Medicine and Health Sciences Commons^™

Targeting Ho-1 By Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury Via Anti-Oxidative Stress And Anti-Inflammation Pathways., Zhao Gao, Yu Han, Yunhui Hu, Xiaoyan Wu, Yongbin Wang, Xiaoqun Zhang, Jinjuan Fu, Xue Zou, Jun Zhang, Xiongwen Chen, Pedro A. Jose, Xi Lu, Chunyu Zeng

Medicine Faculty Publications

Both oxidative stress and inflammation are involved in the pathogenesis of contrast-induced nephropathy (CIN). Epigallocatechin-3-gallate (EGCG), a purified catechin from green tea, has antioxidant and anti-inflammatory effects. However, it is unknown whether or not EGCG is effective in treating CIN. Our present study found that intravenous administration of EGCG, either before or just after the establishment of CIN, had a protective effect, determined by normalization of serum creatinine and blood urea nitrogen levels, improvement in renal histopathological scoring and alleviation of apoptosis, accompanied by decreased oxidative stress and inflammation. Because EGCG is a potent inducer of the antioxidant heme oxygenase-1 …

Vera Paoletti, Vera Paoletti, Kelsey Duinkerken

Jefferson Nursing Oral Histories

Vera Paoletti became interested in nursing as a teenager after watching a close family member succumb to leukemia. This experience led her to work as a candy striper at Jefferson Hospital through her high school years and then enroll in the Jefferson Hospital School of Nursing in 1966. Once she graduated in 1969 Ms. Paoletti began her career as a nurse at Jefferson, first in surgery on Ninth Pavilion and then in oncology on Eleventh Pavilion before becoming head nurse first of a nineteen-bed unit reserved for VIPs and then two years later of Sixth Main. In 1975 she left …

Selective Binding Of Airapl Tandem Uims To Lys48-Linked Tri-Ubiquitin Chains, Simin Rahighi, Ilauna Braunstein, Nicola Ternette, Benedikt Kessler, Masato Kawasaki, Ryuichi Kato, Tsutomu Matsui, Ariel Stanhill, Soichi Wakatsuki

Pharmacy Faculty Articles and Research

Lys48-linked ubiquitin chains act as the main targeting signals for protein degradation by the proteasome. Here we report selective binding of AIRAPL, a protein that associates with the proteasome upon exposure to arsenite, to Lys48-linked tri-ubiquitin chains. AIRAPL comprises two ubiquitin-interacting motifs in tandem (tUIMs) that are linked through a flexible inter-UIM region. In the complex crystal structure UIM1 binds the proximal ubiquitin, whereas UIM2 (the double-sided UIM) binds non-symmetrically to the middle and distal ubiquitin moieties on either side of the helix. Specificity of AIRAPL for Lys48-linked ubiquitin chains is determined by UIM2, and the flexible inter-UIM linker increases …

Plan Quality And Treatment Efficiency For Radiosurgery To Multiple Brain Metastases: Non-Coplanar Rapidarc Vs. Gamma Knife., Haisong Lui Phd, David W. Andrews Md, James J. Evans, Maria Werner-Wasik, Yan Yu, Adam Dicker Md, Phd, Wenyin Shi

Department of Radiation Oncology Faculty Papers

OBJECTIVES: This study compares the dosimetry and efficiency of two modern radiosurgery [stereotactic radiosurgery (SRS)] modalities for multiple brain metastases [Gamma Knife (GK) and LINAC-based RapidArc/volumetric modulated arc therapy], with a special focus on the comparison of low-dose spread.

METHODS: Six patients with three or four small brain metastases were used in this study. The size of targets varied from 0.1 to 10.5 cc. SRS doses were prescribed according to the size of lesions. SRS plans were made using both Gamma Knife(®) Perfexion and a single-isocenter, multiple non-coplanar RapidArc(®). Dosimetric parameters analyzed included RTOG conformity index (CI), gradient index (GI), …

Infant Vaccination Timing: Beyond Traditional Coverage Metrics For Maximizing Impact Of Vaccine Programs, An Example From Southern Nepal., Michelle M Hughes, Joanne Katz, Janet A Englund, Subarna K Khatry, Laxman Shrestha, Steven C Leclerq, Mark Steinhoff, James M. Tielsch

Global Health Faculty Publications

Background

Immunization programs currently measure coverage by assessing the proportion of children 12–24 months who have been immunized but this does not address the important question of when the scheduled vaccines were administered. Data capturing the timing of vaccination in first 6 months, when severe disease is most likely to occur, are limited.

