Medicine and Health Sciences Commons^™

Time To Ask: An Alcohol Education Pilot For Healthcare Professionals. Clinical Needs Assessment, Mary Lindsey Smith Phd, Martha Elbaum Williamson Mpa, Jennifer Pratt Ba, Rachel M. Gallo Mph, Katie Rosingana Ba, Jacey Keller Mph, Mark Richards Bs

Substance Use Research & Evaluation

No abstract provided.

20-Hete Activates The Transcription Of Angiotensin-Converting Enzyme Via Nuclear Factor-Κb Translocation And Promoter Binding, Victor Garcia, Brian Shkolnik, Laura Milhau, John R. Falck, Michal Laniado Schwartzman

NYMC Faculty Publications

Increased vascular 20-hydroxyeicosatetraenoic acid (20-HETE), a cytochrome P450 arachidonic acid metabolite, promotes vascular dysfunction, injury, and hypertension that is dependent, in part, on the renin angiotensin system (RAS). We have shown that, in human microvascular endothelial cells, 20-HETE increases angiotensin-converting enzyme (ACE) mRNA, protein, and ACE activity via an epidermal growth factor receptor (EGFR)/tyrosine kinase/mitogen-activated protein kinase (MAPK)/inhibitor of κB kinase (IKK)β-mediated signaling pathway. In this work, we show that, similar to epidermal growth factor (EGF), 20-HETE (10 nM) activates EGFR by stimulating tyrosine phosphorylation; however, unlike 20-HETE, EGF does not induce ACE expression, and pretreatment with a neutralizing antibody …

Reactive Strength Index-Modified In Different Plyometric Tasks, Josh Walker, Sarah B. Clarke, Emma Waller, Aaron Robey-Broome, Randall L. Jensen

Conference Presentations

No abstract provided.

Bioethics: Preparing For The Unknown- Abstracts, The Center For The Study Of Ethics In Society, Western Michigan University

Bioethics: Preparing for the Unknown

Abstracts from the March 17-18, 2016 conference on Bioethics: Preparing for the Unknown. This was the 30th anniversary conference for The Center for the Study of Ethics in Society at Western Michigan University.

Childhood Obesity Prevalence, Determinants, Disparities, And Interventions: A Review Of The Current Literature, Robin M. Mertens

Kinesiology and Public Health

No abstract provided.

Animal Health Matters, Russ Daly, Jane Hennings

Animal Health MATTERS Newsletter

[Page] 1 VBSD/ADRDL Researchers Benefit from new Oscar Olson Research Laboratories at SDSU
[Page] 2 Director's Message: The ADRDL in State Statute
[Page] 3 Darrell Johnson Honored by Department
[Page] 3 Pork Quality Assurance Advisor Training Scheduled at SDSU
[Page] 4 Specimen Receiving and Necropsy Sections at the ADRDL: Getting the Diagnostic Process off to a Great Start
[Page] 6 New Anaplasmosis PCR test online at ADRDL
[Page] 6 Laura Schanning Joins ADRDL in Specimen Receiving
[Page] 6 Reminder: Case History Helps Calf Scours Diagnosis
[Page] 6 Dr. Beverly Shelbourn Joins Veterinary and Biomedical Sciences Department as Instructor
[Page] 6 …

Service Learning In Undergraduate Nursing Education: Strategies To Facilitate Meaningful Reflection, Nola A. Schmidt, Janet M. Brown

Nursing and Health Professions Faculty Publications

Service learning is recognized as a valuable pedagogy involving experiential learning, reflection, and reciprocal learning. Students develop critical thinking and social awareness by using the crucial activity of reflecting upon their experiential learning with community partners. The purpose of this paper is to demystify the process of reflection by identifying best practices to enhance reflection and offering suggestions for grading. By understanding “the what” and “the how” of reflection, educators can implement service learning experiences designed to include the essential component of reflection. Strategies for facilitating meaningful reflection are described including descriptions of what students should reflect upon and how …

Reliability Assessment Of A Peer Evaluation Instrument In A Team-Based Learning Course, Joy Wahawisan, Miguel Salazar, Robin Walters, Fadi M. Alkhateeb, Omar F. Attarabeen

Pharmacy Practice & Administration

Objective: To evaluate the reliability of a peer evaluation instrument in a longitudinal team-based learning setting.

