Medicine and Health Sciences Commons^™

A 5'-Upstream Short Open Reading Frame Encoded Peptide Regulates Angiotensin Type 1a Receptor Production And Signalling Via The Β-Arrestin Pathway, Gina L. Yosten, Jun Liu, Hong Ji, Kathryn Sandberg, Robert Speth, Willis K. Samson

HPD Articles

AUG sequences and short open reading frames are commonly present in the 5'-leader sequence of G protein-coupled receptor mRNAs. The presence of these upstream AUG sequences has been demonstrated to inhibit downstream receptor translation efficiency and, most recently, receptor signal transduction. A seven amino acid peptide encoded by a short open reading frame in exon 2 of the angiotensin type 1a receptor has been shown to inhibit non-G protein-coupled signalling of angiotensin II, without altering the classical G protein-coupled pathway activated by the ligand. This finding may lead to the development of a new class of angiotensin receptor antagonists with …

Ex Vivo And In Vivo Methods And Related Compositions For Regenerating Hematopoietic Stem Cell Populations, Gary Van Zant, Ying Liang

Markey Cancer Center Faculty Patents

Various embodiments provide methods and related compositions for increasing the population size ofhematopoietic stem cells (HSCs) in patients that may benefit from reconstitution of stem cells and/or differentiated cells of the blood lineage. The present methods enable the production ofHSCs ex vivo and in vivo by reducing latexin expression and/or latexin activity within HSC exposed to various antagonists. Inhibition of latexin expression and/or latexin activity by various antagonists can promote HSC proliferation and/or inhibit HSC apoptosis. Antagonists that can reduce latexin expression and/or latexin activity can be utilized to regenerate endogenous HSCs within patients affected with disorders, diseases, cancers, or …

Toward Earlier Inclusion Of Pregnant And Postpartum Women In Tuberculosis Drug Trials: Consensus Statements From An International Expert Panel., Amita Gupta, Jyoti S. Mathad, Susan M. Abdel-Rahman, Jessica D. Albano, Radu Botgros, Vikki Brown, Renee S. Browning, Liza Dawson, Kelly E. Dooley, Devasena Gnanashanmugam, Beatriz Grinsztejn, Sonia Hernandez-Diaz, Patrick Jean-Philippe, Peter Kim, Anne D. Lyerly, Mark Mirochnick, Lynne M. Mofenson, Grace Montepiedra, Jeanna Piper, Leyla Sahin, Radojka Savic, Betsy Smith, Hans Spiegel, Soumya Swaminathan, D Heather Watts, Amina White

Manuscripts, Articles, Book Chapters and Other Papers

Tuberculosis is a major cause of morbidity and mortality in women of childbearing age (15-44 years). Despite increased tuberculosis risk during pregnancy, optimal clinical treatment remains unclear: safety, tolerability, and pharmacokinetic data for many tuberculosis drugs are lacking, and trials of promising new tuberculosis drugs exclude pregnant women. To advance inclusion of pregnant and postpartum women in tuberculosis drug trials, the US National Institutes of Health convened an international expert panel. Discussions generated consensus statements (>75% agreement among panelists) identifying high-priority research areas during pregnancy, including: (1) preventing progression of latent tuberculosis infection, especially in women coinfected with human …

Incidence, Persistence, And Recurrence Of Anogenital Α- Mucosal Hpv Infections (Hpv 6, 11, 16, 18, 31, 33, 45, 52 And 58), Shitaldas J. Pamnani

USF Tampa Graduate Theses and Dissertations

Objectives: The aims of this study were to: 1) Assess whether naturally induced anti-HPV antibodies are associated with subsequent acquisition of genital HPV 6, 11, 16, and 18 infections in men, 2) assess the recurrence (redetection) of genital HPV infections of the 9-valent vaccine HPV types and investigate factors associated with recurrent infections among men, and 3) assess the risk of type-specific sequential acquisition of anal HPV infection following a genital HPV infection of the 9-valent vaccine HPV types among men who have sex with women (MSW).

Methods: 4,123 healthy men were followed every six months (median follow-up time 4.1 …

Factors Associated With Sexually Transmitted Infections (Stis) And Multiple Sti Co-Infections: Results From The Evri Hiv Prevention Preparedness Trial, Ubin Pokharel

USF Tampa Graduate Theses and Dissertations

Objective: The objective of this study was to describe the prevalence of sexually transmitted co-infections and assess factors associated with a single infection and co-infections.

