Medicine and Health Sciences Commons^™

Learning By Living: Empathy Learned Through An Extended Medical Education Immersion Project, Ianna Hondros-Mccarthy, Philip Barber, Marilyn R. Gugliucci

Geriatric Medicine Faculty Publications

Introduction: Medical student training and experiences in nursing homes are often viewed as negative; however, long-term care services represent a growing aspect of our medical system that receives little attention in medical education. The University of New England College of Osteopathic Medicine Learning by Living Nursing Home Immersion Project accelerates students learning about older adult care and the importance of empathy. Methods: Learning by Living applies qualitative ethnographic/autobiographic research methods to answer the question: “What is it like for me to live the life of an older adult nursing home resident?” Two first year medical students (female, 25 y/o & …

Targeting Iκb Kinase Β In Adipocyte Lineage Cells For Treatment Of Obesity And Metabolic Dysfunctions, Robert N. Helsley, Yipeng Sui, Se-Hyung Park, Zun Liu, Richard G. Lee, Beibei Zhu, Philip A. Kern, Changcheng Zhou

Clinical and Translational Science Faculty Publications

IκB kinase β (IKKβ), a central coordinator of inflammation through activation of nuclear factor-κB, has been identified as a potential therapeutic target for the treatment of obesity-associated metabolic dysfunctions. In this study, we evaluated an antisense oligonucleotide (ASO) inhibitor of IKKβ and found that IKKβ ASO ameliorated diet-induced metabolic dysfunctions in mice. Interestingly, IKKβ ASO also inhibited adipocyte differentiation and reduced adiposity in high-fat (HF)-fed mice, indicating an important role of IKKβ signaling in the regulation of adipocyte differentiation. Indeed, CRISPR/Cas9-mediated genomic deletion of IKKβ in 3T3-L1 preadipocytes blocked these cells differentiating into adipocytes. To further elucidate the role of …

Perceptions Of Infant Physical Activity And Weight: A Parents Perspective, Danae M. Dinkel, Anastasia Kyvelidou, Jung-Min Lee, Kailey Snyder

Research Presentations

Background: Approximately 10% of infants and toddlers in the U.S. are already overweight. One modifiable factor that may impact weight is physical activity (PA). Historically, society has thought that infants (0-1 year of age) are “active enough” and not in need of efforts to promote PA to expend energy. However, increases in technology have led to less PA in children of all ages. There is a vital need to improve knowledge about factors that may impact the promotion of PA to infants. Since parents are the primary caregivers for infants, their beliefs about weight and PA may influence the amount …

The Good Food Jobs Nexus: A Strategy For Promoting Health, Employment, And Economic Development, Nicholas Freudenberg, Michele Silver, Lesley Hirsch, Nevin Cohen

Publications and Research

In the aftermath of the Great Recession, cities have looked to the rapidly growing food sector as a promising source of new employment, and yet most of the sector’s growth has come from low-wage, dead-end food jobs. A strategy to simultaneously increase food employment, improve conditions for food workers, and enhance access to healthy and affordable food to improve public health requires pursuing a “good food jobs” approach that supports policies and programs that advance all three goals. To inform such a strategy, this article analyzes policies and programs to create good food jobs in New York City and discusses …

Efektivitas Teknik Relaksasi Dalam Konseling Kelompok Behavioral Untuk Menurunkan Stres Belajar Siswa Sma, Istiana Nurcahyani, Lutfi Fauzan

Jurnal Kajian Bimbingan dan Konseling

This research purpose to know the effectiveness of relaxation technique in behavioral group counseling to reducing academic stress at senior high school students. Research use one-group pretest-posttest design. The subject are selected 5 students based on high scores academic stress scale. Instruments used the scale academic stress was developed from various theories stress by Hans Selye (1976), Lazarus and Folkman (1984) with reliability is 0.898 and item validity > 0.3. Data were analyzed using wilcoxon signed ranks test. The analysis showed the Z count value is -2.032 with significance level of 0.042 <0.05 which can be concluded that relaxation techniques effective for reducing academic stress of senior high school students.

