Medicine and Health Sciences Commons^™

Potential Roles Of Amiloride-Sensitive Sodium Channels In Cancer Development, Siguang Xu, Cui Liu, Yana Ma, Hong-Long Ji, Xiumin Li

Cellular and Molecular Biology Faculty Publications and Presentations

The ENaC/degenerin ion channel superfamily includes the amiloride-sensitive epithelial sodium channel (ENaC) and acid sensitive ionic channel (ASIC). ENaC is a multimeric ion channel formed by heteromultimeric membrane glycoproteins, which participate in a multitude of biological processes by mediating the transport of sodium (Na+) across epithelial tissues such as the kidney, lungs, bladder, and gut. Aberrant ENaC functions contribute to several human disease states including pseudohypoaldosteronism, Liddle syndrome, cystic fibrosis, and salt-sensitive hypertension. Increasing evidence suggests that ion channels not only regulate ion homeostasis and electric signaling in excitable cells but also play important roles in cancer cell behaviors such …

(13)C Mrs And Lc-Ms Flux Analysis Of Tumor Intermediary Metabolism., Alexander A. Shestov, Seung-Cheol Lee, Kavindra Nath, Lili Guo, David S. Nelson, Jeffrey C. Roman, Dennis B. Leeper, Mariusz A. Wasik, Ian A. Blair, Jerry D. Glickson

Department of Radiation Oncology Faculty Papers

We present the first validated metabolic network model for analysis of flux through key pathways of tumor intermediary metabolism, including glycolysis, the oxidative and non-oxidative arms of the pentose pyrophosphate shunt, the TCA cycle as well as its anaplerotic pathways, pyruvate-malate shuttling, glutaminolysis, and fatty acid biosynthesis and oxidation. The model that is called Bonded Cumomer Analysis for application to (13)C magnetic resonance spectroscopy ((13)C MRS) data and Fragmented Cumomer Analysis for mass spectrometric data is a refined and efficient form of isotopomer analysis that can readily be expanded to incorporate glycogen, phospholipid, and other pathways thereby encompassing all the …

Medicare Reimbursement For Total Joint Arthroplasty: The Driving Forces., Eric M. Padegimas, Kushagra Verma, Benjamin Zmistowski, Richard H. Rothman, James J. Purtill, Michael Howley

Department of Orthopaedic Surgery Faculty Papers

BACKGROUND: Total joint arthroplasty is a large and growing part of the U.S. Medicare budget, drawing attention to how much providers are paid for their services. The purpose of this study was to examine the variables that affect total joint arthroplasty reimbursement. Along with standard economic variables, we include unique health-care variables. Given the focus on value in the Affordable Care Act, the model examines the relationship of the quality of care to total joint arthroplasty reimbursement. We hoped to find that reimbursement patterns reward quality and reflect standard economic principles.

METHODS: Multivariable regression was performed to identify variables that …

Ozone Treatment Of Recurrent Aphthous Stomatitis: A Double Blinded Study, Mahmoud K. Al-Omiri, Mohannad Alhijawi, Bader K. Alzarea, Raed S. Abul Hassan, Edward Lynch

Dental Medicine Faculty Research

This study aimed to evaluate the use of ozone to treat recurrent aphthous stomatitis (RAS). Consecutive sixty-nine participants with RAS were recruited into this non-randomized double blind, controlled cohort observational study (test group). A control group of 69 RAS patients who matched test group with age and gender was recruited. RAS lesions in test group were exposed to ozone in air for 60 seconds while controls received only air. Ulcer size and pain were recorded for each participant at baseline and daily for 15 days. Ulcer duration was determined by recording the time taken for ulcers to disappear. The main …

Outcomes And National Trends For The Surgical Treatment Of Lumbar Spine Trauma., Doniel Drazin, Miriam Nuno, Faris Shweikeh, Alex R. Vaccaro, Eli Baron, Terrence T. Kim, J. Patrick Johnson

