attenuate the chronic hypertensive effects of AngII. Presently, we tested the hypothesis that elevated levels of superoxide (O2 (∙-)) in the OVLT contribute to the hypertensive effects …

The Mixed Lineage Kinase-3 Inhibitor Urmc-099 Improves Therapeutic Outcomes For Long-Acting Antiretroviral Therapy., Gang Zhang, Dongwei Guo, Prasanta Dash, Mariluz Araínga, Jayme Wiederin, Nicole A. Haverland, Jaclyn Knibbe-Hollinger, Andrea Martinez-Skinner, Pawel Ciborowski, Val S. Goodfellow, Tadeusz A. Wysocki, Beata J. Wysocki, Larisa Y. Poluektova, Xin-Ming Liu, Joellyn Mcmillan, Santhi Gorantla, Harris A. Gelbard, Howard Gendelman

Journal Articles: Pharmacology & Experimental Neuroscience

During studies to extend the half-life of crystalline nanoformulated antiretroviral therapy (nanoART) the mixed lineage kinase-3 inhibitor URMC-099, developed as an adjunctive neuroprotective agent was shown to facilitate antiviral responses. Long-acting ritonavir-boosted atazanavir (nanoATV/r) nanoformulations co-administered with URMC-099 reduced viral load and the numbers of HIV-1 infected CD4+ T-cells in lymphoid tissues more than either drug alone in infected humanized NOD/SCID/IL2Rγc-/- mice. The drug effects were associated with sustained ART depots. Proteomics analyses demonstrated that the antiretroviral responses were linked to affected phagolysosomal storage pathways leading to sequestration of nanoATV/r in Rab-associated recycling and late endosomes; sites associated with viral …

Rnaseq Analyses Identify Tumor Necrosis Factor-Mediated Inflammation As A Major Abnormality In Als Spinal Cord, David G. Brohawn, Laura C. O'Brien, James P. Bennett Jr.

Physiology and Biophysics Publications and Presentations

ALS is a rapidly progressive, devastating neurodegenerative illness of adults that produces disabling weakness and spasticity arising from death of lower and upper motor neurons. No meaningful therapies exist to slow ALS progression, and molecular insights into pathogenesis and progression are sorely needed. In that context, we used high-depth, next generation RNA sequencing (RNAseq, Illumina) to define gene network abnormalities in RNA samples depleted of rRNA and isolated from cervical spinal cord sections of 7 ALS and 8 CTL samples. We aligned >50 million 2X150 bp paired-end sequences/sample to the hg19 human genome and applied three different algorithms (Cuffdiff2, DEseq2, …

Validity Of Intracerebral Haemorrhge Score In Predicting Prognosis Of Hemorrhagic Stroke, Muhammad Aslam Rind, Muzaffar Sheikh, Manzoor Ali Lakhair, Maria Nazir, Sadia Sheikh

Pakistan Journal of Neurological Sciences (PJNS)

Stroke is a common neurological disorder, leading cause of death and disability worldwide. Intra cerebral hemorrhage comprises of 10-15% of all strokes but associated with high risk of morbidity and mortality than cerebral infraction .The ICH Score is a good prognostic tool calculated very easily, when it is used to predict 30 day morality. Objective:To determine the validity of Intracerebral hemorrhagic score in predicting prognosis (adverse outcome or death) in patients of hemorrhagic stroke.Material&Methods:This case series study was carried out at department of medicine Liaquat medical University Hospital Jamshoro and Hyderabad from June 16th 2012 to December 15th 2012.Eighty nine …

Demographic Profile And Associations Of Dialysis Dependent Chronic Kidney Disease Patients In Federal Capital Of Pakistan., Ali Zohair Nomani, Mansoor Iqbal, Faisal Bacha, Shahzad Mughal, Haris Majid Rajput, Mazhar Badshah, Rao Suhail Yasin Khan

Pakistan Journal of Neurological Sciences (PJNS)