Perspektif “Family System Intervency” Untuk Proteksi Karakter Kebajikan Siswa Sma, Im Hambali

Jurnal Kajian Bimbingan dan Konseling

Today's high school students receive sharp attention from society. This happened because there were many bad incidents involving high school students, including brawls between high school students. The family system perspective study is an argument that provides insight into how family involvement in formal education can be implemented. This research uses a qualitative approach with the type of library research. This research aims to explain how a family intervention perspective can contribute to the implementation of independent character education. The results of this study show that although the idea of family intervention is developing in North American families, Indonesian culture …

Pengembangan Media Letter Sharing Untuk Meningkatkan Keterampilan Komunikasi Siswa Introvert, Elian Iwi Afifah, Triyono Triyono, Yuliati Hotifah

Jurnal Kajian Bimbingan dan Konseling

Communication skills are the most important things for teenagers. There is a leaning that the teenagers who have low communication skills can be called as someone who is introvert personality. People who are introvert personality tend to be difficult to communicate and express verbally. The purpose of developing letter sharing media is to improve communication skills of introvert student. This research is development research by adopting Borg and Gall research model. The development result showed that this product has the criteria of usefulness, feasibility, accuracy, and attractiveness and appropriate when used to facilitate students to express communication skills in writing.

International Nursing Collaboration: Finland And Russia: 2013-2015, Leslie Miles

Journal of Undergraduate Research

1) Evaluation of how well the academic objectives of the proposal were met.

Twenty nursing students participated in this international collaboration in Russia and Finland, with two of the students in the role of research assistants (RA). One outcome was for students to be able to closely analyze other healthcare systems. These RAs utilized research principles by devising and editing a research questionnaire to collect quantitative and qualitative data about nursing student’s perceptions about international collaboration activities. In addition the students were mentored to analyze the data and compare to current literature. Several student presentations have resulted.

Minimizing Pain During Childhood Vaccination Injections: Improving Adherence To Vaccination Schedules, Lacey M. Eden, Janelle L.B. Macintosh, Karlen E. Luthy, Renea L. Beckstrand

Journal of Undergraduate Research

Pain experienced in childhood can lead to long-term and psychologically detrimental effects. Unfortunately, the most common pain experienced in childhood is caused by vaccinations and may lead to non-adherence to the recommended vaccination schedule. As a result, it is the health care provider’s responsibility to take measures to reduce vaccination pain; however, there are a plethora of pain relieving interventions during immunizations and it is unclear which interventions are most cost efficient, timely, and effective. Studies have been conducted to investigate the efficacy of different pain management interventions during vaccinations. This review evaluates various pain relieving interventions and provide health …

Mobile Application For Biosensor Colorimetric Analysis, Eui Bin You

Honors Theses

Inexpensive paper-based biosensors can be valuable screening tools to test for various illnesses, but it is often challenging to design them to produce a visual change that can easily be identified by untrained users. This research examines one method of compensating for the lack of distinct visual cues by developing and testing a mobile application that uses a machine learning algorithm (k-Nearest Neighbors) to analyze a picture of a sensor and determine whether it shows a positive or negative result. The machine learning algorithm was trained on a set of labeled sensor images and k-fold cross-validation was used to analyze …

Analysis Of Mammalian Carboxypeptidase O Expression Patterns, Christian Bardan

Honors Theses

Carboxypeptidase 0 (CPO) is a protease that cuts acidic amino acids from the carboxy termini of substrate proteins. This study aims to describe the expression patterns of CPO in small mammals. We have sampled tissue from four different species: thirteen-lined ground squirrel, eastern chipmunk, eastern mole, and northern short-tailed shrew. Samples were analyzed via Western blot using two CPO antibodies. Immunoreactive bands likely to be CPO, with molecular weights approximately 42 kDa, were seen predominantly in kidney, liver, and intestinal tissue samples. This suggests CPO could play a specific physiological function in these organs.