Methods: Student pharmacists were instructed to evaluate the contributions of their peers. Evaluations were analyzed for the variance of the scores by identifying low, medium, and high scores. Agreement between performance ratings within each group of students was assessed via intra-class correlation coefficient (ICC).

Results: We found little variation in the standard deviation (SD) based on the score means among the high, medium, and low scores within each group. The lack of variation in SD of results between groups suggests that …

Dementia Care: Confronting Myths In Clinical Management, Shirley M. Neitch Md, Charles Meadows Md, Eva Patton-Tackett Md, Kevin W. Yingling Md

Internal Medicine

Enormous challenges of this pervasive life-changing condition. Seeking help, often grasping at straws, victims, and their care providers are confronted with misinformation and myths when they search the internet or other sources. When Persons with Dementia (PWD) and their caregivers believe and/or act on false information, proper treatment may be delayed, and ultimately damage can be done. In this paper, we review commonly misunderstood issues encountered in caring for PWD. Our goal is to equip Primary Care Practitioners (PCPs) with accurate information to share with patients and families, to improve the outcomes of PWD to the greatest extent possible.

While …

Premedical Programs Newsletter, March 2016, University Of Dayton

Pre-Health Resource Center Campus Communications

Newsletter for students, staff, and faculty in the premedical and predental programs.

Does Environmental Enrichment Promote Recovery From Stress In Rainbow Trout?, Kieran C. Pounder, Jennifer L. Mitchell, Jack S. Thomson, Tom G. Pottinger, Jonathan Buckley, Lynne U. Sneddon

Experimental Research and Animal Welfare Collection

The EU Directive on animal experimentation suggests that all protected animals should have enrichment to improve welfare yet relatively little research has been conducted on the impact of enrichment in fish. Studies employing enrichment in zebrafish have been contradictory and all fish species should be provided with species-specific enrichments relevant to their ecology. Salmonids are important experimental models in studies within aquaculture, toxicology and natural ecosystems. This study therefore sought to establish whether an enriched environment in an experimental aquarium may promote improved welfare in rainbow trout (Oncorhynchus mykiss) by enhancing their recovery from invasive procedures. Trout were …

Circulating Amino Acids In Blood Plasma During The Peripartal Period In Dairy Cows With Different Liver Functionality Index, Z. Zhou, J. J. Loor, F. Piccioli-Cappelli, F. Librandi, G. E. Lobley, E. Trevisi

Physiology Collection

The liver functionality index (LFI) measures the changes of albumin, cholesterol, and bilirubin concentrations between 3 and 28 d postpartum. This composite index, based on variables with direct relevance to liver-specific plasma protein synthesis (albumin), hepatic/intestinal lipoprotein synthesis (cholesterol), and clearance of breakdown products of heme catabolism (bilirubin), provides a tool for evaluating manifestations of hepatic disease. Both energy and protein metabolism are likely to be affected by various physiological challenges in this period but have not been tested systematically. The present study was conducted to profile AA in cows with high or low LFI during the peripartal period …

Assembly And Structure Of Human Mitochondrial Transcription Initiation Complex, Yaroslav Morozov

Graduate School of Biomedical Sciences Theses and Dissertations

Mitochondria play a key role in energy metabolism in nearly all eukaryotic cells. Apart from that, they participate in many other biochemical pathways, such as amino acid and nucleotide metabolism, and biosynthesis of cholesterol, heme, and iron-sulfur clusters. Mitochondria are also involved in cell signaling, apoptosis and regulation of cell cycle. Abnormalities of mitochondrial morphology and function are often associated with tumor progression, neurodegeneration and aging.

Mitochondria are unique organelles in mammalian cells because they have their own genomic DNA, transcription and translation systems. Various mutations and defects in mitochondrial gene expression lead to severe diseases that include various mitochondrial …

Retrospective Studies In Lower Urinary Tract Dysfunction Do Matter, Israel Franco

NYMC Faculty Publications

Comment on Clinical course of a cohort of children with non-neurogenic daytime urinary incontinence symptoms followed at a tertiary center. [J Pediatr (Rio J). 2016]

Violent Death Rates: The United States Compared To Other High-Income Oecd Countries, 2010, Erin Grinshteyn, David Hemenway

Nursing and Health Professions Faculty Research and Publications

Background: Violent death is a serious problem in the US. Previous research showing US rates of violent death compared with other high-income countries used data that are more than a decade old.

