Medicine and Health Sciences Commons^™

Soluble Forms Of Intercellular And Vascular Cell Adhesion Molecules Independently Predict Progression To Type 2 Diabetes In Mexican American Families, Hemant Kulkarni, Manju Mamtani, Juan M. Peralta, Marcio Almeida, Thomas D. Dyer, Harald H. H. Goring, Matthew P. Johnson, Ravindranath Duggirala, Michael C. Mahaney, Rene L. Olvera, Laura Almasy, David C. Glahn, Sarah Williams-Blangero, Joanne E. Curran, John Blangero

School of Medicine Publications

Objective: While the role of type 2 diabetes (T2D) in inducing endothelial dysfunction is fairly well-established the etiological role of endothelial dysfunction in the onset of T2D is still a matter of debate. In the light of conflicting evidence in this regard, we conducted a prospective study to determine the association of circulating levels of soluble intercellular adhesion molecule 1 (sICAM-1) and soluble vessel cell adhesion molecule 1 (sVCAM-1) with incident T2D.

Methods: Data from this study came from 1,269 Mexican Americans of whom 821 initially T2D-free individuals were longitudinally followed up in the San Antonio Family Heart Study. These …

Image-Based 3d Morphometric Analysis Of The Clavicle Intramedullary (Im) Canal, Jazmine Aira

USF Tampa Graduate Theses and Dissertations

Midshaft clavicle fractures are very common. Current treatment of choice involves internal fixation with superior or anterior clavicle plating, however their clinical success and patient satisfaction are slowly decreasing. The design of intramedullary (IM) devices is on the rise, but data describing the IM canal parameters is lacking. The aim of this study is to quantify morphometry of the clavicle and its IM canal, and to evaluate the effect of gender and anatomical side. This study used 3-dimensional (3D) image-based models with novel and automated methods of standardization, normalization and bone cross-section evaluation. The data obtained in this thesis presents …

Comparison Of Urinary Pahs Among Firefighters And Asphalt Pavers, Theodore Aquino

USF Tampa Graduate Theses and Dissertations

Firefighters and asphalt pavers are exposed to polycyclic aromatic hydrocarbons (PAHs) during various work activities. The purpose of this study was to evaluate urinary PAH levels and compare these bio-monitoring levels among firefighters, asphalt pavers, and non-occupationally exposed individuals. The National Institute of Standards and Technology (NIST) urinary PAH levels were used for non-occupationally exposed controls. When compared to the NIST standard for smokers and non-smokers, firefighters demonstrated statistically significant differences in urinary concentration differences for the following metabolites: 2-OH-fluorene, 3-OH-fluorene and 1-OH-pyrene, which were lower in firefighters than the NIST mean for smokers. 1-OH-phenanthrene, 2-OH-phenanthrene and 3-OH-phenanthrene were higher …

Risk Factors Associated With Non-Compliance With The Respiratory Protection Program Among Firefighters, Brandon Dawkins

USF Tampa Graduate Theses and Dissertations

Introduction: Non-compliance with respiratory protection programs among firefighters may put them at increased risk of injury and illness from occupational exposures during fire extinguishing activities. This research aims to characterize respiratory protection practices among Florida firefighters. This information will allow better understanding of factors that are associated with non-compliance with respiratory protection guidelines.

Methods: Survey questionnaire was used to characterize Florida fire departments in this cross sectional study. Four hundred and seventy-seven surveys were administered to Florida firefighters both in person and electronically to collect information regarding firefighter knowledge and participation in their respective respiratory protection programs during the past …

Conversion To Eslicarbazepine Acetate Monotherapy: A Pooled Analysis Of 2 Phase Iii Studies., Michael R Sperling, Jacqueline French, Mercedes P Jacobson, Ladislav Pazdera, Mallory Gough, Hailong Cheng, Todd Grinnell, David Blum

Department of Medicine Faculty Papers

OBJECTIVE: To assess the efficacy and safety of eslicarbazepine acetate (ESL) monotherapy.

