Medicine and Health Sciences Commons^™

Institutional Silence: Re-Victimization Of Sexual Assault Victims At Bgsu, Kendall Lake

Honors Projects

This study investigates the causes and effects of the lack of Sexual Assault Nurse Examiners (SANEs) at the Bowling Green State University (BGSU). The study draws on previous research about sexual assault reporting, deterrents to reporting, national prevalence studies, how psychological re-victimization occurs, and the importance of sexual assault nurse examiners. The data included is previous literature, interviews, and ethnographic research about the town Bowling Green, OH. The primary data for this research comes from interviews with the SANEs at the Wood County Hospital. Seven nurses were interviewed, and findings concluded that residential students at BGSU are not receiving medical …

Engineering A Mutation In The Heparin Binding Pocket Of The Human Fibroblast Growth Factor, Roshni Patel

Chemistry & Biochemistry Undergraduate Honors Theses

Fibroblast growth factors (FGFs) are family of proteins that belong to a group of growth factors that are found in mammals and play an important role in angiogenesis, differentiation, organogenesis, and tissue repair. In summary, their main functionality is involved in cell division and proliferation. Because FGFs plays such a vital role in cell proliferation, they are mainly involved in the process of wound healing and injuries. FGF binds to its ligand, heparin—a heavily sulfated glycosaminoglycan. The binding of heparin to FGF occurs through electrostatic interactions, specifically between the negatively charged sulfate groups on heparin and positively charged residues such …

Impact Of Delay In Admission On The Outcome Of Critically Ill Patients Presenting To The Emergency Department Of A Tertiary Care Hospital From Low Income Country, Badar Afzal Khan, Nishi Shakeel, Emad Uddin Siddiqui, Ghazala Kazi, Irum Qamar Khan, Munawer Khursheed, Asher Feroze, Kiran Ejaz, Sumaiya Tauseeq Khan, Hatem Adel

Department of Emergency Medicine

Objective: To assess the impact of admission delay on the outcome of critical patients.Methods: The retrospective chart review was done at Aga Khan University Hospital, Karachi, and comprised adult patients visiting the Emergency Department during 2010. Outcome measures assessed were total hospital length of stay, total cost of the visit and in-hospital mortality. Patients admitted within 6 hours of presentation at Emergency Department were defined as non-delayed. Data was analysed using SPSS 19.Results: Of the 49,532 patients reporting at the Emergency Department during the study period, 17,968 (36.3%) were admitted. Of them 2356(13%) were admitted to special or intensive care …

University Of New England’S College Of Osteopathic Medicine 2016 Peter Morgane Research Fellowship Recipients, University Of New England College Of Osteopathic Medicine

Peter Morgane Research Fellowships

2016 recipients of the University of New England College of Osteopathic Medicine's Peter Morgane Research Fellowship.

Smoking Perceptions Among Adult Cameroonian Men Who Smoke Cigarettes, Elvis N. Ngyia

Nursing Dissertations - Archive

Background: Over five million people die annually from smoking related illnesses. As more people consider quitting smoking in industrialized nations, the rate of smoking has been rising in African countries, also referred to as low and middle-income countries. The projected population growth in Africa has led tobacco manufacturers to strategically target African teenagers who do not clearly understand the adverse effects of smoking cigarettes. In developed countries such as the United States, public education about the dangers of smoking and the availability of structured smoking cessation programs have been influential in helping smokers quit. Unfortunately in most developing countries in …

Engagement With Activity And Functional Status Among Older Adults, Thomas A. Dombrowsky

Nursing Dissertations - Archive

This study reports on the relationship between engagement with activity and functional status in a sample of 92 older adults. Engagement was found to be a significant predictor of functional status as measured by the Lawton-Brody Instrumental Activities of Daily Living Scale, but was not statistically significant when functional status was measured using the Katz Index of Independence in Activities of Daily Living. Age was found to be a significant covariate, but comorbidity, depression, and marital status were not statistically significant in the models tested.

