Medicine and Health Sciences Commons^™

Cutis Verticis Gyrata In A Patient With Multiple Basal Cell Carcinomas; Case Presentation And Review Of The Literature, Simona Roxana Georgescu, Maria Isabela Sârbu, Cristina Iulia Mitran, Mădălina Irina Mitran, Alice Rusu, Vasile Benea, Mircea Tampa

Journal of Mind and Medical Sciences

Cutis verticis gyrata is a rare disease characterized by convoluted folds and deep furrows of the scalp, resembling the gyri and sulci of the cerebral cortex. Basal cell carcinoma is the most frequent cancer in Caucasians, patients frequently presenting multiple tumors. We report the case of a 62 year old male, Caucasian patient, from the urban area, who addressed the dermatology department of our hospital for multiple tumors located on the face and upper trunk. A careful examination revealed cerebriform folding of the skin of the scalp. Neurological, psychological, ophthalmological and endocrine disorders were disproven. The patient was diagnosed with …

Finasteride Adverse Effects And Post-Finasteride Syndrome; Implications For Dentists, Stana Paunica, Marina Giurgiu, Andrei Vasilache, Ioana Paunica, Ion Motofei, Adriana Vasilache, Horia Traian Dumitriu, Anca Silvia Dumitriu

Journal of Mind and Medical Sciences

Finasteride is a 5α-reductase inhibitor widely used in present in the therapeutic approach of androgenic alopecia. Adverse effects consist in variable sign and symptoms, the most common being represented by mental troubles (reduced feeling of life pleasure or emotions, depression), physical impairments (loss of muscle tone and/or mass) and sexual complains (loss of libido and sexual potency). An increasing number of studies identify and describe even a post-finasteride syndrome (persistent adverse affects three months or more after finasteride cessation) or new adverse effects including but not limited at the skin level or oral cavity (marginal periodontium).

We intend to present …

Emergency Peripartum Hysterectomy, Physical And Mental Consequences: A 6-Year Study, Denisa Oana Balalau, Romina Marina Sima, Nicolae Bacalbașa, Liana Pleș, Anca Daniela Stănescu

Journal of Mind and Medical Sciences

Emergency peripartum hysterectomy (EPH) is performed for massive postpartum hemorrhage following a cesarean delivery or vaginal delivery, in order to save the patient’s life. The current study was performed on a sample of 13.162 patients, which underwent cesarean or vaginal delivery during a period of 6 years, from 2010 to 2015, in Bucur Maternity Hospital. There were two subsequential groups consisting in: 6593 patients with cesarean operations and 6569 patients with vaginal delivery. In 12 cases occurred one or more of the risk factors that lead to EPH, divided equally across the two groups above.

The main two types of …

Determination Of Tramadol In Human Plasma By Hplc With Fluorescence Detection, Daniela Luiza Baconi, Miriana Stan, Zainab Abdul Jalil Ebrahim, Cristian Tuchila, Cristian Balalau

Journal of Mind and Medical Sciences

Tramadol is a centrally acting analgesic, atypical opioid, and although it is generally considered as a medicinal drug with a low potential for dependence, there is growing evidence of tramadol abuse in some countries. The ultraviolet detection is not suitable for analysis of tramadol in plasma, due to the lack of sensitivity and selectivity. However, it was shown that tramadol has a weak fluorescence, and the latest techniques for determination of tramadol in plasma include liquid chromatographic methods with fluorescence detection (FL). The objective of the paper was to develop a HPLC-FL method applicable for quantification of tramadol in human …

Differential Involvement Of Hippocampal Angiotensin 1 Receptors In Learning And Memory Processes In Bulbectomized Rats, Roman Tashev, Margarita Ivanova, Stiliana Belcheva, Iren Belcheva

Journal of Mind and Medical Sciences

There is conflicting evidence regarding the effect of AT1 receptor antagonists on learning and memory processes. The effects of angiotensin II and losartan administration into CA1 hippocampal area on the avoidance performance in olfactory bulbectomized (OBX) rats using active avoidance (shuttle box) test and passive avoidance (step through) test were investigated. Rats were microinjected unilaterally through implanted guide cannulas into the CA1 area of the dorsal hippocampus and the drugs were administered separately, 5 minutes before each training session. The microinjections of losartan into the left, but not the right CA1 hippocampal area improved the acquisition and retention of active …

