Medicine and Health Sciences Commons^™

Antimalarial Exoerythrocytic Stage Drug Discovery And Resistance Studies, Lynn Dong Blake

USF Tampa Graduate Theses and Dissertations

Malaria is a devastating global health issue that affects approximately 200 million people yearly and over half a million deaths are caused by this parasitic protozoan disease. Most commercially available drugs only target the blood stage form of the parasite, but the only way to ensure proper elimination is to treat the exoerythrocytic stages of the parasite development cycle. There is a demand for the discovery of new liver stage antimalarial compounds as there are only two current FDA approved drugs for the treatment of liver stage parasites, one of which fails to eliminate dormant forms and the other inducing …

The Integration Of Quantitative Genetics, Paleontology, And Neontology Reveals Genetic Underpinnings Of Primate Dental Evolution, Leslea J. Hlusko, Christopher A. Schmitt, Tesla A. Monson, Marianne F. Brasil, Michael Mahaney

School of Medicine Publications

Significance

Experimental research on mice has yielded tremendous biological insight. However, the ∼140 million y of evolution that separate mice from humans pose a hurdle to direct application of this knowledge to humans. We report here that considerable progress for identifying genetically patterned skeletal phenotypes beyond the mouse model is possible through transdisciplinary approaches that include the anatomical sciences. Indeed, anatomy and paleontology offer unique opportunities through which to develop and test hypotheses about the underlying genetic mechanisms of the skeleton for taxa that are not well suited to experimental manipulation, such as ourselves.

Abstract

Developmental genetics research on mice …

Utilitarianism Generalized To Include Animals, Yew-Kwang Ng

Animal Sentience

In response to the seventeen commentaries to date on my target article on reducing animal suffering, I propose that the term “welfarism” (when used pejoratively by animal advocates) should be qualified as “anthropocentric welfarism” so as to leave “welfarism” simpliciter to be used in its generic sense of efforts to improve conditions for those who need it. Welfarism in this benign sense — even in its specific utilitarian form (maximizing the sum total of net welfare) with long-term future effects and effects on others (including animals) appropriately taken into account — should be unobjectionable (even if not considered sufficient by …

Dance Movement Therapy And Holism: Moving Beyond Body/Mind/Spirit, Laura Miller

Creative Arts Therapies Theses

The purpose of this research was to explore the phenomenon of holism and its meaning to the field of dance/movement therapy (DMT.) This research focused specifically on the meaning of holism for dance/movement therapy because holistic is a word that is used to describe a variety of interventions in a variety of fields and contexts, and it can be interpreted in many different ways. In this phenomenological qualitative study, data was collected through interviews with dance/movement therapists, who identified themselves as taking a holistic approach to their work. From the data, themes were identified, which revealed how dance/movement therapists perceive …

Medical School Watercooler Newsletter - July 10, 2016, Lindsey Lyle

Watercooler Newsletter

This is the July 10, 2016 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• USA Welcomes Dr. Steve Cordina
• USAMC First in State For Excellence in Stroke Care
• July Med School Café – Cancer Update 2016: The Significance of Familial Cancer Syndromes
• National Authority on Hospital Overcrowding, Patient Flow Speaks at USA
• Pediatrics Hosting Grand Rounds July 15

Food Habits, Lifestyle Factors, And Risk Of Prostate Cancer In Central Argentina: A Case Control Study Involving Self-Motivated Health Behavior Modifications After Diagnosis, Winston J. Craig, Sandaly O. S. Pacheco, Fabio J. Pacheco, Gimena M. J. Zapata, Julieta M. E. Garcia, Carlos A. Previale, Hector E. Cura

Faculty Publications

Cancer is the second most important non-communicable disease worldwide and disproportionately impacts low- to middle-income countries. Diet in combination with other lifestyle habits seems to modify the risk for some cancers but little is known about South Americans. Food habits of Argentinean men pre- and post-diagnosis of prostate cancer (n = 326) were assessed along with other lifestyle factors. We studied whether any of the behaviors and risk factors for prostate cancer were found in men with other cancers (n = 394), compared with control subjects (n = 629). Before diagnosis, both cases reported a greater mean consumption of meats …