Preoperative Depression And Postopertive Outcomes In Older Adult Cardiac Surgery Patients, Alaina Michelle Tellson

Nursing Dissertations - Archive

Depression following cardiac surgery has been reported in older adults; however, the evidence to date does not clearly specify the onset of depression and its relationship to cardiac surgery. The purpose of this descriptive, correlational study was to examine the association between preoperative depression and selected postoperative outcomes in older adults following CABG surgery. The five selected postoperative outcomes were 30 day readmission rate, hospital length of stay, intensive care unit length of stay, ventilator time, and 30 day mortality. A sample size of 87 older adult cardiovascular surgery patients was selected for this study. Thirteen (14.9%) of the participants …

New Dentist News (May 2016), Ada Committee On The New Dentist

New Dentist News

New Dentist News offers timely information on scientific, social, educational, political and economic developments affecting new dentists. This collection is historical and items may not reflect current standards. For up-to-date information contact the ADA. The New Dentist News was alternately titled ADA Lifeline, 1997-June 2001.

Velar–Vowel Coarticulation In A Virtual Target Model Of Stop Production, Stefan A. Frisch, Sylvie M. Wodzinski

Communication Sciences and Disorders Faculty Publications

Velar–vowel coarticulation in English, resulting in so-called velar fronting in front vowel contexts, was studied using ultrasound imaging of the tongue during /k/ onsets of monosyllabic words with no coda or a labial coda. Ten native English speakers were recorded and analyzed. A variety of coarticulation patterns that often appear to contain small differences in typical closure location for similar vowels was found. An account of the coarticulation pattern is provided using a virtual target model of stop consonant production where there are two /k/ allophones in English, one for front vowels and one for non-front vowels. Small differences in …

Changes In Physical Functioning And Muscle Strength In Men Receiving Androgen Deprivation Therapy For Prostate Cancer: A Controlled Comparison, Brian D. Gonzalex, Heather S. L. Jim, Brent J. Small, Mayer N. Fishman, Babu Zachariah, Randy V. Heysek, Paul B. Jacobsen

Aging Studies Faculty Publications

Purpose: The purpose of the study is to examine changes in muscle strength and self-reported physical functioning in men receiving androgen deprivation therapy (ADT) for prostate cancer compared to matched controls.

Methods: Prostate cancer patients scheduled to begin ADT (n = 62) were assessed within 20 days of starting ADT and 6 and 12 months later. Age and geographically matched prostate cancer controls treated with prostatectomy only (n = 86) were assessed at similar time intervals. Grip strength measured upper body strength, the Chair Rise Test measured lower body strength, and the SF-12 Physical Functioning scale measured self-reported physical functioning. …

African American Female Offender's Use Of Alternative And Traditional Health Services After Re-Entry: Examining The Behavioral Model For Vulnerable Populations, Carrie B. Oser, Amanda M. Bunting, Erin L. Pullen, Danelle Stevens-Watkins

Sociology Faculty Publications

This is the first known study to use the Gelberg-Andersen Behavioral Model for Vulnerable Populations to predict African American women's use of three types of health services (alternative, hospitalization, and ambulatory) in the 18 months after release from prison. In the multivariate models, the most robust predictors of all three types of service utilization were in the vulnerable theoretical domains. Alternative health services were predicted by ethnic community membership, higher religiosity, and HIV/HCV. Hospitalizations were predicted by the lack of barriers to health care and disability. Ambulatory office visits were predicted by more experiences of gendered racism, a greater number …

The Lifestyle-Integrated Functional Exercise Program For Older Adults, Anna Lee, Courtney Beyer, Jessica Lim, Sienna Anderson

