Medicine and Health Sciences Commons^™

Klf4 Deletion Alters Gastric Cell Lineage And Induces Muc2 Expression, Tianxin Yu, Xi Chen, T. Lin, J. Liu, M. Li, W. Zhang, X. Xu, W. Zhao, M. Liu, Dana L. Napier, Chi Wang, B. Mark Evers, Chunming Liu

Markey Cancer Center Faculty Publications

Gastric cancer is one of the most common types of cancer in the world, particularly in underdeveloped countries. The mechanism of gastric cancer is less understood compared with other types of gastrointestinal (GI) cancers. Krüppel-like factor 4 (KLF4) is a zinc-finger transcription factor and is a potential tumor suppressor in GI cancers. In this study, we have generated two mouse models, Rosa-Cre;Klf4^fl/fl and Lgr5-Cre;Klf4^fl/fl. KLF4 was deleted by Rosa-Cre in the gastric epithelia cells or by Lgr5-Cre in the antral stem cells in the adult mice. KLF4 deletion resulted in increased proliferating cells and decreased pit mucous …

Statistical Analysis And Modeling Health Data: A Longitudinal Study, Bhikhari Prasad Tharu

USF Tampa Graduate Theses and Dissertations

Lung cancer has been considered one of the leading causes of deaths while cancer re- mains the second most common cause of deaths in the USA. Understanding the behavior of a disease over time could yield important information to make decisions about the disease. Statistical models could provide crucial clues and help to make a decision about the dis- ease, budget allocation, evaluation, and implement prevention. Longitudinal trend analysis of the diseases helps to understand long term effects and nature. Cholesterol level is one of the most contributing risk factors for Coronary Heart Disease. Studying cholesterol statistically helps to know …

Intensity Of Left Atrial Spontaneous Echo Contrast As A Correlate For Stroke Risk Stratification In Patients With Nonvalvular Atrial Fibrillation., Yuanping Zhao, Lijing Ji, Jian Liu, Juefei Wu, Yan Wang, Shuxin Shen, Shengcun Guo, Rong Jian, Gangbin Chen, Xuan Wei, Wangjun Liao, Shelby Kutty, Yulin Liao, Jianping Bin

Journal Articles: Cardiology

The intensity of left atrial spontaneous echo contrast (LASEC) by transesophageal echocardiography (TEE) has been proposed as an important variable in the stratification of thromboembolic risk, particularly in patients with nonvalvular atrial fibrillation (NVAF). We hypothesized that the quantification of LASEC by ultrasound will improve its utility in predicting subsequent stroke events in patients with NVAF. Patients (n = 206) with definite NVAF receiving TEE were included for this prospective cohort study. Baseline clinical risk factors of stroke, CHADS2 score and CHA2DS2-Vasc, left atrial thrombus (LAT), the five-grades of LASEC and video intensity (VI) value of LASEC were measured. During …

Gambling-Related Problems Of Self-Excluders In Swiss Casinos, Suzanne Lischer

International Conference on Gambling & Risk Taking

No abstract provided.

Interventions For Problem Gamblers In The Correctional System, Nigel E. Turner Ph.D., Flora Matheson

International Conference on Gambling & Risk Taking

The prevalence rates of problem gambling in the adult correctional population are 5 to 10 times higher than those found in the general population. The purpose of this study is to examine the type of interventions used to deal with this population. We conducted a combination of literature review and key informant study to examine the state of programming for problem gambling for clients who experience incarceration. The published literature on this topic is remarkably sparse. In fact only two peer reviewed published studies were identified that formally evaluated a treatment program for problem gambling for clients in these settings. …

Gambling Problems In The General Danish Population: Survey Evidence, Morten Lau, Don Ross

International Conference on Gambling & Risk Taking

We develop surveys of gambling problems in the general Danish population. We compare several popular survey instruments of gambling behavior and gambling propensity to assess if they differ in their classification of individuals. We also examine correlations with standard survey instruments for alcohol use, anxiety, depression and impulsiveness. A feature of our design is that nobody was excluded on the basis of their response to a “trigger,” “gateway” or “diagnostic item” question about previous gambling history, allowing us to check for sample selection bias. Our sample consists of 8,405 adult Danes, which is 12.8% of the sample frame of 65,592 …

Exploring The Utility Of An Extended Theory Of Planned Behaviour Framework For School-Based Gambling Prevention Programs, Renee A. St-Pierre Ph.D., Caroline E. Temcheff Ph.D., Jeffrey L. Derevensky Ph.D., Rina Gupta Ph.D.