Ptsd In The 20th Century American Military: Its Diagnosis, Effects, Treatment, And Management, With A Focus On The Vietnam War, Christy L. Connell

Bound Away: The Liberty Journal of History

Soldiers have been affected by PTSD for as long as war has existed. The American Military in the twentieth century is no exception. PTSD did not become a diagnosable disease until 1980, and before then it was misdiagnosed as different anxiety disorders and neuroses. Symptoms, treatment options, and long-term affects of PTSD are also discussed. Though other other wars in which America was involved are mentioned, those that receive a more thorough analysis are World War II, the Korean War, and the Vietnam War. Although PTSD is an increasing problem in modern times for those involved in military conflicts, there …

Comparative Look At The Depression Treatment Modalities Of Cognitive, Teresa M. Page

Doctoral Dissertations and Scholarly Projects

This integrative review provides a comparative view of cognitive behavioral therapy (CBT) and pharmacotherapy (PCT) as treatment modalities for adult depression. The foci of this integrative review are to examine research articles on CBT and PCT to determine which therapy, monotherapy or combination therapy, provide a higher level of therapy for depression. The metrics utilized are depression symptom remission, response to therapy, recovery from depression, and quality of life. Individual preference and response to treatment vary. This makes the reader more aware that specific populations may be more receptive to one therapy instead of the other.

Could There Be Light At The End Of The Tunnel? Mesocaval Shunting For Refractory Esophageal Varices In Patients With Contraindications To Transjugular Intrahepatic Portosystemic Shunt., Jessica Davis, Albert K Chun, Marie L Borum

Surgery Faculty Publications

Cirrhotic patients with recurrent variceal bleeds who have failed prior medical and endoscopic therapies and are not transjugular intrahepatic portosystemic shunt candidates face a grim prognosis with limited options. We propose that mesocaval shunting be offered to this group of patients as it has the potential to decrease portal pressures and thus decrease the risk of recurrent variceal bleeding. Mesocaval shunts are stent grafts placed by interventional radiologists between the mesenteric system, most often the superior mesenteric vein, and the inferior vena cava. This allows flow to bypass the congested hepatic system, reducing portal pressures. This technique avoids the general …

Written And Online Residency Guidebook To Improve Resident Efficiency And Knowledge Of Best Patient Care Practices, Michael Ortiz, Mary C. Ottolini, Dewesh Agrawal

E-Learning Modules

**Contains time-sensitive information that will likely be inaccurate, obsolete, or irrelevant by December 01, 2018**

Residents at most institutions change rotations every 2 to 4 weeks. It often takes significant time for residents to become acclimated to the different protocols, expectations, and environments of each unique rotation. As a result, residents often spend time searching for answers, time that could be spent in outside learning and direct patient care. The goal of this resource is to provide a novel guidebook that improves residents’ efficiency and knowledge of best patient care practices. The guidebook begins with an introductory chapter with …

The Α-Arrestin Arrdc3 Regulates The Endosomal Residence Time And Intracellular Signaling Of The Β2-Adrenergic Receptor., Xufan Tian, Roshanak Irannejad, Shanna L. Bowman, Yang Du, Manojkumar A. Puthenveedu, Mark Von Zastrow, Jeffrey L. Benovic

Department of Biochemistry and Molecular Biology Faculty Papers

Arrestin domain-containing protein 3 (ARRDC3) is a member of the mammalian α-arrestin family, which is predicted to share similar tertiary structure with visual-/β-arrestins and also contains C-terminal PPXY motifs that mediate interaction with E3 ubiquitin ligases. Recently, ARRDC3 has been proposed to play a role in regulating the trafficking of G protein-coupled receptors, although mechanistic insight into this process is lacking. Here, we focused on characterizing the role of ARRDC3 in regulating the trafficking of the β2-adrenergic receptor (β2AR). We find that ARRDC3 primarily localizes to EEA1-positive early endosomes and directly interacts with the β2AR in a ligand-independent manner. Although …