Dissertations, Masters Theses, Capstones, and Culminating Projects

According to the Centers for Disease Control and Prevention, falls are the most common cause of fatal and non-fatal injuries among older adults over the age of 65 (Centers for Disease Control and Prevention [CDC], 2009). Falls can lead to a myriad of traumatic physical and emotional consequences. Integrated exercise programs such as the Lifestyle-integrated Functional Exercise (LiFE) program are effective in preventing falls and increasing fall efficacy in individuals who have previously fallen (Clemson et al., 2012). The purpose of our study was to examine if the LiFE program is as effective in reducing fall risk and increasing fall …

Increasing Occupational Participation Of Older Adults With Low Vision Through An Occupation-Based Exercise Video, Valerie J. Deroos, Skyler Moon

Dissertations, Masters Theses, Capstones, and Culminating Projects

With the increasingly large population of older adults with low vision, many older adults would benefit from having a guide dog as an assistive device. When walking with a guide dog, different upper extremity muscles and postures are adopted to handle the guide dog. However, older adults with low vision may not be in the proper physical condition to meet the strenuous demands of handling a guide dog due to the normal aging process and decreased mobility. To prevent pain and injury, stretching and strengthening muscles used when handling a guide dog may benefit older adults before entering the Guide …

Preventing And Reducing Falls In Assisted Living Facilities: An Educational Intervention, Jennifer A. Borcich, Raquel F. Ramos, Taylor S. Wong

Dissertations, Masters Theses, Capstones, and Culminating Projects

As the number of older adults continues to rise, falling in older adults has become a national health care issue. Many older adults who fall reside in assisted living facilities. Every time a fall incident occurs, first responders are called, utilizing a significant amount of first responder’s time and resources. Therefore, the purpose of this project was to implement a fall prevention program for residents of an assisted living facility (ALF) to reduce fall risk and fall-related calls to the local fire department. The project consisted of a four-week course given once weekly for 60 minutes to residents at an …

Capturing Success At Autistry Studios: A Qualitative Study, Ali Ives, Vince Colombano, Joey Bava

Dissertations, Masters Theses, Capstones, and Culminating Projects

This qualitative study examined the perceived outcomes of participation at Autistry Studios among young adult students with Autism Spectrum Disorder (ASD). Autistry Studios is a unique program offering services to individuals with ASD similar to that of a pre-vocational training program. The mission of Autistry Studios is to help students with ASD become independent adults by engaging in “project-based therapy.” A setting is provided where individuals with ASD can achieve personal and functional growth with the use of creative resources like art supplies, raw materials, and power tools to pursue and complete a project that is client-centered. The purpose of …

Human Neonatal Fc Receptor Mediates Transcytosis Of Immunoglobulin-G-Bound Ovalbumin, Farah Gazi

MCB Articles

Introduction: There is increasing evidence that allergies, like many other chronic diseases of childhood, may have origins during the prenatal period. It is also known that mothers, have a stronger influence than fathers, on the development of allergic disease in their children. While the mechanisms responsible for this maternal influence are not known, studies have indicated the possibility of transplacental allergen transfer via immunoglobulin G (IgG) containing immune complexes.

Objective: In this study, we investigated the ability of the neonatal Fc receptor for IgG transport (FcRn) to bind and transport the model allergen ovalbumin in the form of an IgG-ovalbumin …

The Effect Of Sleep Quality And High Intensity Physical Activity On Inflammation And Cardiovascular Disease Risk Factors In College Students, Catherine Abraham

Honors Scholar Theses

Background: Inflammation is the common denominator in chronic conditions such as obesity, diabetes, and depression. While adequate physical activity and optimal sleep quality may help maintain normal inflammation levels, evidence is somewhat conflicting. Aim: This cross-sectional observational study aimed to assess how sleep quality and high intensity physical activity associated with cardiovascular disease (CVD) risk factors and inflammatory biomarkers in a sample of young adults (n=106, ages 18-25 years). Methods: Laboratory-based assessments included lifestyle behaviors (sleep quality, Pittsburgh Sleep Quality Index; self-reported frequency/intensity of physical activity; Healthy Behavior Index derived from reported preference for diet and physical activity), CVD risk …

