Medicine and Health Sciences Commons^™

Exploration Of Bivalent Ligands Targeting Putative Mu Opioid Receptor And Chemokine Receptor Ccr5 Dimerization, Christopher K. Arnatt, Bethany A. Falls, Yunyun Yuan, Thomas J. Raborg, Ruturaj R. Masvekar, Nazira El-Hage, Dana E. Selley, Anthony V. Nicola, Pamela E. Knapp, Kurt F. Hauser, Yan Zhang

Medicinal Chemistry Publications

Modern antiretroviral therapies have provided HIV-1 infected patients longer lifespans and better quality of life. However, several neurological complications are now being seen in these patients due to HIV-1 associated injury of neurons by infected microglia and astrocytes. In addition, these effects can be further exacerbated with opiate use and abuse. One possible mechanism for such potentiation effects of opiates is the interaction of the mu opioid receptor (MOR) with the chemokine receptor CCR5 (CCR5), a known HIV-1 co-receptor, to form MOR-CCR5 heterodimer. In an attempt to understand this putative interaction and its relevance to neuroAIDS, we designed and synthesized …

Speaking Up: Using Ostes To Understand How Medical Students Address Professionalism Lapses, Constance R. Tucker, Beth A. Choby, Andrew Moore, Robert Scott Parker Ii, Benjamin R. Zambetti, Sarah Naids, Jillian Scott, Jennifer Loome, Sierra Gaffney

Publications from the Office of the Dean

Background: Objective-structured teaching encounters (OSTEs) are used across many disciplines to assess teaching ability. The OSTE detailed in this paper assesses 191 fourth-year medical students’ (M4) ability to identify and address lapses in professionalism based on Association of American Medical Colleges’ professionalism competencies. The research questions addressed are:

• How frequently do M4s address professionalism lapses observed during an OSTE?
• What factors influence whether M4s provide feedback when they observe professionalism lapses in an OSTE?

Methods: Standardized patients (SPs) and standardized learners (SLs) were recruited and trained to participate in a standardized encounter with specific cognitive, social, and behavioral …

Bone - Prosthesis Junction For Active Tendon Implants: A Biomechanical Comparison Of Two Fixation Techniques, Imran Khatri, Jennifer S. Wayne Phd

MD Student Summer Research Fellowship Program Posters

End-to-end repair of damaged tendon is not possible in many instances of injury. Staged flexor tendon reconstruction has been proven to be a valuable method of addressing complex flexor tendon injuries when the patient presents late, has failed primary repair, or the injury mandates it (1). Silicone implants have been used for two-stage flexor tendon reconstructions with reports of long-term use as active implants (2,3). Implants have been reported functional approximately one year post-surgery with some still in use up to 25 years after reconstruction (4). This suggests the potential of the implant serving as a permanent prosthesis. The biomechanical …

Family-Centered Rounds And Medical Student Performance On The Nbme Pediatrics Subject (Shelf) Examination: A Retrospective Cohort Study, Tiffany N. Kimbrough, Victor Heh, N. Romesh Wijesooriya, Michael S. Ryan

Pediatrics Publications

Objective

To determine the association between family-centered rounds (FCR) and medical student knowledge acquisition as assessed by the National Board of Medical Examiners (NBME) pediatric subject (shelf) exam.

Methods

A retrospective cohort study was conducted of third-year medical students who graduated from Virginia Commonwealth University School of Medicine between 2009 and 2014. This timeframe represented the transition from ‘traditional’ rounds to FCR on the pediatric inpatient unit. Data collected included demographics, United States Medical Licensing Examination (USMLE) Step 1 and 2 scores, and NBME subject examinations in pediatrics (PSE), medicine (MSE), and surgery (SSE).

Results

Eight hundred and sixteen participants …

Endothelial Progenitor Cells And Neural Progenitor Cells Synergistically Protect Cerebral Endothelial Cells From Hypoxia/Reoxygenation-Induced Injury Via Activating The Pi3k/Akt Pathway, Jinju Wang, Yusen Chen, Yi Yang, Xiang Xiao, Shuzhen Chen, Cheng Zhang, Bradley S. Jacobs, Bin Zhao, Ji C. Bihl, Yanfang Chen

Pharmacology and Toxicology Faculty Publications

Background

Protection of cerebral endothelial cells (ECs) from hypoxia/reoxygenation (H/R)-induced injury is an important strategy for treating ischemic stroke. In this study, we investigated whether co-culture with endothelial progenitor cells (EPCs) and neural progenitor cells (NPCs) synergistically protects cerebral ECs against H/R injury and the underlying mechanism.