Exposure Of Human Lung Cells To Tobacco Smoke Condensate Inhibits The Nucleotide Excision Repair Pathway, Nathaniel C. Holcomb, Mamta Goswami, Sung Gu Han, Samuel Clark, David K. Orren, C. Gary Gairola, Isabel Mellon

Toxicology and Cancer Biology Faculty Publications

Exposure to tobacco smoke is the number one risk factor for lung cancer. Although the DNA damaging properties of tobacco smoke have been well documented, relatively few studies have examined its effect on DNA repair pathways. This is especially true for the nucleotide excision repair (NER) pathway which recognizes and removes many structurally diverse DNA lesions, including those introduced by chemical carcinogens present in tobacco smoke. The aim of the present study was to investigate the effect of tobacco smoke on NER in human lung cells. We studied the effect of cigarette smoke condensate (CSC), a surrogate for tobacco smoke, …

Intrinsic Disorder In Transmembrane Proteins: Roles In Signaling And Topology Prediction, Jérôme Bürgi, Bin Xue, Vladimir N Uversky, F Gisou Van Der Goot

Molecular Biosciences Faculty Publications

Intrinsically disordered regions (IDRs) are peculiar stretches of amino acids that lack stable conformations in solution. Intrinsic Disorder containing Proteins (IDP) are defined by the presence of at least one large IDR and have been linked to multiple cellular processes including cell signaling, DNA binding and cancer. Here we used computational analyses and publicly available databases to deepen insight into the prevalence and function of IDRs specifically in transmembrane proteins, which are somewhat neglected in most studies. We found that 50% of transmembrane proteins have at least one IDR of 30 amino acids or more. Interestingly, these domains preferentially localize …

Relations Between Past-Week Physical Activity And Recent Nonsuicidal Self-Injury In Treatment-Seeking Psychiatric Adults, Stephanie Jarvi Steele, Bridget A. Hearon, Kristen L. Batejan, Stephanie Gironde, Thröstur Björgvinsson

Psychology: Faculty Publications

Objective: This research study examines the relationship between past-week physical activity and recent (i.e., within the past 30 days) nonsuicidal self-injury (NSSI) in a sample of treatment-seeking adults.

Method: Participants included 353 (49.29% female; mean age = 35.16 years) adults attending a partial hospitalization program for acute psychiatric issues. Data were extracted from the program's admission battery of computer-based self-report measures completed by each participant on the first treatment day.

Results: Participants with a recent history of NSSI (i.e., within the past 30 days) engaged in significantly less past-week physical activity than those without a history of NSSI. Group differences …

Estimation Of Long-Term Area-Average Pm2.5 Concentrations For Area-Level Health Analyses, Sun-Young Kim, Casey Olives, Neal Fann, Joel Kaufman, Sverre Vedal, Lianne Sheppard

UW Biostatistics Working Paper Series

Introduction: There is increasing evidence of an association between individual long-term PM_2.5 exposure and human health. Mortality and morbidity data collected at the area-level are valuable resources for investigating corresponding population-level health effects. However, PM_2.5 monitoring data are available for limited periods of time and locations, and are not adequate for estimating area-level concentrations. We developed a general approach to estimate county-average concentrations representative of population exposures for 1980-2010 in the continental U.S.

Methods: We predicted annual average PM_2.5 concentrations at about 70,000 census tract centroids, using a point prediction model previously developed for estimating annual average …

The Mitochondrial Unfoldase-Peptidase Complex Clpxp Controls Bioenergetics Stress And Metastasis., Jae Ho Seo, Dayana B. Rivadeneira, M. Cecilia Caino, Young Chan Chae, David W. Speicher, Hsin-Yao Tang, Valentina Vaira, Silvano Bosari, Alessandro Palleschi, Paolo Rampini, Andrew V. Kossenkov, Lucia R. Languino, Dario C. Altieri