Pengembangan Panduan Pelatihan Creative Problem Solving Untuk Mencegah Bullying Di Smp, Triwibowo Probo Sukarno, Dany Moenindyah Handarini

Jurnal Kajian Bimbingan dan Konseling

This research aims to developing the creative problem solving manual for preventing bullying among junior high school students which acceptable on accuracy, utility, and implementatively. This research method is adapted from procedural research and development Borg & Gall model (1983). Expert and prospective user analyzed by inter-rater agreement (Grinnell, 1988). Agreement result of 3 guidance and counseling experts from accuracy aspect is high, utility is high, and implementatiely is very high. Agreement of 3 prospective users from accuracy is high, utility is high, and implementatively is very high. The conclusion of the test is, this training guide product acceptable.

Keefektifan Konseling Kelompok Adler Untuk Meningkatkan Keterampilan Interpersonal Siswa Smp, Mega Rahma Fitriani, Nur Hidayah

Jurnal Kajian Bimbingan dan Konseling

Interpersonal skills is one of the skills that must be owned by a person in a relationship with other people. A person who failed in developing their interpersonal skills will be found difficulty in many aspects their life, especially on their social aspects. The purpose of this study is to know the effectiveness of Adler group counseling for improving interpersonal skills of junior high school students. This type of study is an quasi experimental method and program of study interrupted time series. From the result of hypotheses which is using wilcoxon signed ranks test, it is concluded if Adler group …

Pengembangan Media Permainan Simulasi Ular Tangga Untuk Meningkatkan Tanggung Jawab Belajar Siswa Smp, Sekar Ariyanti Putri, M. Ramli

Jurnal Kajian Bimbingan dan Konseling

The purpose of this research development is to generating snakes and ladders simulation game media for increasing academic responsibility of junior high school students that meet eligibility criteria. The step development is (1) initial data collection, (2) planning, (3) developing product, (4) validity product, (5) test run product, (6) revision final product. Research result showed that snakes and ladders simulation game for increasing academic responsibility of junior high school students are qualified and worthy of display media used to provide guidance about academic responsibility.

Efektifitas Penggunaan Media Film Untuk Meningkatkan Empati Siswa Kelas Vii Smp, Alan Auliyah, Elia Flurentin

Jurnal Kajian Bimbingan dan Konseling

This study aims to determine the effectiveness of the use of film to improving emphaty sevents grade students junior high school. The study design used a quasi-experimental design using the design of one group pretest-posttest design. Subjects in this study were six students who have the lowest levels of emphaty in the classroom. The research instrument used is the scale of emphaty and guidance experiment. The hypothesis testing is using the Wilcoxon test. Wilcoxon test results showed that the difference value (z) is-2.201 with a significance value of 0.028. Significance value less than 0.05, which means that Ho is rejected, …

The Effects Of Omega-3 Fatty Acids On Intracellular Inositol Levels In Saccharomyces Cerevisiae, Jee Yeon (Joanne) Lee

Honors Theses

Bipolar disorder is a severe and chronic debilitating mental disorder characterized by extreme mood swings between mania and depression. The current medications for bipolar disorder, lithium and valproate, have been associated with numerous negative side effects. Although the therapeutic mechanism by which lithium and valproate (VPA) exert their effect is unknown, a leading hypothesis implicates inositol depletion as a mechanism of action. On the other hand, omega-3-fatty acids have been shown to relieve symptoms of bipolar disorder. In this study, we compare the effects of VPA to the effects of decosahexaenoic acid (DHA) on Saccharomyces cerevisiae growth and intracellular inositol …

Exploration Of The Pregnancy-Related Health Information Seeking Behavior Of Women Who Gave Birth In The Past Year, Laura Kathleen Merrell