Results

EPCs and NPCs were respectively generated from inducible pluripotent stem cells. Human brain ECs were used to produce an in vitro H/R-injury model. Data showed: 1) Co-culture with EPCs and NPCs synergistically inhibited H/R-induced reactive oxygen species (ROS) over-production, apoptosis, and improved the angiogenic and barrier functions (tube formation and permeability) in …

Metabolism And Metabolic Inhibition Of Xanthotoxol In Human Liver Microsomes, Zhongnv Ma, Xianbao Shi, Gang Zhang, Feng Guo, Lina Shan, Jiqun Cai

Medicinal Chemistry Publications

Cytochrome p450 (CYP450) enzymes are predominantly involved in Phase I metabolism of xenobiotics. In this study, the CYP450 isoforms involved in xanthotoxol metabolism were identified using recombinant CYP450s. In addition, the inhibitory effects of xanthotoxol on eight CYP450 isoforms and its pharmacokinetic parameters were determined using human liver microsomes. CYP1A2, one of CYP450s, played a key role in the metabolism of xanthotoxol compared to other CYP450s. Xanthotoxol showed stronger inhibition on CYP3A4 and CYP1A2 compared to other isoenzymes with the IC50 of 7.43 μM for CYP3A4 and 27.82 μM for CYP1A2. The values of inhibition kinetic parameters (Ki) were 21.15 …

Baystate Medical Practices Annual Report - 2016, Andrew Artenstein Md

Baystate Medical Practices Annual Report

No abstract provided.

The Musashi 1 Controls The Splicing Of Photoreceptor-Specific Exons In The Vertebrate Retina, Daniel Murphy, Benjamin Cieply, Russ Carstens, Visvanathan Ramamurthy, Peter Stoilov

Faculty & Staff Scholarship

Alternative pre-mRNA splicing expands the coding capacity of eukaryotic genomes, potentially enabling a limited number of genes to govern the development of complex anatomical structures. Alternative splicing is particularly prevalent in the vertebrate nervous system, where it is required for neuronal development and function. Here, we show that photoreceptor cells, a type of sensory neuron, express a characteristic splicing program that affects a broad set of transcripts and is initiated prior to the development of the light sensing outer segments. Surprisingly, photoreceptors lack prototypical neuronal splicing factors and their splicing profile is driven to a significant degree by the Musashi …

Estradiol-Mediated Spine Changes In The Dorsal Hippocampus And Medial Prefrontal Cortex Of Ovariectomized Female Mice Depend On Erk And Mtor Activation In The Dorsal Hippocampus, J. J. Tuscher, V. Luine, M. Frankfurt, K. M. Frick

Journal Articles

No abstract provided.

Simeprevir Plus Sofosbuvir (12 And 8 Weeks) In Hepatitis C Virus Genotype 1-Infected Patients Without Cirrhosis: Optimist-1, A Phase 3, Randomized Study, P. Kwo, N. Gitlin, R. Nahass, D. Bernstein, K. Etzkorn, S. Rojter, E. Schiff, M. Davis, P. Ruane, J. Witek, +8 Additional Authors

Journal Articles

No abstract provided.

Efficacy Of Direct-Acting Antiviral Combination For Patients With Hepatitis C Virus Genotype 1 Infection And Severe Renal Impairment Or End-Stage Renal Disease, P. J. Pockros, K. R. Reddy, P. S. Mantry, E. Cohen, M. Bennett, M. S. Sulkowski, D. E. Bernstein, D. E. Cohen, N. S. Shulman, E. Lawitz, +4 Additional Authors

Journal Articles

© 2016 AGA Institute. Background & Aims Although hepatitis C virus (HCV) infection is common in patients with end-stage renal disease, highly efficacious, well-tolerated, direct-acting antiviral regimens have not been extensively studied in this population. We investigated the safety and efficacy of ombitasvir co-formulated with paritaprevir and ritonavir, administered with dasabuvir (with or without ribavirin) in a prospective study of patients with stage 4 or 5 chronic kidney disease (CKD). Methods We performed a single-arm, multicenter study of treatment-naïve adults with HCV genotype 1 infection, without cirrhosis and with CKD stage 4 (estimated glomerular filtration rate, 15-30 mL/min/1.73 m2) or …

Cytoplasmic, Full Length And Novel Cleaved Variant, Tblr1 Reduces Apoptosis In Prostate Cancer Under Androgen Deprivation, G. Daniels, X. Zhang, X. Zhong, L. Santiago, L. H. Wang, X. Wu, J. Y. Zhang, F. Liang, X. Li, P. Lee, +6 Additional Authors

Journal Articles

No abstract provided.