Department of Orthopaedic Surgery Faculty Papers

Introduction. Operative treatment of lumbar spine compression fractures includes fusion and/or cement augmentation. Our aim was to evaluate postoperative differences in patients treated surgically with fusion, vertebroplasty, or kyphoplasty. Methods. The Nationwide Inpatient Sample Database search for adult vertebral compression fracture patients treated 2004-2011 identified 102,316 surgical patients: 30.6% underwent spinal fusion, 17.1% underwent kyphoplasty, and 49.9% underwent vertebroplasty. Univariate analysis of patient and hospital characteristics, by treatment, was performed. Multivariable analysis was used to determine factors associated with mortality, nonroutine discharge, complications, and patient safety. Results. Average patient age: fusion (46.2), kyphoplasty (78.5), vertebroplasty (76.7) (p < .0001). Gender, race, household income, hospital-specific characteristics, and insurance differences were found (p ≤ .001). Leading comorbidities were hypertension, osteoporosis, and diabetes. Risks for higher mortality (OR 2.0: CI: 1.6-2.5), nonroutine discharge (OR 1.6, CI: 1.6-1.7), complications (OR 1.1, CI: 1.0-1.1), and safety related events (OR 1.1, CI: 1.0-1.1) rose consistently with increasing age, particularly among fusion patients. Preexisting comorbidities and longer in-hospital length of stay were associated with increased odds of nonroutine discharge, complications, and patient safety. Conclusions. Fusion patients had higher rates of poorer outcomes compared to vertebroplasty and kyphoplasty cohorts. Mortality, nonroutine discharge, complications, and adverse events increased consistently with older age.

Inhibiting The Interaction Between Grp94 And Myocilin To Treat Primary Open-Angle Glaucoma, Andrew Stothert

USF Tampa Graduate Theses and Dissertations

Glaucoma is a neurodegenerative protein misfolding disorder classified by increases in IOP, damage to retinal ganglion cells (RGCs), optic nerve (ON) head damage, and progressive irreversible blindness. Primary open-angle glaucoma (POAG) is the most common form of glaucoma, constituting over 90% of clinical cases. POAG is observed in patients where normal outflow channels, mainly the trabecular meshwork (TM), are exposed at the angle formed by the iris and cornea. However, due to TM cellular dysfunction, aqueous outflow resistance is increased preventing normal circulation of aqueous humor. Recent studies have shown that in 2-4% of POAG cases, increased intracellular levels of …

Impeding Access To Quality Patient Care And Patient Rights: How Myriad Genetics' Gene Patents Are Unknowingly Killing Cancer Patients And How To Calm The Ripple Effect, Marisa Noelle Pins

Journal of Intellectual Property Law

No abstract provided.

2016 June 14 - Medical Student Education Committee Minutes, Medical Student Education Committee, East Tennessee State University

Medical Student Education Committee Minutes

No abstract provided.

Total Versus Partial Splenectomy In Pediatric Hereditary Spherocytosis: A Systematic Review And Meta-Analysis, Leonardo Guizzetti

Epidemiology and Biostatistics Publications

To compare the clinical effectiveness of total (TS) or partial (PS) splenectomy in pediatric hereditary spherocytosis, a systematic review and meta-analysis was performed (PROSPERO registration CRD42015030056). There were 14 observational studies comparing pre- and post- operative hematologic parameters. Secondary outcomes include in-hospital infections, surgical complications, symptomatic recurrence and biliary disease. TS is more effective than PS to increase hemoglobin (3.6 g/dL vs 2.2 g/dL) and reduce reticulocytes (12.5% vs 6.5%) after one year; outcomes following PS are stable for at least 6 years. There were no cases of overwhelming post-splenectomy sepsis. A population-based patient registry is needed for long-term follow-up.

Histological And Molecular Analysis Of A Progressive Diffuse Intrinsic Pontine Glioma And Synchronous Metastatic Lesions: A Case Report., Javad Nazarian, Gary E Mason, Cheng Ying Ho, Eshini Panditharatna, Madhuri Kambhampati, Louis Gilbert Vezina, Roger J. Packer, Eugene I Hwang

Genomics and Precision Medicine Faculty Publications

There is no curative treatment for patients with diffuse intrinsic pontine glioma (DIPG). However, with the recent availability of biopsy and autopsy tissue, new data regarding the biologic behavior of this tumor have emerged, allowing greater molecular characterization and leading to investigations which may result in improved therapeutic options. Treatment strategies must address both primary disease sites as well as any metastatic deposits, which may be variably sensitive to a particular approach.In this case report, we present a patient with DIPG treated with irradiation and serial investigational agents. The clinical, pathological and molecular phenotypes of both the progressive primary tumor …