Methods: A total of 388 women were included in this study. At enrollment of the EVRI trial women were tested for five STIs: Human papilloma virus (HPV), Chlamydia trachomatis, Neisseria gonorrhoeae, Herpes simplex virus-2 (HSV-2) and Treponema pallidum. Prevalence of STI infections and proportion of women with different combinations of co-infections were calculated. Factors associated with single infection and STI co-infection were assessed using a polytomous logistic regression model and odds ratio …

Ablation Of Matrix Metalloproteinase-9 Prevents Cardiomyocytes Contractile Dysfunction In Diabetics., Priyanka Prathipati, Naira Metreveli, Shyam Sundar Nandi, Suresh C. Tyagi, Paras K. Mishra

Journal Articles: Cellular & Integrative Physiology

Elevated expression and activity of matrix metalloproteinase-9 (MMP9) and decreased contractility of cardiomyocytes are documented in diabetic hearts. However, it is unclear whether MMP is involved in the regulation of contractility of cardiomyocytes in diabetic hearts. In the present study, we tested the hypothesis that MMP9 regulates contractility of cardiomyocytes in diabetic hearts, and ablation of MMP9 prevents impaired contractility of cardiomyocytes in diabetic hearts. To determine the specific role of MMP9 in cardiomyocyte contractility, we used 12-14 week male WT (normoglycemic sibling of Akita), Akita, and Ins(2+∕-)/MMP9(-∕-) (DKO) mice. DKO mice were generated by cross-breeding male Ins2(+∕-) Akita (T1D) …

Ectopic Mineralization Of Cartilage And Collagen-Rich Tendons And Ligaments In Enpp1asj-2j Mice., Jieyu Zhang, Nathaniel A Dyment, David W Rowe, Sarah Y Siu, John P Sundberg, Jouni Uitto, Qiaoli Li

Department of Dermatology and Cutaneous Biology Faculty Papers

Generalized arterial calcification of infancy (GACI), an autosomal recessive disorder caused by mutations in the ENPP1 gene, manifests with extensive mineralization of the cardiovascular system. A spontaneous asj-2J mutant mouse has been characterized as a model for GACI. Previous studies focused on phenotypic characterization of skin and vascular tissues. This study further examined the ectopic mineralization phenotype of cartilage, collagen-rich tendons and ligaments in this mouse model. The mice were placed on either control diet or the "acceleration diet" for up to 12 weeks of age. Soft connective tissues, such as ear (elastic cartilage) and trachea (hyaline cartilage), were processed …

Proteome And Protein Network Analyses Of Memory T Cells Find Altered Translation And Cell Stress Signaling In Treated Human Immunodeficiency Virus Patients Exhibiting Poor Cd4 Recovery, Sausan Azzam, Daniela M. Schlatzer, Sean Maxwell, Xiaolin Li, Douglas Bazdar, Yanwen Chen, Robert Asaad, Jill S. Barnholtz-Sloan, Mark R. Chance, Scott F. Sieg

Faculty Scholarship

Background. Human immunodeficiency virus (HIV) patients who experience poor CD4 T-cell recovery despite viral suppression during antiretroviral therapy (ART) are known as immunological nonresponders. The molecular mechanism(s) underlying incomplete immune restoration during ART is not fully understood. Methods. Label-free quantitative proteomics on single-cell type central memory T cells were used to reveal relative protein abundance changes between nonresponder, responder (good CD4 recovery during ART), and healthy individuals. Proteome changes were analyzed by protein pathway and network analyses and verified by selected reaction monitoring mass spectrometry. Results. Proteomic analysis across groups detected 155 significant proteins from 1500 nonredundant proteins. Pathway and …

Heart Rhythm Monitoring Strategies For Cryptogenic Stroke: 2015 Diagnostics And Monitoring Stroke Focus Group Report., Gregory W. Albers, Richard A. Bernstein, Johannes Brachmann, John Camm, J. Donald Easton, Peter Fromm, Shinya Goto, Christopher B. Granger, Stefan H. Hohnloser, Elaine Hylek, Amir K. Jaffer, Derk W. Krieger, Rod Passman, Jesse M. Pines, Shelby D. Reed, Peter M. Rothwell, Peter R. Kowey

Department of Medicine Faculty Papers

No abstract provided.

Pharmacy Research On Medication Disposal Practices Using Service-Learning, Patricia L. Darbishire, Anne Packard, Maryam Noureldin, Sumaya Bahrami

Engagement & Service-Learning Summit

Abstract

The purpose was to engage students in local communities to determine what types of medications commonly go unused, discover common medication disposal practices, gauge the public’s opinion on medication disposal, and collect unwanted medications.

Student pharmacists and a faculty mentor hosted 15 medication take-back events in conjunction with community partners, and administered a survey to participants exploring disposal practices, opinions and returned medication(s). Educational brochures on safe disposal methods were distributed to participants.

