Medicine and Health Sciences Commons^™

The Germans And Their Nazi Past: To What Extent Have They Accepted Responsibility?, Martin Hille

Center for the Study of Ethics in Society Papers

No abstract provided.

2016 Touro College Of Pharmacy Senior Yearbook, College Of Pharmacy

Touro Yearbooks

2016 College of Pharmacy Senior Yearbook

Examining The Validity Of The Preschool Kitchen Task Assessment, Christine Kim, Angelica Soltis

Dissertations, Masters Theses, Capstones, and Culminating Projects

Background and purpose. Executive function (EF) skills are necessary to set a strong foundation for play development, school readiness and social participation in young children. However, few ecologically valid assessments are available to detect potential executive function deficits in preschool aged children. The Preschool Kitchen Task Assessment (PKTA) is a new tool that measures EF in preschool aged children. The PKTA was adapted from the Kitchen Task Assessment and The Children Task Assessment by Christine Berg, Ph.D., OTR/L. This study aimed to validate the PKTA as an ecological assessment of EF in preschool aged children.

Subjects. Twenty-four typically developing children …

Segmental Excision Versus Intralesional Curettage With Adjuvant Therapy For Giant Cell Tumour Of Bone, Omar Yacob, Masood Umer, Marrium Gul, Irfan Qadir

Department of Radiology

Abstract

PURPOSE:

To review the functional outcome and local recurrence rate of 29 patients who underwent segmental excision or intralesionalcurettage with adjuvant therapy for giant cell tumour (GCT) of bone.

METHODS:

Records of 17 men and 12 women (mean age, 30.17 years) who underwent segmental excision (n=18) or intralesional curettage followed by adjuvant therapy (n=11) for GCT of the femur (n=13), tibia (n=8), radius (n=6), or ulna (n=2) were reviewed. Nine of the patients had recurrent GCT of bone and had undergone segmental excision (n=6) or intralesional curettage (n=3) elsewhere. Functional outcome was evaluated using the Musculoskeletal Tumour Society (MSTS) …

Membrane Channel Gene Expression In Human Costal And Articular Chondrocytes, A. Asmar, R. Barrett-Jolley, A. Werner, R. Kelly Jr., M. Stacey

Bioelectrics Publications

Chondrocytes are the uniquely resident cells found in all types of cartilage and key to their function is the ability to respond to mechanical loads with changes of metabolic activity. This mechanotransduction property is, in part, mediated through the activity of a range of expressed transmembrane channels; ion channels, gap junction proteins, and porins. Appropriate expression of ion channels has been shown essential for production of extracellular matrix and differential expression of transmembrane channels is correlated to musculoskeletal diseases such as osteoarthritis and Albers-Sch€onberg. In this study we analyzed the consistency of gene expression between channelomes of chondrocytes from human …

Un Análisis Post-Colonial: La Encarnación De La Pérdida Histórica En La Manifestación De Depresión En Personas Mapuche En El Contexto Urbano, Haley Case

Independent Study Project (ISP) Collection

Esta investigación buscaba evaluar las manifestaciones cualitativas y simbólicas de la depresión en la población Mapuche de la región de Santiago a través de la aplicación de teoría que aborda del sufrimiento social y la violencia estructural. Métodos etnográficos se fueron utilizados por la realización de observaciones y entrevistas semi-estructuradas con personas involucradas en la comunidad Mapuche y el sistema de salud biomédico en las comunas de La Pintana y Lampa en la Región Metropolitana. Según la cosmovisión Mapuche, la salud tiene base fundamental en la armonización del cuerpo, alma, espíritu y mente de un ser humano con su familia, …

Hypertensive Disorders Of Pregnancy In Rural Maharashtra: A Preventative Approach To Risk Factor Reduction Through Lifestyle Interventions, Jess Wiken