Depression is quite prevalent in patients with chronic kidney disease. Knowing the frequency of depression in such patients and its association with different variables may be helpful in devising strategies for better and timely management of such patients in our setup. Materials and methods: This cross sectional study was conducted by recruiting 315 patients of either gender, ≥ 18 years of age with chronic kidney disease (CKD) and receiving care at Pakistan Institute of Medical Sciences, Islamabad. Patients were divided into two groups; group A: pre-dialysis and group B: dialysis (End Stage Renal Disease). Prevalence of depression in CKD and …

Lung Functions Among Patients With Pulmonary Tuberculosis In Dar Es Salaam – A Cross-Sectional Study, Mohamed Manji, Grace Shayo, Simon Mamuya, Rose Mpembeni, Ahmed Jusabani, Ferdinand Mugusi

Faculty of Health Sciences, East Africa

Background

Approximately 40–60 % of patients remain sufferers of sequela of obstructive, restrictive or mixed patterns of lung disease despite treatment for pulmonary tuberculosis (PTB). The prevalence of these abnormalities in Tanzania remains unknown.

Methods

A descriptive cross-sectional study was carried out among 501 patients with PTB who had completed at least 20 weeks of treatment. These underwent spirometry and their lung functions were classified as normal or abnormal (obstructive, restrictive or mixed). Logistic regression models were used to explore factors associated with abnormal lung functions.

Results

Abnormal lung functions were present in 371 (74 %) patients. There were …

A Century Of Morphological Variation In Cyprinidae Fishes, Stephen J. Jacquemin, Mark Pyron

Biological Sciences Faculty Publications

Background

Aquatic habitats have been altered over the past century due to a variety of anthropogenic influences. Ecomorphology is an area of aquatic ecology that can both directly and indirectly assess the effects of habitat alterations on organisms. However, few studies have explored long term trends in morphological variation. Long term changes in morphology can potentially impact niche and ultimately contribute to organismal success and the ecosystem. Therefore, in this study we assessed long term morphological variation with body size, sex, time, and hydrology using museum collections of five species of Cyprinidae (Minnows) from lentic and lotic systems over the …

Historical Marker Commemorating Founding Of Medical Library Association In Philadelphia Unveiled!, Daniel G. Kipnis, Msi

Academic Commons and Scott Memorial Library Staff Papers and Presentations

On Wednesday, November 4, 2015, the Pennsylvania Historical and Museum Commission, MLA and the Philadelphia Regional Chapter of MLA unveiled a historical marker commemorating MLA's founding in 1898.

Exercise Beliefs During Pregnancy In A Predominantly Low-Income, Urban Minority Population, Lindsay S. Mcalpine, Msiii, Christine A. Marschilok, Pgy-3, Amber S. Maratas, Md, Jeremy D. Close, Md

CwiC Posters

In 2002, and reaffirmed in 2009, The American College of Obstetricians and Gynecologists recommended that healthy pregnant women exercise for at least thirty minutes most days of the week. Exercise during a healthy pregnancy is safe and has many maternal and fetal benefits. Identified benefits include management of weight gain, improvement in mood, and preparation for labor. Previous research has evaluated women’s beliefs and practices of exercise in pregnancy, but it has focused on affluent, ethnic majority populations. This survey study was performed to assess beliefs about exercise in pregnancy in a predominantly low-income, urban minority population.

Evaluation Of Guideline-Recommended Combined Antiretroviral Treatment Regimens In Commercially-Insured Patients Living In The United States Between 2007 And 2009, Joye Brigitte Allen

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Background: Randomized clinical trials of combination antiretroviral therapy (cART) inform the use of specific antiretrovirals (ARV) and their combination for optimizing therapeutic efficacy. It is critical that patients have access to and receive the most appropriate first-line treatment.

Objective: To examine factors that impact receiving initial guideline-recommended cART within a cohort of commercially insured patients in the United States (US)

Research Design: A population based cohort study.

Data Sources: A secondary administrative insurance claims database.