The Effects Of Acoustic Bandwidth On Simulated Bimodal Benefit In Children And Adults With Normal Hearing, Sterling W. Sheffield, Michelle Simha, Kelly N. Jahn, René H. Gifford

Communication Sciences and Disorders Faculty Publications

Objectives—The primary purpose of this study was to examine the effect of acoustic bandwidth on bimodal benefit for speech recognition in normal-hearing children with a cochlear implant (CI) simulation in one ear and low-pass filtered stimuli in the contralateral ear. The effect of acoustic bandwidth on bimodal benefit in children was compared to the pattern of adults with normal hearing. Our hypothesis was that children would require a wider acoustic bandwidth than adults to 1) derive bimodal benefit, and 2) obtain asymptotic bimodal benefit.

Design—Nineteen children (6–12 years) and ten adults with normal hearing participated in the study. Speech recognition …

Qualitative Exploration Of Spirituality In Heart Failure Patients, Abigail M. Reggio

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Background.

Heart failure (HF) is a severe, progressive disease that afflicts large numbers of

individuals around the world. One significant factor affecting quality of life in persons

with HF is the extent to which spiritual needs are met. Developing an understanding of

spirituality in the HF patient is essential in order for the healthcare professional to

provide the highest quality care possible. This study focused on examining spirituality

in HF patients by means of conducting in-depth interviews with individuals diagnosed

with HF and completing a descriptive analysis of the responses. The goal of this study

was to gain insight into …

The Influence Of Socioeconomic Status And Ethnicity On Body Mass Index In Children In Northwest Arkansas, Madison E. Davidson

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Body Mass Index (BMI) is a measure of body fat that is calculated based on the height, weight, age, and gender of a child. Body Mass Index (BMI) is an important indicator of potential health risks in children. Determining correlations between ethnicity, socioeconomic status, and BMI may assist in identifying children at risk for comorbidities associated with either an elevated or low BMI. An elevated BMI may lead to complications later in life such as hypertension, hyperlipidemia, type 2 diabetes, obesity in adulthood, and psychosocial issues (Geason & Dodd, 2009). On the other hand, a low BMI could lead to …

Association Of Self-Care Confidence And Hospital Readmission Following Student Nurse Led Congestive Heart Failure Transitional Care Project, Peyton A. Phelps

The Eleanor Mann School of Nursing Undergraduate Honors Theses

Abstract

Over 5 million Americans have been diagnosed with heart failure, and that number is growing. This disease is burdensome to the patient as it lessens their quality of life and to the healthcare system due to costliness and frequent readmissions. This study aims to evaluate if a student nurse led transitional care program can increase patient self-care confidence, in turn reducing 30 day hospital readmission rates. Twenty patients completed the Self Care of Heart Failure Index before and after a 14-week transitional care program. These reported data were compared using a paired samples t-test. There was not a …

Legacy Mining Metal Exposures Contribute To Circulating Oxidized Low Density Lipoprotein And Serum Inflammatory Potential In A Native Community, Molly E. Harmon

Biomedical Sciences ETDs

Numerous abandoned uranium mines (AUM) within the Navajo Nation contribute uranium (U), arsenic (As) and other metals to the soil, air and groundwater that continue to pose potential health risks to Navajo residents. The prevalence of inflammatory-related cardiovascular disease (CVD) and type 2 diabetes (T2D) has increased among the Navajo community in recent decades. Environmental exposure to metal contaminants may alter the circulation in ways that are associated with the inflammation-driven process of atherosclerotic plaque formation. Thus, we hypothesize that exposures to AUM metal contaminants are associated with pro-atherogenic changes in the circulation as evidenced by increased low-density lipoprotein (LDL) …

Apolipoprotein E And Clusterin Can Magnify Effects Of Personality Vulnerability On Declarative Memory Performance In Non‐Demented Older Adults, Sharaddha Sapkota, Sandra A. Wiebe, Brent J. Small, Roger A. Dixon

Aging Studies Faculty Publications

Objectives: Recent research has linked psychological (personality) factors and specific genetic risk polymorphisms to performance on neurocognitive phenotypes. We examined whether episodic or semantic memory performance is associated with (a) three personality traits (i.e. neuroticism, extraversion, and openness to experience), (b) two neurodegenerative‐related polymorphisms (i.e. Apolipoprotein E (APOE; rs7412; rs429358), Clusterin (CLU; rs11136000)), and (c) cross‐domain risk interactions (magnification effects).