Objective

To estimate the time to Bacillus Calmette–Guérin (BCG) (recommended at birth), diphtheria-tetanus-pertussis-H, influenza b-hepatitis B (DTP-Hib-HepB), and oral polio vaccine (OPV) (recommended at 6, 10, and 14 weeks) vaccinations and risk factors for vaccination delay in infants <6 months of age in a district in southern Nepal where traditional coverage metrics are high.

Design/methods

Infants enrolled in a randomized controlled trial of …

Fda Has A Banner Quarter To Finish Out 2016, Rodney Richmond

Faculty Research ​and Publications

No abstract provided.

AΒ40 Reduces P-Glycoprotein At The Blood-Brain Barrier Through The Ubiquitin-Proteasome Pathway, Anika M. S. Hartz, Yu Zhong, Andrea Wolf, Harry Levine Iii, David S. Miller, Björn Bauer

Sanders-Brown Center on Aging Faculty Publications

Failure to clear amyloid-β (Aβ) from the brain is in part responsible for Aβ brain accumulation in Alzheimer's disease (AD). A critical protein for clearing Aβ across the blood–brain barrier is the efflux transporter P-glycoprotein (P-gp) in the luminal plasma membrane of the brain capillary endothelium. P-gp is reduced at the blood–brain barrier in AD, which has been shown to be associated with Aβ brain accumulation. However, the mechanism responsible for P-gp reduction in AD is not well understood. Here we focused on identifying critical mechanistic steps involved in reducing P-gp in AD. We …

Recruitment And Retention Of Hispanic Nursing Students: Through The Lens Of Associate Degree Nursing Program Administrators And Hispanic Nursing Students, Debra Jean Handlos Devoe

Theses and Dissertations

The Hispanic population in the United States is changing and will constitute 30% of the population in 2050; however, the Hispanic registered nurse population is less than 3%. Cultural differences between patients and nurses may cause harm and a mistrust that can affect patient outcomes. A mixed methods convergent research study was done by an electronic survey, non-electronic surveys, telephone interviews, and focus groups to compare the perceptions of nursing program administrators at seven community colleges in a Mid-Atlantic state, in the United States, and the perceptions of 15 Hispanic nursing students regarding the challenges, barriers, and obstacles of Hispanic …

Pi(4)P Promotes Phosphorylation And Conformational Change Of Smoothened Through Interaction With Its C-Terminal Tail, Kai Jiang, Yajuan Liu, Junkai Fan, Jie Zhang, Xiang-An Li, B. Mark Evers, Haining Zhu, Jianhang Jia

Markey Cancer Center Faculty Publications

In Hedgehog (Hh) signaling, binding of Hh to the Patched-Interference Hh (Ptc-Ihog) receptor complex relieves Ptc inhibition on Smoothened (Smo). A longstanding question is how Ptc inhibits Smo and how such inhibition is relieved by Hh stimulation. In this study, we found that Hh elevates production of phosphatidylinositol 4-phosphate (PI(4)P). Increased levels of PI(4)P promote, whereas decreased levels of PI(4)P inhibit, Hh signaling activity. We further found that PI(4)P directly binds Smo through an arginine motif, which then triggers Smo phosphorylation and activation. Moreover, we identified the pleckstrin homology (PH) domain of G protein-coupled receptor kinase 2 (Gprk2) as an …

Maternal Anxiety Associated With Newborn Hearing Screening, Stephen J. Tueller, Karl R. White

Journal of Early Hearing Detection and Intervention

The purpose of this study was to determine if newborn hearing screening increases maternal anxiety. Mothers whose infants were screened for hearing were asked how worried they were prior to hospital discharge and again six weeks later. They were also asked if they were more concerned about their baby’s hearing than they were about other aspects of the infant’s health and behavior.