METHODS: This post hoc pooled analysis of 2 randomized double-blind studies (093-045 and -046) included adults with partial-onset seizures medically uncontrolled by 1 or 2 antiepileptic drugs (AEDs). Following the baseline period (8 weeks), eligible patients were randomized 2:1 to receive ESL 1,600 mg or 1,200 mg once daily for 18 weeks; the primary endpoint was study exit by meeting predefined exit criteria (signifying worsening seizure control). In each study, treatment was considered effective if the upper 95% confidence limit for exit rate was lower than the historical …

Dielectric Properties Measurements Of Brown And White Adipose Tissue In Rats From 0.5 To 10 Ghz, Dario B. Rodrigues, Paul R. Stauffer, E. Colebeck, A. Z. Hood, S. Salahi, P. F. Maccarini, E. Topsakal

Department of Radiation Oncology Faculty Papers

Brown adipose tissue (BAT) plays an important role in whole body metabolism and with appropriate stimulus could potentially mediate weight gain and insulin sensitivity. Although imaging techniques are available to detect subsurface BAT, there are currently no viable methods for continuous acquisition of BAT energy expenditure. Microwave (MW) radiometry is an emerging technology that allows the quantification of tissue temperature variations at depths of several centimeters. Such temperature differentials may be correlated with variations in metabolic rate, thus providing a quantitative approach to monitor BAT metabolism. In order to optimize MW radiometry, numerical and experimental phantoms with accurate dielectric properties …

Variants In Cxcr4 Associate With Juvenile Idiopathic Arthritis Susceptibility., Terri H. Finkel, Jin Li, Zhi Wei, Wei Wang, Haitao Zhang, Edward M. Behrens, Emma L. Reuschel, Sophie Limou, Carol Wise, Marilynn Punaro, Mara L. Becker, Jane E. Munro, Berit Flatø, Øystein Førre, Susan D. Thompson, Carl D. Langefeld, David N. Glass, Joseph T. Glessner, Cecilia E. Kim, Edward Frackelton, Debra K. Shivers, Kelly A. Thomas, Rosetta M. Chiavacci, Cuiping Hou, Kexiang Xu, James Snyder, Haijun Qiu, Frank Mentch, Kai Wang, Cheryl A. Winkler, Benedicte A. Lie, Justine A. Ellis, Hakon Hakonarson

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease among children, the etiology of which involves a strong genetic component, but much of the underlying genetic determinants still remain unknown. Our aim was to identify novel genetic variants that predispose to JIA.

METHODS: We performed a genome-wide association study (GWAS) and replication in a total of 1166 JIA cases and 9500 unrelated controls of European ancestry. Correlation of SNP genotype and gene expression was investigated. Then we conducted targeted resequencing of a candidate locus, among a subset of 480 cases and 480 controls. SUM test was performed …

Multistable Perception In Older Adults: Constructing A Whole From Fragments, Khushi Patel, Maureen Reed

Publications

Visual perception is constructive in nature; that is, a coherent whole is generated from ambiguous fragments that are encountered in dynamic visual scenes. Creating this coherent whole from fragmented sensory inputs requires one to detect, identify, distinguish and organize sensory input. The organization of fragments into a coherent whole is facilitated by the continuous interactions between lower level sensory inputs and higher order processes. However, age-related declines are found in both neural structures and cognitive processes (e.g., attention and inhibition). The impact of these declines on the constructive nature of visual processing was the focus of this study. Here we …

Trends In Survival Of Chronic Lymphocytic Leukemia Patients In Germany And The Usa In The First Decade Of The Twenty-First Century., Dianne Pulte, Felipe A Castro, Lina Jansen, Sabine Luttmann, Bernd Holleczek, Alice Nennecke, Meike Ressing, Alexander Katalinic, Hermann Brenner

Cardeza Foundation for Hematologic Research

BACKGROUND: Recent population-based studies in the United States of America (USA) and other countries have shown improvements in survival for patients with chronic lymphocytic leukemia (CLL) diagnosed in the early twenty-first century. Here, we examine the survival for patients diagnosed with CLL in Germany in 1997-2011.

METHODS: Data were extracted from 12 cancer registries in Germany and compared to the data from the USA. Period analysis was used to estimate 5- and 10-year relative survival (RS).

