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Medical School Watercooler Newsletter - March 13, 2016, Lindsey Lyle

Watercooler Newsletter

This is the March 13, 2016 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• USA Senior Medical Students Celebrate Residencies at Match Day 2016
• March Med School Café - 'Hard to Breathe? Let's Talk about COPD'
• Register Now: 25th Annual OBGYN Conference
• ‘An Amazing Place with Precious People’
• March 17 DSS to Feature Dr. Michael Matthay
• Mark Your Calendar: Greater Gulf Coast Trauma and Acute Care Surgery Symposium
• William A. L. Mitchell Endowed Lectureship to Feature Dr. L.D. Britt
• 2016 Match Day - Watch Live March 18

Systematic Review On Human Resources For Health Interventions To Improve Maternal Health Outcomes: Evidence From Low- And Middle-Income Countries, Zohra S. Lassi, Nabiha B. Musavi, Blerta Maliqi, Nadia Mansoor, Andres De Francisco, Kadidiatou Toure, Zulfiqar A. Bhutta

Department of Paediatrics and Child Health

There is a broad consensus and evidence that shows qualified, accessible, and responsive human resources for health (HRH) can make a major impact on the health of the populations. At the same time, there is widespread recognition that HRH crises particularly in low- and middle-income countries (LMICs) impede the achievement of better health outcomes/targets. In order to achieve the Sustainable Development Goals (SDGs), equitable access to a skilled and motivated health worker within a performing health system is need to be ensured. This review contributes to the vast pool of literature towards the assessment of HRH for maternal health and …

The Insight Of Bsn Prepared Nurses On The Link Between Simulation Experiences And Success On The Nclex, Kacy Kirk

Research Horizons Day Posters

No abstract provided.

Musical Training Influences Auditory Temporal Processing, Saravanan Elangovan, Nicole Payne, Jacek Smurzynski, Marc A. Fagelson

ETSU Faculty Works

Background: A link between musical expertise and auditory temporal processing abilities was examined.

Material and methods: Trained musicians (n=13) and non-musicians (n=12) were tested on speech tasks (phonetic identification, speech recognition in noise) and non-speech tasks (temporal gap detection).

Results: Results indicated musicians had shorter between-channel gap detection thresholds and sharper phonetic identification functions, suggesting that perceptual reorganization following musical training assists basic temporal auditory processes.

Conclusions: In general, our results provide a conceptual advance in understanding how musical training influences speech processing, an ability which, when impaired, can affect speech and reading competency.

Evolution Of The Intracranial Approaches To Jugular Foramen Tumors: A Surgeon's Personal Perspective Through Three Illustrative Cases., Walter C. Jean Md, Daniel Felbaum

Department of Surgery

Tumors of the jugular foramen remain challenging lesions despite advances in surgical technique and medical technology. Tumors with extensive extra- and intracranial components necessitate both radical neck dissection maneuvers combined with skull base approaches. We present a single surgeon's perspective in managing these difficult tumors.

Cd34(+) Therapy-Related Acute Promyelocytic Leukemia In A Patient Previously Treated For Breast Cancer, John Savooji, Fouzia Shakil, Humayun Islam, Delong Liu, Karen Seiter

NYMC Faculty Publications

Therapy-related acute myeloid leukemia (AML) is a long term complication of chemotherapy for a variety of cancers. In most cases, the marrow demonstrates high risk cytogenetics and the prognosis is poor. In a minority of patients "good risk" cytogenetics, including t(15;17)(q22;q12), are seen and the patient's prognosis is similar to those who have de novo disease. Currently we present a patient who developed therapy-related acute promyelocytic leukemia (APL) after chemoradiotherapy for breast cancer. This case was especially atypical because the leukemic cells were CD34(+), which is an unusual immunophenotype for APL. Recognition that this patient had APL, rather than the …

Adults Using Long-Term Services And Supports: Population And Service Use Trends In Maine, Sfy 2014, Kimberly I. Snow Mhsa, Ba, Tina Gressani, Louise Olsen, Catherine Mcguire Bs, Stuart Bratesman Mpp, Karen Mauney, Jason Theriault

