Medicine and Health Sciences Commons^™

Modeling Of Ambient Glutamate Concentration Measurement In The Mammalian Nervous System, Denis M. Shchepakin, Michael Kavanaugh, Leonid Kalachev

Biomedical and Pharmaceutical Sciences Faculty Publications

A neuron is an electrically excitable cell that processes and transmits information through electrical and chemical signals. Neurons connect and pass signals to other cells through the structure called synapse. We focus on synapses through which the signals are transferred by signaling molecules called neurotransmitters. One of the predominant excitatory neurotransmitters in the central nervous system of the mammals, including humans, is glutamate. It is directly or indirectly involved in most brain functions. However, the excessive stimulation of the glutamate receptors is toxic to neurons, therefore it is important to rapidly clear the glutamate from the extra-cellular space and keep …

D-Serine Is A Substrate For Neutral Amino Acid Transporters Asct1/Slc1a4 And Asct2/Slc1a5, And Is Transported By Both Subtypes In Rat Hippocampal Astrocyte Cultures, Alan C. Foster, Jill Farnsworth, Genevieve Lind, Yong-Xin Lin, Jia-Ying Yang, Van Dang, Mahmud Penjwini, Veena Viswanath, Ursula Staubli, Michael Kavanaugh

Biomedical and Pharmaceutical Sciences Faculty Publications

N-methyl-D-aspartate (NMDA) receptors play critical roles in synaptic transmission and plasticity. Activation of NMDA receptors by synaptically released L-glutamate also requires occupancy of co-agonist binding sites in the tetrameric receptor by either glycine or D-serine. Although D-serine appears to be the predominant co-agonist at synaptic NMDA receptors, the transport mechanisms involved in D-serine homeostasis in brain are poorly understood. In this work we show that the SLC1 amino acid transporter family members SLC1A4 (ASCT1) and SLC1A5 (ASCT2) mediate homo- and hetero-exchange of D-serine with physiologically relevant kinetic parameters. In addition, the selectivity profile of D-serine uptake in cultured rat hippocampal …

Male Pattern Baldness In Relation To Prostate Cancer–Specific Mortality: A Prospective Analysis In The Nhanes I Epidemiologic Follow-Up Study, Cindy Ke Zhou, Paul H Levine, Sean D. Cleary, Heather J. Hoffman, Barry I Graubard, Michael B. Cook

Epidemiology Faculty Publications

We used male pattern baldness as a proxy for long-term androgen exposure and investigated the association of dermatologist-assessed hair loss with prostate cancer–specific mortality in the first National Health and Nutrition Examination Survey Epidemiologic Follow-up Study. From the baseline survey (1971–1974), we included 4,316 men who were 25–74 years of age and had no prior cancer diagnosis. We estimated hazard ratios and used Cox proportional hazards regressions with age as the time metric and baseline hazard stratified by baseline age. A hybrid framework was used to account for stratification and clustering of the sample design, with adjustment for the variables …

Oxidative Stress-Induced Dna Damage And Homocysteine Accumulation May Beinvolved In Ovarian Cancer Progression In Both Young And Old Patients, Shazia Anwer Bukhari, Kashaf Zafar, Muhammad Ibrahim Rajoka, Zubair Ibrahim, Sadia Javed, Rafshan Sadiq

Turkish Journal of Medical Sciences

Background/aim: Biochemical, environmental, and genetic factors such as oxidative stress-induced DNA damage and homocysteine (Hcy) accumulation in the blood are involved in the development and progression of ovarian cancer. This study measured some biomarkers closely linked to the progression of ovarian cancer and also found their correlates. Materials and methods: Thirty patients were diagnosed with ovarian cancer using pelvic examination, transvaginal ultrasound, and cancer antibody (CA-125) measurement. Total oxidative stress (TOS), DNA damage, Hcy, malondialdehyde (MDA), total antioxidant status (TAS), and other biochemical parameters were determined. Results: TOS and DNA damage were positively and significantly correlated between themselves and were …

See Me Smoke-Free: Protocol For A Research Study To Develop And Test The Feasibility Of An Mhealth App For Women To Address Smoking, Diet, And Physical Activity, Peter Giacobbi Jr, Melanie Hingle, Thienne Johnson, James K. Cunningham, Julie Armin, Judith S. Gordon