Department of Cancer Biology Faculty Papers

Mitochondria must buffer the risk of proteotoxic stress to preserve bioenergetics, but the role of these mechanisms in disease is poorly understood. Using a proteomics screen, we now show that the mitochondrial unfoldase-peptidase complex ClpXP associates with the oncoprotein survivin and the respiratory chain Complex II subunit succinate dehydrogenase B (SDHB) in mitochondria of tumor cells. Knockdown of ClpXP subunits ClpP or ClpX induces the accumulation of misfolded SDHB, impairing oxidative phosphorylation and ATP production while activating "stress" signals of 5' adenosine monophosphate-activated protein kinase (AMPK) phosphorylation and autophagy. Deregulated mitochondrial respiration induced by ClpXP targeting causes oxidative stress, which …

The Immunomodulatory Role Of Adjuvants In Vaccines Formulated With The Recombinant Antigens Ov-103 And Ov-Ral-2 Against Onchocerca Volvulus In Mice., Jessica A. Hess Ligas, Bin Zhan, April R. Torigian, John B. Patton, Nikolai Petrovsky, Tingting Zhan, Maria Elena Bottazzi, Peter J. Hotez, Thomas R. Klei, Sara Lustigman, David Abraham

Department of Microbiology and Immunology Faculty Papers

BACKGROUND: In some regions in Africa, elimination of onchocerciasis may be possible with mass drug administration, although there is concern based on several factors that onchocerciasis cannot be eliminated solely through this approach. A vaccine against Onchocerca volvulus would provide a critical tool for the ultimate elimination of this infection. Previous studies have demonstrated that immunization of mice with Ov-103 and Ov-RAL-2, when formulated with alum, induced protective immunity. It was hypothesized that the levels of protective immunity induced with the two recombinant antigens formulated with alum would be improved by formulation with other adjuvants known to enhance different types …

Design Of Nanoparticle-Based Carriers For Targeted Drug Delivery, Xiaojiao Yu, Ian Trase, Muqing Ren, Kayla Duval, Xing Guo, Zi Chen

Dartmouth Scholarship

Nanoparticles have shown promise as both drug delivery vehicles and direct antitumor systems, but they must be properly designed in order to maximize efficacy. Computational modeling is often used both to design new nanoparticles and to better understand existing ones. Modeled processes include the release of drugs at the tumor site and the physical interaction between the nanoparticle and cancer cells. In this paper, we provide an overview of three different targeted drug delivery methods (passive targeting, active targeting, and physical targeting) and compare methods of action, advantages, limitations, and the current stages of research. For the most commonly used …

Teacher Child Interaction Therapy: An Ecological Approach To Intervening With Young Children Who Display Disruptive Behaviors, Sara Marie Hinojosa

USF Tampa Graduate Theses and Dissertations

A model of Teacher Child Interaction Therapy (TCIT) was implemented in two kindergarten classrooms of students (n = 2) who successfully completed Parent Child Interaction Therapy, but continued to demonstrate disruptive behaviors in the classroom. The current study first indicated that TCIT was implemented with integrity by both the therapists and teacher participants. Next, the effects of this intervention on the teacher’s skills, students’ disruptive behaviors, teacher’s stress, and teacher-child relationships were investigated. The treatment acceptability was also examined. Both visual and statistical analyses found a treatment effect in both cases was seen for both teachers’ increased use of positive …

The Relationship Of Attributions And Parental Characteristics With Parental Problem Recognition, Lindsey Heath Steding

USF Tampa Graduate Theses and Dissertations

A significant number of youth experience mental health disorders for which they suffer negative consequences. Although there are evidence-based therapies available to help children and their families, most youth do not receive treatment. Parental problem recognition is likely a primary barrier in this process. This study begins to address why parents may have difficulty recognizing mental health problems by extending existing models and integrating evidence about parental perceptions. Specifically, the study aimed to investigate the relationship between parental attributions and parents’ problem determination, and to examine the influence that parental characteristics have on this judgment process. Participants included 164 parents …

Oral Cryptococcosis In A Patient With Chronic Lymphocytic Leukemia, Sachin Patel, Maria Navas, Courtney Batt, Robin L.P. Jump

Faculty Scholarship

No abstract provided.