Methods: We examined 2010 mortality data obtained from the WHO for populous, high-income countries (n=23). Death rates per 100,000 population were calculated for each country and for the aggregation of all non-US countries overall and by age and sex. Tests of significance were performed using Poisson and negative binomial regressions. Results: US homicide rates were 7.0 times higher than other high-income countries, driven by a gun homicide rate …

Department Of Surgery Update, March 2016, Wright State University Department Of Surgery

Department of Surgery Updates

A four page newsletter created by the Department of Surgery documenting changes to the department. This issue contains a message from the chair, a list of important dates, committee meetings, scholarly activity and more.

Motor And Hippocampal Dependent Spatial Learning And Reference Memory Assessment In A Transgenic Rat Model Of Alzheimer's Disease With Stroke, Jennifer L. Au, Nina Weishaupt, Hayley J. Nell, Shawn N. Whitehead, David F. Cechetto

Anatomy and Cell Biology Publications

Alzheimer's disease (AD) is a debilitating neurodegenerative disease that results in neurodegeneration and memory loss. While age is a major risk factor for AD, stroke has also been implicated as a risk factor and an exacerbating factor. The co-morbidity of stroke and AD results in worsened stroke-related motor control and AD-related cognitive deficits when compared to each condition alone. To model the combined condition of stroke and AD, a novel transgenic rat model of AD, with a mutated form of amyloid precursor protein (a key protein involved in the development of AD) incorporated into its DNA, is given a small …

Recovery Of Sleep Or Recovery Of Self? A Grounded Theory Study Of Residents' Decision Making Regarding How To Spend Their Nonclinical Postcall Time, Taryn S. Taylor, Jeff Nisker, Pim W. Teunissen, Tim Dornan, Lorelei Lingard

Paediatrics Publications

Purpose As resident work hours policies evolve, residents' off-duty time remains poorly understood. Despite assumptions about how residents should be using their postcall, off-duty time, there is little research on how residents actually use this time and the reasoning underpinning their activities. This study sought to understand residents' nonclinical postcall activities when they leave the hospital, their decision-making processes, and their perspectives on the relationship between these activities and their well-being or recovery. Method The study took place at a Liaison Committee on Medical Education-accredited Canadian medical school from 2012 to 2014. The authors recruited a purposive and convenience sample …

Toward A Mixed-Methods Research Approach To Content Analysis In The Digital Age: The Combined Content-Analysis Model And Its Applications To Health Care Twitter Feeds, Eradah O. Hamad, Marie Y. Savundranayagam, Jeffrey D. Holmes, Elizabeth Anne Kinsella, Andrew M. Johnson

Health and Rehabilitation Sciences Publications

BACKGROUND: Twitter’s 140-character microblog posts are increasingly used to access information and facilitate discussions among health care professionals and between patients with chronic conditions and their caregivers. Recently, efforts have emerged to investigate the content of health care-related posts on Twitter. This marks a new area for researchers to investigate and apply content analysis (CA). In current infodemiology, infoveillance and digital disease detection research initiatives, quantitative and qualitative Twitter data are often combined, and there are no clear guidelines for researchers to follow when collecting and evaluating Twitter-driven content.

OBJECTIVE: The aim of this study was to identify studies on …

Pulmonary Ct And Mri Phenotypes That Help Explain Chronic Pulmonary Obstruction Disease Pathophysiology And Outcomes, Eric A Hoffman, David A Lynch, R Graham Barr, Edwin J R Van Beek, Grace Parraga

Medical Biophysics Publications

Pulmonary x-ray computed tomographic (CT) and magnetic resonance imaging (MRI) research and development has been motivated, in part, by the quest to subphenotype common chronic lung diseases such as chronic obstructive pulmonary disease (COPD). For thoracic CT and MRI, the main COPD research tools, disease biomarkers are being validated that go beyond anatomy and structure to include pulmonary functional measurements such as regional ventilation, perfusion, and inflammation. In addition, there has also been a drive to improve spatial and contrast resolution while at the same time reducing or eliminating radiation exposure. Therefore, this review focuses on our evolving understanding of …

Imaging How And Where We Breathe Oxygen: Another Big Short?, Dante P I Capaldi, Fumin Guo, Grace Parraga

Medical Biophysics Publications

The Big Short tells the story of a small group of skeptics who profited from the financial crisis in 2007 by betting against collateralized (mortgage) debt obligations (CDO). Importantly, the novel paints a clear picture of the eccentric nature of contrarians who think divergently and against the grain or bet against an accepted truth or “sure” thing. In a similar manner, Ishii and co-workers’ recent work describes their team’s development of a pulmonary imaging technology that provides divergent and disruptive in vivo lung measurements of oxygen partial pressure in the context of the prevailing and longstanding consensus around FEV1 as …