Identification Of Ecdysone Hormone Receptor Agonists As A Therapeutic Approach For Treating Filarial Infections, Amruta S Mhashilkar, Sai L Vankayala, Canhui Liu, Fiona Kearns, Priyanka Mehrotra, George Tzertzinis, Subba R Palli, H. Lee Woodcock Iii, Thomas R Unnasch

Chemistry Faculty Publications

BACKGROUND: A homologue of the ecdysone receptor has previously been identified in human filarial parasites. As the ecdysone receptor is not found in vertebrates, it and the regulatory pathways it controls represent attractive potential chemotherapeutic targets.

METHODOLOGY/ PRINCIPAL FINDINGS: Administration of 20-hydroxyecdysone to gerbils infected with B. malayi infective larvae disrupted their development to adult stage parasites. A stable mammalian cell line was created incorporating the B. malayi ecdysone receptor ligand-binding domain, its heterodimer partner and a secreted luciferase reporter in HEK293 cells. This was employed to screen a series of ecdysone agonist, identifying seven agonists active at sub-micromolar concentrations. …

Somatic And Vicarious Pain Are Represented By Dissociable Multivariate Brain Patterns, Anjali Krishnan, Choong-Wan Woo, Luke J. Chang, Luka Ruzic, Xiaosi Gu, Marina Lopez-Sola, Philip L. Jackson, Jesus Pujol, Jin Fan, Tor D. Wager

Publications and Research

Understanding how humans represent others’ pain is critical for understanding pro-social behavior. ‘Shared experience’ theories propose common brain representations for somatic and vicarious pain, but other evidence suggests that specialized circuits are required to experience others’ suffering. Combining functional neuroimaging with multivariate pattern analyses, we identified dissociable patterns that predicted somatic (high versus low: 100%) and vicarious (high versus low: 100%) pain intensity in out-of-sample individuals. Critically, each pattern was at chance in predicting the other experience, demonstrating separate modifiability of both patterns. Somatotopy (upper versus lower limb: 93% accuracy for both conditions) was also distinct, located in somatosensory versus …

High Activity Mutants Of Butyrylcholinesterase For Cocaine Hydrolysis, Chang-Guo Zhan, Fang Zheng, Wenchao Yang, Liu Xue, Shurong Hou

Pharmaceutical Sciences Faculty Patents

Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE polypeptide variant having an enhanced catalytic efficiency for (−)-cocaine. A method of the presently-disclosed subject matter for treating a cocaine-induced condition includes administering to an individual an effective amount of a BChE polypeptide variant, as disclosed herein, to lower blood cocaine concentration.

Traumatic Brain Injury Increases Levels Of Mir-21 In Extracellular Vesicles: Implications For Neuroinflammation, Emily B. Harrison, Colleen G. Hochfelder, Benjamin G. Lamberty, Brittney M. Meays, Brenda M. Morsey, Matthew L. Kelso, Howard S. Fox, Sowmya V. Yelamanchili

Journal Articles: Pharmacology & Experimental Neuroscience

No abstract provided.

Ice (Interactive Curricula Experience) Platform & App Adoption, Use & Evaluation Across Thomas Jefferson University, Julie Phillips, Phd, Martha Langley Ankeny, Med.

Thomas Jefferson University Faculty Days

iCE or the Interactive Curricula Experience Platform and App is a content delivery system designed specifically for the iPad but available to any learner with a web-enabled device.

Poster presented at 2016 8th Annual Faculty Days at Thomas Jefferson University.

Using A Smartphone App To Teach Students Practical Epidemiological Skills, Russell K. Mcintire, Mph, Phd, Kathleen Day, Ms, Sean Dyer, Bs

Thomas Jefferson University Faculty Days

Background:

Despite the evidence that shows the pedagogical benefits of experiential education, epidemiology instructors rarely utlize experiential activities to teach epidemiological concepts and skills.

Poster presented at 8th annual 2016 Thomas Jefferson University Faculty Days.

The Sustainable Development Goals: Implications And Integration Across The Curricula, Lucille B. Pilling, Mph, Edd, Rn, Kathleen C. Ashton, Phd, Rn, Acns-Bc

Thomas Jefferson University Faculty Days

Poster presented at 8th annual Faculty Days at Thomas Jefferson University.