Disability & Aging

Prepared by research staff at the University of Southern Maine's Muskie School of Public Service for the Maine Office of Aging and Disability Services (the Office), this chartbook provides information on Maine adults who use long term services and supports. This is the first chartbook to reflect all the populations served by the Office: older adults; adults with physical disabilities; adults with intellectual disabilities/autism spectrum disorder or other related conditions; and adults with acquired brain injury. Long term services and supports are a vital lifeline for the thousands of Maine adults who need them, and they account for a significant …

Community And District Empowerment For Scale-Up (Codes): A Complex District-Level Management Intervention To Improve Child Survival In Uganda: Study Protocol For A Randomized Controlled Trial., Peter Waiswa, Thomas O'Connell, Danstan Bagenda, Pricila Mullachery, Flavia Mpanga, Dorcus K. Henriksson, Anne R. Katahoire, Eric Ssegujja, Anthony K. Mbonye, Stefan S. Peterson

Journal Articles: Epidemiology

BACKGROUND: Innovative and sustainable strategies to strengthen districts and other sub-national health systems and management are urgently required to reduce child mortality. Although highly effective evidence-based and affordable child survival interventions are well-known, at the district level, lack of data, motivation, analytic and planning capacity often impedes prioritization and management weaknesses impede implementation. The Community and District Empowerment for Scale-up (CODES) project is a complex management intervention designed to test whether districts when empowered with data and management tools can prioritize and implement evidence-based child survival interventions equitably.

METHODS: The CODES strategy combines management, diagnostic, and evaluation tools to identify …

Design, Synthesis, And Evaluation Of Chitosan Conjugated Ggrgdsk Peptides As A Cancer Cell-Targeting Molecular Transporter, Naglaa Salem El-Sayed, Amir Nasrolahi Shirazi, Magda Goda El-Meligy, Ahmed Kamel El-Ziaty, Zenat A. Nagieb, Keykavous Parang, Rakesh Tiwari

Pharmacy Faculty Articles and Research

Targeting cancer cells using integrin receptor is one of the promising targeting strategies in drug delivery. In this study, we conjugated an integrin-binding ligand (GGRGDSK) peptide to chitosan oligosaccharide (COS) using (sulfo-SMCC) bifunctional linker affording COS-SMCC-GGRGDSK. The conjugated polymer was characterized by FT-IR, ¹H NMR, ¹³C NMR, and SEM. COS-SMCC-GGRGDSK did not show cytotoxicity up to a concentration of 1 mg/mL in the human leukemia cell line (CCRF-CEM). The conjugate was evaluated for its ability to enhance the cellular uptake of cell-impermeable cargoes (e.g., FAM and F′-G(pY)EEI phosphopeptide) in CCRF-CEM, and human ovarian carcinoma (SK-OV-3) cancer …

Community And District Empowerment For Scale-Up (Codes): A Complex District-Level Management Intervention To Improve Child Survival In Uganda: Study Protocol For A Randomized Controlled Trial., Peter Waiswa, Thomas O'Connell, Danstan Bagenda, Pricila Mullachery, Flavia Mpanga, Dorcus Kiwanuka Henriksson, Anne Ruhweza Katahoire, Eric Ssegujja, Anthony K. Mbonye, Stefan Swartling Peterson

Journal Articles: Epidemiology

BACKGROUND: Innovative and sustainable strategies to strengthen districts and other sub-national health systems and management are urgently required to reduce child mortality. Although highly effective evidence-based and affordable child survival interventions are well-known, at the district level, lack of data, motivation, analytic and planning capacity often impedes prioritization and management weaknesses impede implementation. The Community and District Empowerment for Scale-up (CODES) project is a complex management intervention designed to test whether districts when empowered with data and management tools can prioritize and implement evidence-based child survival interventions equitably.

METHODS: The CODES strategy combines management, diagnostic, and evaluation tools to identify …

Acid-Base Equilibria In Organic-Solvent/Water Mixtures And Their Relevance To Gas/Particle Partitioning In The Atmosphere And In Tobacco Smoke, Julia Lynn Degagne

Dissertations and Theses

Acid-base equilibria in organic particulate matter (PM) are poorly understood, but have important implications for air quality and public health. First, acid-base reactions in organic particulate matter affect the gas/particle partitioning of organic compounds in the atmosphere, and these processes are not currently represented in atmospheric and climate change models. Second, the acid-base balance of tobacco smoke affects the amount of nicotine absorbed by the smoker, and a greater understanding of this balance would help to relate cigarette smoke composition to the addictive properties of cigarettes. This work presents data related to both air quality and tobacco smoke modeling.