Subjects: Employed, commercially insured individuals with HIV who were continuously eligible for insurance coverage from January 2007 through December 2009 and received a new ARV …

Undiagnosed Pulmonary Obstruction And Restriction And Dust Exposure: Pilot Investigations Examining The Relationship Among Agricultural Workers, Caroline E. Holsinger

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Chronic obstructive pulmonary disease (COPD) is a progressive disease that is characterized by limited airflow.1 In the United States (U.S.) alone, COPD is the third leading cause of death.2,3 While smoking remains the strongest risk factor for COPD, 20 percent of patients who die from COPD have never smoked.5–7 The American Thoracic 3 Society showed that about 15% of COPD cases might be attributable to workplace exposure.8 Agricultural dust exposure has long been recognized as a cause of decreased respiratory function, and exposures to both forms of dust may exacerbate other important risk factors of COPD and lead to the …

An Assessment Of Workplace Injury In Kentucky’S Commercial Logging Industry, Logan Ray

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Objective: To identify demographic, operational, and task-related characteristics associated with increased frequency and severity of injury in Kentucky’s commercial loggers.

Methods: Kentucky Master Loggers attending mandatory continued education courses completed a survey tool eliciting demographic and operational characteristics of their companies, and details of any on-site injury in the years 2012 through 2015 that led to medical costs, lost days or time, and/or decreased production. Associations to injury frequency and injury severity were assessed using logistic regression analysis.

Results: 86 Kentucky Master Loggers representing 66 of Kentucky’s 120 counties reported 33 accounts of non-fatal logging injury. Master Loggers were full-time …

Cross Sectional Analysis Of Patients With Alpha-1 Antitrypsin Deficiency Enrolled In A Disease Management And Prevention Program, Jordan T. Perkins

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Background: Alpha-1 antitrypsin deficiency is a heritable genetic condition that is largely underdiagnosed and has been estimated to affect 1 out of every 5,000-7,000 people in North America. The condition is characterized by a decrease in the production or activity of the alpha-1 antitrypsin protein, increasing risk for chronic lung or liver inflammation, that may lead to disease. Currently, there is no cure for the condition and augmentation therapy, which replaces the lost protein, has shown mixed results, meaning preventive measures taken by the patient are a large component of the prescribed treatment. Thus, patients with the condition are strongly …

The Association Between Latent Tuberculosis Infection And Diabetes Mellitus Control In The United States, Whitney L. Remy

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Rationale: Diabetes mellitus (DM) is recognized as a common comorbid condition for tuberculosis (TB). Those with comorbid conditions are more likely to develop active TB, to have trouble with treatment, and to have more severe symptoms.

Objective: To measure the prevalence and distribution of latent tuberculosis infection (LTBI) and DM control in the United State and test their association when measured by tuberculin skin test (TST) or QuantiFERON®-TB Gold In-Tube blood test (QFT-GIT) and by HbA1c, respectively. Literature Review: One-third of the world population is infected with TB. Ten percent of TB cases worldwide are linked to diabetes mellitus. Studies …

Occupational Risks For Recent Asthma Episodes Among Adults, Molly Reese

Theses and Dissertations--Public Health (M.P.H. & Dr.P.H.)

Objective

Asthma affects more than 37 million Americans at some point in their lives, making it one of the most common, but costly chronic conditions. There are many known risk factors for asthma, but additional research on environmental and occupational factors is needed to better understand the association between these variables and asthma. This study investigates the associations between occupational exposures and asthma episodes among adults.

Methods

Data was obtained from the 2011-2013 Behavioral Risk Factor Surveillance System (BRFSS) Asthma Call-back Survey for adults. There was a final study population of 11,408 participants after the exclusion criteria were applied. The …

Bullying In Senior Living Facilities: A Qualitative Study, Felicia Jo Vandenest

All Graduate Theses, Dissertations, and Other Capstone Projects

Resident-to resident bullying has attracted some attention in the popular press and is well-known to many who work with seniors in long-term care facilities. However, this is very little empirical literature that has address the topic of "senior bullying". The aim of the proposed qualitative study is to better understand the phenomenon of resident-to-resident bullying from the perspective of staff who work in long-term care facilities. Staff members (n=45) responded to a combination of open- and close-ended interview questions regarding their observations of senior-to-senior bullying. Results indicate that the majority of staff members (98%) have observed resident-to-resident bullying within senior …

An Analysis Of Western Medicine Mistrust Among Selected African Immigrant Women In Minnesota, Wanjiru Julie Gicheru