Grants Information Service, Helena Washington, Mls, Paul Hunter, Dmd, Mlis

Thomas Jefferson University Faculty Days

Poster presented at 8th annual Faculty Days at Thomas Jefferson University.

Authors, Monitor Your Publications And Their Impact With Scopus And Orcid, Gary E. Kaplan, Mslis, Ahip, Patricia Wynne, Bsn, Rn, Mslis

Thomas Jefferson University Faculty Days

Poster presented at 8th annual Faculty Days at Thomas Jefferson University.

Pruning Or Tuning? Maturational Profiles Of Face Specialization During Typical Development, Xun Zhu, Ramesh S. Bhatt, Jane E. Joseph

Psychology Faculty Publications

Introduction: Face processing undergoes significant developmental change with age. Two kinds of developmental changes in face specialization were examined in this study: specialized maturation, or the continued tuning of a region to faces but little change in the tuning to other categories; and competitive interactions, or the continued tuning to faces accompanied by decreased tuning to nonfaces (i.e., pruning). Methods: Using fMRI, in regions where adults showed a face preference, a face- and object-specialization index were computed for younger children (5-8 years), older children (9-12 years) and adults (18-45 years). The specialization index was scaled to each subject's maximum activation …

Identification Of Ecdysone Hormone Receptor Agonists As A Therapeutic Approach For Treating Filarial Infections, Amruta S. Mhashilkar, Sai L. Vankayala, Canhui Liu, Fiona Kearns, Priyanka Mehrotra, George Tzertzinis, Subba R. Palli, H. Lee Woodcock, Thomas R. Unnasch

Entomology Faculty Publications

Background A homologue of the ecdysone receptor has previously been identified in human filarial parasites. As the ecdysone receptor is not found in vertebrates, it and the regulatory pathways it controls represent attractive potential chemotherapeutic targets.

Methodology/ Principal Findings Administration of 20-hydroxyecdysone to gerbils infected with B. malayi infective larvae disrupted their development to adult stage parasites. A stable mammalian cell line was created incorporating the B. malayi ecdysone receptor ligand-binding domain, its heterodimer partner and a secreted luciferase reporter in HEK293 cells. This was employed to screen a series of ecdysone agonist, identifying seven agonists active at …

Occupational Therapy On College Campuses: Facilitating Student Success Through Occupation, Kristy Coen, Carlin Daley, Kieran Lewis, Susan Madigan, Karen Mccarthy, Clodagh Nolan, Áine O'Dea, Linda Reen, Liath Sheehan, Orla Sullivan

Occupational Therapy | Faculty Conference Presentations

Purpose: To explore how occupational therapy services fit into a supported education model on college campuses.

Rationale: College students present with many strengths and challenges in college settings. There are limited services for young adults to succeed in college and students with various diagnoses face challenges in the areas of time management, organization, academic skills, and in social areas of college (Orentlicher, & Olson, 2010; Rogers, Kash-MacDonald, Bruker, & Maru, 2010). Higher education is a role emerging area for occupational therapists, and there are some pioneering occupational therapists who have discovered multiple ways to provide services to students who are …

Endoscopic Endonasal Approach For Transclival Resection Of A Petroclival Meningioma: A Technical Note., Walter C. Jean Md, Daniel R Felbaum, Amjad Anaizi, Timothy R Deklotz

Department of Surgery

The endoscopic endonasal transclival approach has been widely described for its use to resect clivus chordomas, but there have only been isolated reports of its use for petroclival meningiomas. These tumors are most often resected utilizing open transpetrosal approaches, but these operations, difficult even in the hands of dedicated skull base surgeons, are particularly challenging if the meningiomas are medially-situated and positioned mainly behind the clivus. For this subset of petroclival meningiomas, a transclival approach may be preferable. We report a meningioma resected via an endoscopic endonasal transclival technique. The patient was a 63-year-old man who presented originally for medical …

Cardiovascular Disease Risk Scores And Novel Risk Factors In Relation To Race And Gender, Johanna Wilson