International Conference on Gambling & Risk Taking

The theory of planned behaviour (TPB) and the concept of negative anticipated emotions (NAE) have attracted research attention in the formulation of effective preventive interventions. This approach has identified several key constructs of the TPB (i.e., intentions, attitudes, subjective norms, perceptions of behavioural control) and NAE as valid predictors of gambling behaviours and problems among young people (Martin et al., 2010, 2011; St-Pierre et al., 2015). However, no empirical investigation has utilized all of these constructs in the design or evaluation of an adolescent problem gambling preventive intervention. The current research aimed to assess the efficacy of targeting NAE and …

Gamblerization Of Post-Communist Society In Central Europe, Zdeněk Szczyrba, David Fiedor, Irena Smolová

International Conference on Gambling & Risk Taking

Countries of Central European region (Czech Republic, Slovakia, Poland and Hungary) joined a new stage of their development after 1989. In these countries, there was a building process of capitalism which went in parallel with far-reaching structural economic and social changes; such as the privatization of economies, de-industrialization but also gamblerization of society. Clarifying this term, gamblerization, it could be described as the process of a continuous penetration of gaming facilities in the area accompanied by an increased availability and accessibility of gaming machines in the society. It is important to say that this process was particularly allowed owing to …

Facing Our Demons: Psychiatric Perspectives On Exorcism Rituals, Joel R. Sanford

The Hilltop Review

Belief in possession by malevolent spirits exists in many cultures and religions throughout the world, and such beliefs often serve as explanations for a variety of psychological and emotional afflictions. Traditional remedies in these cases often involve exorcism rituals, which are believed to expel spirits from a person's mind and/or body. Some of the cases commonly attributed to involuntary spirit possession are diagnosed within the psychiatric community as schizophrenia or some sort of dissociative disorder and treated with psychotherapy and/or medicine. For some in the psychiatric community, exorcisms and their use by patients are viewed as problematic due to their …

Meeting The Unique Treatment Needs Of Female Gamblers: A Workbook And Webinar Effectiveness Pilot Study, Roberta R. Boughton, Farah Jindani, Nigel Turner

International Conference on Gambling & Risk Taking

While past decades have seen a dramatic increase in the number of women who gamble and develop consequent problems, treatment services are being underutilized in Ontario, especially by women.

This pilot aimed to be responsive to this concern, circumventing barriers by inviting access to support through the use of two interventions. One was a mailed self-help workbook designed for women. The second utilized the workbook in a clinician facilitated group context using teleconferencing in conjunction with webinar technology. This small pragmatic pilot aimed to both get feedback on the helpfulness of the workbook and to explore the feasibility of using …

Generational Differences In Gambling Behavior And Attitudes, Don Feeney, Todd Maki

International Conference on Gambling & Risk Taking

The five generations that make up the adult population of North America and Europe differ greatly in their gambling behavior and their beliefs and attitudes towards gambling. This presentation will discuss data that demonstrate the extent of these differences as well as the cultural background and formative experiences that led to them. It will conclude with a discussion of implications for the gambling industry, responsible gambling, public policy, and for those concerned with the prevention and treatment of gambling problems.

Etiology And Stability Of Problem Gambling, Robert Williams, Rachel A. Volberg

International Conference on Gambling & Risk Taking

Prevention of problem gambling hinges on having research that clearly identifies the variables that are etiologically involved, their temporal sequence, and their causal connections. Longitudinal research is the best way of disentangling the chronology and causal relationships between variables. The present research describes the results of the two major longitudinal studies of gambling in Canada: the Quinte Longitudinal Study (QLS) (n = 4,121) and the Leisure, Lifestyle, Lifecycle Project (LLLP) (n = 1,808). The first part of the presentation describes the stability of gambling classifications over a 5 year period. This is followed by an identification of the univariate and …

A Critical Conversation On Responsible Gaming In Canada And Beyond, Lena Quilty

International Conference on Gambling & Risk Taking

No abstract provided.