Methods: Linear growth models were examined to test independent associations between personality traits and declarative memory performance, and potential interaction effects with APOE and CLU genetic risk. Normal older adults (n = 282) with personality …

การพัฒนาแบบสอบถามปัญหาการนอนของเด็กฉบับภาษาไทย, พัทธ์ธีรา ดิษยวรรณวัฒน์, ณัทธร พิทยรัตน์เสถียร

Chulalongkorn Medical Journal

เหตุผลของการทำวิจัย : การนอนให้เพียงพอและคุณภาพของการนอนนั้นสำคัญต่อสุขภาพของเด็กและวัยรุ่น การนอนที่ไม่เพียงพอนั้นส่งผลต่อชีวิตของเด็กในหลายด้าน ตั้งแต่ด้านพุทธิปัญญา (cognitive function) ด้านสมาธิ(attention) และความสามารถในการจดจ่อ (concentration) และส่งผลต่อการเรียน การควบคุมอารมณ์ ซึ่งทำให้เกิดปัญหาพฤติกรรมและพยาธิสภาพและยังส่งผลโดยตรงต่อสุขภาพ โดยอาจจะเพิ่มความเสี่ยงของการเกิดอุบัติเหตุและอาจจะส่งผลต่อโรคระบบหัวใจและหลอดเลือดแบบสอบถามปัญหาการนอนของเด็ก (CSHQ) นั้นถูกออกแบบมาเพื่อคัดกรองปัญหาการนอนที่พบบ่อยในเด็ก โดยมีข้อคำถามที่มีคะแนนทั้งหมด 33 ข้อวัตถุประสงค์ : งานวิจัยนี้มีวัตถุประสงค์เพื่อพัฒนาและแปลแบบสอบถาม CSHQเป็นฉบับภาษาไทย ซึ่งใช้ในเด็กอายุ 4 - 10 ปี และได้ทำการตรวจสอบความเที่ยงตรงตามเนื้อหา (Content validity) และวัดค่าความเชื่อมั่น(Reliability)รูปแบบการวิจัย : การวิจัยเชิงพรรณนาสถานที่ : โรงพยาบาลจุฬาลงกรณ์และโรงเรียนสมาคมสตรีไทยวิธีการศึกษา : การดำเนินการแปลโดยผู้วิจัยแปลแบบสอบถามเป็นภาษาไทย หลังจากนั้นตรวจสอบความหมายและแปลกลับจากภาษาไทยเป็นภาษาอังกฤษผู้วิจัยได้ปรับปรุงก่อนทำการตรวจสอบความเที่ยงตรงตามเนื้อหา(Content validity) โดยผู้ทรงคุณวุฒิ 3 ท่าน และหลังจากปรับปรุงแล้วได้นำไปวัดค่าความเชื่อมั่น (Reliability) จากกลุ่มตัวอย่างผู้ปกครองของเด็กจำนวน 60 คนโดยหาค่าสัมประสิทธิ์ครอนแบคอัลฟาผลการศึกษา : จากผลการวิจัยพบว่าค่าความเชื่อมั่นภาพรวมมีค่า 0.83 และรายด้านอยู่ระหว่าง 0.392 - .776 โดยด้านพฤติกรรมก่อนเข้านอนมีค่า 0.47 ด้านระยะเวลาในการนอนมีค่า 0.49 ด้านความวิตกกังวลในการเข้านอนมีค่า0.615 ด้านการตื่นระหว่างหลับมีค่า 0.776 ด้านปัญหาพฤติกรรมการนอนในช่วงระหว่างการนอนมีค่า 0.736 ด้านปัญหาการนอนที่เกี่ยวข้องกับการหายใจมีค่า 0.392 ด้านการตื่นในตอนเช้าและความง่วงระหว่างวันมีค่า 0.742สรุป : ค่าความเชื่อมั่นภาพรวมอยู่ในเกณฑ์ที่เชื่อถือได้ แต่ความเชื่อมั่นรายด้านคือด้านเวลาการเข้านอนและด้านการตื่นในช่วงกลางคืนยังคงต้องพัฒนาต่อไป.