All Graduate Theses, Dissertations, and Other Capstone Projects

Mistrust in Western medicine contributes to many individuals noncompliance, avoidance of treatment, or seeking other outlets or alternative treatments. As a result, health outcomes are poorer for those individuals who proactively avoid treatment from health care professionals. Factors that contribute to racial and ethnic health disparities have been accounted for in research and literature; however, immigrant health disparities have not been well studied. The primary purpose of this study was to analyze factors that contributed to Western medicine mistrust among selected African immigrant women in Minnesota. Participants were recruited from community centers, churches, and by snowball sampling within the Minneapolis-Saint …

Empower Me! Don’T Abuse Me”: An Occupational Therapy Approach To Violence Prevention, Canique Brown

Occupational Therapy Doctorate Capstone Projects

Background: Domestic violence is becoming more prevalent among African American female ages 16 to 24 years. Occupational therapists are trained health care professionals that are able to work with these individuals. This is topic has limited research within the field of occupational therapy; hence, this Capstone Project was conducted with nine adolescent female African American women ages from a local church in the West Palm Beach, Florida, area.

Purpose: The purpose of this study was to test the effectiveness of an occupational therapy violence prevention program for young African American females ages 16 to 24, the age at …

Container Culture: An Educational Program To Reduce The Overuse, Ashleigh R. Toy

Occupational Therapy Doctorate Capstone Projects

The increased pace of society, improved safety, mobility and the need for parent efficiency have created a vast market of infant products to meet these demands: car seats that clip in and out of everything from the car to the grocery cart, jumpers, walkers, exersaucers, swings, bouncers and bumbos. These infant equipment products are helpful and can be beneficial if used effectively, however, the problem synthesized from the literature and clinical observation is that these containers designed to support safety and mobility are being overused causing a decrease in tummy time and human interaction which is leading to delays in …

Assesement Of An Occupation-Based Practice Module For An Occupational Therapy Assistant Curriculum, Mary Kim Qualls

Occupational Therapy Doctorate Capstone Projects

Background: Occupational therapy practitioners who also serve as fieldwork educators are not utilizing the profession's historically distinctive qualities and purpose of occupation-based practice, and that the occupational therapy assistant student needs to be prepared with these skills upon beginning fieldwork.

Purpose: The primary purpose of this capstone is to improve the understanding of occupation-based practice by occupational therapy assistant students through an additional educational module focused on occupation-based principles by their ability to implement an occupation-based practice intervention.

Theoretical Framework: The occupation-based practice module has a knowledge component (look), an activity component (think), and evaluation/simulation component (act) (Skinner, …

Airline Pilots In Recovery From Alcoholism: A Quantitative Study Of Cognitive Change, Heather Christina Hamilton

Walden Dissertations and Doctoral Studies

In order to perform their duties, airline pilots must have no clinical diagnosis of mental illness or any substance use disorder. However, provisions have been in place since the 1970s that provide for a return to work for airline pilots with alcohol problems. To date, over 5,000 airline pilots have undergone rehabilitation for Alcohol Use Disorder (AUD) and successfully returned to work. An important gap in the literature remains with regard to what extent improvements in cognitive performance may be experienced by airline pilots who complete treatment and to what extent age influences the amount of change. This study examined …

Risk Factors For Tuberculosis And Multidrug-Resistant Tuberculosis Complications Among Foreign-Born Persons In Houston, Texas, James N. Isaboke

Walden Dissertations and Doctoral Studies

Tuberculosis (TB) is a leading public health problem across the world. For various reasons, TB and multidrug-resistant tuberculosis (MDR-TB) have increased. Clarification on TB/HIV co-infection and homelessness as risk factors for TB and MDR-TB is required to inform policy interventions to reduce TB-related morbidity, mortality, and healthcare costs. In this quantitative study, data from the Houston Health Department (N = 341) were analyzed to explore the relationship between TB and MDR-TB outcomes and TB/HIV co-infection and type of housing/homelessness. Foreign-born persons are disproportionately affected in the United States. The socio-ecological model provided a theoretical framework for the investigation. Multiple and …