The Expanding Phenotype Of Melas Caused By The M.3291t > C Mutation In The Mt-Tl1 Gene, E. Keilland, C. A. Rupar, Asuri N. Prasad, K. Y. Tay, A. Downie, C. Prasad

Bone and Joint Institute

Crown Copyright © 2016 Published by Elsevier Inc. m.3291T > C mutation in the MT-TL1 gene has been infrequently encountered in association with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS), however remains poorly characterized from a clinical perspective. In the following report we describe in detail the phenotypic features, long term follow up (> 7 years) and management in a Caucasian family with MELAS due to the m.3291T > C mutation and review the literature on m.3291T > C mutation. The clinical phenotype in the proposita included overlapping features of MELAS, MERRF (Myoclonic epilepsy and ragged-red fiber syndrome), MNGIE (Mitochondrial neurogastrointestinal …

Character, Incidence, And Predictors Of Knee Pain And Activity After Infrapatellar Intramedullary Nailing Of An Isolated Tibia Fracture, William Obremskey, Julie Agel, Kristin Archer, Philip To, Paul Tornetta, Mohit Bhandari, Gordon Guyatt, David W. Sanders, Emil H. Schemitsch, Marc Swiontkowski, Stephen Walter, Sheila Sprague, Diane Heels-Ansdell, Lisa Buckingham, Pamela Leece, Helena Viveiros, Tashay Mignott, Natalie Ansell, Natalie Sidorkewicz, Claire Bombardier, Jesse A. Berlin, Michael Bosse, Bruce Browner, Brenda Gillespie, Alan Jones, Peter O'Brien, Rudolf Poolman, Mark D. Macleod, Timothy Carey, Kellie Leitch, Stuart Bailey, Kevin Gurr, Ken Konito

Bone and Joint Institute

© Copyright 2015 Wolters Kluwer Health, Inc. All rights reserved. Objective: To study the activity and incidence of knee pain after sustaining an isolated tibia fracture treated with an infrapatellar intramedullary nail at 1 year. Design: Retrospective review of prospective cohort. Setting: Multicenter Academic and Community hospitals. Patients: Four hundred thirty-seven patients with an isolated tibia fracture completed a 12-month assessment on pain and self-reported activity. Intervention: Infrapatellar intramedullary nail. Outcomes: Demographic information, comorbid conditions, injury characteristics, and surgical technique were recorded. Knee pain was defined on a 1-7 scale with 1 being "no pain" and 7 being a "very …

Reaming Does Not Affect Functional Outcomes After Open And Closed Tibial Shaft Fractures: The Results Of A Randomized Controlled Trial, Carol A. Lin, Marc Swiontkowski, Mohit Bhandari, Stephen D. Walter, Emil H. Schemitsch, David Sanders, Paul Tornetta

Bone and Joint Institute

© Copyright 2015 Wolters Kluwer Health, Inc. All rights reserved. Objectives: We sought to determine the effect of reaming on 1-year 36-item short-form general health survey (SF-36) and short musculoskeletal function assessment (SMFA) scores from the Study to Prospectively Evaluate Reamed Intramedullary Nails in patients with Tibial Fractures. Design: Prospective randomized controlled trial.1319 patients were randomized to reamed or unreamed nails. Fractures were categorized as open or closed. Setting: Twenty-nine academic and community health centers across the US, Canada, and the Netherlands. Patients/Participants: One thousand three hundred and nineteen skeletally mature patients with closed and open diaphyseal tibia fractures. Intervention: …

Notochord Cells In Intervertebral Disc Development And Degeneration, Matthew R. Mccann, Cheryle A. Séguin

Bone and Joint Institute

© 2015 by the authors. All right reserved. The intervertebral disc is a complex structure responsible for flexibility, multi-axial motion, and load transmission throughout the spine. Importantly, degeneration of the intervertebral disc is thought to be an initiating factor for back pain. Due to a lack of understanding of the pathways that govern disc degeneration, there are currently no disease-modifying treatments to delay or prevent degenerative disc disease. This review presents an overview of our current understanding of the developmental processes that regulate intervertebral disc formation, with particular emphasis on the role of the notochord and notochord-derived cells in disc …