Psychological Profile Of Laryngectomized Patients, Bogdan Popescu, Oana A. Paun, Razvan V. Scaunasu, Cristian Balalau, Serban V. Bertesteanu

Journal of Mind and Medical Sciences

Larynx cancer is one of the most susceptible form of cancer susceptible to induce alteration of the patient’s psychological profile due to the social role that the larynx has in communication. Oral communication is severely impaired even after voice rehabilitation of the laryngectomized patients, so that the social rehabilitation is somewhat not only a medical but also a social problem. The psychological profile of these patients is altered in a way that dealing with the disease is sometimes neglected and the interaction with the outside world in terms of oral communication is totally abandoned. The starting point for depression in …

Pain In Photodynamic Therapy, Mircea Tampa, Maria Isabela Sârbu, Mădălina Irina Mitran, Cristina Iulia Mitran, Adrian Dumitru, Vasile Benea, Simona Roxana Georgescu

Journal of Mind and Medical Sciences

Photodynamic therapy is a modern treatment with applications in several medical specialties, which has been intensely studied in the last years. The main indications in dermatology are actinic keratosis, superficial basal cell carcinoma and Bowen's disease- common skin disorders in which photodynamic therapy proved its efficacy. At present, the use of photodynamic therapy for the treatment of other skin disorders is profoundly researched. Pain is the most common and redoubtable adverse effect of photodynamic therapy and it is the most important factor affecting the patient's adherence to treatment. The aim of this article is to look over the most recent …

Conservative Surgery Of Breast Cancer In Women; Psychological Benefits, Razvan V. Scaunasu Md, Traean Burcoș, Ștefan Voiculescu, Bogdan A. Popescu, Șerban V. Bertesteanu, Oana-Denisa Bălălău, Nicolae Bacalbasa, Cristian Bălălău

Journal of Mind and Medical Sciences

Breast surgery was one of the most dynamic fields of medicine which benefited from significant progress during the last decades. The transition from aggressive and mutilating amputations to conservative, oncoplastic and reconstructive techniques has been constant, offering improved and rewarding results, viewed from both, oncological and aesthetical perspectives.

Conservative techniques, especially those which preserve the nipple areola complex, are followed by improved patient’s perception of their body image, confidence and sexuality, with the only drawback of increased anxiety linked to recurrence risk.

The Mind Body Problem, Part Three: Ascension Of Sexual Function To Cerebral Level, Ion G. Motofei, David L. Rowland

Journal of Mind and Medical Sciences

Physiologically, the somatic nervous system intervenes in external interaction between the body and environment, while autonomic nervous system ensures the functioning of internal organs. We present in this paper a psycho-physiological perspective suggesting that mental function (somatic in nature, because coordinates environmental interaction) is closer to and more aligned with the physiologic functioning of autonomic nervous system (due to autonomy, duality, etc.). At opposite end, sexual function (autonomic in nature, erection for example being a parasympathetic vasodilatory reflex) seems to be compatible and even dependent by a somatic participation (erectile response is rather induced by environmental stimuli than internal visceral …

Perforated Small Intestine In A Patient With T-Cell Lymphoma; A Rare Cause Of Peritonitis, Petrisor Banu, Vlad D. Constantin, Florian Popa, Mihaela F. Nistor

Journal of Mind and Medical Sciences

The nontraumatic perforations of the small intestine are pathological entities with particular aspects in respect to diagnosis and treatment. These peculiarities derive from the nonspecific clinical expression of the peritonitis syndrome, and from the multitude of causes that might be the primary sources of the perforation: foreign bodies, inflammatory diseases, tumors, infectious diseases, etc. Accordingly, in most cases intestinal perforation is discovered only by laparotomy and the definitive diagnosis is available only after histopathologic examination. Small bowel malignancies are rare; among them, lymphomas rank third in frequency, being mostly B-cell non Hodgkin lymphomas. Only 10% of non-Hodgkin lymphomas are with …

Prevention Of Glaucoma-Induced Retinal Ganglion Cell Loss Using Alpha7 Nachr Agonists, P J. Birkholz, C A. Gossman, M K. Webster, David M. Linn, Cindy L. Linn

Peer Reviewed Articles

In this study, the neuroprotective effect of various nicotinic alpha7 acetylcholine receptor agonists in an in-vivo model of glaucoma using adult Long Evans rats was analyzed. Glaucoma-like conditions were induced in the eyes of Long Evans rats after injection of hypertonic saline into episcleral veins to create scar tissue and increase the animal’s intraocular pressure. This procedure produced significant loss of retinal ganglion cells within one month and was associated with an increase of intraocular pressure. Using this model system, various alpha7 nicotinic acetylcholine receptor (a7 nAChR) agonists were applied at different doses as eye drops to the right eye …