Responsible Gambling Training In Ontario Canada, Janine Robinson

International Conference on Gambling & Risk Taking

No abstract provided.

Responsible Gambling Training: How Do We Know What’S Working?, Janine Robinson

International Conference on Gambling & Risk Taking

No abstract provided.

A Multidisciplinary Approach To Understanding Gambling And The Millennial Generation, Don Feeney

International Conference on Gambling & Risk Taking

While numerous studies have been done on the gambling habits of the Millennial Generation, we can learn much about their reaction to gambling through an interdisciplinary approach that incorporates insights from demography, cultural anthropology, history, sociology and other fields. In particular, an analysis of formative experiences and how they differ from previous generations tells us much about their gambling behavior and attitudes. In addition to a discussion of key findings, the presentation will focus on the implications of these findings for the gambling industry and for programs that raise awareness of, prevent, and treat gambling problems.

Parents’ Perception Of Youth Gambling And Other Risk Behaviors, Valentina Kranzelic, Neven Ricijas, Dora Dodig Hundric, Toni Maglica, Martina Feric

International Conference on Gambling & Risk Taking

Recently conducted national prevalence study of youth gambling in Croatia indicated high prevalence of adolescent gambling (especially sports betting), as well as perceived parental acceptance of such behavior (Ricijas et al, 2011). As international research suggest positive correlations between parental perception of gambling and other risk behaviors with the intensity of their childrens' participation in these behaviors (Meerkamper, Derevensky, Cutajar, 2008; Farrington, Loeber, Ttofi, 2011; Cambell et al, 2011), a new study on parental perception of gambling is currently being conducted, using two comparable perspectives - parents and their adolescent children.

Research is being conducted in two largest Croatian cities …

Early Initiation Into Gambling Among Boys And Girls With Conduct Problems: A Prospective Study, Renee A. St-Pierre Ph.D., Véronique Frenette, Caroline E. Temcheff Ph.D., Michèle Déry Ph.D., Jean-Pascal Lemelin Ph.D., Jean Toupin Ph.D., Pierrette Verlaan Ph.D.

International Conference on Gambling & Risk Taking

Context. Both early initiation into gambling (Rahman et al., 2012; Slutske et al., 2014) and conduct problems (Welte et al., 2009, 2011) have been identified as independent risk factors for later gambling problems. However, few longitudinal studies have examined the associations between these two risk factors, as well as their predictive relationship with gambling initiation among children and adolescents. Research Question. Are conduct problems a risk factor for early initiation into gambling, over and above other known risk factors?

Method. This study used data from an ongoing prospective, longitudinal study at the Université de Sherbrooke in order to examine gambling …

The Calgets Story: The Impact Of 5 Years Of State-Funded Treatment, Timothy W. Fong, Terri Sue Canale-Dalman, Michael Campos, Richard Rosenthal, Rory Reid, Brett Abarbanel

International Conference on Gambling & Risk Taking

This presentation will review the history, development and current state-funded treatment programs offered in California. Treatment outcome data from 5 years of operations will be reviewed highlighting the impact that treatment has had on gambling disorder and affected individuals. Clinical characteristics and predictors of treatment success and treatment failures from both residential treatment and outpatient treatment settings will be presented. This presentation will also describe the pitfalls, successes and lessons learned in creating a statewide treatment program that will help in inform and educate any policy maker, administrator, healthcare provider or legislator who is responsible for creating and delivering government-sponsored …

Psychiatric Comorbidities In Gambling And The Clubsnsw Chaplaincy Program (Australia), Melanie Hartmann, Alex Blaszczynski, Rowan Cameron

International Conference on Gambling & Risk Taking

A recent systematic review of population studies conducted over the last 12 years indicated that 57.5% of individuals meeting criteria for a gambling disorder have a comorbid substance use disorder, 60.1% a nicotine dependence, 57.5% a mood disorder, and 37.4%, any anxiety disorder. In a proportion of these, the comorbid condition predates the onset of gambling disorders suggesting these might represent a vulnerability factor. These findings suggest important implications for gambling prevention and treatments. Instead of promoting only gambling specific interventions and treatments, the emphasis needs to be on a more holistic approach that includes screening for and treating comorbid …

Iowa Gambling Treatment Outcomes: Factors Influencing Recovery, Eric Preuss, Ki Hyung Park Dr

International Conference on Gambling & Risk Taking

Recovery from gambling addiction, for those who received treatment, may be better understood in a follow up assessment. This study examines which of the factors (individual and environmental) may be associated with sustaining recovery after completion of treatment.