Four hundred and seventy-eight surveys were collected and 4,993 medications were identified and analyzed. The top three reasons for bringing medications to collection events included: medication …

Student And Community Perceptions On Reasons For Medication Non-Adherence, Patricia L. Darbishire, Daraoun Mashrah

Engagement & Service-Learning Summit

Abstract

The purpose of this research was to improve medication adherence by exploring and reflecting on differences in the perceptions of pharmacy students and the public regarding factors contributing to medication non-adherence.

Two hundred eighty six pharmacy students and 310 patients participated in this study. Patients were recruited by pharmacy students from Midwest community pharmacies, while the students completed an experiential rotation. Students identified their patients based on evidence of non-adherence from medication profiles and asked patients to participate in the assignment. Data was collected over a four-year period, resulting in two years of information on patient perceptions and two …

Hunger Doesn't Take A Spring Break, Jessica Isaacs

Engagement & Service-Learning Summit

The rates of food insecurity amongst Hoosier children is slightly above the national average. For many of these children, school lunches are their primary source of nutrition. During school breaks, these children are at risk of going hungry. While Purdue Nutrition Society wishes that we could help all Hoosier children stay fed with nutritious meals, for now we are focusing on helping 20 local elementary students most at risk of going hungry over spring break. Working with Glen Acres Elementary in Lafayette, Indiana, a school where in 2014, over 71% of the students qualified for free or reduced lunches, we …

Development Of A Pharmacy Service-Learning Course About Vulnerable And Underserved Patient Care, Josephine P. Aranda, Jeffrey D. Luke, Kimberly S. Plake

Engagement & Service-Learning Summit

No abstract provided.

Drug Abuse/Addiction Education (Phrm 316): A Service-Learning Course, Elizabeth J. Dowell, Ashley M. Schinker, Jane E. Krause, Richard M. Van Rijn, Val J. Watts

Engagement & Service-Learning Summit

No abstract provided.

Universal Heath Record, Tyler D. Kronewitter, Sharon Lee, Andrew Espar

Engagement & Service-Learning Summit

No abstract provided.

Community-Scale Water Treatment Systems In The Dominican Republic, Water Supply In The Dr

Engagement & Service-Learning Summit

No abstract provided.

Unraveling The Complexity Of A Current Problem In Healthcare: Using An Interprofessional Approach, Deborah Poling

Engagement & Service-Learning Summit

Engagement Service Learning Summit and Poster Session

Senior Nursing Students' Knowledge, Attitudes, And Confidence With End-Of-Life Care, Blanca E. Miller

Student Theses, Dissertations and Capstones

Background: Advance directives allow patients to put in writing the type of health care they want if they are unable to make decisions due to their medical condition. Purpose: The purpose of this study was to determine if there were differences in senior nursing students’ knowledge, attitudes, and confidence based on when the information is positioned in the curriculum. Theoretical: Social cognitive learning theory and Zimmerman’s self-regulation model provided the theoretical framework. Methods: This study reflected a non-experimental, exploratory design, with a convenience sample of senior nursing students from 2 different nursing programs in central Illinois. One program offers advance …

Localized Jnk Signaling Regulates Organ Size During Development., Helen Rankin Willsey, Xiaoyan Zheng, José Carlos Pastor-Pareja, A Jeremy Willsey, Philip A Beachy, Tian Xu

Anatomy and Regenerative Biology Faculty Publications

A fundamental question of biology is what determines organ size. Despite demonstrations that factors within organs determine their sizes, intrinsic size control mechanisms remain elusive. Here we show that Drosophila wing size is regulated by JNK signaling during development. JNK is active in a stripe along the center of developing wings, and modulating JNK signaling within this stripe changes organ size. This JNK stripe influences proliferation in a non-canonical, Jun-independent manner by inhibiting the Hippo pathway. Localized JNK activity is established by Hedgehog signaling, where Ci elevates dTRAF1 expression. As the dTRAF1 homolog, TRAF4, is amplified in numerous cancers, these …

What's Happening: March 14, 2016, Maine Medical Center

What's Happening

No abstract provided.

Presentation: 125 Years Of Nursing At Jefferson, Daniel G. Kipnis, Msi

Jefferson Digital Commons News

Michael Angelo, University Archivist and Special Collections Librarian, presented a webinar to Jefferson Nursing Alumni as part of the Jefferson College of Nursing’s 125th anniversary celebration. Now you can view his image-rich presentation,“From Probationer to Doctorate: 125 Years of Nursing at Jefferson”, in the Jefferson Digital Commons.