USF Tampa Graduate Theses and Dissertations

Background: Pregnancy is a significant period of time for individual women. Promoting optimal health behaviors and supporting individuals during critical periods of health (such as pregnancy) is an important aspect of public health research and practice. One way of supporting individuals in promoting positive health behaviors and outcomes is by increasing their health literacy. The ability to find appropriate health information is the first step in the health literacy process. This process of finding information in health contexts is called Health Information Seeking Behavior (HISB). Whereas, HISB has been extensively studied in chronic health contexts, little research has been conducted …

Medical School Watercooler Newsletter - March 27, 2016, Lindsey Lyle

Watercooler Newsletter

This is the March 27, 2016 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• USA Team Awarded for Novel Approach to Concussion Education
• USA Health System Information Services Department Hosts Chili Cook-Off for its Employees
• USA Neurology to Host Annual Spring Symposium
• Owen Bailey Named Chief Operating Officer of USA Health

Tissue- And Serum-Associated Biomarkers Of Hepatocellular Carcinoma, Ranjit Chauhan

School of Medicine

Hepatocellular carcinoma (HCC), one of the leading causes of cancer deaths in the world, is offering a challenge to human beings, with the current modes of treatment being a palliative approach. Lack of proper curative or preventive treatment methods encouraged extensive research around the world with an aim to detect a vaccine or therapeutic target biomolecule that could lead to development of a drug or vaccine against HCC. Biomarkers or biological disease markers have emerged as a potential tool as drug/vaccine targets, as they can accurately diagnose, predict, and even prevent the diseases. Biomarker expression in tissue, serum, plasma, or …

Peripheral (Deep) But Not Periventricular Mri White Matter Hyperintensities Are Increased In Clinical Vascular Dementia Compared To Alzheimer's Disease, Charles D. Smith, Eleanor S. Johnson, Linda J. Van Eldik, Gregory A. Jicha, Frederick A. Schmitt, Peter T. Nelson, Richard J. Kryscio, Richard R. Murphy, Clinton V. Wellnitz

Neurology Faculty Publications

Background and purpose: Vascular dementia (VAD) is a complex diagnosis at times difficult to distinguish from Alzheimer's disease (AD). MRI scans often show white matter hyperintensities (WMH) in both conditions. WMH increase with age, and both VAD and AD are associated with aging, thus presenting an attribution conundrum. In this study, we sought to show whether the amount of WMH in deep white matter (dWMH), versus periventricular white matter (PVH), would aid in the distinction between VAD and AD, independent of age. Methods: Blinded semiquantitative ratings of WMH validated by objective quantitation of WMH volume from standardized MRI image acquisitions. …

Impact Of Individual Acute Phase Serum Amyloid A Isoforms On Hdl Metabolism In Mice, Myung-Hee Kim, Maria C. De Beer, Joanne M. Wroblewski, Richard J. Charnigo, Ailing Ji, Nancy R. Webb, Frederick C. De Beer, Deneys R. Van Der Westhuyzen

Internal Medicine Faculty Publications

The acute phase (AP) reactant serum amyloid A (SAA), an HDL apolipoprotein, exhibits pro-inflammatory activities, but its physiological function(s) are poorly understood. Functional differences between SAA1.1 and SAA2.1, the two major SAA isoforms, are unclear. Mice deficient in either isoform were used to investigate plasma isoform effects on HDL structure, composition, and apolipoprotein catabolism. Lack of either isoform did not affect the size of HDL, normally enlarged in the AP, and did not significantly change HDL composition. Plasma clearance rates of HDL apolipoproteins were determined using native HDL particles. The fractional clearance rates (FCRs) of apoA-I, apoA-II, and SAA were …

A Case-Control Genome-Wide Association Study Identifies Genetic Modifiers Of Fetal Hemoglobin In Sickle Cell Disease., Li Liu, Alexander Pertsemlidis, Liang-Hao Ding, Michael D Story, Martin H Steinberg, Paola Sebastiani, Carolyn Hoppe, Samir K. Ballas, Betty S Pace

