Medicine and Health Sciences Commons^™

Overexpression Of Pd2 Leads To Increased Tumorigenicity And Metastasis In Pancreatic Ductal Adenocarcinoma., Arokia Priyanka Vaz, Shonali Deb, Satyanarayana Rachagani, Parama Dey, Sakthivel Muniyan, Imayavaramban Lakshmanan, Saswati Karmakar, Lynette M. Smith, Sonny L. Johansson, Subodh M. Lele, M Ouellette, Moorthy P. Ponnusamy, Surinder K. Batra

Journal Articles: Biochemistry & Molecular Biology

Pancreatic differentiation 2 (PD2), an important subunit of the human PAF complex, was identified after differential screening analysis of 19q13 amplicon, and its overexpression induces oncogenic transformation of NIH3T3 cells, hence raising the possibility of a role for PD2 in tumorigenesis and metastasis. To test this hypothesis, we analyzed here the functional role and clinical significance of PD2 in pancreatic ductal adenocarcinoma (PDAC) and its pathogenesis. Using immunohistochemical analysis, we found that PD2 is detected in the acini but not in the ducts in the normal pancreas. In human PDAC specimens, PD2 was instead primarily detected in the ducts (12/48 …

Clinical Alarm Management, Jo Ann Aberilla

All Publications

No abstract provided.

The Effect Of An Educational Intervention On The Knowledge And Management Of Ponv Among Anesthesia Providers: A Pilot Study, Eleazar Comprendio, Juan E. Ruan, H. Mohammad Zayed, Julie Lamoureux, Feliciano Villalba

All Publications

No abstract provided.

Promoting A Healthy Work Environment In The Emergency Department, Becky Maya, Eleni Miralles, Katrina Lino, Monica Duart, Julie Lamoureux

All Publications

No abstract provided.

Determining Final Diagnosis In Patients With Syncope In A Community Hospital: A Preliminary Analysis, Andres Soto, Tanya Cohn, Michelle Smith, Eva Mitra, Julie Lamoureux

All Publications

No abstract provided.

Discharge Alternative Non-Urgent Care Education (D.A.N.C.E.) Protocol: Addressing Emergency Department Misuse, Samantha Leon

All Publications

No abstract provided.

Medication Cabinets In Patients' Rooms: Impact On Nurses' Satisfaction Of Medication Administration, Medication Charge Accuracy, And Errors (Published 2013), Mavel Arinal, Tanya Cohn, Carmen Avila-Quintana

All Publications

No abstract provided.

The Need For Speed: Shared Governance Impacting Nursing Practice Over A 3 Year Magnet Journey Of A Newly Opened Hospital, Rosalina Butao, Julie Lamoureux, Tanya Cohn, Victoria Mccue, Fatima Garcia

All Publications

No abstract provided.

Assessing Potential Relationship Between Medical/Surgical Nurse’S Certification Rate To Patient Outcome In A Newly Designated Magnet Hospital, Eva Mitra, Rosalina Butao, Julie Lamoureux

All Publications

No abstract provided.

Impact Of Pharmacist-Driven Transition Of Care Program In A Community Hospital, Felicia Seiler, Ana Lopez-Samblas, Maria Rojo-Carlo, Abby Marrero, Aixa Rey

All Publications

No abstract provided.

Impact Of Pharmacy Patient Education Programs On Medication Related Hcahps Scores, Ana Lopez-Samblas, Maria Rojo-Carlo, Aixa Rey, Maria Perez Arias

All Publications

No abstract provided.

Impact Of Pharmacist Post Discharge Follow Up Phone Call Program On Adherence And Medication Related Problems, Sady Castane, Ana Lopez-Samblas, Maria Rojo-Carlo, Abby Marrero, Aixa Rey, Maria Perez Arias

All Publications

No abstract provided.

What's Happening: January 18, 2016, Maine Medical Center

What's Happening

No abstract provided.

Ada News - 01/18/2016, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Genomic Diversity Of Epec Associated With Clinical Presentations Of Differing Severity, Tracy H. Hazen, Michael S. Donnenberg, Sandra Panchalingam, Martin Antonio, Anowar Hossain, Inacio Mandomando, John Benjamin Ochieng, Shahida Qureshi, Farheen Quadri, Anita K. M. Zaidi

Department of Paediatrics and Child Health

Enteropathogenic Escherichia coli (EPEC) are diarrhoeagenic E. coli, and are a significant cause of gastrointestinal illness among young children in developing countries. Typical EPEC are identified by the presence of the bundle-forming pilus encoded by a virulence plasmid, which has been linked to an increased severity of illness, while atypical EPEC lack this feature. Comparative genomics of 70 total EPEC from lethal (LI), non-lethal symptomatic (NSI) or asymptomatic (AI) cases of diarrhoeal illness in children enrolled in the Global Enteric Multicenter Study was used to investigate the genomic differences in EPEC isolates obtained from individuals with various clinical outcomes. A …