ภาวะสุขภาพจิตและอาการผิดปกติทางจิตภายหลังเผชิญภยันตรายของผู้ป่วยทหารราชการสนามที่รับการรักษาในโรงพยาบาลพระมงกุฎเกล้า, กังสดาล เพ็งล่อง, เดชา ลลิตอนันต์พงศ์

Chulalongkorn Medical Journal

ที่มาของปัญหาวิจัย : การศึกษาเกี่ยวกับภาวะสุขภาพจิตและอาการผิดปกติทางจิตภายหลังเผชิญภยันตรายในครั้งนี้ จะเป็นประโยชน์ในการนำข้อมูลที่ได้ไปใช้ในการวางแผน กำหนดแนวทาง ส่งเสริมให้ทหารราชการสนามมีสุขภาพจิตที่ดีวัตถุประสงค์ : เพื่อศึกษาสุขภาพจิต อาการผิดปกติทางจิตภายหลังเผชิญภยันตราย และปัจจัยที่มีความสัมพันธ์กับสุขภาพจิตและอาการผิดปกติทางจิตภายหลังเผชิญภยันตรายของผู้ป่วยทหารราชการสนามที่มารับการรักษาพยาบาลในโรงพยาบาลพระมงกุฎเกล้ารูปแบบการวิจัย : การศึกษาเชิงพรรณนา โดยศึกษา ณ จุดเวลาใด เวลาหนึ่งประเภทโรงพยาบาล : แผนกผู้ป่วยทหารราชการสนาม โรงพยาบาลพระมงกุฎเกล้า กรุงเทพมหานครวิธีวิจัย : รวบรวมข้อมูลจากผู้ป่วยทหารราชการสนาม จำนวน 108 คน โดยการใช้แบบสอบถาม 3 ส่วน คือ แบบสอบถามข้อมูลทั่วไป แบบวัดสุขภาพจิตSCL.90 และแบบประเมินภาวะสุขภาพจิตหลังภาวะวิกฤต GHQ 12Plus-R ส่วนที่ 2PTSD Screening Test ใช้การวิเคราะห์ Univariate Analysisเพื่อหาปัจจัยที่เกี่ยวข้องและมีความสัมพันธ์กับสุขภาพจิตและอาการผิดปกติทางจิตภายหลังเผชิญภยันตรายผลการศึกษา : ผู้ป่วยทหารราชการสนามส่วนใหญ่มีปัญหาสุขภาพจิต ร้อยละ 73.1 ซึ่งมีปัญหาสุขภาพจิตด้านการย้ำคิดย้ำทำมากที่สุด ร้อยละ 50.0 โดยพบปัจจัยที่เกี่ยวข้องกับสุขภาพจิต คือสาเหตุที่ทำให้ได้รับบาดเจ็บในขณะปฏิบัติภารกิจราชการสนามด้วยการถูกสะเก็ดระเบิด ส่วนอาการผิดปกติทางจิตภายหลังเผชิญภยันตรายนั้น พบว่าผู้ป่วยทหารราชการสนามส่วนใหญ่ไม่มีอาการผิดปกติทางจิตภายหลังเผชิญภยันตราย ร้อยละ 77.8 โดยพบปัจจัยที่เกี่ยวข้องกับอาการผิดปกติทางจิตภายหลังเผชิญภยันตราย ได้แก่ อายุและสถานภาพสมรสสรุป : ผู้ป่วยทหารราชการสนามส่วนใหญ่มีปัญหาสุขภาพจิต แต่ไม่มีอาการผิดปกติทางจิตภายหลังเผชิญภยันตราย.