Independent Study Project (ISP) Collection

The primary purpose of this study is to assess the contribution and correlation between lifestyle behaviors and modifiable risk factors (MRF) established in adolescence and during pregnancy with development of hypertensive disorders of pregnancy (HDP) exclusive to preeclampsia (PE), eclampsia, and pregnancy induced hypertension (PIH). MRF include but are not exclusive to diet and nutrition, physical activity, and Mishri use. Associations of HDP with increased premature cardiovascular risk in the affected woman and child indicate the importance of healthy lifestyle modifications that promote cardiovascular health and longevity and reduction of risk factors through prevention. While cardiac conditions are primarily associated …

Attention Demands Of Language Production In Adults Who Stutter, Nathan D. Maxfield, Wendy L. Olsen, Daniel Kleinman, Stefan A. Frisch, Victor S. Ferreira, Jennifer J. Lister

Communication Sciences and Disorders Faculty Publications

Objective: We investigated whether language production is atypically resource-demanding in adults who stutter (AWS) versus typically-fluent adults (TFA).

Methods: Fifteen TFA and 15 AWS named pictures overlaid with printed Semantic, Phonological or Unrelated Distractor words while monitoring frequent low tones versus rare high tones. Tones were presented at a short or long Stimulus Onset Asynchrony (SOA) relative to picture onset. Group, Tone Type, Tone SOA and Distractor Type effects on P3 amplitudes were the main focus. P3 amplitude was also investigated separately in a simple tone oddball task.

Results: P3 morphology was similar between groups in the simple task. In …

Mechanistic Binding Insights For 1-Deoxy-D-Xylulose-5-Phosphatesynthase, The Enzyme Catalyzing The First Reaction Of Isoprenoid Biosynthesis In The Malaria-Causing Protists, Plasmodium Falciparum And Plasmodium Vivax, Matthew R. Battistini, Christopher Shoji, Sumit Handa, Leonid Breydo, David J. Merkler

Chemistry Faculty Publications

We have successfully truncated and recombinantly-expressed 1-deoxy-D-xylulose-5-phosphate synthase (DXS) from both Plasmodium vivax and Plasmodium falciparum. We elucidated the order of substrate binding for both of these ThDP-dependent enzymes using steady-state kinetic analyses, dead-end inhibition, and intrinsic tryptophan fluorescence titrations. Both enzymes adhere to a random sequential mechanism with respect to binding of both substrates: pyruvate and D-glyceraldehyde-3-phosphate. These findings are in contrast to other ThDP-dependent enzymes, which exhibit classical ordered and/or ping-pong kinetic mechanisms. A better understanding of the kinetic mechanism for these two Plasmodial enzymes could aid in the development of novel DXS-specific inhibitors that might prove useful …

Nsu Sharks Rx-Spring, 2016, Nova Southeastern University

NSU Sharks Rx

No abstract provided.

Perspectives On Pediatric Pain, Donald E. Greydanus, Dilip R. Patel, Colleen Dodich, Hatim A. Omar, Joav Merrick

Pediatrics Faculty Publications

No abstract provided.

Can Parasitized Lambs Self-Medicate Through Preferred Consumption Of Sericea Lespedeza Pellets?, Mallory Alicia Garcia

Honors Capstones

No abstract provided.

Development And Use Of A Tablet-Based Resuscitation Sheet For Improving Outcomes During Intensive Patient Care, Wasif Bokahri, Vimla L. Patel, Ashish Amresh, Ayan Sen

Publications

Data documentation from resuscitation events in hospitals, termed "code blue" events, utilizes a paper form, which is institution-specific. Problems with data capture and transcription exists, due to the challenges of dynamic documentation of patient, event and outcome variables as the code blue event unfolds. We hypothesize that an electronic version of code blue real-time data capture would lead to improved resuscitation data transcription, and enable clinicians to address deficiencies in quality of care. To this effect, we present the design of a tablet-based application and its use by 20 nurses at the Mayo Clinic hospital. The results showed that the …

Pharmacy Newsletter : April 2016, Pharmacy Department

Department of Pharmacy Archives

Content:

• Medication Management in Geriatrics | Overview of Beers Criteria 2015
• Zika Virus Disease (ZVD) – An Emerging Culprit
• Emerging Avenues for Botulinium Toxin Therapy
• Novel Treatment Approach of Pancreatic Cancer
• FDA Podcast 2015
• Extra Care is Needed Because Warfarin is High - Alert Medicine
• Reporting of ADR
• ADR Trends of 2015 at AKUH