The …

Awareness Of Rabies And Response To Dog Bites In A Bangladesh Community, Sumon Ghosh, Sukanta Chowdhury, Najmul Haider, Rajub K. Bhowmik, Md. S. Rana, Aung S. Prue Marma, Muhammad B. Hossain, Nitish C. Debnath, Be-Nazir Ahmed

Publications and Research

Community awareness regarding rabies and treatment seeking behaviours are critical both for the prevention and control of the disease in human and animals. We conducted a study to explore people’s awareness about rabies, their attitudes towards dogs and practices associated with treating dog bites in Satkhira Sadar, a southwestern sub-district of Bangladesh. Of the total 3200 households (HHs) surveyed, the majority of the respondents have heard about rabies (73%) and there was a high level of awareness that dog bite is the main cause of rabies (86%), and that rabies can be prevented by vaccination (85%). However, 59% of the …

Health, Healing & Hope: World-Renowned Lifestyle Doctor Presents At Andrews, Becky St. Clair

Andrews Agenda: Campus News

No abstract provided.

Antibiotic Review: Focus On Older Adults, Lisa M. Avery

Pharmacy Faculty/Staff Publications

Learning Objectives:

• Discuss spectrum of activity of antimicrobials commonly prescribed to geriatric patients.
• Review antimicrobial adverse reactions and drug interactions that occur in the geriatric population.
• Determine appropriate antimicrobial dosing recommendations for geriatric patients.

Oscillatory Neural Responses Evoked By Natural Vestibular Stimuli In Humans, Steven Gale, Mario Prsa, Aaron Schurger, Annietta Gay, Aurore Paillard, Bruno Herbelin, Jean-Philippe Guyot, Christophe Lopez, Olaf Blanke

Psychology Faculty Articles and Research

While there have been numerous studies of the vestibular system in mammals, less is known about the brain mechanisms of vestibular processing in humans. In particular, of the studies that have been carried out in humans over the last 30 years, none has investigated how vestibular stimulation (VS) affects cortical oscillations. Here we recorded high-density electroencephalography (EEG) in healthy human subjects and a group of bilateral vestibular loss patients (BVPs) undergoing transient and constant-velocity passive whole body yaw rotations, focusing our analyses on the modulation of cortical oscillations in response to natural VS. The present approach overcame significant technical challenges …

Billboards: An Old – But Also New – Way Of Projecting The Huntington's Cause, Kenneth P. Serbin

At Risk for Huntington's Disease

No abstract provided.

Training Emr In Case-Based Curriculum, Anthony J. Frisby, Phd, Steven Herrine, Md, Deborah Ziring, Md

Department of Medicine Posters

Introduction:

The Sidney Kimmel Medical College (SKMC) at Thomas Jefferson University (TJU) is creating a new medical curriculum (JeffMD), in which more learning will take place in small groups and individual activities.

In their small groups, students will focus on core case studies that will become increasingly complex, each building on the prior phase of the curriculum.

Aligning Delivery & Financing Systems To Advance A Culture Of Health, Glen P. Mays

Health Management and Policy Presentations

The Robert Wood Johnson Foundation's Systems for Action Research Program supports research on how best to organize, finance, and deliver the constellation of services and supports that promote health and well-being in American communities, including but extending beyond the medical care and public health sectors. This session describes work underway through the S4A program and future research priorities, building on a strong scientific foundation in the fields of health services research (HSR) and public health services & systems research (PHSSR).