Today - May 2016, Loma Linda University Health

TODAY

Inside this Issue:

-- More than 3,000 attend Loma Linda University Health Vision 2020 Groundbreaking Event
-- Sold-out LLUH Women's Conference inspires attendees to 'Be the Artist of Your Life'
-- Daniel Samano's two big home runs
-- Loma Linda University Health helps community discover 'Your Best Pathway to Health'
-- Annual Children's Day teaches kids about health care in a fun, safe environment
-- LLU alumna appointed as Florida surgeon general
-- ECMO open house displays new CARDIOHELP technology to help critically ill children survive
-- President Hart leads work bee to uncover original Loma Linda Sanitarium steps
-- …

Intimate Partner Violence In Early Adolescence: The Role Of Gender, Socioeconomic Factors And The School, A. J. Mason-Jones, P De Koker, S. M. Eggers, Marleen Temmerman, E. Leye, P. J De Vries, H De Vries

Obstetrics and Gynaecology, East Africa

Background: Intimate partner violence (IPV) among adolescents is common worldwide, but our understanding of perpetration, gender differences and the role of social-ecological factors remains limited.

Objectives: To explore the prevalence of physical and sexual IPV perpetration and victimisation by gender, and associated risk and protective factors.

Methods: Young adolescents (N=2 839) from 41 randomly selected public high schools in the Western Cape region of South Africa (SA), participating in the PREPARE study, completed a self-administered questionnaire.

Results: The participants’ mean age was 13.65 years (standard deviation 1.01), with 19.1% (541/2 839) reporting being victims/survivors of IPV and 13.0% (370/2 839) …

Immune Modulating Functions By Soypeptide Lunasin In Cancer Immunotherapy, Chun-Yu Tung

Open Access Dissertations

Chemotherapy is currently the mainstay of treatment for most cancer patients. Despite its efficacy in eliminating cancer cells, a high percentage of chemotherapy patients eventually relapse or suffer progression of the disease. Immunosurveillance is capable of recognizing and eliminating continuously arising transformed mutant cells, and thus cancer immunotherapy is one of the emerging therapeutic strategies that harnesses the power of the immune system to eradicate chemotherapy-resistant cancerous cells. However, the adverse side effects of chemotherapy impede the therapeutic effects of immunotherapy. Our previous studies demonstrate that lymphoma patients are refractory to clinical immunotherapy because of chemotherapy-induced immune dysfunction. In addition, …

Eating Local At Uri: The Real Food Challenge, Kayleigh M. Hill

Senior Honors Projects

Over the past decade sustainability has become more than just a buzzword at the University of Rhode Island. We have adapted it into the fabric of our school and created a student body that is focused on the health of our future, on promoting environmental, social and economic prosperity that is created and sustained by action on a local level. In other words, we have realized that before we can “Think Big”, we have to first consider the impact our actions have on every level of society. This project focuses on how the action of eating is a direct reflection …

The Impact Of Polybrominated Diphenyl Ether (Bde-47) Administration In Mice And Its Implications In Non-Alcoholic Fatty Liver Disease, Kristen Ciampi

Senior Honors Projects

Non-alcoholic fatty liver disease (NAFLD) is a disease characterized by the accumulation of fat in liver cells that is not due to alcohol consumption. Steatosis results when more than 5-10% of the liver’s weight consists of fat. People who are overweight, or who have diabetes or high cholesterol are more likely to develop NAFLD. Over time, NAFLD can advance to cause cirrhosis, and eventually, liver cancer or failure.

Polybrominated diphenyl ethers (PBDEs, BDEs) are brominated flame- retardants, and are found in many plastics and household products such as cars, textiles, televisions, and computers. BDEs are released into the environment and …