Cardeza Foundation for Hematologic Research

Sickle cell disease (SCD) is a group of inherited blood disorders that have in common a mutation in the sixth codon of the β-globin (HBB) gene on chromosome 11. However, people with the same genetic mutation display a wide range of clinical phenotypes. Fetal hemoglobin (HbF) expression is an important genetic modifier of SCD complications leading to milder symptoms and improved long-term survival. Therefore, we performed a genome-wide association study (GWAS) using a case-control experimental design in 244 African Americans with SCD to discover genetic factors associated with HbF expression. The case group consisted of subjects with HbF≥8.6% (133 samples) …

Cerebrospinal Fluid Leak After Microvascular Reconstruction Of Large Craniofacial Defects With Orbital Exenteration, Kurren Gill, Ba, David Hsu, Md, Patrick Tassone, Md,, John Pluta, Md, Gurston G. Nyquist, Md, Howard Krein, Md, Phd, Jurij Bilyk, Md, Ann P. Murchison, Md, Alfred Iloreta, Md, James J. Evans, Md, Ryan N. Heffelfinger, Md, Joseph M. Curry, Md

Department of Otolaryngology - Head and Neck Surgery Posters

Abstract

Objectives: To assess risk factors for cerebrospinal fluid (CSF) leak after microvascular reconstruction of extensive cranio-orbitofacial resection with orbital exenteration (CFOE).

Study Design: Retrospective Case Series

Methods: 70 consecutive patients at a tertiary hospital underwent 76 procedures with microvascular reconstruction of CFOE defects. Patients were stratified by extent of skull base exposure and presence or absence of dural resection. Patients with exposure of the orbital apex and roof alone were classified as minimal skullbase exposure (MSE, n=32). Those with exposure beyond the orbital apex and roof were classified as significant skullbase exposure (SSE, n=38), including those with dural resection …

Central Role Of Glutamate Metabolism In The Maintenance Of Nitrogen Homeostasis In Normal And Hyperammonemic Brain, Arthur J. Cooper, Thomas M. Jeitner

NYMC Faculty Publications

Glutamate is present in the brain at an average concentration-typically 10-12 mM-far in excess of those of other amino acids. In glutamate-containing vesicles in the brain, the concentration of glutamate may even exceed 100 mM. Yet because glutamate is a major excitatory neurotransmitter, the concentration of this amino acid in the cerebral extracellular fluid must be kept low-typically µM. The remarkable gradient of glutamate in the different cerebral compartments: vesicles > cytosol/mitochondria > extracellular fluid attests to the extraordinary effectiveness of glutamate transporters and the strict control of enzymes of glutamate catabolism and synthesis in well-defined cellular and subcellular compartments in the …

The Health Habits And Physical Activity Of Student Truck Drivers, Shalace Rose, Janet Wojcik

The Winthrop McNair Research Bulletin

This study examined health habits and physical activity levels of student truck drivers to determine if they are already at risk of developing health conditions that are shown in the truck driving industry. Student truck drivers from a technical college (N=52) participated in this study. They completed a modified version of a truck driver survey from the Transport Engineering Research Limited in New Zealand (2008). Questions regarding the students’ health habits, physical activity (PA), and wellness in the workplace were included in the anonymous questionnaire. The mean age was 35 +/- 11.03 years. Mean body mass index was 29.4 +/- …

Metabolomics Reveals New Mechanisms For Pathogenesis In Barth Syndrome And Introduces Novel Roles For Cardiolipin In Cellular Function, Yana Sandlers, Kelly Mercier, Wimal Pathmasiri, Jim Carlson, Susan Mcritchie, Susan Sumner, Hilary J. Vernon

Chemistry Faculty Publications

Barth Syndrome is the only known Mendelian disorder of cardiolipin remodeling, with characteristic clinical features of cardiomyopathy, skeletal myopathy, and neutropenia. While the primary biochemical defects of reduced mature cardiolipin and increased monolysocardiolipin are well-described, much of the downstream biochemical dysregulation has not been uncovered, and biomarkers are limited. In order to further expand upon the knowledge of the biochemical abnormalities in Barth Syndrome, we analyzed metabolite profiles in plasma from a cohort of individuals with Barth Syndrome compared to age-matched controls via ¹H nuclear magnetic resonance spectroscopy and liquid chromatography-mass spectrometry. A clear distinction between metabolite profiles of …