Faculty & Staff Scholarship

Background: This paper presents the protocol for an ongoing research study to develop and test the feasibility of a multi-behavioral mHealth app. Approximately 27 million women smoke in the US, and more than 180,000 women die of illnesses linked to smoking annually. Women report greater difficulties quitting smoking. Concerns about weight gain, negative body image, and low self-efficacy may be key factors affecting smoking cessation among women. Recent studies suggest that a multi-behavioral approach, including diet and physical activity, may be more effective at helping women quit. Guided imagery has been successfully used to address body image concerns and self-efficacy …

Benchmarking Academic Anatomic Pathologists: The Association Of Pathology Chairs Survey, Barbara S. Ducatman Md, Tristram Parslow Md, Phd

Faculty & Staff Scholarship

The most common benchmarks for faculty productivity are derived from Medical Group Management Association (MGMA) or Vizient-AAMC Faculty Practice Solutions Center1 (FPSC) databases. The Association of Pathology Chairs has also collected similar survey data for several years. We examined the Association of Pathology Chairs annual faculty productivity data and compared it with MGMA and FPSC data to understand the value, inherent flaws, and limitations of benchmarking data. We hypothesized that the variability in calculated faculty productivity is due to the type of practice model and clinical effort allocation. Data from the Association of Pathology Chairs survey on 629 surgical pathologists …

Unique Footprint In The Scl1.3 Locus Affects Adhesion And Biofilm Formation Of The Invasive M3-Type Group A Streptococcus, Beth A. Bachert, Soo J. Choi, Paul R. Lasala, Tiffany I. Harper, Dudley H. Mcnitt, Dylan T. Boehm, Clayton C. Caswell, Pawel Ciborowski, Douglas R. Keene, Anthony R. Flores, James M. Musser, Flavia Squeglia, Daniela Marasco, Rita Berisio, Slawomir Lukomski

Faculty & Staff Scholarship

The streptococcal collagen-like proteins 1 and 2 (Scl1 and Scl2) are major surface adhesins that are ubiquitous among group A Streptococcus (GAS). Invasive M3-type strains, however, have evolved two unique conserved features in the scl1 locus: (i) an IS1548 element insertion in the scl1 promoter region and (ii) a nonsense mutation within the scl1 coding sequence. The scl1 transcript is drastically reduced in M3-type GAS, contrasting with a high transcription level of scl1 allele in invasive M1-type GAS. This leads to a lack of Scl1 expression in M3 strains. In contrast, while scl2 transcription and Scl2 production are elevated in …

Hypertrophy-Promoting Effects Of Leucine Supplementation And Moderate Intensity Aerobic Exercise In Pre-Senescent Mice, Zhi Xia, Jason Cholewa, Yan Zhao, Yue-Qin Yang, Hua-Yu Shang, Lucas Guimaraes-Ferreira, Marshall Alan Naimo, Quan-Sheng Su, Nelo Eidy Zanchi

Faculty & Staff Scholarship

Several studies have indicated a positive influence of leucine supplementation and aerobic training on the aging skeletal muscle signaling pathways that control muscle protein balance and muscle remodeling. However, the effect of a combined intervention requires further clarification. Thirteen month old CD-1® mice were subjected to moderate aerobic exercise (45 min swimming per day with 3% body weight workload) and fed a chow diet with 5% leucine or 3.4% alanine for 8 weeks. Serum and plasma were prepared for glucose, urea nitrogen, insulin and amino acid profile analysis. The white gastrocnemius muscles were used for determination of muscle size and …

Integrated Analysis Of Dysregulated Ncrna And Mrna Expression Profiles In Humans Exposed To Carbon Nanotubes, Anna A. Shvedova, Naveena Yanamala, Elena R. Kisin, Timur O. Khailullin, M. Eileen Birch, Liliya M. Fatkhutdinova

Faculty & Staff Scholarship

Background As the application of carbon nanotubes (CNT) in consumer products continues to rise, studies have expanded to determine the associated risks of exposure on human and environmental health. In particular, several lines of evidence indicate that exposure to multi-walled carbon nanotubes (MWCNT) could pose a carcinogenic risk similar to asbestos fibers. However, to date the potential markers of MWCNT exposure are not yet explored in humans.

