Medicine and Health Sciences Commons^™

Portable, Parallel 9-Wavelength Near-Infrared Spectral Tomography (Nirst) System For Efficient Characterization Of Breast Cancer Within The Clinical Oncology Infusion Suite, Yan Zhao, Brian W. Pogue, Steffen J. Haider, Jiang Gui, Roberta Diflorio-Alexander, Keith Paulsen, Shudong Jiang

Dartmouth Scholarship

A portable near-infrared spectral tomography (NIRST) system was developed with simultaneous frequency domain (FD) and continuous-wave (CW) optical measurements for efficient characterization of breast cancer in a clinical oncology setting. Simultaneous FD and CW recordings were implemented to speed up acquisition to 3 minutes for all 9 wavelengths, spanning a range from 661nm to 1064nm. An adjustable interface was designed to fit various breast sizes and shapes. Spatial images of oxy- and deoxy-hemoglobin, water, lipid, and scattering components were reconstructed using a 2D FEM approach. The system was tested on a group of 10 normal subjects, who were examined bilaterally …

A Randomized Controlled Trial Of A Faith-Placed, Lay Health Advisor Delivered Smoking Cessation Intervention For Rural Residents, Nancy E. Schoenberg, Christina R. Studts, Brent J. Shelton, Meng Liu, Richard Clayton, Jordan Baeker Bispo, Nell Fields, Mark Dignan, Thomas Cooper

Behavioral Science Faculty Publications

Introduction. Rural US residents smoke at higher rates than urban or suburban residents. We report results from a community-based smoking cessation intervention in Appalachian Kentucky.

Study design. Single-blind, group-randomized trial with outcome measurements at baseline, 17 weeks and 43 weeks.

Setting/participants. This faith-placed CBPR project was located in six counties of rural Appalachian Kentucky. A total of 590 individual participants clustered in 28 churches were enrolled in the study.

Intervention. Local lay health advisors delivered the 12-week Cooper/Clayton Method to Stop Smoking program, leveraging sociocultural factors to improve the cultural salience of the program for Appalachian smokers. Participants met with …

The Story Of Patrick’S: The First Center For Children With Autism In Nigeria, Dotun Akande, Alissa Briggs, Hatim A. Omar

Pediatrics Faculty Publications

Autism Spectrum Disorder (ASD) is one of the most common developmental disorders. However, there are still no epidemiological studies of ASD in African countries. In Nigeria, many children are diagnosed with ASD late or only if there are symptoms that severely inhibit their ability to function. Moreover, there are limited treatment options. This paper will describe the efforts of Patrick Speech and Languages Centre (Patrick’s), the first center in Nigeria specifically for children with ASD, which was set up to assess and treat autism.

Influence Of Curing Protocol On Bond Strength Of Self-Etching Adhesives, Sara Adel Botros, Farid Sabry El-Askary, Mohamed Salah Nassef

Dentistry

No abstract provided.

Effect Of Light Distance Specimen Length On Flexural Strength Of Resin-Composite, Sara Adel Botros, Farid Sabry El-Askary, Mohamed Salah Nassef

Dentistry

No abstract provided.

Perforated Sub-Hepatic Appendix; Rare Presentation Of A Common Disease., Huzaifa Ali Jaliawala, Fatima Mannan, Roger Gill, Abdul Rehman Alvi

Department of Surgery Docs

Abstract

An elderly gentleman presented to our emergency with a 10-day history of right upper quadrant pain and nausea with associated tenderness on examination. His white cell counts were raised with predominant neutrophils with ultrasound evidence of a heterogeneous sub-hepatic collection, not associated with fever, diarrhoea or vomiting. He had a similar episode 3 weeks ago, which resolved with antibiotics. Initially thought to be a perforated acute appendicitis or a liver abscess a CT scan was done to further substantiate our finding. This to the contrary revealed a perforated sub hepatic appendix. Patient was treated conservatively with IV fluids and …

Volume V (2016), Unm Department Of Orthopaedic Surgery

UNM Orthopaedic Research Journal

No abstract provided.