Ubiquitin-Specific Peptidase 10 (Usp10) Deubiquitinates And Stabilizes Muts Homolog 2 (Msh2) To Regulate Cellular Sensitivity To Dna Damage, Mu Zhang, Chen Hu, Dan Tong, Shengyan Xiang, Kendra Williams, Wenlong Bai, Guo-Min Li, Gerold Bepler, Xiaohong Zhang

Toxicology and Cancer Biology Faculty Publications

MSH2 is a key DNA mismatch repair protein, which plays an important role in genomic stability. In addition to its DNA repair function, MSH2 serves as a sensor for DNA base analogs-provoked DNA replication errors and binds to various DNA damage-induced adducts to trigger cell cycle arrest or apoptosis. Loss or depletion of MSH2 from cells renders resistance to certain DNA-damaging agents. Therefore, the level of MSH2 determines DNA damage response. Previous studies showed that the level of MSH2 protein is modulated by the ubiquitin-proteasome pathway, and histone deacetylase 6 (HDAC6) serves as an ubiquitin E3 ligase. However, the deubiquitinating …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Georgia Southern hosts the 2016 Healthcare Symposium, "Truths and Myths behind Childhood Vaccinations"
• Georgia Southern Examines Improved Nonparametric Estimations
• Georgia Southern Conducts a State-Level Analysis of MCH Partnerships
• Georgia Southern Examines Correction of Verification Bias

Beyond Traditional Scenarios: Simulation Techniques In Hospital Education, Amy E. Droskinis Msn, Rn, Ccrn

Department of Education

No abstract provided.

The Fertility Problem Inventory And Infertility-Related Stress: A Case Study, Staci L. Born, Jennifer J. Preston

The Qualitative Report

More than seven million people of childbearing age in the United States experience infertility. Oftentimes, for women, the experience of infertility is stressful. The Fertility Problem Inventory (FPI) has been used to quantitatively measure women’s experience of infertility-related stress. However, the construct of infertility-related stress is poorly described in existing literature. The purpose of this case study was to understand how women experience the FPI as a measure of infertility-related stress. To address this issue, women who were undergoing infertility treatment completed the FPI and participated in unstructured interviews. Archival documents were also retrieved to corroborate findings and satisfy saturation. …

Manual Unloading Of The Lumbar Spine: Can It Identify Immediate Responders To Mechanical Traction In A Low Back Pain Population? A Study Of Reliability And Criterion Referenced Predictive Validity, John Carlos Jr., Brian T. Swanson, Sean P. Riley, Mark P. Cote, Robin L. Leger, Isaac L. Moss

Faculty Publications

Background:: To date, no research has examined the reliability or predictive validity of manual unloading tests of the lumbar spine to identify potential responders to lumbar mechanical traction.

Purpose:: To determine: (1) the intra and inter-rater reliability of a manual unloading test of the lumbar spine and (2) the criterion referenced predictive validity for the manual unloading test.

Methods:: Ten volunteers with low back pain (LBP) underwent a manual unloading test to establish reliability. In a separate procedure, 30 consecutive patients with LBP (age 50·86±11·51) were assessed for pain in their most provocative standing position (visual analog scale (VAS) 49·53±25·52 …

Health & Kinesiology News, Georgia Southern University

Health Sciences & Kinesiology: News & Publications (2015-2023)

• SoTL Award Winner- Dr. John Dobson

Week Of March 14, 2016, New York Medical College

InTouch

• SHSP Welcomes New Chairman of the Department of Health Policy and Management
• Camille A. Clare, M.D., M.P.H. '11, Is Named Interim Associate Dean of Diversity and Inclusion for the School of Medicine
• Department of Cell Biology and Anatomy Hosts Research Forum
• 60th Annual AOA Visiting Professor Lecture Set for March 23

Health Policy & Management News, Georgia Southern University

Health Policy & Community Health: News & Publications (2011-2018)

• Georgia Southern hosts the 2016 Healthcare Symposium, “Truths and Myths behind Childhood Vaccinations”
• Georgia Southern Conducts a State-Level Analysis of MCH Partnerships

Helping Nurses Cope With Patient Death: Coping Resource Bundle, Brittany Esgro Bsn, Rn, Amy Gust Bsn, Rn, Kate Saunders Bsn, Rn, Courtney Yankelitis Bsn, Rn

Patient Care Services / Nursing

Esgro, B., Gust, A., Saunders, K., Yankelitis, C. (2016, March 14-17). Helping Nurses Cope with Patient Death. Poster presented at: Annual Nurse Residency Program Meeting, Bonita Springs, FL.

Esgro, B., Gust, A., Saunders, K., Yankelitis, C. (2016, 2015, September 10). Helping Nurses Cope with Patient Death. Philadelphia Area Magnet Meeting.

Esgro, B., Gust, A., Saunders, K., Yankelitis, C. (2016, March 14). Helping Nurses Cope with Patient Death: Coping Resource Bundle. Poster presented at: UHC/AACN Nurse Residency Program™ 2016 Annual Meeting & Chief Nursing Officers Council Meeting, Bonita Springs, FL.

Esgro, B., Gust, A., Saunders, K., Yankelitis, C. (2016, October 28). …