USF Tampa Graduate Theses and Dissertations

The use of cardiovascular risk scores remains the foundation for risk stratification to guide clinical management. Clinicians have access to several cardiovascular risk scores in practice settings. While having several risk scores with different risk factors may provide more information, it does not imply accuracy of the cardiovascular risk score used to calculate individual patient cardiovascular risk. The objective of this study was to compare the Framingham Risk score, Reynolds Risk scores, and the Pooled Cohort Risk Equation (3 commonly used equations) scores with respect to ability to predict cardiovascular events in a diverse ethnic population. Additionally, the potential predictive …

Delinking Investment In Antibiotic Research And Development From Sales Revenues: The Challenges Of Transforming A Promising Idea Into Reality, Kevin Outterson, Unni Gopinathan, Charles Clift, Anthony So, Chantal Morel, John-Arne Røttingen

Faculty Scholarship

1. The current business model for antibiotics is plagued by market failures and perverse incentives that both work against conservation efforts and provide insufficient rewards to drive the development of much-needed new treatments for resistant infection.

2. Many new incentive mechanisms have been proposed to realign incentives and support innovation and conservation over the long term. The most promising of these are based on the idea of delinking rewards from sales volume of the antibiotic — the notion of “delinkage.”

3. Some critical design issues for delinkage remain, such as how to secure access to badly needed new products when …

Progressive Bidirectional Age-Related Changes In Default Mode Network Effective Connectivity Across Six Decades, Karl Li, Angela R. Laird, Larry R. Price, D. Reese Mckay, John Blangero, David C. Glahn, Peter T. Fox

School of Medicine Publications

The default mode network (DMN) is a set of regions that is tonically engaged during the resting state and exhibits task-related deactivation that is readily reproducible across a wide range of paradigms and modalities. The DMN has been implicated in numerous disorders of cognition and, in particular, in disorders exhibiting age-related cognitive decline. Despite these observations, investigations of the DMN in normal aging are scant. Here, we used blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) acquired during rest to investigate age-related changes in functional connectivity of the DMN in 120 healthy normal volunteers comprising six, 20-subject, decade …

Download Entire Issue- Collaborative Healthcare: Interprofessional Practice, Education, And Evaluation (Jcipe), Spring 2016, Volume 7, Issue 1

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

Download entire issue- Collaborative HealthCare: Interprofessional Practice, Education, and Evaluation (JCIPE), Spring 2016, Volume 7, Issue 1

Interprofessional Practice Increasingly Influences Jefferson Students' University Selection

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

• Data supplied by the Office of Institutional Research and drawn from its New Student Survey question “Please identify why you selected Thomas Jefferson University over other institutions.”

• Students given 29 options and asked to select the top three (3) reasons that influenced their decision.

• Five items are generally cited as major reasons that students select Jefferson, including academic reputation, quality of faculty, campus location, affiliation with Thomas Jefferson University Hospital and clinical opportunities available.

• Despite the above consistent (and expected/desired) reasons and the change in question format to require students to select only their top three …

Jcipe And The Jefferson Digital Commons, Daniel G. Kipnis, Msi

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

In June 2014, the Middle States Commission on Higher Education Review Board re-accredited Thomas Jefferson University and in their report they made sure to highlight the exemplar work being done by the Jefferson Center for InterProfessional Education (JCIPE). JCIPE, founded in 2007, was commended by the accreditation committee for its work during the committee’s most recent visit to Philadelphia in June 2014.

To help foster the mission of JCIPE, the Jefferson Digital Commons has partnered to archive the JCIPE eNewsletter. Archiving the newsletter has allowed JCIPE to continue promoting their mission to an international community and has allowed the international …

A Community College Interprofessional Nurse Managed Center Practice Model, Donna Meyer, Msn, Rn, Anef

Collaborative Healthcare: Interprofessional Practice, Education and Evaluation (JCIPE)

Lewis and Clark Community College (L&C) has initiated an innovative interprofessional collaborative practice (IPCP) model at its Family Health Clinic (FHC), a nurse managed center, located at the main campus in Godfrey, Illinois. The FHC previously operated successfully for seven years, and has exceeded the projected impact with the numbers of individuals served in the community. The project is innovative and distinctive in providing an IPCP model in that it is inter-institutional, with several of the participating practitioners from institutions other than L&C. The core leadership of the model remains with the nursing professionals at the FHC. It is important …