North Douglas County Community Needs Health Assessment (Phase 1), Callie H. Lambarth, Diane Reid, Beth L. Green

Early Childhood

Beginning in February 2016, the North Douglas County (NDC) communities of Drain, Elkton, and Yoncalla, Oregon engaged in a Community Health Needs Assessment (CHNA) planning process, focusing on children ages birth-to-8 and their families. The purpose of this process was to explore, understand, and integrate linkages between early learning and young child and family health; identify health-related resources currently available and accessible to NDC families; and prioritize health areas of interest to be explored during the CHNA.

The North Douglas County CHNA builds on community partnerships already established in the region through initiatives that aim to coordinate and align early …

Gene Delivery Using Calcium Phosphate Nanoparticles: Optimization Of The Transfection Process And The Effects Of Citrate And Poly(L-Lysine) As Additives, Mohammed A. Khan, Victoria M. Wu, Shreya Ghosh, Vuk Uskoković

Pharmacy Faculty Articles and Research

Despite the long history of nanoparticulate calcium phosphate (CaP) as a non-viral transfection agent, there has been limited success in attempts to optimize its properties for transfection comparable in efficiency to that of viral vectors. Here we focus on the optimization of: (a) CaP nanoparticle precipitation conditions, predominantly supersaturation and Ca/P molar ratios; (b) transfection conditions, mainly the concentrations of the carrier and plasmid DNA; (c) the presence of surface additives, including citrate anion and cationic poly(l-lysine) (PLL). CaP nanoparticles significantly improved transfection with plasmid DNA encoding enhanced green fluorescent protein (eGFP) in pre-osteoblastic MC3T3-E1 cells compared to a commercial …

Preventing Stroke At Door Step– Need For A Paradigm Shift In Delivery Of Preventive Healthcare, Ismail A. Khatri, Saad Farooq, Muneeza A. Khatri

Pakistan Journal of Neurological Sciences (PJNS)

Although stroke is a preventable disease, it is increasing globally. Only few risk factors are responsible for much of the leading noncommunicable diseases, yet those remain poorly controlled, despite being the most affordable way of promoting health and preventing disease [1]. Lifestyle modification including cessation of smoking, making aerobic physical activity a routine, certain changes in diet, and aggressive management of risk factors are all part of stroke prevention strategies [2].

Frequency Of Cranial Autonomic Symptoms (Cas) In Migraine Patients, Sadaf Nasir, Naureen Abrar, Khalid Sher, Shahnaz Shahnaz

Pakistan Journal of Neurological Sciences (PJNS)

Of all the painful states that afflict humans, headache is undoubtedly the most frequent and common reason for seeking medical help. Headache has over 300 different types and different etiologies; migraine is one of them and continues being an under diagnosed condition in many of cases as it can be accompanied by symptoms commonly associated with other causes of facial pain. Out of 28 million people in USA who have history of headache and symptoms which mimic the typical migraine only 48% are diagnosed of migraine.

Two Cases Of Hyperkalemia Presenting As Acute Demyelinating Polyneuropathy: Clinical And Electrophysiological Reversibility With In 72 Hours With Potassium Correction., Waseem Tariq, Arsalan Ahmad,Md

Pakistan Journal of Neurological Sciences (PJNS)

GullianBarre syndrome (GBS) is the most common cause of acute flaccid paralysis.Hypokalemia can present with flaccid paralysis and nerve conduction studies show axonal neuropathy.Here we present two cases who were initially admitted with suspicion of GBS but later on baseline investigations showed very high serumpotassium and in both cases nerve conduction showed acute demyelinating polyneuropathy.They were admitted in high dependency units and urgent dialysis was done.In first case NCS were repeated 72 hours of correction of hyperkalemia and they showed significant improvement. In second patient NCSwere repeated after 24 hours and they showed mild improvement in all parameters.

Frequency Of Intraventricular Extension In Intracerebral Hemorrhage And Its Outcome At Day 30., Farheen Niazi,, Muhammad Irshad

Pakistan Journal of Neurological Sciences (PJNS)

Intracerebral hemorrhage (ICH) accounts for 10 to 15% of all strokes, and is found to have a disproportionately high morbidity and mortality.1 Extension of the hemorrhage intothe ventricles (40% occurrence) can happen early or late in the course of events.2 OBJECTIVE: To determine the frequency of Intraventricular extension in patients with intracerebralhaemorrhage and its outcome at day 30 by measuring disability using Modified Rankin Scale.STUDY DESIGN: Descriptive case series.PLACE AND DURATION OF STUDY: Study was carried out from 1st December 2010 to 31st May, 2011 in the department of Neurology, PIMS, Islamabad, Pakistan SUBJECT AND METHODS:93 patients of intracerebralhaemorrhage were …

10thannual Neurology Research Day, May 2016 Abstracts Shifa International Hospital, Islamabad, Rohaan Noor, Komal Gilani, Umer Farooq, Sabul Zafar, Fatima Aurangzaib.