Methods In the present study, global mRNA and ncRNA expression profiles in the blood of exposed workers, having direct contact with MWCNT aerosol for at least 6 months (n = 8), were compared …

M.S. In Public Health Curriculum, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Bachelor Of Health Science Curriculum, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Micro-Computed Tomographic Assessment On Marginal Adaptation To Dentin Of Biodentine And Mta In Blood Contaminated Furcation Repair, Rangsit Makarukpinyo, Chootima Ratisoontorn

Chulalongkorn University Dental Journal

Objective The aim of this study was to evaluate the marginal adaptation of Biodentine and MTA in the presence and absence of blood in simulated furcation perforation cavities using microcomputed tomographic (micro-CT) assessment. Materials and methods Furcation perforation cavities were prepared on 64 extracted human mandibular first molars. Samples were randomly divided into 4 groups: Biodentine with blood contamination group, Biodentine without blood contamination group, MTA with blood contamination group, and MTA without blood contamination group. All samples were scanned using microcomputed tomography to measure cavity volume and material volume at initial setting time and at 24 hours after setting. …

Translational Significance Of Heme Oxygenase In Obesity And Metabolic Syndrome, Nader G. Abraham, Joshua M. Junge, George S. Drummond

NYMC Faculty Publications

The global epidemic of obesity continues unabated with sequelae of diabetes and metabolic syndrome. This review reflects the dramatic increase in research on the role of increased expression of heme oxygenase (HO)-1/HO-2, biliverdin reductase, and HO activity on vascular disease. The HO system engages with other systems to mitigate the deleterious effects of oxidative stress in obesity and cardiovascular disease (CVD). Recent reports indicate that HO-1/HO-2 protein expression and HO activity have several important roles in hemostasis and reactive oxygen species (ROS)-dependent perturbations associated with metabolic syndrome. HO-1 protects tissue during inflammatory stress in obesity through the degradation of pro-oxidant …

Privacy And Accountability In Black-Box Medicine, Roger Allan Ford, W. Nicholson Price Ii

Law Faculty Scholarship

Black-box medicine—the use of big data and sophisticated machine learning techniques for health-care applications—could be the future of personalized medicine. Black-box medicine promises to make it easier to diagnose rare diseases and conditions, identify the most promising treatments, and allocate scarce resources among different patients. But to succeed, it must overcome two separate, but related, problems: patient privacy and algorithmic accountability. Privacy is a problem because researchers need access to huge amounts of patient health information to generate useful medical predictions. And accountability is a problem because black-box algorithms must be verified by outsiders to ensure they are accurate and …

Perceptions From Athletic Training Students Involved In An Intentional Peer-Assisted Learning Pedagogy, Dana K. Bates

Faculty Publications - Department of Kinesiology

Context: Peer-assisted learning (PAL) has been shown to benefit students across educational levels. Current research has investigated perceptions of PAL, postgraduate impact, as well as prevalence. This study investigated athletic training students’ perceptions of an intentional PAL pedagogy on both the peer-student and peer-tutor. In this study, the peer-tutors had training prior to implementation.

Objective: To explore athletic training students’ perceptions of an intentional PAL pedagogy.

Design: Qualitative study using a phenomenological approach.

Setting: Focus group interviews with professional undergraduate athletic training students.

Patients or Other Participants: Eleven athletic training students from 1 accredited athletic training program volunteered for this …

Validity Of The Promis Physical Performance Scale In Determining Frailty And Physical Ability In Community-Dwelling Elderly, Jeff Houck, Tomoko Iwanaga, Christine Kieu, Keegan Lerma, Chelan Murasaki, Tawny Souza

Student-Faculty Research - College of Physical Therapy

In many clinical settings, therapists are continuously seeking efficient and valid assessments for older adults to determine their physical abilities and functional status. The Patient Reported Outcome Instrument System (PROMIS) is a newly developed computer adapted test (CAT) that is being incorporated into electronic medical records and has been reported to assess a person’s physical function. The current gold standard to assess different levels of frailty and physical function in older individuals is the Modified Physical Performance Test (mPPT). However, the mPPT is a lengthy performance based outcome measure that takes time to administer. The purpose of this study is …

The Use Of The Modified Vestibular Activities Of Daily Living Scale In The Examination Of Older Adults, Lauren Calvert, Shane Durando, Bethany Nguyen, Gregory Schuft, Luke Snelling, Theresa Raudsepp, Cindy Zablotny

Student-Faculty Research - College of Physical Therapy

•30-60% community dwelling older adults fall each year, which is the leading cause of injury, death, and traumatic hospital admissions in the elderly.1 This costs the U.S. health care system $20-30 billion per year.2 Currently used older adult self-report measures demonstrate poor responsiveness3, thus failing to detect a decline in function on early enough for preventative physical therapy intervention.