RESULTS: Five- and 10-year RS estimates in 2009-2011 of 80.2 and 59.5%, respectively, in Germany and 82.4 and 64.7%, respectively, in the USA were …

Are Dietary Intakes Related To Obesity In Children?, Dimitrios Papandreou, Kali Makedou, Areti Zormpa, Maria Karampola, Anastasia Ioannou, Areti Hitoglou-Makedou

All Works

AIM: The purpose of this study was to report obesity status and identify any dietary substances that may be related to obesity in healthy school children from Northern Greece. METHODS: Four hundred and twenty-five (n = 425) children were randomly selected to participate in the study. A 24-h recall of three days (two weekdays and one weekend day) was used to analyze the dietary data of the subjects. RESULTS: Out of 425 subjects, 146 (34.3%) of them were found to be overweight and obese. Energy, protein, carbohydrate and thiamin intake was statistically positively correlated with obesity while dietary iron intake …

Concerns Of Water Scarcity And Water Quality Among Two Andean Communities In Peru, Kelsey Anne Anderson

USF Tampa Graduate Theses and Dissertations

This thesis sought to explore the perceptions and experiences of Andean women regarding water quality, water scarcity, and health among two communities in Carhuaz province of Ancash, Peru. Household surveys (n=25), semi-structured interviews (n=10), unstructured interviews (n=2), and participant observation were conducted with local women to investigate their concerns and perceptions of water and health. An additional two unstructured interviews were conducted with a local water authority and doctor in order gain another perspective on the issues of water security and health.

The pressure of a changing climate and of a problematic water governance system in Andean Peru create an …

What's Happening: March 21, 2016, Maine Medical Center

What's Happening

No abstract provided.

Hiv-1 Cellular And Tissue Replication Patterns In Infected Humanized Mice., Mariluz Araínga, Hang Su, Larisa Y Poluektova, Santhi Gorantla, Howard Gendelman

Journal Articles: Pharmacology & Experimental Neuroscience

Humanized mice have emerged as a testing platform for HIV-1 pathobiology by reflecting natural human disease processes. Their use to study HIV-1 biology, virology, immunology, pathogenesis and therapeutic development has served as a robust alternative to more-well developed animal models for HIV/AIDS. A critical component in reflecting such human pathobiology rests in defining the tissue and cellular sites for HIV-1 infection. To this end, we examined the tissue sites for viral infection in bone marrow, blood, spleens, liver, gut, brain, kidney and lungs of human CD34+ hematopoietic stem cell engrafted virus-infected NOD.Cg-Prkdc(scid) Il2rg(tm1Wjl)/SzJ mice. Cells were analyzed by flow cytometry …

Hiv-1 Cellular And Tissue Replication Patterns In Infected Humanized Mice., Mariluz Araínga, Hang Su, Larisa Y Poluektova, Santhi Gorantla, Howard Gendelman

Journal Articles: Pharmacology & Experimental Neuroscience

Humanized mice have emerged as a testing platform for HIV-1 pathobiology by reflecting natural human disease processes. Their use to study HIV-1 biology, virology, immunology, pathogenesis and therapeutic development has served as a robust alternative to more-well developed animal models for HIV/AIDS. A critical component in reflecting such human pathobiology rests in defining the tissue and cellular sites for HIV-1 infection. To this end, we examined the tissue sites for viral infection in bone marrow, blood, spleens, liver, gut, brain, kidney and lungs of human CD34+ hematopoietic stem cell engrafted virus-infected NOD.Cg-Prkdc(scid) Il2rg(tm1Wjl)/SzJ mice. Cells were analyzed by flow cytometry …

Physical Therapy Capstone Posters In The Jefferson Digital Commons, Daniel G. Kipnis, Msi

Jefferson Digital Commons News

New Department of Physical Therapy capstone posters have been loaded in the Jefferson Digital Commons.

Ada News - 03/21/2016, American Dental Association, Publishing Division

ADA News

Established in 1970 as the official newspaper of the American Dental Association, the ADA News serves practicing dentists and others allied to the dental profession in the U.S. and internationally. It is the No. 1 source of news and information about the many benefits and services the ADA delivers to members daily as well as timely information on scientific, social, political and economic developments affecting dentistry and health care.