Today - April 2016, Loma Linda University Health

TODAY

Inside this issue:

-- Loma Linda University Health family and surrounding communities invited to historic groundbreaking on May 22
-- Press conference highlights $6.29 million NIH grant for hypoxia research at Center for Perinatal Biology
-- Front entrance to adult and children's hospitals moved across from Prospect Avenue; patient and visitors receive free valet
-- Record number of high school students apply for summer research experience
-- Leo's story: celebrating occupational and speech therapists during April and May
-- Hero of Family Medicine for 2016 announced
-- Big Hearts for Little Hearts Desert Guild ends 2015-2016 season with evening of …

Provisional Tic Disorder: What To Tell Parents When Their Child First Starts Ticcing, Kevin J. Black, Elizabeth Rose Black, Deanna J. Greene, Bradley L. Schlaggar

Open Access Publications

No abstract provided.

Similarities And Differences In Sexual Risk Behaviors Between Young Black Msm Who Do And Do Not Have Sex With Females, Richard A. Crosby, Leandro Mena, Angelica Geter, Demarc Hickson

Health, Behavior & Society Faculty Publications

The objective of this study is to determine whether young Black MSM who also have sex with females report similar levels of sexual risk behaviors as those not having sex with females. YBMSM (N = 400) were recruited from an STI clinic, located in the Southern U.S. Men completed an audio-computer assisted self-interview and donated specimens for STI/HIV testing. Forty-three percent recently engaged in penile-vaginal sex. They were less likely to report having concurrent partners (P = .01), unprotected fellatio (P = .04), multiple partners as a bottom (P < .02), any unprotected anal sex as a bottom (P < .013), and any anal sex (P = .007). They were equally likely …

Using Security Risk Analysis: Is The Bring Your Own Device Policy Becoming A Liability Risk Within Healthcare?, Lee Alexander Cavett

Open Access Theses

Using computer simulation modeling, this research examined the problems contributing to data breaches within healthcare industry. The study attempted to answer two questions: 1) is the Bring Your Own Device policy becoming a liability risk within hospitals causing an increase in data breaches and 2) is there a lower risk compared to using wired desktops. An iPad was the primary focused device as one of many Bring Your Own Devices. The study used a randomly generated sample of an approximate 2,700 patients, one nurse and doctor on a eight hour work-day within the clinic (eight A.M five P.M) considering a …

Mhealth To Improve The Diet Among Low-Income Populations Enrolled In An Established U.S. Nutrition Program: Design And Rationale Of A Randomized Controlled Trial, Lukas T. Ingersoll

Open Access Theses

Aim: To describe the theoretical basis, and implementation of a randomized controlled trial to improve the diet and nutrition of low-income families in Indiana.

Background: Changing difficult behaviors requires more than education. Beyond education, people benefit from counseling that focuses on increasing motivation and confidence, assistance with overcoming barriers, identifying social support, and creating specific action plans. Widespread use of short-message services (SMS), commonly known as text messaging, provides one potential tool for researchers to help individuals change difficult behaviors.

Although promising, one of the limitations with current SMS interventions is that most have relied on providing reminder texts at …

Densified Collagen-Fibril Biomaterials For Bone Tissue Engineering, Lauren E. Watkins

Open Access Theses

Millions of craniofacial bone defects occur annually as a result of trauma, congenital defects, disease, or tooth extraction. When present in the oral cavity, these defects are associated with adverse impacts on speech, mastication, and aesthetics. Thus, there is a clinical need for interventional strategies to restore and preserve alveolar bone mass to improve the success of future treatment options intended to reestablish functionality and aesthetics. Guided bone regeneration using bone grafts and a membrane represent the current standard of care for repairing alveolar bone defects, but face a number of limitations related to resorption time and structural integrity. Improvements …

Evaluation Of Negative Energy And Mineral Balance In Periparturient Holstein-Friesian Cattle, Ameer Ahmed Abdelhameed

Open Access Dissertations

Most cows experience a state of negative energy and mineral balance during the periparturient period. This imbalance is a major problem in the dairy industry and it is more frequently seen in multiparous cattle due to their high milk production. A large amount of fat and protein is mobilized in order to address the energy deficit during the periparturient period. The ability to accurately monitor energetics and electrolytes status using accurate, rapid, and low cost point-of-care instruments will assist in optimizing animal health and productivity.