Pakistan Journal of Neurological Sciences (PJNS)

Burden of headache has been assessed in adults in countries worldwide, and is high, but data for children and adolescents is sparse. The objective of this study is to fill the information gap for adolescents.

Surgical Outcome Of Benign Intracranial Hypertension In Terms Of Improvement In Vision, Naeem Ul Haq, Naseer Hassan, Muhammad Ishaq, Muhammad Usman

Pakistan Journal of Neurological Sciences (PJNS)

To know about surgical outcome of benign intracranial hypertension in terms of improvement of vision.METHODOLOGY ; This Prospective observational study was conducted at of 22 patients operated in neurosurgery unit lady reading hospital Peshawar from Jan 2011 to Jun2014. Written consent was obtained from all the patients or their relatives All patients of either age and sex with Diagnosed cases of BIH were included in the study, Patients with depressed conscious level, malignant hypertension, space occupying lesion in brain on MRI and those Patients unfit or unwilling for surgery were excluded from the study. Patients particulars like age ,gender , …

Editorial - Jam June 2016, Rafat Jan, Edwin Van Teijlingen

Journal of Asian Midwives (JAM)

No abstract provided.

News & Events

Journal of Asian Midwives (JAM)

No abstract provided.

Needs And Expectations: A Membership Survey Of The Midwifery Association In Afghanistan, Sabera Turkmani, Cristina De Nicolás, Fatima Gohar, Pashtoon Azfar Zyaee

Journal of Asian Midwives (JAM)

A survey of the Afghan Midwives Association (AMA) members was conducted in April 2013 to determine the profile of the midwifery workforce, and to provide guidance on the professional needs and expectations of midwives in the future. Of the estimated 3,000 members across the country, around 500 participated in the Annual Congress, 400 questionnaires were distributed randomly among participants, and 357 were returned (89% response rate representing 12% of the overall membership).

The results showed that most members are pleased with the Association, and value its work, particularly its ability to advocate on their behalf with the Ministry of Public …

Birthing Centres In Nepal: Recent Developments, Obstacles And Opportunities, Preeti K. Mahato, Edwin Van Teijlingen, Padam Simkhada, Catherine Angell

Journal of Asian Midwives (JAM)

Background: Establishing and promoting birthing centers (BCs) can be one strategy to increase access to emergency obstetric care and skilled attendants at birth, to avert many maternal deaths. BCs are a component of local health service delivery, whereby midwives (or health care professionals with midwifery competencies) provide maternity services to generally healthy women with uncomplicated pregnancies, mostly in the community setting.
Methods: A literature review was carried out involving searches and appraisals of relevant literature on birthing centers in Nepal, South Asia, and other similar settings.
Findings//Conclusion: In Nepal, midwife-led care in BCs was found to be …

Perceptions Of The Role Of The Man In Family Planning, During Pregnancy And Childbirth: A Qualitative Study With Fifteen Nepali Men, Magdalena Mattebo, Bharati Sharma, Erica Dahlkvist, Eleonor Molinder, Kerstin Erlandsson

Journal of Asian Midwives (JAM)

Introduction: In Nepal, by tradition, family life and marriage are generally controlled by patriarchal norms, sanctions, values and gender differences. Women in Nepal have limited possibilities to make decisions regarding their sexual and reproductive health, as the husbands and other elders in the family make most of the decisions regarding family planning, pregnancy and childbirth.
Aim: To describe the perceptions of Nepali men regarding the role of the man with respect to family planning, pregnancy and childbirth.
Methods: A qualitative study was conducted with 15 Nepali men in both urban and rural areas. The material was analyzed through inductive …