A 22-Year-Old Man With Pleural Tuberculosis Associated Hydropneumothorax: Case Report And Literature Review., Lauren A Sharan, Thea Price, Md, Boyd Hehn, David Manoff, Md, Scott W. Cowan, Md

Department of Medicine Faculty Papers

A 22-year-old Asian male presented with fever, non-productive cough, right-sided pleuritic chest pain and was found to have a large right hydropneumothorax. A chest tube was placed. Pleural fluid analysis revealed a lymphocytic predominant exudate and he was subsequently started on four-drug daily anti-tuberculosis therapy (isoniazid, ethambutol, rifampin, pyrazinamide). Pleural biopsy revealed acid-fast bacilli. Given his persistent pleural effusion, he was given four doses of intrapleural tissue plasminogen activator (tPA) and dornase alpha (DNase) via his chest tube over a period of 6 days resulting in clinical and radiologic improvement. Pleural biopsy and pleural fluid culture specimens later revealed Mycobacterium …

Tumor Suppressor Spred2 Interaction With Lc3 Promotes Autophagosome Maturation And Induces Autophagy-Dependent Cell Death, Ke Jiang, Min Liu, Guibin Lin, Beibei Mao, Wei Cheng, Han Liu, Jozsef Gal, Haining Zhu, Zengqiang Yuan, Wuguo Deng, Quentin Liu, Peng Gong, Xiaolin Bi, Songshu Meng

Molecular and Cellular Biochemistry Faculty Publications

The tumor suppressor Spred2 (Sprouty-related EVH1 domain-2) induces cell death in a variety of cancers. However, the underlying mechanism remains to be elucidated. Here we show that Spred2 induces caspase-independent but autophagy-dependent cell death in human cervical carcinoma HeLa and lung cancer A549 cells. We demonstrate that ectopic Spred2 increased both the conversion of microtubule-associated protein 1 light chain 3 (LC3), GFP-LC3 puncta formation and p62/SQSTM1 degradation in A549 and HeLa cells. Conversely, knockdown of Spred2 in tumor cells inhibited upregulation of autophagosome maturation induced by the autophagy inducer Rapamycin, which could be reversed by the rescue Spred2. These data …

Student Performance In A Pharmacotherapy Oncology Module Before And After Flipping The Classroom, John B. Bossaer, Peter Panus, David W. Stewart, Nick E. Hagemeier, Joshua George

ETSU Faculty Works

Objective. To determine if a flipped classroom improved student examination performance in a pharmacotherapy oncology module.

Design. Third-year pharmacy students in 2012 experienced the oncology module as interactive lectures with optional case studies as supplemental homework. In 2013, students experienced the same content in a primarily flipped classroom. Students were instructed to watch vodcasts (video podcasts) before in-class case studies but were not held accountable (ie, quizzed) for preclass preparation. Examination questions were identical in both cohorts. Performance on examination questions was compared between the two cohorts using analysis of covariance (ANCOVA), with prior academic performance variables (grade point average …

Quantifying The Association Between Active Tuberculosis Incidence And Migrant Farm Worker Populations Among Florida Counties, 2009-2013: An Ecological Study, Ryan Nicolas Ortega

USF Tampa Graduate Theses and Dissertations

Nearly 20 studies conducted in the last 40 years indicate that tuberculosis (TB) represents a major health concern among migrant farm worker (MFW) populations, but their role in the transmission of TB within the broader community is poorly understood. To this end an ecological study was undertaken which examined 67 Florida counties between years 2009 through 2013. Its aims were as follows: (1) to describe the demographic, geographic, and temporal distribution of the incidence of active TB, (2) to examine the effect of agriculturally relevant seasonal periods on the incidence of active TB, and (3) to quantify the strength and …