•The Vestibular Activities of Daily Living Scale (VADL) is a self-report measure developed to determine activity & participation restrictions in patients with vestbular dysfunction. This scale clearly delineates important tasks and categories of independence, which would be applicable to the assessment …

Can The Nordic Hamstring Test Identify Collegiate Athletes At Risk For A Time-Loss Hamstring Injury?, Nathanael Bush, Erica Haessler, Jennifer Peet, Lisa Koslicki, Jake Watson, Jason Brumitt

Student-Faculty Research - College of Physical Therapy

Why Nordic Hamstring?

• Hamstrings are the most commonly injured muscle in sprinting and

  kicking sports (soccer, football and rugby).

• Recurrent hamstring injuries lead to longer time loss than the original injury.

• Despite the presence of preventa- tive programs, research has not yet documented an effective, low-cost, widely accessible test to determine hamstring injury risk.

Exploring The Importance Of Team Psychological Safety In The Development Of Two Interprofessional Teams, Denise O'Leary

Articles

It has been previously demonstrated that interactions within interprofessional teams are characterised by effective communication, shared decision-making, and knowledge sharing. This article outlines aspects of an action research study examining the emergence of these characteristics within change management teams made up of nurses, general practitioners, physiotherapists, care assistants, a health and safety officer, and a client at two residential care facilities for older people in Ireland. The theoretical concept of team psychological safety (TPS) is utilised in presenting these characteristics. TPS has been defined as an atmosphere within a team where individuals feel comfortable engaging in discussion and reflection without …

Getting ‘In’ And ‘Out Of Alignment’: Some Insights Into The Cultural Imagery Of Fitness From The Perspective Of Experienced Gym Adherents, Ross D. Neville, Catherine Gorman

Articles

While the identification of risks associated with sedentary lifestyles provided a strong foundation for what we understand by ‘fitness’ today, research across the social sciences and humanities has been rather more ambivalent about the term. One important cause for concern here is the cultural proximity of ‘fitness’ to consumer culture by means of the ‘fitness industry’. It has been shown, for example, that the pursuit of fitness has become increasingly, if not exclusively, a matter of attending to the body as a marker of social status: something to be consumed for; something to be consumed by others. In this paper, …

A Pilot Investigation Of The Effect Of Postural Control Strategies And Balance In Children With Unilateral Lower-Limb Amputation, Mark Geil

Faculty Articles

No abstract provided.

Medical Education Digest, Vol. 18 No. 1 (January-February 2016), Nova Southeastern University

Medical Education Digest

No abstract provided.

The Experiences Of Black Mft Doctoral Degree Holders With White Professors: A Phenomenological Study, Juliana M. Deans

Department of Family Therapy Dissertations and Applied Clinical Projects

The purpose of this research is to explore the experiences of Black doctoral degree holders’ interactions with their White professors in a Marriage and Family Therapy (MFT) program. There are a number of studies on the effectiveness of White professors and Black graduate students, but few focus specifically on the field of Marriage and Family Therapy. This study employed existential phenomenological methodology to examine Black MFT doctoral degree holders’ perceptions of their White professors. The experiences of six Black doctoral degree holders who attended COAMFTE-accredited programs were examined. The process involved an in-depth semi-structured interview. The study also revealed five …

Speaking Of Urgent Care Centers: Language Matters, Sayeedul Islam, Michael H. Chetta, Andrzej Kozikowski, Samantha Misner

Department of Behavioral Science Publications and Research

With the adoption of the Affordable Care Act, it is necessary for health care facilities to focus on patient perceptions and care experience. The urgent care industry has grown exponentially as demand for more accessible patient services has increased. There is little research on how patients perceive their care experiences and what influences their satisfaction in the urgent care setting. The present study proposes a series of research questions exploring the relationship between language and ratings of urgent care facilities. This study aimed to: (1) identify which words were tied to patient experience, (2) identify the language used by satisfied …

Pericardiocentesis Followed By Thoracotomy And Repair Of Penetrating Cardiac Injury Caused By Nail Gun Injury To The Heart, Vasu Chirumamilla, Kartik Prabhakaran, Patrizio Petrone, John A. Savino, Corrado Marini, Zobair Zoha

NYMC Faculty Publications

INTRODUCTION: Work site injuries involving high projectile tools such as nail guns can lead to catastrophic injuries. Generally, penetrating cardiac injuries are associated with a high mortality rate.