Results showed that mothers worried as much or more about many other aspects of their infants’ health and behavior as about hearing. Mothers whose infants had a false positive screening result were initially more worried about hearing than …

Readability, User-Friendliness, And Key Content Analysis Of Newborn Hearing Screening Brochures, Nannette C. Nicholson, Samuel R. Atcherson, Patti F. Martin, Mary Gunn Spragins, Lauren Schlagenhauf, Richard I. Zraick

Journal of Early Hearing Detection and Intervention

Readability, user-friendliness, and key content are important components of newborn screening brochure design. Health information at a sixth grade or below reading level, designed for ease of navigation, with easily identifiable “action steps” can help adults with limited literacy skills find, understand, and use health information. The purpose of this study was to quantify the readability, user-friendliness, and key content components of newborn hearing screening brochures. Five readability formulae (FRE, F–K GL, FOG, FORCAST, and SMOG) were used to estimate reading levels of English language EHDI brochures (N = 48). Twenty-three participants assessed brochures for user-friendliness. Three participants assessed …

Wic Participation As A Risk Factor For Loss To Follow-Up In The Wisconsin Ehdi System, Elizabeth L. Seeliger, Rebecca A. Martin, Andrea N. Gromoske, Anne B. Harris

Journal of Early Hearing Detection and Intervention

In 2011, Wisconsin’s Early Hearing Detection and Intervention (EHDI) program, Wisconsin Sound Beginnings (WSB), developed multiple strategies to reduce loss to follow-up (LTFU) for babies who did not pass their newborn hearing screening: Medical Outreach, Family Outreach, Regional Outreach and WIC Alert. WSB evaluated the outcomes of babies identified as at-risk for LTFU to determine whether WIC participation was an indicator of their risk for LTFU. Additionally, WSB evaluated whether babies who were identified as at-risk for LTFU and receiving WIC services in two WIC projects serving areas and populations with known health disparities, were at even greater risk for …

Professional Competence To Promote Resilience For Children Living In Poverty, Jenna M. Voss, Susan Lenihan

Journal of Early Hearing Detection and Intervention

Poverty has a tremendous impact on the educational results of all children, including those who are deaf or hard of hearing. With targeted, evidence-based interventions during the first three years of life, Early Hearing Detection and Intervention (EHDI) professionals can protect children from the numerous risk factors which impede development. While EHDI professionals often serve children and families living in poverty, it remains the case that the professional preparation programs offer limited instruction and experience in how to best serve children and families living in poverty. The purpose of this study was to explore professional preparedness to serve children who …

Outsourcing Hospital-Based Newborn Hearing Screening: Key Questions And Considerations, Randi L. Winston, Jackson Roush

Journal of Early Hearing Detection and Intervention

This article reviews the essential components of a high quality newborn hearing screening program and it examines important questions and considerations for hospitals considering outsourcing of newborn hearing screening. Specific issues include hiring, training, and evaluation of personnel; special considerations for the NICU; implications of a screening model that requires families to “opt-in”; implications for choice of technology; instrumentation and screening protocols; tracking and surveillance for infants who do not pass the initial screening; billing and collection practices; and the impact of outsourcing on a hospital’s institutional mission.

The Role Of Family-Led Disability Organizations In Supporting Families With Hearing-Related Concerns, Diane D. Behl, Janet Desgeorges, Karl R. White

Journal of Early Hearing Detection and Intervention

A survey was conducted with state level chapters from Family Voices, Parent Training and Information Centers, and Parent–to-Parent USA to understand their current activities support families of children with hearing-related concerns and to identify gaps in their ability to support families of children who are D/HH. these organizations reported that they are contacted with parent requests for information in regard to family support opportunities, early intervention, referral sources pertaining to hearing concerns, financial help, and providing information about legal rights. Results showed that the greatest challenges for these organizations were related to needing to connect families to financial resources pertaining …

Effective And Efficient Pre-School Hearing Screening: Essential For Successful Ehdi, James W. Hall

Journal of Early Hearing Detection and Intervention

Effective and efficient pre-school hearing screening is an essential component of a successful EHDI program.