Medial Prefrontal And Anterior Insular Connectivity In Early Schizophrenia And Major Depressive Disorder: A Resting Functional Mri Evaluation Of Large-Scale Brain Network Models, Jacob Penner, Kristen A. Ford, Reggie Taylor, Betsy Schaefer, Jean Theberge, Richard W. J. Neufeld, Elizabeth A. Osuch, Ravi S. Menon, Nagalingam Rajakumar, John M. Allman, Peter C. Williamson

Anatomy and Cell Biology Publications

Anomalies in the medial prefrontal cortex, anterior insulae, and large-scale brain networks associated with them have been proposed to underlie the pathophysiology of schizophrenia and major depressive disorder (MDD). In this study, we examined the connectivity of the medial prefrontal cortices and anterior insulae in 24 healthy controls, 24 patients with schizophrenia, and 24 patients with MDD early in illness with seed based resting state functional magnetic resonance imaging analysis using Statistical Probability Mapping. As hypothesized, reduced connectivity was found between the medial prefrontal cortex and the dorsal anterior cingulate cortex and other nodes associated with directed effort in patients …

Transient Pupil Dilation After Subsaccadic Microstimulation Of Primate Frontal Eye Fields., Sebastian J Lehmann, Brian D Corneil

Brain and Mind Institute Researchers' Publications

UNLABELLED: Pupillometry provides a simple and noninvasive index for a variety of cognitive processes, including perception, attention, task consolidation, learning, and memory. The neural substrates by which such cognitive processes influence pupil diameter remain somewhat unclear, although cortical inputs to the locus coeruleus mediating arousal are likely involved. Changes in pupil diameter also accompany covert orienting; hence the oculomotor system may provide an alternative substrate for cognitive influences on pupil diameter. Here, we show that low-level electrical microstimulation of the primate frontal eye fields (FEFs), a cortical component of the oculomotor system strongly connected to the intermediate layers of the …

Single-Nucleotide Polymorphisms In Psca And The Risk Of Breast Cancer In A Chinese Population., Meng Wang, Xijing Wang, Sidney W. Fu, Zhijun Dai, Tianbo Jin, + 10 Additional Authors

Medicine Faculty Publications

This study explored the associations between common PSCA single-nucleotide polymorphisms (rs2294008, rs2978974, and rs2976392) and breast cancer among 560 breast cancer cases and 583 controls (Chinese Han women). We found rs2294008 was significantly associated with a high risk of breast cancer (homozygote model, odds ratio [OR]: 1.67, 95% confidence interval [CI]: 1.06–2.59; recessive, OR: 1.64, 95% CI: 1.06–2.53). And stratification by menopausal status revealed an association of the minor allele of rs2294008 with breast cancer risk among premenopausal (homozygote model, OR: 2.41, 95% CI: 1.03–5.66; recessive, OR: 2.80, 95 % CI: 1.21–6.47) and postmenopausal women (allele model, OR: 1.29, 95% …

Mining The Csdcas Data: Uses For Admission Tables, Grant Preparation, And Caa Reports, Larry Boles, Jim Tsiamtsiouris

School of Pharmacy Faculty Presentations

No abstract provided.

Muscle-Specific Loss Of Bmal1 Leads To Disrupted Tissue Glucose Metabolism And Systemic Glucose Homeostasis, Brianna D. Harfmann, Elizabeth Schroder, Maureen T. Kachman, Brian A. Hodge, Xiping Zhang, Karyn Esser

Center for Muscle Biology Faculty Publications

Background: Diabetes is the seventh leading cause of death in the USA, and disruption of circadian rhythms is gaining recognition as a contributing factor to disease prevalence. This disease is characterized by hyperglycemia and glucose intolerance and symptoms caused by failure to produce and/or respond to insulin. The skeletal muscle is a key insulin-sensitive metabolic tissue, taking up ~80 % of postprandial glucose. To address the role of the skeletal muscle molecular clock to insulin sensitivity and glucose tolerance, we generated an inducible skeletal muscle-specific Bmal1 ^−/− mouse (iMSBmal1 ^−/−).