Resident Training Curriculum In Adolescent Depression And Suicide Screening, Angela Stanley, Gayathri Chelvakumar, Paula Cody, Mandakini Sadhir, Melodee Nugent, Raymond Hoffmann, Pippa Simpson

Pediatrics Faculty Publications

Introduction: Routine screening of adolescents for depression and suicide risk is now considered best clinical practice. However, due to a lack of training, many physicians do not engage in screening. The goal of this curriculum is to improve learner knowledge of and comfort in adolescent depression and suicide risk assessment and management. Methods: The didactic session typically takes 60-90 minutes to complete. In addition to a teaching PowerPoint that provides instruction in both the assessment and management of adolescent depression and suicide risk, the curriculum also includes a suicide assessment and management protocol. This protocol outlines an algorithm that assists …

The Homophilic Domain – An Immunological Archetype, Heinz Kohler, Jagadeesh Bayry, Srinivas V. Kaveri

Microbiology, Immunology, and Molecular Genetics Faculty Publications

The homophilic potential emerges as an important biological principle to boost the potency of immunoglobulins. Since homophilic antibodies in human and mouse sera exist prior environmental exposure, they are part of the natural antibody repertoire. Nevertheless, hemophilic properties are also identified in induced antibody repertoire. The use of homophilicity of antibodies in the adaptive immunity signifies an archetypic antibody structure. The unique feature of homophilicity in the antibody repertoire also highlights an important mechanism to boost the antibody potency to protect against infection and atherosclerosis as well to treat cancer patients.

Altered Multifidus Recruitment During Walking In Young Asymptomatic Individuals With A History Of Low Back Pain, Jo Armour Smith, Kornelia Kulig

Physical Therapy Faculty Articles and Research

Study Design

Cross sectional, laboratory study.

Background

Individuals with low back pain have impaired activation of multifidus during postural adjustments and increased activity of the erector spinae musculature during walking. However, it is unclear if these alterations in muscle activity are evident during locomotion in individuals with a history of low back pain when they are between symptomatic episodes.

Objectives

To compare paraspinal muscle activity in young healthy individuals and young individuals with a history of low back pain during walking turns.

Methods

14 asymptomatic individuals with a history of low back pain and 14 controls performed 90° walking turns …

Public Access To Naloxone: Exploring Intention To Prescribe Among Tennessee Nurse Practitioners, Kathryn L. Dambrino

DNP Projects

Background

Drug overdose deaths have become an escalating epidemic in the U.S. and surpassed motor vehicle collisions as the leading cause of accidental death. To combat opioid overdose, naloxone distribution to the public has been initiated in some states as a harm reduction strategy. Naloxone has been used for many years among hospital professionals as a life-saving antidote to reverse the respiratory depression effects of opioids, and the FDA has approved take-home naloxone devices for layperson use. Though legislation has been introduced in many states, such as Tennessee, to allow provider prescription of naloxone to laypersons, minimal data have been …

The Inhibitory Site Of A Diguanylate Cyclase Is A Necessary Element For Interaction And Signaling With An Effector Protein, Kurt M. Dahlstrom, Krista M. Giglio, Holger Sondermann, George A. O'Toole

Dartmouth Scholarship

Many bacteria contain large cyclic diguanylate (c-di-GMP) signaling networks made of diguanylate cyclases (DGCs) and phosphodiesterases that can direct cellular activities sensitive to c-di-GMP levels. While DGCs synthesize c-di-GMP, many DGCs also contain an autoinhibitory site (I-site) that binds c-di-GMP to halt excess production of this small molecule, thus controlling the amount of c-di-GMP available to bind to target proteins in the cell. Many DGCs studied to date have also been found to signal for a specific c-di-GMP-related process, and although recent studies have suggested that physical interaction between DGCs and target proteins may provide this signaling fidelity, the importance …

Week Of March 21, 2016, New York Medical College

InTouch

• Lori Solomon, M.D. '99, M.P.H. '09, Is Named Associate Dean for Community Health Affairs for the School of Medicine
• 28th Annual GSRF Highlights Impressive Student Research
• Town Hall Meeting Introduces NYMC TouroOne Student Portal

Using The Teaching Tools For Young Children With Challenging Behavior (Ttyc) In Kindergarten Classrooms, Katherine Theresa Cameron

USF Tampa Graduate Theses and Dissertations

The purpose of this study was to evaluate the process and outcomes of using the Teaching Tools for Young Children with Challenging Behavior (TTYC) with two kindergarten classroom teachers and two high functioning children with autism spectrum disorders engaging in moderate problem behavior during daily classroom routines. The focus was to evaluate the extent to which the kindergarten teachers could adequately use the TTYC toolkit with minimal behavioral consultation in the assessment and intervention process and to examine its impact on student behavior. A multiple baseline design across routines was used for each child to evaluate the child outcomes. The …