Misconceptions And Mismanagement Of Menstruation Among Adolescents Girls Who Do Not Attend School In Pakistan, Naghma Rizvi, Tazeen Saeed Ali

Journal of Asian Midwives (JAM)

Background: Menstruation is perceived and interpreted differently under different social and cultural norms. There are a number of different practices, conceptions and misconceptions that have been reported in studies conducted in various countries. In Pakistan, there is a dearth of knowledge related to hygienic and unhygienic practices, discomforts, misconceptions related to nutrition, and restrictions imposed during menstruation. Therefore, this study was conducted with the objectives to identify the conceptions and misconceptions about menstruation, explore hygienic and unhygienic practices during menstruation along with the socio- cultural and religious restrictions imposed, and the discomforts with its management among adolescents who do not …

Universal Weight Machine, Oscar Andrade, Bibiana Koch, Robert Molloy, Haley Rentfro, Emily Woods

Mechanical Engineering

The purpose of this project is to design and build an inexpensive, universally accessible multi-station exercise machine for the physical and mental well-being of athletes of the Special Olympics and Pathpoint Life Education & Advancement Program. The machine has three sides tiered to higher resistance: the first station offers a minimal resistance aerobic exercise focused on moving the arms with an ergometer, the second station provides numerous locations to latch on resistance bands that will build strength in the athlete’s arms and chest, and the final station has a donated weight machine that offers lat pulldowns and flys with maximum …

Comparison Of The Lonidamine Potentiated Effect Of Nitrogen Mustard Alkylating Agents On The Systemic Treatment Of Db-1 Human Melanoma Xenografts In Mice., Kavindra Nath, David S. Nelson, Mary E. Putt, Dennis B. Leeper, Bradley Garman, Katherine L. Nathanson, Jerry D. Glickson

Department of Radiation Oncology Faculty Papers

Previous NMR studies demonstrated that lonidamine (LND) selectively diminishes the intracellular pH (pHi) of DB-1 melanoma and mouse xenografts of a variety of other prevalent human cancers while decreasing their bioenergetic status (tumor βNTP/Pi ratio) and enhancing the activities of melphalan and doxorubicin in these cancer models. Since melphalan and doxorubicin are highly toxic agents, we have examined three other nitrogen (N)-mustards, chlorambucil, cyclophosphamide and bendamustine, to determine if they exhibit similar potentiation by LND. As single agents LND, melphalan and these N-mustards exhibited the following activities in DB-1 melanoma xenografts; LND: 100% tumor surviving fraction (SF); chlorambucil: 100% SF; …

Bh3 Mimetic Abt-737 Sensitizes Colorectal Cancer Cells To Ixazomib Through Mcl-1 Downregulation And Autophagy Inhibition., Lifeng Yang, Juefeng Wan, Sheng Xiao, Darryll Barkhouse, Ji Zhu, Guichao Li, Bo Lu, Zhen Zhang

Department of Radiation Oncology Faculty Papers

The proteasome inhibitor MLN9708 is an orally administered drug that is hydrolyzed into its active form, MLN2238 (ixazomib). Compared with Bortezomib, MLN2238 has a shorter proteasome dissociation half-life and a lower incidence and severity of peripheral neuropathy, which makes it an attractive candidate for colorectal cancer treatment. In the present study, we observed that MLN2238 induced autophagy, as evidenced by conversion of the autophagosomal marker LC3 from LC3I to LC3II, in colorectal cancer cell lines. Mcl-1, an anti-apoptotic Bcl-2 family protein, was markedly elevated after treating a colorectal cancer cell line with MLN2238. We proved that inhibiting Mcl-1 expression enhances …

A Novel Rare Sugar Inhibitor Of Murine Herpes Simplex Keratitis., Syed M. Muniruzzaman, M. Mcintosh,, Ahamed Hossain, K. Izumori, Partha S. Bhattacharjee

Faculty and Staff Publications

Purpose To determine the therapeutic efficacy of a novel rare sugar, L-psicose, for the treatment of HSV-1 induced herpetic stromal keratitis (HSK) in a mouse eye model. Methods One rare sugar L-psicose was assayed for HSV-1 inhibition of in vitro virus adsorption. The IC50 and IC90 values of L-psicose were determined using plaque reduction assay (PRA) in CV-1 cell. Female Balb/c mice were corneally infected with HSV-1, strain KOS-GFP; A topical eye drop treatment of L-psicose was started 24 h after infection and continued four times daily for ten consecutive days. The severity of HSK was monitored by slit lamp …