Results: Progressive changes in body composition (decreases in …

Student Reflections Of Psychiatric/Mental Health: Using Journals And Creative Expressions, Melinda Hermanns, Barbara K. Haas

Nursing Faculty Publications and Presentations

Second semester undergraduate nursing students in their psychiatric/mental health clinical rotation express an array of emotions as they frequently view the setting as foreign. Two assignments, reflective journaling and a form of expression were incorporated into clinical to provide students an opportunity to reflect and convey their thoughts and feelings concerning their clinical experiences. Thematic analysis was used to analyze 10 journals and 10 art forms with a written description. Two content themes emerged: A Change in Perspective and Insight. Exemplars of the students’ perspectives are provided. As evidenced by students’ submissions, reflective journaling and creative expression can be an …

Global Engagement: Problem Solving And Information Exchange, Vinaya Manchaiah, Brenda Louw

ETSU Faculty Works

This interactive session provides opportunities (1) to share ideas for infusing global perspectives and goals into CAPCSD projects, conferences, and the work of committees and task forces; (2) to discuss ways to collaborate in an ongoing global engagement projects and help include content for 2017 conference; and (3) to create how-to guides for ethical and culturally attuned translational research, and clinical education, and service learning.

Nrp2 Transcriptionally Regulates Its Downstream Effector Wdfy1., Samikshan Dutta, Sohini Roy, Navatha S. Polavaram, Gustavo B. Baretton, Michael H. Muders, Surinder K. Batra, K Datta

Journal Articles: Biochemistry & Molecular Biology

Neuropilins (NRPs) are cell surface glycoproteins that often act as co-receptors for plexins and VEGF family receptors. Neuropilin-2 (NRP2), a family member of NRPs, was shown to regulate autophagy and endocytic trafficking in cancer cells, a function distinctly different from its role as a co-receptor. WD Repeat and FYVE domain containing 1 (WDFY1)-protein acts downstream of NRP2 for this function. Our results indicated that NRP2 maintains an optimum concentration of WDFY1 by negatively regulating its expression. Since increased expression of WDFY1 reduces the endocytic activity, maintenance of WDFY1 level is crucial in metastatic cancer cells to sustain high endocytic activity, …

The Potential Role Of Nitric Oxide In Halting Cancer Progression Through Chemoprevention, Huzefa Vahora, Munawwar Ali Khan, Usama Alalami, Arif Hussain

All Works

Nitric oxide (NO) in general plays a beneficial physiological role as a vasorelaxant and the role of NO is decided by its concentration present in physiological environments. NO either facilitates cancer-promoting characters or act as an anti-cancer agent. The dilemma in this regard still remains unanswered. This review summarizes the recent information on NO and its role in carcinogenesis and tumor progression, as well as dietary chemopreventive agents which have NO-modulating properties with safe cytotoxic profile. Understanding the molecular mechanisms and cross-talk modulating NO effect by these chemopreventive agents can allow us to develop better therapeutic strategies for cancer treatment.

The Ethics Of Animal Research: A Survey Of The Public And Scientists In North America, Ari R. Joffe, Meredith Bara, Natalie Anton, Nathan Nobis

Morality and Ethics of Animal Experimentation Collection

Background: To determine whether the public and scientists consider common arguments (and counterarguments) in support (or not) of animal research (AR) convincing.

Methods: After validation, the survey was sent to samples of public (Sampling Survey International (SSI; Canadian), Amazon Mechanical Turk (AMT; US), a Canadian city festival and children’s hospital), medical students (two second-year classes), and scientists (corresponding authors, and academic pediatricians). We presented questions about common arguments (with their counterarguments) to justify the moral permissibility (or not) of AR. Responses were compared using Chi-square with Bonferonni correction.

Results: There were 1220 public [SSI, n = 586; AMT, n = …

Occupational Needs Of Female Ex-Offenders During Community Reentry, Leah N. Sowers

MOT Student Capstones

Purpose: The objective of the capstone project was to identify the most significant areas of occupation in which female ex-offenders participate and to determine ways in which occupational therapy could benefit the participants of Transitional Options for Women (TOFW), a transitional housing program that provides a safe environment and eight-step life-skills program for ex-offenders. This objective reflected a need in assisting the staff of TOFW in understanding areas of occupation the participants utilize and rely on during their transition from prison or jail into the community. The project was completed through provision of a community resource manual reflecting identified areas …