Using data collected for the Iowa Gambling Treatment Outcomes Report: 2014, there were 755 clients discharged from May 2012 to March 2015. Of these, 307 clients consented to be part of the 6 month post discharge follow-up study, and 141 participated in the follow-up assessment.

The demographic characteristics, discharge status (complete or incomplete treatment), and length of service for the 141 …

Barriers To Anticoagulation In Atrial Fibrillation Among Cardiologists, Internists And Family Physicians, Jad Al Danaf, Md, Mph, Mitul Kanzaria, Md, John U. Doherty, Md

House Staff Quality Improvement and Patient Safety Conference (2016-2019)

Current Performance:

The rates of AC in patients 18 years or older who visited general internists & family physicians not seen by cardiologists from 4/30/2013 to 4/30/2015, cardiologists from 11/29/2012 to 11/29/2014 and all 3 specialties from 1/30/2014 to 1/30/2016 were derived from the EHR.

A 12-question survey was shared using RedCap with these physicians to examine potential reasons for not prescribing AC.

Exploring Body Mass Index Changes In Left Ventricular Assist Device Patients, Raquel E. Thomas, Corrine Hanson, Glenda Woscyna, Brian D. Lowes

The VAD Journal

Background: Current treatment options for end-stage heart failure, such as transplantation, can be limited by obesity guidelines. Mechanical devices such as Left Ventricular Assistive Devices (LVAD) can bridge heart failure patients to transplantation, however, after implantation; some patients may experience weight gain that precludes them from transplantation. Therefore, the objective of this study was to evaluate weight changes after the implantation of an LVAD.

Methods: A retrospective review of 130 patients receiving an LVAD were divided into two groups based on BMI at the time of implantation: obese (>30 kg/m²) and non-obese (/m²). Patients were …

Spatial Heterogeneity Analysis In Evaluation Of Cell Viability And Apoptosis For Colorectal Cancer Cells, Aydin Saribudak, Herman Kucharavy, Karen Hubbard, Muharrem Umit Uyar

Publications and Research

In evaluation of cell viability and apoptosis, spatial heterogeneity is quantified for cancerous cells cultured in 3-D in vitro cell-based assays under the impact of anti-cancer agents. In 48-h experiments using human colorectal cancer cell lines of HCT-116, SW-620, and SW-480, incubated cells are divided into control and drug administered groups, to be grown in matrigel and FOLFOX solution, respectively. Our 3-D cell tracking and data acquisition system guiding an inverted microscope with a digital camera is utilized to capture bright field and fluorescent images of colorectal cancer cells at multiple time points. Identifying the locations of live and dead …

Safety Of Lobar Hepatic Arterial Embolization In Metastatic Uveal Melanoma Patients With Underlying Gilbert's Disease, David C. Feldstein, Md, Robert D. Adamo, Md, Carin F. Gonsalves, Md, Fsir, David J. Eschelman, Ms, Fsir, Medical Oncology, Thomas Jefferson University Hospital, Philadelphia, Pa, Takami Sato, Md, Phd

Department of Medical Oncology Posters

Introduction

❖ Uveal melanoma is the most common primary intraocular malignant tumor in adults.

❖ Up to half of all patients develop systemic metastases, with liver involvement in >90% of patients.¹

❖ Various liver-directed, locoregional therapies (i.e. chemoembolization, immunoembolization, radioembolization, and ablation) have played a significant role in prolonging the lives of patients with metastatic uveal melanoma.²

❖ Elevated bilirubin levels are typically considered a relative contraindication for lobar hepatic arterial embolization treatment, given mainly the increased risk of precipitating hepatic failure.