An Examination Of The Distribution Of Diabetes Mellitus Among Tb Patients With Pulmonary Tuberculosis And Drug Resistant Tuberculosis In The State Of Florida, Usa., Mandzisi Mbongeni Mkhontfo

USF Tampa Graduate Theses and Dissertations

Background: Pulmonary Tuberculosis (PTB) is considered a disease of the past but it remains a major cause of mortality among immune compromised patients and continues to be a significant threat to public health globally. Notably, the prevalence of diabetes mellitus (DM) has increased over the years. The biological link of TB and DM has been reported in numerous literature with DM attributed to three folds increase in the risk of TB and linked to Drug Resistant TB, especially amongst aged diabetic patients. The aim of the study was to examine the distribution of DM among TB patients and explore …

Influence Of Visual Feedback On Dynamic Balance Control In Chronic Stroke Survivors, Eric R. Walker, Allison S. Hyngstrom, Brian D. Schmit

Physical Therapy Faculty Research and Publications

Chronic stroke survivors have an increased incidence of falls during walking, suggesting changes in dynamic balance control post-stroke. Despite this increased incidence of falls during walking, balance control is often studied only in standing. The purpose of this study was to quantify deficits in dynamic balance control during walking, and to evaluate the influence of visual feedback on this control in stroke survivors. Ten individuals with chronic stroke, and ten neurologically intact individuals participated in this study. Walking performance was assessed while participants walked on an instrumented split-belt treadmill with different types of visual feedback. Dynamic balance control was quantified …

Medical School Watercooler Newsletter - March 20, 2016, Lindsey Lyle

Watercooler Newsletter

This is the March 20, 2016 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• USA Mourns Loss of Dr. J. Allan Tucker
• Telehealth Equipment Donated to USA Pediatric Healthy Life Center to Facilitate Child Obesity Study

The Pribram – Bohm Hypothesis, Shelli R. Joye

CONSCIOUSNESS: Ideas and Research for the Twenty-First Century

A holoflux theory of consciousness as modulated energy is hypothesized and shown to support both local and non-local properties. This thesis emerges from an integral evaluation of evidence drawn from: (1) the holonomic mind/brain theories of Karl Pribram, (2) the ontological interpretation of quantum theory by David Bohm. Applying an integral methodology to superimpose and correlate seemingly disparate concepts from among these sources and others, a composite-theory emerges, a “holoflux” theory of consciousness, after the term favored by Karl Pribram to describe David Bohm’s “holomovement” between an explicate order andan implicate order. This Pribram–Bohm composite holoflux theory is shown to …

Presence And The Paradox Of Love, Joanne Burtch

CONSCIOUSNESS: Ideas and Research for the Twenty-First Century

Spiritual experiences often seem unrelated to the intellectual orientation of science. However, some discussion of the laboratory study of spiritual practice does attempt to include the mystery and the human experience in its dialogue. An exploration of the paradox of love demonstrates how it might be possible to find a relationship between the scientific understanding of spirituality and the profundity of spiritual experience.

Eugene Taylor: An Appreciation, Simon Senzon

CONSCIOUSNESS: Ideas and Research for the Twenty-First Century

By sharing Professor Taylor’s impact on me with you in this way, I hope to offer a glimpse of the depth he pointed us to. Rather than just tell you his stories and his theories, I am sharing layers of my own experience both in similar synchronicities from my own personal mythology and also the meaning I make for myself as I go deeper in understanding what he was really teaching. If you can see that I am sharing something beyond the words themselves, then you know what he meant by soteriological writing. The words are used to help you …

Beyond Perennialist And Participatory Spiritualities: Transformation And Culture, Joanne Burtch

CONSCIOUSNESS: Ideas and Research for the Twenty-First Century

A comparison of perennialism, participatory spirituality, and Gebser’s structures of consciousness demonstrates how deeper inquiry is required to understand how perennialism and participatory spirituality would address the relationship between individuals and culture with regard to how transformation happens. By reviewing how each of these philosophies approach context, the interpersonal, transformation, cultural relativity, pluralism, and multiplicity, the article identifies ambiguities that offer perennialism and participatory spirituality scholars the opportunity to explore their suppositions about spirituality more deeply.