Mass Culturing Soil Bacteria From Radium Springs And Analysis Of Antibiotic Activity, Amanda Nguyen

PCOM Biomedical Studies Student Scholarship

Antibiotics have become a regularity in human life. Discovered accidentally, they proved to be vital to public health. Since then, they have become integrated into a variety of widely used products such as detergents, soaps, and clothes. Unfortunately, the overuse of antibiotics as a precautionary tool for the betterment of public health has led to an era in which bacterial strains have evolved resistance and antibiotics are becoming increasingly useless. For example, Enterococcus faecalis, one of six ESKAPE pathogens prevalent in nosocomial infections, is commonly found in the GI tract, but frequently causes infections leading to endocarditis, urinary tract infections, …

A Literature Review Of Studies Evaluating Rotator Cuff Activation During Early Rehabilitation Exercises For Post-Op Rotator Cuff Repair, Samuel N. Wells, Jodi R. Schilz, Timothy L. Uhl, A. Burke Gurney

Physical Therapy Faculty Publications

Despite the modern advancement of surgical repair equipment and techniques, many rotator cuff repairs do not clinically heal. Prescribed rehabilitative exercises must appropriately load the repaired muscle-tendon complex to promote healing and prevent capsular adhesions without damaging the repair. The clinician must possess an understanding of the anatomy and physiology of the healing rotator cuff, and understand the importance of the plane of movement, speed of the movement, position of the extremity, level of assistance, and type of resistance used. Electromyography (EMG) provides a useful means to determine muscle activation levels during specific exercises. Descriptions of specific exercises and EMG …

Factors Associated With Uptake Of Visual Inspection With Acetic Acid (Via) For Cervical Cancer Screening In Western Kenya, Elkanah Omenge, Juddy Wachira, Fredrick Chite Asirwa, Naftali Busakhala, Violet Naanyu, Job Kisuya, Grieven Otieno, Alfred Keter, Ann Mwangi, Thomas Inui

Obstetrics and Gynaecology, East Africa

Purpose: Cervical cancer screening has been successful in reducing the rates of cervical cancer in developed countries, but this disease remains the leading cause of cancer deaths among women in sub-Saharan Africa. We sought to understand factors associated with limited uptake of screening services in our cervical cancer-screening program in Western Kenya.

Participants and Methods: Using items from a previously validated cancer awareness questionnaire repurposed for use in cervical cancer and culturally adapted for use in Kenya, we interviewed 2,505 women aged 18–55 years receiving care in gynecology clinics or seeking other services in 4 health facilities in Western Kenya …

Piloting A Screening Tool For Eating And Eating-Related Behavior, Michael N. Reynolds

Dissertations

Obesity is a common medical condition associated with negative health and social outcomes. Obesity has a primary malleable behavioral cause, eating more calories than are metabolized. While metabolic rate is malleable with exercise, eating can more quickly add calories than exercising can subtract them. In the past, behavioral weight-loss treatment studies relied on multi-component package interventions that have shown reliable patterns of participant weight-loss during treatment and weight-regain in follow-up. Those findings could be conceptualized as an ABA withdrawal design, eating behavior returns to baseline after the prosthetic contingencies of the treatment study are withdrawn. We must develop ways to …

A Phenotypically Silent Vanb2 Operon Carried On A Tn1549-Like Element In Clostridium Difficile, Daniel R. Knight, Grace O. Androga, Susan A. Ballard, Benjamin P. Howden, Thomas Riley

Research outputs 2014 to 2021

In the last decade, Clostridium difficile infection (CDI) has reached an epidemic state with increasing incidence and severity in both health care and community settings. Vancomycin is an important first-line therapy for CDI, and the emergence of resistance would have significant clinical consequences. In this study, we describe for the first time a vanB2 vancomycin resistance operon in C. difficile, isolated from an Australian veal calf at slaughter. The operon was carried on an ~ 42-kb element showing significant homology and synteny to Tn1549, a conjugative transposon linked with the emergence and global dissemination of vancomycin-resistant enterococci …