This dissertation contains three studies that evaluated point-of-care instruments for measuring blood and plasma glucose, …

Investigating The Role Of The Basic Helix-Loop-Helix Transcription Factor Mist1 In Pancreatic Diseases, Anju Karki

Open Access Dissertations

Acinar cells of the exocrine pancreas are dedicated to synthesize, package and secrete immense quantities of pro-digestive enzymes to maintain proper metabolic homeostasis for the organism. Dysregulation of enzyme secretion in acinar cells can give rise to exocrine diseases including acute pancreatitis (AP), a disease that targets acinar cells, leading to acinar-ductal metaplasia (ADM), inflammation and fibrosis—events that can transition into the earliest stages of pancreatic ductal adenocarcinoma (PDAC). The focus of this thesis is to interrogate transcriptional regulatory networks that are susceptible to AP and the role that these networks play in acinar cell and exocrine pancreas responses. The …

Influence Of The 3d Microenvironment On Glioblastoma Migration And Drug Response, Ruth Marisol Herrera Perez

Open Access Dissertations

Glioblastoma (GBM) is a highly invasive brain cancer characterized by poor prognosis. Despite significant efforts by the basic and clinical research community our understanding of GBM progression and recurrence has been incremental. Improvements in therapeutic response have been dismal, and GBM continues to be the deadliest tumor of the central nervous system, with patient average survival rate of 12 months. Synergistic relationships that the tumor cells establish with the brain microenvironment have been proven fundamental for successful tumor progression and maintenance. Yet, many in vitro GBM studies are performed in formats that fail to recapitulate the most essential component of …

Neonatal Abstinence Syndrome: Pharmacologic Strategies For The Mother And Infant., Walter K. Kraft, Megan W. Stover, Jonathan M. Davis

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Opioid use in pregnancy has increased dramatically over the past decade. Since prenatal opioid use is associated with numerous obstetrical and neonatal complications, this now has become a major public health problem. In particular, in utero opioid exposure can result in neonatal abstinence syndrome (NAS) which is a serious condition characterized by central nervous system hyperirritability and autonomic nervous system dysfunction. The present review seeks to define current practices regarding the approach to the pregnant mother and neonate with prenatal opiate exposure. Although the cornerstone of prenatal management of opioid dependence is opioid maintenance therapy, the ideal agent has yet …

"Paying For Success": Structuring Reimbursement Of Free Healthcare For Pre-Insured Patients Using The Social Equity Bond Model, Nikkole Turgeon

Senior Honors Projects

Millions of Americans without insurance under the Affordable Care Act expansion fall into two categories: the ‘coverage gap’ and the ‘citizenship gap’. These two groups are disproportionately affected by health disparities due to low-income or legal status. Health disparities affect individuals in many aspects of their lives, including their health, finances, and overall quality of life. To improve the lives of uninsured individuals in Providence, Rhode Island Clínica Esperanza/Hope Clinic (CEHC) proposes to set up a Social Investment Bond Pay for Success program. CEHC has teamed with the Rhode Island Office of Health and Human Services and other RI organizations …

Oncolog, Volume 61, Number 04, April 2016, Joe Munch, Bryan Tutt, K Werner

OncoLog MD Anderson's Report to Physicians (All issues) Archives

• Aggressive Multimodality Salvage Therapy for Locally Recurrent Rectal Cancer Offers Hope to Patients: For patients with locally recurrent rectal cancer, multimodality salvage therapy presents the only chance for a cure. Such therapy is offered at just a handful of specialized referral institutions, including The University of Texas MD Anderson Cancer Center.
• Rapid Assessment, Clinical Trials Could Improve Outcomes for Anaplastic Thyroid Cancer Patients: Anaplastic thyroid cancer is extremely aggressive-only 20% of patients survive 1 year after their diagnosis-so patients require immediate assessment and treatment. A program at The University of Texas MD Anderson Cancer Center expedites the care of patients …