Caregiver Training In Mindfulness-Based Positive Behavior Supports (Mbpbs): Effects On Caregivers And Adults With Intellectual And Developmental Disabilities, Nirbhay N. Singh, Giulio E. Lancioni, Bryan T. Karazsia, Rachel E. Myers

Faculty Articles

Caregivers often manage the aggressive behavior of individuals with intellectual and developmental disabilities that reside in community group homes. Sometimes this results in adverse outcomes for both the caregivers and the care recipients. We provided a 7-day intensive Mindfulness-Based Positive Behavior Support (MBPBS) training to caregivers from community group homes and assessed the outcomes in terms of caregiver variables, individuals’ behaviors, and an administrative outcome. When compared to pre-MBPBS training, the MBPBS training resulted in the caregivers using significantly less physical restraints, and staff stress and staff turnover were considerably reduced. The frequency of injury to caregivers and peers caused …

Short-Term Effects Of Rhythmic Sensory Stimulation In Alzheimer’S Disease: An Exploratory Pilot Study, Amy Clements-Cortés, Heidi Ahonen, Michael Evans, Morris Freedman, Lee Bartel

Music Faculty Publications

This study assessed the effect of stimulating the somatosensory system of Alzheimer’s disease (AD) patients at three stages of their illness with 40 Hz sound. In this AB cross-over study design, 18 participants (6 mild, 6 moderate, 6 severe) each participated in 13 sessions: one intake and 12 treatment. Treatment A consisted of 40 Hz sound stimulation and Treatment B consisted of visual stimulation using DVDs, each provided twice a week over 6 weeks for a total of 6 times per treatment. Outcome measures included: St. Louis University Mental Status Test (SLUMS), Observed Emotion Rating Scale, and behavioral observation by …

Hospital Discharge Planning In Medicare: Current Requirements And Proposed Changes, Sally Coberly

National Health Policy Forum

Medicare's specific minimum health and safety standards for hospitals, known as conditions of participation, include requirements for discharge planning for patients who need such services. Discharge planning is intended to ensure smooth transitions from hospital to home or other health care facility. This publication reviews the current discharge planning requirements for hospitals as well as changes included in a proposed rule published by the Centers for Medicare & Medicaid Services on November 3, 2015. Key proposed changes include an expanded definition of which patients must receive discharge planning services, a requirement that providers responsible for follow-up care receive timely …

Medical Students' Perceptions Of Dementia After Participation In Poetry Workshop With People With Dementia., Alaina J Garrie, Shruti Goel, Martin M Forsberg

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Purpose. Researchers assessed whether medical students' participation in a poetry workshop with people with Alzheimer's disease and related dementias (ADRD) affected their attitudes towards persons with ADRD. Objective. To add to the growing body of research summarizing the impact of nonclinical interventions on medical students' perspectives about people with ADRD. Design. Researchers used dementia attitudes scale (DAS) and interpretive phenomenological analysis (IPA) to analyze participants' attitudes. Setting. Osteopathic medical school and dementia care unit in the state of New Jersey. Participants. Eleven out of fourteen medical students completed the study. Measurements. Emerging themes were classified from the postintervention semistructured interviews …

Knowledge, Attitude And Practices: Assessing Maternal And Child Health Care Handbook Intervention In Vietnam, Hirotsugu Aiga, Vinh Duc Nguyen, Cuong Dinh Nguyen, Tho Thi Thi Nguyen, Lien Thi Phuong Nguyen

Global Health Faculty Publications

Background

Maternal and Child Health (MCH) Handbook, an integrated MCH home-based record, was piloted in four provinces of Vietnam (Dien Bien, Hoa Binh, Thanh Hoa and An Giang). The study is aimed at assessing the changes in pregnant women’s behavior towards the frequencies of their antenatal care service utilizations and their subsequent breastfeeding practices up to six months of age, through the MCH Handbook intervention. This is because the levels of pregnant women’s knowledge, attitude and practices (KAP) towards their antenatal care service utilizations and exclusive breastfeeding practices have been previously neither analyzed nor reported in relation to MCH home-based …