Differential Effect Of Clomipramine On Habituation And Prepulse Inhibition In Dominant Versus Subordinate Rats., Alvin Yang, Tahira Daya, Karen Carlton, Jin Hui Yan, Susanne Schmid

Brain and Mind Institute Researchers' Publications

Many patients with depression have comorbidities associated with an impairment of sensorimotor gating, such as e.g. schizophrenia, Parkinson Disease, or Alzheimer disease. Anti-depressants like clomipramine that modulate serotonergic or norepinephrinergic neurotransmission have been shown to impact sensorimotor gating, it is therefore important to study potential effects of clomipramine in order to rule out an exacerbation of sensorimotor gating impairment. Prior studies in animals and humans have been inconclusive. Since serotonin and norepinephrine levels are closely related to anxiety and stress levels and therefore to the social status of an animal, we tested the hypothesis that acute and chronic effects of …

Trajectories Of Symbolic And Nonsymbolic Magnitude Processing In The First Year Of Formal Schooling, Anna A. Matejko, Daniel Ansari

Brain and Mind Institute Researchers' Publications

Sensitivity to numerical magnitudes is thought to provide a foundation for higher-level mathematical skills such as calculation. It is still unclear how symbolic (e.g. Arabic digits) and nonsymbolic (e.g. Dots) magnitude systems develop and how the two formats relate to one another. Some theories propose that children learn the meaning of symbolic numbers by scaffolding them onto a pre-existing nonsymbolic system (Approximate Number System). Others suggest that symbolic and nonsymbolic magnitudes have distinct and non-overlapping representations. In the present study, we examine the developmental trajectories of symbolic and nonsymbolic magnitude processing skills and how they relate to each other in …

Structure And Function Of Gene Regulatory Networks Associated With Worker Sterility In Honeybees., Julia A Sobotka, Mark Daley, Sriram Chandrasekaran, Benjamin D Rubin, Graham J Thompson

Brain and Mind Institute Researchers' Publications

A characteristic of eusocial bees is a reproductive division of labor in which one or a few queens monopolize reproduction, while her worker daughters take on reproductively altruistic roles within the colony. The evolution of worker reproductive altruism involves indirect selection for the coordinated expression of genes that regulate personal reproduction, but evidence for this type of selection remains elusive. In this study, we tested whether genes coexpressed under queen-induced worker sterility show evidence of adaptive organization within a model brain transcriptional regulatory network (TRN). If so, this structured pattern would imply that indirect selection on nonreproductive workers has influenced …

Effects Of A Consistent Target Or Masker Voice On Target Speech Intelligibility In Two- And Three-Talker Mixtures., Fabienne Samson, Ingrid S Johnsrude

Brain and Mind Institute Researchers' Publications

When the spatial location or identity of a sound is held constant, it is not masked as effectively by competing sounds. This suggests that experience with a particular voice over time might facilitate perceptual organization in multitalker environments. The current study examines whether listeners benefit from experience with a voice only when it is the target, or also when it is a masker, using diotic presentation and a closed-set task (coordinate response measure). A reliable interaction was observed such that, in two-talker mixtures, consistency of masker or target voice over 3-7 trials significantly benefited target recognition performance, whereas in three-talker …

In Vivo Mri Signatures Of Hippocampal Subfield Pathology In Intractable Epilepsy., Maged Goubran, Boris C Bernhardt, Diego Cantor-Rivera, Jonathan C Lau, Charlotte Blinston, Robert R Hammond, Sandrine De Ribaupierre, Jorge G Burneo, Seyed M Mirsattari, David A Steven, Andrew G Parrent, Andrea Bernasconi, Neda Bernasconi, Terry M Peters, Ali R Khan

Brain and Mind Institute Researchers' Publications

OBJECTIVES: Our aim is to assess the subfield-specific histopathological correlates of hippocampal volume and intensity changes (T1, T2) as well as diff!usion MRI markers in TLE, and investigate the efficacy of quantitative MRI measures in predicting histopathology in vivo.

EXPERIMENTAL DESIGN: We correlated in vivo volumetry, T2 signal, quantitative T1 mapping, as well as diffusion MRI parameters with histological features of hippocampal sclerosis in a subfield-specific manner. We made use of on an advanced co-registration pipeline that provided a seamless integration of preoperative 3 T MRI with postoperative histopathological data, on which metrics of cell loss and gliosis were quantitatively …