The Liberty Study: Design Of A Prospective, Observational, Multicenter Trial To Evaluate The Acute And Long-Term Clinical And Economic Outcomes Of Real-World Endovascular Device Interventions In Treating Peripheral Artery Disease., George L Adams, Jihad Mustapha, William Gray, Nick J Hargus, Brad J Martinsen, Gary Ansel, Michael R Jaff

Heart and Vascular Articles

Background: Most peripheral artery disease (PAD) clinical device trials are supported by commercial manufacturers and designed for regulatory device approval, with extensive inclusion/exclusion criteria to support homogeneous patient populations. High-risk patients with advanced disease, including critical limb ischemia (CLI), are often excluded leading to difficulty in translating trial results into real-world clinical practice. As a result, physicians have no direct guidance regarding the use of endovascular devices. There is a need for objectively assessed studies to evaluate clinical, functional, and economic outcomes in PAD patient populations.

Study design: LIBERTY is a prospective, observational, multicenter study sponsored by Cardiovascular Systems Inc …

Adam10 Localization In Temporomandibular Joint Disk With Internal Derangement: An Ex Vivo Immunohistochemical Study, Carla Loreto, Giovanni Paolo Salvatore Chiarenza, Giuseppe Musumeci, Paola Castrogiovanni, Rosa Imbesi, Alessandra Ruggeri, Luis Eduardo Almeida, Rosalia Leonardi

School of Dentistry Faculty Research and Publications

The purpose of this study was to determine the presence of ADAM10 in temporomandibular joint disk with internal derangement. Twenty-five paraffin blocks of displaced temporomandibular joint (TMJ) disk specimens from earlier investigations were retrieved from the archives of the University of Catania. Of these 16 had been removed from females and 9 from males; 11 with anterior disk displacement with reduction (ADDwR) and 14 with anterior disk displacement without reduction (ADDwoR). The sections were dehydrated, embedded in paraffin and cut. Then they were incubated in 0.3% H₂O₂/methanol and half of sections from each sample were incubated …

The Relationship Between E-Cigarette Use And Tobacco Status Among Youth In Public Health Tobacco Cessation Programs, Sophia Brasil

McNair Scholars Research Journal

E-cigarette use is an emerging and fast-growing trend particularly among youth and young adults that has not been thoroughly researched in terms of quit rates and abstinence rates. The objective of this research was to determine whether there is an association between e-cigarette use and cessation rates of youth in tobacco cessation programs. This research, compiled in Fiscal Year 2015, analyzes quantitative evaluation data gathered from statewide public health tobacco cessation programs in Idaho in order to explore the relationship between e-cigarette use and quit rates. This research evaluates data from participants of tobacco cessation programs (N=2127) and the association …

Transcatheter Aortic Valve Replacement (Tavr) Is Associated With A Higher Rate Of Permanent Pacemaker Implantation Compared To Surgical Aortic Valve Replacement (Savr): A Propensity Matched Analysis, Neeraj Shah Md, Achint Patel Mbbs, Nileshkumar Patel Md, Vratika Agarwal Md, Jalaj Garg Md, Nainesh C. Patel Md, David A. Cox Md

Department of Medicine

Background

Occurrence of conduction abnormalities requiring permanent pacemaker implantation (PPI) is a serious complication after both transcatheter (TAVR) & surgical (SAVR) aortic valve replacement.

Methods

Nationwide Inpatient Sample was queried from August 2011 to December 2012 using ICD-9 codes 35.05 & 35.06 for TAVR and 35.21 & 35.22 for SAVR. Patients undergoing other valve surgeries, bypass grafting & those with prior pacemakers or defibrillators were excluded. Propensity matching was performed (1:1) to match TAVR & SAVR cohorts on age, gender, right bundle branch block (RBBB), first degree AV block, bifascicular or trifascicular block, hospital region, teaching hospital status & hospital …