❖ Gilbert's syndrome, also known as benign unconjugated hyperbilirubinemia, is a hereditary disorder of bilirubin conjugation. …

Health Care Seeking Behaviours In Pregnancy In Rural Sindh, Pakistan: A Qualitative Study, Rahat Najam Qureshi, Sana Sheikh, Asif Raza Khowaja, Zahra Hoodbhoy, Shujaat Zaidi, Diane Sawchuck, Marianne Vidler, Zulfiqar A. Bhutta, Peter Von Dadeslzen

Department of Paediatrics and Child Health

Background: Pakistan has alarmingly high numbers of maternal mortality along with suboptimal care-seeking behaviour. It is essential to identify the barriers and facilitators that women and families encounter, when deciding to seek maternal care services. This study aimed to understand health-seeking patterns of pregnant women in rural Sindh, Pakistan.
Methods: A qualitative study was undertaken in rural Sindh, Pakistan as part of a large multi-country study in 2012. Thirty three focus group discussions and 26 in-depth interviews were conducted with mothers [n=173], male decision-makers [n=64], Lady Health Workers [n=64], Lady Health Supervisors [n=10], Women Medical Officers [n=9] and Traditional Birth …

3d Dynamic Motion Planning For Robot-Assisted Cannula Flexible Needle Insertion Into Soft Tissue, Yanjiang Zhao, Wenqiang Wu, Yongde Zhang, Ruixue Wang, Jingchun Peng, Yan Yu

Department of Radiation Oncology Faculty Papers

In robot-assisted needle-based medical procedures, insertion motion planning is a crucial aspect. 3D dynamic motion planning for a cannula flexible needle is challenging with regard to the nonholonomic motion of the needle tip, the presence of anatomic obstacles or sensitive organs in the needle path, as well as uncertainties due to the dynamic environment caused by the movements and deformations of the organs. The kinematics of the cannula flexible needle is calculated in this paper. Based on a rapid and robust static motion planning algorithm, referred to as greedy heuristic and reachability-guided rapidly-exploring random trees, a 3D dynamic motion planner …

Investigating The Origin And Functions Of A Novel Small Rna In Escherichia Coli, Fenil Rashmin Kacharia

Dissertations and Theses

Non-coding small RNAs (sRNAs) regulate various cellular processes in bacteria. They bind to a chaperone protein Hfq for stability and regulate gene expression by base-pairing with target mRNAs. Although the importance of sRNAs in bacteria has been well established, the mode of origination of novel sRNA genes is still elusive, mainly because the rapid rate of evolution of sRNAs obscures their original sources. To overcome this impediment, we identified a recently formed sRNA (EcsR2) in E. coli, and show that it evolved from a degraded bacteriophage gene. Our analyses also revealed that young sRNAs such as EcsR2 are expressed …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Georgia Southern Examines HAIs and the Changing Role of the Healthcare Environment
• Georgia Southern examines the legal Landscape of HAI Public reporting

Breast-Cancer-Specific Mortality In Patients Treated Based On The 21-Gene Assay: A Seer Population-Based Study, Valentina I. Petkov, Dave P. Miller, Nadia Howlader, Nathan Gliner, Will Howe, Nicola Schussler, Kathleen Cronin, Frederick L. Baehner, Rosemary Cress, Dennis Deapen, Sally L. Glaser, Brenda Y. Hernandez, Charles F. Lynch, Lloyd Mueller, Ann G. Schwartz, Stephen M. Schwartz, Antoinette Stroup, Carol Sweeney, Thomas C. Tucker, Kevin C. Ward, Charles Wiggins, Xiao-Cheng Wu, Lynne Penberthy, Steven Shak

Markey Cancer Center Faculty Publications

The 21-gene Recurrence Score assay is validated to predict recurrence risk and chemotherapy benefit in hormone-receptor-positive (HR+) invasive breast cancer. To determine prospective breast-cancer-specific mortality (BCSM) outcomes by baseline Recurrence Score results and clinical covariates, the National Cancer Institute collaborated with Genomic Health and 14 population-based registries in the the Surveillance, Epidemiology, and End Results (SEER) Program to electronically supplement cancer surveillance data with Recurrence Score results. The prespecified primary analysis cohort was 40–84 years of age, and had node-negative, HR+, HER2-negative, nonmetastatic disease diagnosed between January 2004 and December 2011 in the entire SEER population, and Recurrence Score results …