Medical School Watercooler Newsletter - January 17, 2016, Lindsey Lyle

Watercooler Newsletter

This is the January 17, 2016 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• 9th Annual COM Research Forum Winners Announced
• USA Radiologist Provides Insight on Updated Recommendations for Breast Cancer Screening
• Students, Residents and Faculty Named to USA Chapter of Arnold P. Gold Humanism Honor Society
• Jan. 21 DSS to Feature Dr. Mary Jane Thomassen

U.S. Biological Quarantine: A Look At The Legal Framework, Katherine T. Rooney

Journal of Legislation

Biological terrorism is a growing problem. Search and seizure protections have an on-going balancing relationship with national security that is balanced by a least restrictive means test. The Kaci Hickox case exposed the difficulty of maintaining the civil rights protections of search and seizure while combating a potentially catastrophic danger.

Group-Based Exercise And Cognitive-Physical Training In Older Adults With Self-Reported Cognitive Complaints: The Multiple-Modality, Mind-Motor (M4) Study Protocol, Michael A. Gregory, Dawn P. Gill, Erin M. Shellington, Teresa Liu-Ambrose, Ryosuke Shigematsu, Guangyong Zou, Kevin Shoemaker, Adrian M. Owen, Vladimir Hachinski, Melanie Stuckey, Robert J. Petrella

Anatomy and Cell Biology Publications

Background: Dementia is associated with cognitive and functional deficits, and poses a significant personal, societal, and economic burden. Directing interventions towards older adults with self-reported cognitive complaints may provide the greatest impact on dementia incidence and prevalence. Risk factors for cognitive and functional deficits are multifactorial in nature; many are cardiovascular disease risk factors and are lifestyle-mediated. Evidence suggests that multiple-modality exercise programs can provide cognitive and functional benefits that extend beyond what can be achieved from cognitive, aerobic, or resistance training alone, and preliminary evidence suggests that novel mind-motor interventions (i.e., Square Stepping Exercise; SSE) can benefit cognition and …

Promoting Consistent Use Of The Communication Function Classification System (Cfcs), Barbara Jane Cunningham, Mary Jo Hidecker, Nancy Thomas-Stonell, Peter Rosenbaum

PRECISe Preschool Speech and Language Publications

Purpose: We developed a Knowledge Translation (KT) intervention to standardize the way speech-language pathologists working in Ontario Canada’s Preschool Speech and Language Program (PSLP) used the Communication Function Classification System (CFCS). This tool was being used as part of a provincial program evaluation and standardizing its use was critical for establishing reliability and validity within the provincial dataset.

Method: Two theoretical foundations – Diffusion of Innovations and the Communication Persuasion Matrix – were used to develop and disseminate the intervention to standardize use of the CFCS among a cohort speech-language pathologists. A descriptive pre-test/post-test study was used to evaluate the …

A Comparison Of Increases In Volume Load Over 8 Weeks Of Low-Versus High-Load Resistance Training, Brad J. Schoenfeld, Dan Ogborn, Bret Contreras, Tom Cappaert, Alex Silva Ribeiro, Brent A. Alvar, Andrew D. Vigotsky

Publications and Research

Background: It has been hypothesized that the ability to increase volume load (VL) via a progressive increase in the magnitude of load for a given exercise within a given repetition range could enhance the adaptive response to resistance training.

Objectives: The purpose of this study was to compare changes in volume load (VL) over eight weeks of resistance training (RT) in high-versus low-load protocols.

Materials and Methods: Eighteen well-trained men were matched according to baseline strength were randomly assigned to either a low-load RT(LOW,n= 9) where 25 - 35 repetitions were performed per exercise, or a high-load RT (HIGH,n= 9) …

Cloning And Transcriptional Activity Of The Mouse Omi/Htra2 Gene Promoter., Dan Liu, Xin Liu, Ye Wu, Wen Wang, Xin-Liang Ma, Huirong Liu

Department of Medicine Faculty Papers

HtrA serine peptidase 2 (HtrA2), also named Omi, is a pro-apoptotic protein that exhibits dramatic changes in expression levels in a variety of disorders, including ischemia/reperfusion injury, cancer, and neurodegeneration. In our study, Omi/HtrA2 protein levels were high in the heart, brain, kidney and liver, with elevated heart/brain expression in aging mice. A similar expression pattern was observed at the mRNA level, which suggests that the regulation of Omi/HtrA2 is predominately transcriptional. Promoter binding by transcription factors is the main influencing factor of transcription, and to identify specific promoter elements that contribute to the differential expression of mouse Omi/HtrA2, we …

Defeating Huntington’S Disease Starts With Taking Care Of Yourself And Joining Enroll-Hd, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Vaccines And The Looming Threat Of Syphilis, Charles T. Ambrose