Differential Protein Expression In Small Intestinal Neuroendocrine Tumors And Liver Metastases, M. K. Kim, F. Ye, D. Wang, M. Cui, S. C. Ward, R. R. Warner, S. Roayaie, M. Schwartz, D. Zhang, S. Itzkowitz, +1 Additional Author

Journal Articles

OBJECTIVE: Small intestinal neuroendocrine tumors (SI-NETs) are often detected after they have become metastatic. Using a novel protein array, we identified pathways important in SI-NET metastasis development in surgically resected patients. METHODS: Paired primary tumors and liver metastases from 25 patients undergoing surgical resection for metastatic SI-NETs were harvested. Extracted proteins were separated by sodium dodecyl sulfate gel and multiplex immunoblots were performed with 136 antibodies. Significant Analysis of Microarray was used to select for differentially expressed proteins. A tissue microarray was constructed from 27 archived specimens and stained by immunohistochemistry. RESULTS: Comparing primary SI-NETs with matched normal small-bowel mucosa, …

Acalabrutinib (Acp-196) In Relapsed Chronic Lymphocytic Leukemia, J. C. Byrd, B. Harrington, S. O'Brien, J. A. Jones, A. Schuh, S. Devereux, J. Chaves, W. G. Wierda, J. C. Barrientos, R. R. Furman, +20 Additional Authors

Journal Articles

Background Irreversible inhibition of Bruton's tyrosine kinase (BTK) by ibrutinib represents an important therapeutic advance for the treatment of chronic lymphocytic leukemia (CLL). However, ibrutinib also irreversibly inhibits alternative kinase targets, which potentially compromises its therapeutic index. Acalabrutinib (ACP-196) is a more selective, irreversible BTK inhibitor that is specifically designed to improve on the safety and efficacy of first-generation BTK inhibitors. Methods In this uncontrolled, phase 1-2, multicenter study, we administered oral acalabrutinib to 61 patients who had relapsed CLL to assess the safety, efficacy, pharmacokinetics, and pharmacodynamics of acalabrutinib. Patients were treated with acalabrutinib at a dose of 100 …

First Trimester Fetal Heart Rate As A Predictor Of Newborn Sex, L. A. Bracero, D. J. Seybold, S. Witsberger, L. Rincon, A. Modak, L. V. Baxi

Journal Articles

OBJECTIVE: To predict the sex of newborns using first trimester fetal heart rate (FHR). METHODS: This was a retrospective review of medical records and ultrasounds performed between 8 and 13 weeks of gestation. Continuous variables were compared using Student's t-tests while categorical variables were compared using Chi-square test. RESULTS: We found no significant differences between 332 (50.7%) female and 323 (49.3%) male FHRs during the first trimester. The mean FHR for female fetuses was 167.0 +/- 9.1 bpm and for male fetuses 167.3 +/- 10.1 bpm (p = 0.62). There was no significant difference in crown rump length between female …

The Relationship Between Sleep Quality And Memory, Brittany Holcomb, Brooke N. Raisin, Kaitlyn Gravitt, Lindsey Herrick, Nicole Mitchell

The Corinthian

Sleep quality and memory are both relevant topics in today’s society, especially among college students.

Purpose: To determine if there is a correlation between sleep quality and short-term memory including objective and subjective measures.

Methods: This study consisted of 25 participants, 6 males and 19 females, ages ranging from 19 to 22 (20.8±0.8 years), who avoided stimulants, caffeine or other sleep altering drugs for at least eight hours. Our participants were recruited via word of mouth, poster, and discussions in classroom settings. Participants memorized a list of 30 words for two minutes and then had two minutes to …

Point-Of-Care Testing In Primary Care May Reduce Overall Cost And Improve Both Patient Satisfaction And Efficiency, Eric A. Sadler

Physician Assistant Scholarly Project Posters

• Objective: Increased demands for primary care are forcing clinical offices to deliver cost and time efficient care while providing exceptional patient experiences. Traditional lab testing methods require multiple steps for the patient and provider. Test results are not available until a later time which may delay decision making, patient discussion and medical planning. Point-of-care testing (POCT) provides an alternative that allows the patient to have testing, discuss the results and establish a treatment plan during a single office appointment.

• Design: A review of literature examined studies that compare cost-effectiveness, patient satisfaction and efficiency of POCT with traditional laboratory …

Conducting Research In Health Professions Education: From Idea To Publication, Anthony R. Artino Jr

Health, Human Function, and Rehabilitation Sciences Faculty Publications

No abstract provided.