A Literature Review Of Barriers To Immunization In Preterm, Low-Birth-Weight And Very-Low Birth Weight Infants, Sandra Burkinshaw, Janelle L. B. Macintosh

Student Works

Approximately 500,000 infants are born each year prior to 37 weeks gestation in the United States. Despite the increased immunologic risk for infants born pre-term (PT), low birth weight (LBW), or very low birth weight (VLBW), infants in the neonatal intensive care unit are often under immunized, if they are immunized at all. Factors that have been identified to inhibit immunization uptake in the NICU population include: immunization effectiveness, safety and adverse events, provider belief, and policy guidelines regarding vaccination in this population. Providers caring for these vulnerable infants can increase the immunization rates by implementing evidenced based education, developing …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Georgia Southern Recieves NIH R21 grant Explore the role of interplay between environmental exposures, respiratory tract microbiome, and immune responses in children
• Georgia Southern Examine Porblems of Air Monitoring during Destruction of Bio-Weopon Facilities

Environmental Health News, Georgia Southern University

Biostatistics, Epidemiology & Environmental Health Sciences: News & Publications (2011-2018)

• Georgia Southern Examine Problems of Air Monitoring during Destruction of Bio-weopon facilities
• Georgia Southern Receives NIH R21 grant to explore the role of interplay between environmental exposures, respiratory tract microbiome, and immune responses in children

Factors Influencing The Variation In Gms Prescribing Expenditure In Ireland, Aisling Conway Lenihan, S. Ahern, J. Cronin, N. Woods

Dept. of Management & Enterprise Publications

Background

Pharmaceutical expenditure growth is a familiar feature in many Western health systems and is a real concern for policymakers. A state funded General Medical Services (GMS) scheme in Ireland experienced an increase in prescription expenditure of 414 % between 1998 and 2012. This paper seeks to explore the rationale for this growth by investigating the composition (Anatomical Therapeutic Chemical (ATC) Group level 1 & 5) and drivers of GMS drug expenditure in Ireland in 2012.

Methods

A cross-sectional study was carried out on the Health Service Executive-Primary Care Reimbursement Service (HSE-PCRS) population prescribing database (n = 1,630,775). Three …

Investigating Pakistan’S Contraception Rate Plateau: A Multilevel Analysis To Understand The Association Between Community Contextual Factors And Modern Contraception Use, Mahmooda Khaliq Pasha

USF Tampa Graduate Theses and Dissertations

South Asia has the highest absolute number of women with an unmet need for contraception in the world. The total number of women with unmet need is 142 million. Of this, Asia accounts for 84 million followed by Sub-Saharan Africa at 32 million. Within South Asia, some countries have seen unmet need decrease and the contraception rate increase; however, Pakistan remains the exception to the rule. Pakistan has a low rate of contraception use, high rate of contraception discontinuation, high unmet need and high rate of unwanted fertility.

A number of theories have hypothesized that community-level factors influence a couple’s …

Annual Unit-Based Validation Using Simulation, Carolyn Lamparella Rn, Terua Everk Bsn, Rn, Renee Grow Bsn, Rn, Dara Patton Rn, Samantha A. Rabenold Bsn, Rn, Linda Reinhart Msn, Rn, Cns, Angela Strausser Rn, Susan Steidel Rn, Eileen Wasson Msn, Rn, Ccrn, Nicole L. Steuer Bsn, Rn, Julia Werkheiser Rn

Patient Care Services / Nursing

No abstract provided.

What's Happening: March 28, 2016, Maine Medical Center

What's Happening

No abstract provided.

Almond Supplementation Reduces Serum Uric Acid In Coronary Artery Disease Patients: A Randomized Controlled Trial., Humaira Jamshed, Anwar Gilani, Fateh Ali Tipoo Sultan, Faridah Amin, Jamshed Arslan Arslan, Sumaira Ghani, Madiha Masroor

Department of Biological & Biomedical Sciences

Objective

Elevated serum uric acid (UA), a biomarker of renal insufficiency, is also an independent prognostic marker for morbidity in coronary artery disease (CAD) and poses serious health risks. This study reports the effect of almond consumption on UA in CAD patients.

Study design

A randomized controlled clinical trial was conducted with three groups: no-intervention (NI), Pakistani almonds (PA) or American almonds (AA). Patients were recruited from the Cardiology Clinics, Aga Khan University Hospital. Two follow-ups were scheduled at week-6 and week-12. 150 patients were randomly divided in three groups (50 per group). NI was not given almonds, whereas the …