Daily Activity And Nest Occupation Patterns Of Fox Squirrels (Sciurus Niger) Throughout The Year, Thomas Wassmer, Roberto Refinetti

Psychological Sciences Faculty Publications and Presentations

The authors investigated the general activity and nest occupation patterns of fox squirrels in a natural setting using temperature-sensitive data loggers that measure activity as changes in the microenvironment of the animal. Data were obtained from 25 distinct preparations, upon 14 unique squirrels, totaling 1385 recording days. The animals were clearly diurnal, with a predominantly unimodal activity pattern, although individual squirrels occasionally exhibited bimodal patterns, particularly in the spring and summer. Even during the short days of winter (9 hours of light), the squirrels typically left the nest after dawn and returned before dusk, spending only about 7 hours out …

Supply- And Demand-Side Factors Influencing Utilization Of Infant And Young Child Feeding Counselling Services In Viet Nam, Phuong H. Nguyen, Sunny S. Kim, Tuan T. Nguyen, Lan M. Tran, Nemat Hajeebhoy, Edward A. Frongillo Jr., Marie T. Ruel, Rahul Rawat, Purnima Menon

Faculty Publications

Adequate utilization of services is critical to maximize the impact of counselling on infant and young child feeding (IYCF), but little is known about factors affecting utilization. Our study examined supply- and demand-side factors associated with the utilization of IYCF counselling services in Viet Nam. We used survey data from mothers with children <2y >(n = 1,008) and health staff (n = 60) from the evaluation of a program that embedded IYCF counseling into the existing government health system. The frequency of never users, one-time users, repeat users, and achievers of the recommended minimum number of visits at health facilities were …

An Increasing Trend Of Illicit Drug Use Among Romanian University Students From 1999 To 2011, Lucia Maria Lotrean, Edna Arillo Santillan, Jim Thrasher, Valeria Laza

Faculty Publications

Aim

The present study investigates the evolution of illicit drug use among Romanian university students from 1999 to 2011.

Methods

The study was performed in Cluj-Napoca, Romania, in three phases: in 1999 (T1), in 2003 (T2) and in 2011 (T3).The study was carried out by means of anonymous questionnaires among university students aged 19-24.

Results

The results show that among girls the lifetime illicit drugs use increased statistically significantly from 2.5% in 1999 to 7.5% in 2003 and to 15% in 2011. Among boys the trend was also increasing, the prevalence of illicit drug use was 14.2% at T1, 18.1% …

Romidepsin For The Treatment Of Relapsed/Refractory Peripheral T Cell Lymphoma: Prolonged Stable Disease Provides Clinical Benefits For Patients In The Pivotal Trial., Francine Foss, Steven Horwitz, Barbara Pro, H Miles Prince, Lubomir Sokol, Barbara Balser, Julie Wolfson, Bertrand Coiffier

Kimmel Cancer Center Faculty Papers

BACKGROUND: Achievement of durable responses in patients with relapsed/refractory peripheral T cell lymphoma (PTCL) is challenging with current therapies, and there are few data regarding the potential benefits of continuing treatment in patients with the best response of stable disease (SD). Histone deacetylase inhibitors are a novel class of drugs with activity in T cell malignancies. Romidepsin was approved by the US Food and Drug Administration for the treatment of relapsed/refractory PTCL based on a pivotal trial demonstrating an objective response rate of 25 % (33/130), including 15 % with confirmed/unconfirmed complete response and a median duration of response of …

Consequential Considerations When Mapping Trna Fragments., Aristeidis G Telonis, Phillipe Loher, Yohei Kirino, Phd, Isidore Rigoutsos

Computational Medicine Center Faculty Papers

We examine several of the choices that went into the design of tDRmapper, a recently reported tool for identifying transfer RNA (tRNA) fragments in deep sequencing data, evaluate them in the context of currently available knowledge, and discuss their potential impact on the output that the tool generates.

Integrating Evidence Into Practice Through A Nurse Residency Program, Patricia L. Hoak Msn, Rn, Nea-Bc

Patient Care Services / Nursing

No abstract provided.

Back To Basics: Omt Workshop, Drew Keister Md, Jeffrey Lineman Md, Jacqueline S. Weaver-Agostoni Do, Parul Chaudhri Do

Department of Family Medicine

No abstract provided.

Effects Of A Mindfulness-Based Weight Loss Intervention In Adults With Obesity: A Randomized Clinical Trial., Jennifer Daubenmier, Patricia J Moran, Jean Kristeller, Michael Acree, Peter Bacchetti, Margaret E Kemeny, Douglas F. Nixon, +11 Additional Authors

Microbiology, Immunology, and Tropical Medicine Faculty Publications

OBJECTIVE: To determine whether adding mindfulness-based eating and stress management practices to a diet-exercise program improves weight loss and metabolic syndrome components.