University Of South Alabama College Of Medicine Annual Report For 2016-2017, College Of Medicine

COM Annual Reports

This Annual Report of the College of Medicine catalogues accomplishments of our faculty, students, residents, fellows and staff in teaching, research, scholarly and community service during the 2016-2017 academic year.

Iron Acquisition In The Cystic Fibrosis Lung And Potential For Novel Therapeutic Strategies, Jean Tyrrell, Máire Callaghan

Articles

Iron acquisition is vital to microbial survival and is implicated in the virulence of many of the pathogens that reside in the cystic fibrosis (CF) lung. The multifaceted nature of iron acquisition by both bacterial and fungal pathogens encompasses a range of conserved and species-specific mechanisms, including secretion of iron-binding siderophores, utilization of siderophores from other species, release of iron from host iron-binding proteins and haemoproteins, and ferrous iron uptake. Pathogens adapt and deploy specific systems depending on iron availability, bioavailability of the iron pool, stage of infection and presence of competing pathogens. Understanding the dynamics of pathogen iron acquisition …

Most Efficient Methods To Treat Breast Cancer, Esther Ehrman

The Science Journal of the Lander College of Arts and Sciences

Breast cancer is rampant in today’s world. Because there are many different cases and so many different ways to classify breast cancer, a multidisciplinary approach must be taken. Many patients undergo breast conserving surgery which creates a need for the eradication of any remaining tumor residue through radiation. Fifty Gy of radiation should be applied to the breast with an additional 16 Gy as a boost. If a mastectomy is performed to remove a large tumor and 4 or more positive lymph nodes were present, radiation should be applied as well. If the tumor expresses HER2 protein, Trastuzumab should be …

Breaking Down Barriers: The Intersection Of Medicine And Faith, Kaitlyn Lindgren, Ashley Kethcart

Honors Program: Student Scholarship & Creative Works

While medicine and faith are often presented as contradictory concepts, the two play complementary roles in people's health. Christian prayer and Buddhist meditation practices have an impact on health, as well as alternative forms of medicine. These influences can work in tandem to increase the mental and physical health of all people and also demonstrate that science and faith need not always be in opposition.

Sensitization To Food And Inhalant Allergens In Healthy Children In Van, East Turkey, Mehmet Parlak, Ayteki̇n Çikman, Yasemi̇n Bayram, Nesri̇n Ceylan, Ulaş Çalişir, Mustafa Berktaş

Turkish Journal of Medical Sciences

Background/aim: The purpose of this study was to determine the most frequent food and inhalant allergens leading to allergic sensitization in children in Van Province of Turkey. Materials and methods: The study included 1052 serum samples with no diagnosis of allergy. The sera were tested with the Euroline Pediatric IgE test kit (EUROIMMUN, Germany). By using the EUROLineScan digital evaluation system, the intensity of bands was calculated with enzyme allergosorbent test classification. Results: Out of the 1052 tested sera, 143 were found to be cross-reactive carbohydrate determinant-positive and were discarded from the study. Of the remaining 909 sera, 513 (56%) …

Comparison Of Nasal Senses Following Open And Closed Rhinoplasty, Mehmet İhsan Okur, Onur Gökdemi̇r, Necmetti̇n Karasu, Alpagan Mustafa Yildirim

Turkish Journal of Medical Sciences

Background/aim: The objective of this study was to compare the postoperative changes taking place in the nasal senses of patients who underwent a rhinoplasty through the open or closed incision method. Materials and methods: In a prospective study, 15 patients had a closed rhinoplasty surgery and 15 others had an open one. By pinpointing 9 spots in the nose, a sensory assessment was made by means of Semmes-Weinstein monofilaments prior to the surgery and 1 week and 1, 3, and 6 months after the surgery. Results: In the open and closed groups, there was hypoesthesia 1 week after the surgery …

How To Close Open Choledochotomy: Primary Closure, Primary Closurewith T-Tube Drainage, Or Choledochoduodenostomy?, Bülent Aydinli, Gürkan Öztürk, Sabri̇ Selçuk Atamanalp, Bünyami̇ Özoğul, Şükrü Arslan, Ercan Korkut, Abdullah Kisaoğlu, Abdulmeci̇t Kantarci, Rüstem Berhan Pi̇ri̇moğlu, Mehmet İlhan Yildirgan, Nurhak Aksungur