PRESENTATION OF CASE: A construction worker was brought to the emergency room having sustained a nail gun injury to the chest. The patient was hypotensive, tachycardic with prominent jugular venous distention, and had a profound lactic acidosis. Bedside ultrasound confirmed the presence of pericardial fluid. Pericardiocentesis was performed twice using a central venous catheter inserted into the pericardial space, resulting in improvement in the patient's hemodynamics. Thereafter he underwent left anterolateral thoracotomy …

Quality Measurement In Wonderland: The Curious Case Of A Dialysis Readmissions Measure, S. Fishbane, J. B. Wish

Journal Articles

The standardized readmission ratio is a new quality measure for dialysis facilities that will affect public reporting and payment beginning in 2017. Like all quality measures affecting public reporting and payment, the standardized readmission ratio was vetted by a process that included a technical expert panel convened by the US Centers for Medicare and Medicaid Services, and, then, the National Quality Forum. Unlike previous measures, standardized readmission ratio followed a tortuous path that exposed problems in the development and endorsement process. Although it is acknowledged that processes in the dialysis facility can be improved to decrease readmissions, multiple objections to …

Predicting Treatment Related Imaging Changes (Trics) After Radiosurgery For Brain Metastases Using Treatment Dose And Conformality Metrics., B. F. Taylor, J. P. Knisely, J. M. Qian, J. B. Yu, V. L. Chiang

Journal Articles

Purpose: Treatment-related imaging changes (TRICs) after stereotactic radiosurgery (SRS) involves the benign transient enlargement of radiographic lesions after treatment. Identifying the radiation dose volumes and conformality metrics associated with TRICs for different post-treatment periods would be helpful and improve clinical decision making.

Methods: 367 metastases in 113 patients were treated using Gamma Knife SRS between 1/1/2007-12/31/2009. Each metastasis was measured at each imaging follow-up to detect TRICs (defined as ≥ 20% increase in volume). Fluctuations in small volume lesions (less than 108 mm

Results: From 0-6 months, all measures correlated with the incidence of TRICs (p

Conclusions: All metrics except …

Medical Literary Messenger (Vol. 3, No. 2, Spring/Summer 2016)

Medical Literary Messenger

Exposure / Dan Campion -- The Second Floor Shop B / Hil Scott -- Incubator Memory / Meridian Johnson -- Take Me to Richmond / Derick Nelson Jenkins -- Destination Unknown / Derick Nelson Jenkins -- Symmetry / Derick Nelson Jenkins -- The Aide / Erika D. Price -- Subconscious / David Yoffe -- What My Uncle is Thinking / Tamsyn Brennan -- Progression / E. F. Schraeder -- Waiting / Justin Nicholes -- Only 1,482 Steps From the Massey Cancer Center Entrance / Dodge Havens -- At Hardy-Owen Funeral Home, Conveniently Located on Dixie Highway / Monique Kluczykowski -- …

Medical Literary Messenger (Vol. 4, No. 1, Fall/Winter 2016)

Medical Literary Messenger

Irene—London, December 2006 / Katharine Harer -- Today / Antonia Lewandowski -- The Bench / Richard LeBlond -- illustration / Alana Barrett -- After Reading Elizabeth Bishop’s “In the Waiting Room” / Nina Bannett -- How to Open Your Eyes / Angus Woodward -- Stage 3 / Amanda Gomez -- NeuroSkull / Alana Barrett -- It / Grace Fryberger -- The Mammogram, Part II / Katharine Harer -- Old and New / Derick Nelson Jenkins -- The Innoculation / Simon Friedman -- illustrations / Alana Barrett -- Shocking / Phyllis Price -- Boutique Hotel / Lynn Ciesielski -- A Sleeping …

Mir-9 Acts As An Oncomir In Prostate Cancer Through Multiple Pathways That Drive Tumour Progression And Metastasis, S. J. Seashols-Williams, W. Budd, G. C. Clark, Q. Wu, R. Daniel, E. Dragoescu, Z. E. Zehner

Biochemistry and Molecular Biology Publications

Identification of dysregulated microRNAs (miRNAs) in prostate cancer is critical not only for diagnosis, but also differentiation between the aggressive and indolent forms of the disease. miR-9 was identified as an oncomiR through both miRNA panel RT-qPCR as well as high-throughput sequencing analysis of the human P69 prostate cell line as compared to its highly tumorigenic and metastatic subline M12, and found to be consistently upregulated in other prostate cell lines including DU-145 and PC3. While miR-9 has been characterized as dysregulated either as an oncomiR or tumour suppressor in a variety of other cancers including breast, ovarian, and nasopharyngeal …