METHODS: In this study 194 adults with obesity were randomized to a 5.5-month program with or without mindfulness training and identical diet-exercise guidelines. Intention-to-treat analyses with multiple imputation were used for missing data. The primary outcome was 18-month weight change.

RESULTS: Estimated effects comparing the mindfulness to control arm favored the mindfulness arm in (a) weight loss at 12 months, -1.9 kg (95% CI: -4.5, 0.8; P = 0.17), and 18 months, -1.7 kg (95% CI: -4.7, 1.2; …

Comparison Of Protein Phosphatase Inhibition Assay With Lc-Ms/Ms For Diagnosis Of Microcystin Toxicosis In Veterinary Cases, Caroline E. Moore, Jeanette Juan, Yanping Lin, Cynthia L. Gaskill, Birgit Puschner

Veterinary Diagnostic Laboratory Faculty Publications

Microcystins are acute hepatotoxins of increasing global concern in drinking and recreational waters and are a major health risk to humans and animals. Produced by cyanobacteria, microcystins inhibit serine/threonine protein phosphatase 1 (PP1). A cost-effective PP1 assay using p-nitrophenyl phosphate was developed to quickly assess water and rumen content samples. Significant inhibition was determined via a linear model, which compared increasing volumes of sample to the log-transformed ratio of the exposed rate over the control rate of PP1 activity. To test the usefulness of this model in diagnostic case investigations, samples from two veterinary cases were tested. In August …

Combination Of Vatalanib And A 20-Hete Synthesis Inhibitor Results In Decreased Tumor Growth In An Animal Model Of Human Glioma, Adarsh Shankar, Asm Iskander, Meenu Jain, Tom Mikkelsen, Austin M. Guo, Ali Arbab

NYMC Faculty Publications

BACKGROUND: Due to the hypervascular nature of glioblastoma (GBM), antiangiogenic treatments, such as vatalanib, have been added as an adjuvant to control angiogenesis and tumor growth. However, evidence of progressive tumor growth and resistance to antiangiogenic treatment has been observed. To counter the unwanted effect of vatalanib on GBM growth, we have added a new agent known as N-hydroxy-N'-(4-butyl-2 methylphenyl)formamidine (HET0016), which is a selective inhibitor of 20-hydroxyeicosatetraenoic acid (20-HETE) synthesis. The aims of the studies were to determine 1) whether the addition of HET0016 can attenuate the unwanted effect of vatalanib on tumor growth and 2) whether the treatment …

Knowledge Of A1c Predicts Diabetes Self- Management And A1c Level Among Chinese Patients With Type 2 Diabetes, Shengnan Yang, Weimin Kong, Cunyi Hsue, Anne Fish, Yufeng Chen, Xiaohui Guo, Qingqing Lou, Robert Anderson

Nursing Faculty Works

This study was to identify current A1c understanding status among Chinese patients with type 2 diabetes, assess if knowledge of A1c affects their diabetes self-management and their glycemic control and recognize the factors influencing knowledge of A1c among patients with type 2 diabetes. A multi-center, cross-sectional survey was conducted between April and July 2010 in 50 medical centers in the Mainland China. Participants were recruited from inpatients and outpatients who were admitted to or visited those medical centers. The survey included core questions about their demographic characteristics, diabetes self-management behavior, and A1c knowledge. Overall, of 5957 patients, the percentage of …

A Dataset To Assess Providers׳ Knowledge And Attitudes Towards The 2013 American College Of Cardiology/American Heart Association Cholesterol Management Guideline, Yashashwi Pokharel, Lynne Steinberg, Winston Chan, Julia M. Akeroyd, Peter H. Jones, Vijay Nambi, Khurram Nasir, Laura Petersen, Christie M. Ballantyne, Salim S. Virani

Office of the Provost

We previously examined provider׳s understanding of the 2013 American College of Cardiology/American Heart Association (ACC/AHA) cholesterol management guideline (DOI: http://dx.doi.org/10.1016/j.jacl.2015.11.002)(Virani et al., 2013) [1], and also assessed whether a case-based educational intervention could improve providers׳ knowledge gaps and attitudes towards the guideline (DOI: 10.1016/j.atherosclerosis.2015.12.044) (Pokharel, et al., 2016) [2]. Here we describe the dataset that we used to examine our objectives.