Turkish Journal of Medical Sciences

Background/aim: Although common bile duct stones are generally treated endoscopically, surgery is required if endoscopic removal is impossible. The aim of this study was to compare the surgical options in such patients. Materials and methods: A total of 282 patients with common bile duct stones underwent open choledochotomy; primary closure was applied in 48 (17.0%), primary closure with T-tube drainage in 81 (28.7%), and choledochoduodenostomy in 153 (54.3%) patients. Results: Postoperative complications were seen in 8 (16.7%) patients in the primary closure, 33 (40.7%) patients in the primary closure with T-drainage, and 37 (24.2%) patients in the choledochoduodenostomy group. No …

The Effect Of Hip And Knee Exercises On Pain, Function, And Strength In Patientswith Patellofemoral Pain Syndrome: A Randomized Controlled Trial, Mehtap Şahi̇n, Fi̇kri̇ye Fi̇gen Ayhan, Pinar Borman, Hüseyi̇n Atasoy

Turkish Journal of Medical Sciences

Background/aim: The role of hip muscles in the rehabilitation of patellofemoral pain syndrome has recently received interest. The aim of this study was to compare the efficiencies of hip exercises alongside knee exercises versus only knee exercises on pain, function, and isokinetic muscle strength in patients with this syndrome. Materials and methods: Fifty-five young female patients (mean age: 34.1 ± 6.2 years; mean BMI: 25.9 ± 3.9 kg/m2) with patellofemoral pain syndrome were included. The patients were randomized into groups of hip-and-knee exercises and knee-only exercise programs for 6 weeks with a total of 30 sessions at the clinic. Both …

Is The Nexfin Finger Cuff Method For Cardiac Output Measurement Reliableduring Coronary Artery Bypass Grafting? A Prospective Comparison With The Echocardiography And Flotrac/Vigileo Methods, Cem Aritürk, Meltem Açil, Hali̇m Ulugöl, Zehra Serpi̇l Ustalar Özgen, Eyüp Murat Ökten, Si̇nan Dağdelen, Eşref Hasan Karabulut, Hüseyi̇n Cem Alhan, Fevzi̇ Toraman

Turkish Journal of Medical Sciences

Background/aim: The aim of the current study was to assess the accuracy of cardiac output (CO) measurements obtained by the Nexfin finger cuff method as compared with the FloTrac/Vigileo and echocardiography methods in coronary artery bypass grafting (CABG) patients. Materials and methods: First-time elective CABG patients were prospectively enrolled in this study and divided into three groups according to CO measurement method. CO measurements were performed simultaneously by three different contributors and were collected by the fourth one 24 h postoperative in the intensive care unit (ICU). Data were statistically analyzed. Results: Seventeen female and 13 male patients between 42 …

Effect Of Exposure To Violence On The Development Of Burnoutsyndrome In Ambulance Staff, Turgut Deni̇z, Meral Saygun, Oğuz Eroğlu, Hüseyi̇n Ülger, Burcu Azapoğlu

Turkish Journal of Medical Sciences

Background/aim: The aim of this study is to determine the condition of ambulance staff (AS) who have been exposed to any kind of violence and to predict risk of development of burnout syndrome. Materials and methods: Our study was performed with 120 AS working for the Kırıkkale Ambulance Services. During the research, questionnaires collecting descriptive information and the extent of violence to which the AS were exposed were administered; participants were asked to fill out the questionnaire themselves. Results: It was found that 81 (67.5%) participants had been subjected to at least one type of violence (verbal or physical). Sixty-two …

The Role Of Human Papilloma Virus And Herpes Viruses In The Etiology Of Nasal Polyposis, Mücahi̇de Esra Koçoğlu, Firat Zafer Mengeloğlu, Tayfun Apuhan, Şeyda Özsoy, Beyhan Yilmaz

Turkish Journal of Medical Sciences

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Retinopathy Of Prematurity: Incidence, Risk Factors, And Evaluation Of Screening Criteria, Arzu Gebeşçe, Haşi̇m Uslu, Esengül Keleş, Aydin Yildirim, Bülent Gürler, Hamza Yazgan, Bülent Baştürk, Mehmet Demi̇rdöven, Alparslan Tonbul

Turkish Journal of Medical Sciences

Background/aim: The goal of this study was to investigate the incidence of retinopathy of prematurity (ROP) and the relationship between risk factors and disease in premature newborns in our neonatal intensive care unit. Materials and methods: A total of 219 premature subjects were retrospectively evaluated for retinopathy. Demographic information, clinical data, and risk factors were reviewed. Results: The gestational ages of the infants included in the study ranged between 25 and 36 weeks, and the birth weights ranged between 670 and 4460 g. In this study, the incidence of ROP was 20.1% (44) in preterm infants: 16 had stage 1 …