Radiation-Induced Breast Cancer: The Question Of Early Breast Cancer Screening In Hodgkin's Lymphoma Survivors, Talal Hilal, David W. Rudy

Internal Medicine Faculty Publications

Chest irradiation is associated with numerous early and late complications that arise from ionizing radiation-induced damage to cellular structures within the field of therapy. In patients exposed to chest irradiation at an early age as part of the treatment of childhood cancer, specifically Hodgkin's lymphoma, the increased risk of breast cancer in the long run should be considered. A case of a 35-year-old woman who exposed to chest irradiation as part of the treatment of Hodgkin's lymphoma at the age of 20 years is presented here and serves as a reminder of this somewhat overlooked complication. The article presents the …

Influence Of Standard Work Process On Fall Risk Interventions In The Emergency Department, Ashley Mood Bsn, Rn, Kaley E. Blatt Bsn, Rn, Krista Amey Bsn, Rn, Amanda J. Mertz Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Identification Of Medicare Recipients At Highest Risk For Clostridium Difficile Infection In The Us By Population Attributable Risk Analysis, Erik R. Dubberke, Margaret A. Olsen, Dustin Stwalley, Ciarán P. Kelly, Dale N. Gerding, Yinong Young-Xu, Cedric Mahé

Dartmouth Scholarship

Background: Population attributable risk percent (PAR%) is an epidemiological tool that provides an estimate of the percent reduction in total disease burden if that disease could be entirely eliminated among a subpopulation. As such, PAR% is used to efficiently target prevention interventions. Due to significant limitations in current Clostridium difficile Infection (CDI) prevention practices and the development of new approaches to prevent CDI, such as vaccina- tion, we determined the PAR% for CDI in various subpopulations in the Medicare 5% random sample. Methods: This was a retrospective cohort study using the 2009 Medicare 5% random sample. Comorbidities, infections, and healthcare …

Hand Hygiene Compliance, Nicole M. Caby Bsn, Rn, Crystal A. Conboy Bsn, Rn, Ashley N. Sneed Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Acuity Tool Use In A Pediatric Icu, Victoria A. Cognat Bsn, Rn, Yori E. Cozen Bsn, Rn, Katheryn Malcolm Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Mesial Temporal Lobe Epilepsy With Childhood Febrile Seizure., Ali Akbar Asadi-Pooya, Maromi Nei, Cyrus Rostami, Michael R. Sperling

Department of Neurology Faculty Papers

OBJECTIVES: To evaluate the demographic and clinical manifestations of patients with mesial temporal sclerosis and temporal lobe epilepsy (MTS-TLE) with childhood febrile seizure (FS) and establishing the potential differences as compared to those without FS. We also investigated the surgery outcome in these two groups of patients.

MATERIALS AND METHODS: In this retrospective study, all patients with a clinical diagnosis of drug-resistant TLE due to mesial temporal sclerosis, who underwent epilepsy surgery at Jefferson Comprehensive Epilepsy Center, were recruited. Patients were prospectively registered in a database from 1986 through 2014. Postsurgical outcome was classified into two groups; seizure-free or relapsed. …

Comfort Care In The Emergency Department, Sharla M. Kurtz Bsn, Rn, Heather A. Williams Bsn, Rn, Amy L. Zarichniak Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Cream Team: Reeducation Of Skin Care Products, Sara A. Greig Bsn, Rn, Kristen A. Keane Bsn, Rn, Brigid E. Mcnamara Bsn, Rn, Andrea Tasselmyer Bsn, Rn

Patient Care Services / Nursing

No abstract provided.

Implementation Of “Quiet Time” On A Maternity Ward In A Hospital Setting, Jennyfer M. Cruz Bsn, Rn, Eunessy V. Dreibelbis Bsn, Rn, Kate N. Weinberg Bsn, Rn

Patient Care Services / Nursing

No abstract provided.