Examining Differences Between Asian Americans And Whites For Gambling And Drinking, Kanisha Wilson, Gloria Wong-Padoongpatt, Wilson To, Taylor Lott, Naweed Yusufzai, Trevor Neeley, Todeh Toomians, Chase Shropshire, Nolan Zane

AANAPISI Poster Presentations

Limited research have examined the ethnic differences in gambling and drinking among emerging adults, therefore; little is known about what is placing Asian American at-risk for involvement with these behaviors. The purpose of this study was to examine ethnic differences in risk factors between Asian Americans and White Americans for gambling and drinking at the two levels of involvement: abstinence and problems. The main objective 1) if there are ethnic differences among emerging adults in gambling and drinking involvement, 2) why these differences exist, and 3) which impulsivity and psychological distress variables are specific to each of these ethnic groups. …

Perceptions Of Cameroonian Women Regarding Cervical Cancer Prevention, Anna Nkapsah Nji

Walden Dissertations and Doctoral Studies

Women in Cameroon as well as those residing in the Maryland-Washington Metropolitan area and the Diasporas suffer a disproportionate rate of cervical cancer morbidity and mortality due to the vast disproportion in the distribution of healthcare services. The widespread human papillomavirus (HPV) vaccination holds promise for helping to attenuate the disproportion in cervical cancer screening and prevention services. Literature from other countries including Cameroon suggests that barriers to the uptake of cervical cancer screening include: culture, religion, the psychological impact of embarrassment, the influence of husbands, cost, discomfort, and vulnerability. The purpose of this study was to gain an understanding …

Socioeconomic Status-Related Inequities On Maternal Health Services: Trends, Associations, And Outcomes, Nibretie Gobezie Workneh

Walden Dissertations and Doctoral Studies

Maternal Mortality Rate (MMR) in Ethiopia remains one of the highest in the world due in part to very limited use of maternal health services. However, the underlying factors for limited use of the services and hence the high MMR are not well known. The purpose of this study was to identify factors associated with use of maternal health services and maternal health risks, to analyze inequity patterns between use of maternal health services and maternal health risks, and to measure the magnitude and trends in inequity. Behavioral-cultural and structural theories of health inequalities were used to frame the study. …

Hiv Risk Perceptions Of Hiv-Infected Adults Ages 30 To 49 Years In Atlanta, Georgia, Esther Nduta Mune-Ashford

Walden Dissertations and Doctoral Studies

More than 49,081 people were diagnosed with HIV in the United States in 2011. Of those 49,081 HIV-infected persons, 1 in 6 was not aware of being HIV positive. In 2011, Georgia had the 5th highest number of HIV diagnoses among the 50 U.S. states. This phenomenological study aimed to understand the lived experiences of HIV-infected adults, ages 30 to 49 years in Atlanta, Georgia, by understanding their perceptions of risk prior to contracting HIV. The health belief model was used to guide this study because it explains and predicts health-related behaviors and it has been used in previous studies …

Development And Content Validation Of An Emergency Department Ehr Safety Educational Program, Ursula Renee Jernigan

Walden Dissertations and Doctoral Studies

Emergency Department (ED) providers and staff experience challenges with using electronic health record (EHR) software to document and communicate about patient care. These difficulties are often caused by inadequate training in the use of the organization's EHR system. Challenges with EHR use have been linked to increased ED patient wait times, which impacts patient safety by delaying care and increasing the potential for medication errors. Providing education that addresses EHR software; EHR usability; and collaboration among staff, providers, and EHR system managers has been shown to reduce ED wait times and decrease the risk of medication errors. The purpose of …

Public Health Leaders' Perceptions Of And Attitudes Concerning Eating Disorders, Karin L. Lightfoot

Walden Dissertations and Doctoral Studies

Eating disorders are associated with high mortality rates. Most eating disorder prevention research is conducted within the fields of psychology and psychiatry, not in public health. This gap in public health research can lead to insufficient attention to the root causes of eating disorders and minimal upstream prevention efforts. The purpose of this phenomenological study was to identify public health leaders' perceptions of and attitudes concerning eating disorders as a public health issue. Objectification theory was used to describe how societal expectations have created an environment in which people's self-worth is based on their outward physical appearance. Ecological theory was …