Microbiology, Immunology, and Molecular Genetics Faculty Publications

During the past several decades, syphilis has increased in the US and explosively so in China and Russia.While most current cases can be cured by penicillin or second line antibiotics, strains of the syphilis spirochete (Treponema pallidum) resistant to the latter have emerged.And the potential of strains to acquire resistance to penicillin via plasmids has recently been recognized.The 36 million-plus undertreated cases of syphilis in the world represent metaphorically a vast global 37°C incubator allowing exchange of antibiotic resistant genes among the human-borne bacteria and theoretically permitting the emergence of penicillin resistant strains.None has yet been identified but …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Georgia Southern Examines LHD Activities to Address Health Disparities and Inequities

Obesity-Induced Colorectal Cancer Is Driven By Caloric Silencing Of The Guanylin-Gucy2c Paracrine Signaling Axis., Jieru E. Lin, Francheska Colon-Gonzalez, Erik S. Blomain, Gilbert W. Kim, Amanda Aing, Brian Stoecker, Justin Rock, Adam E. Snook, Tingting Zhan, Terry M. Hyslop, Michal Tomczak, Richard S. Blumberg, Scott A. Waldman

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Obesity is a well-known risk factor for colorectal cancer but precisely how it influences risks of malignancy remains unclear. During colon cancer development in humans or animals, attenuation of the colonic cell surface receptor guanylyl cyclase C (GUCY2C) that occurs due to loss of its paracrine hormone ligand guanylin contributes universally to malignant progression. In this study, we explored a link between obesity and GUCY2C silencing in colorectal cancer. Using genetically engineered mice on different diets, we found that diet-induced obesity caused a loss of guanylin expression in the colon with subsequent GUCY2C silencing, epithelial dysfunction, and tumorigenesis. Mechanistic investigations …

The Pseudorabies Virus Protein, Pul56, Enhances Virus Dissemination And Virulence But Is Dispensable For Axonal Transport, Gina R. Daniel, Patricia J. Sollars, Gary E. Pickard, Gregory A. Smith

School of Veterinary and Biomedical Sciences: Faculty Publications

Neurotropic herpesviruses exit the peripheral nervous system and return to exposed body surfaces following reactivation from latency. The pUS9 protein is a critical viral effector of the anterograde axonal transport that underlies this process. We recently reported that while pUS9 increases the frequency of sorting of newly assembled pseudorabies virus particles to axons from the neural soma during egress, subsequent axonal transport of individual virus particles occurs with wild-type kinetics in the absence of the protein. Here, we examine the role of a related pseudorabies virus protein, pUL56, during neuronal infection. The findings indicate that pUL56 is a virulence factor …

Health Policy & Management News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• Georgia Southern Examines LHD Activities to Address Health Disparities and Inequities

The Common Genetic Influence Over Processing Speed And White Matter Microstructure: Evidence From The Old Order Amish And Human Connectome Projects, Peter Kochunov, Paul M. Thompson, Anderson M. Winkler, Mary Morrissey, Mao Fu, Thomas R. Coyle, Xiaoming Du, Florian Muellerklein, Anya Savransky, Christopher Gaudiot

School of Medicine Publications

Speed with which brain performs information processing influences overall cognition and is dependent on the white matter fibers. To understand genetic influences on processing speed and white matter FA, we assessed processing speed and diffusion imaging fractional anisotropy (FA) in related individuals from two populations. Discovery analyses were performed in 146 individuals from large Old Order Amish (OOA) families and findings were replicated in 485 twins and siblings of the Human Connectome Project (HCP). The heritability of processing speed was h(2)=43% and 49% (both p<0.005), while the heritability of whole brain FA was h(2)=87% and 88% (both p<0.001), in the OOA and HCP, respectively. Whole brain FA was significantly correlated with processing speed in the two cohorts. Quantitative genetic analysis demonstrated a significant degree to which common genes influenced joint variation in FA and brain processing speed. These estimates suggested common sets of genes influencing variation in both phenotypes, consistent with the idea that common genetic variations contributing to white matter may also support their associated cognitive behavior.

How Different Are Men Who Do Not Know Their Hiv Status From Those Who Do? Results From An U.S. Online Study Of Gay And Bisexual Men, Christian Grov, H. Jonathon Rendina, Jeffrey T. Parsons

Publications and Research

We compared self-described HIV-positive (31.6%, n=445), HIV-negative (56.8%, n=801), and HIV-unknown (11.6%, n=164) gay and bisexual men (GBM) on sociodemographic and behavioral characteristics. Participants from across the U.S. were enrolled via a popular sexual networking website to complete an online survey. In total, 44.8% of HIV-negative and HIV-unknown men said they had not been tested for HIV in the CDC-recommended last 6 months. HIV-unknown men significantly differed from HIV-negative and HIV-positive men in sexual behavior and HIV status disclosure patterns. HIV-unknown men were more willing than HIV-negative men to take PrEP; however, HIV-unknown men were significantly less likely than others …

Will They Read It?, William H. Lane

English Faculty Publications

The Pennsylvania Health Care Plan Saves Money, But Will Legislators Take Time to Read the Bill?

Al the new year begins, it's time to hitch up our britches and take a look at how things are going with healthcare insurance reform. [excerpt]