Opening And Closing Jaw Movements Of Young Children Who Stutter., Victoria Tumanova, Anthony P. Buhr, Patricia Zevrowski, Jerald Moon, Richard Arenas, Torrey Loucks

Communication Sciences and Disorders - All Scholarship

Objective: In this longitudinal study, we investigated the hypothesis that kinematic measures of jaw movement produced by children who stuttered (CWS) and children who did not stutter (CWNS) would differ between opening and closing speech gestures, across phonetic contexts, and across development.

Methods: Mean amplitude, velocity, and duration of jaw opening and closing gestures during repeated productions of bilabial syllables were analyzed longitudinally at 1-year intervals for 13 CWS and 7 children CWNS. The utterances ranged across four phonetic contexts: single-syllable, two-syllable, three-syllable, and six-syllable. For jaw movement transduction, a strain gauge was attached to a football helmet in a …

P66shc, A Key Regulator Of Metabolism And Mitochondrial Ros Production, Is Dysregulated By Mouse Embryo Culture., Nicole A Edwards, Andrew J Watson, Dean H Betts

Obstetrics & Gynaecology Publications

STUDY QUESTION: Do high oxygen tension and high glucose concentrations dysregulate p66Shc (Src homologous-collagen homologue adaptor protein) expression during mouse preimplantation embryo culture?

SUMMARY ANSWER: Compared with mouse blastocysts in vivo, P66Shc mRNA and protein levels in blastocysts maintained in vitro increased under high oxygen tension (21%), but not high glucose concentration.

WHAT IS KNOWN ALREADY: Growth in culture adversely impacts preimplantation embryo development and alters the expression levels of the oxidative stress adaptor protein p66Shc, but it is not known if p66Shc expression is linked to metabolic changes observed in cultured embryos.

STUDY DESIGN, SAMPLES/MATERIALS, METHODS: We used a …

Effects Of Neonicotinoid Pesticide Exposure On Human Health: A Systematic Review., Andria M Cimino, Abee L Boyles, Kristina A Thayer, Melissa J. Perry

Environmental and Occupational Health Faculty Publications

BACKGROUND: Numerous studies have identified detectable levels of neonicotinoids (neonics) in the environment, adverse effects of neonics in many species including mammals, and pathways through which human exposure to neonics could occur, yet little is known about the human health effects of neonic exposure.

OBJECTIVE: This systematic review sought to identify human population studies on the health effects of neonics.

METHODS: Studies published in English between 2005 and 2015 were searched using PubMed, Scopus, and Web of Science databases. No restrictions were placed on the type of health outcome assessed. Risk of bias was assessed using guidance developed by the …

Neddylation Promotes Stress Granule Assembly, Aravinth Kumar Jayabalan, Anthony Sanchez, Ra Young Park, Sang Pil Yoon, Gum-Yong Kang, Je-Hyun Baek, Paul Anderson, Younghoon Kee, Takbum Ohn

Molecular Biosciences Faculty Publications

Stress granules (SGs) harbour translationally stalled messenger ibonucleoproteins and play important roles in regulating gene expression and cell fate. Here we show that neddylation promotes SG assembly in response to arsenite-induced oxidative stress. Inhibition or depletion of key components of the neddylation machinery concomitantly inhibits stress-induced polysome disassembly and SG assembly. Affinity purification and subsequent mass-spectrometric analysis of Nedd8-conjugated proteins from translationally stalled ribosomal fractions identified ribosomal proteins, translation factors and RNA-binding proteins (RBPs), including SRSF3, a previously known SG regulator. We show that SRSF3 is selectively neddylated at Lys85 in response to arsenite. A non-neddylatable SRSF3 (K85R) mutant do …

College Of Public Health News, Georgia Southern University

College of Public Health: News & Publications

• Georgia Southern Examines Wearable Devices to Improve Physical Activity and Sleep
• Georgia Southern Engages Rural Georgians
• Georgia Southern Examines using the exercise is Medicine on Campus Platform

Dasatinib-Loaded Albumin Nanoparticles Possess Diminished Endothelial Cell Barrier Disruption And Retain Potent Anti-Leukemia Cell Activity, Chunling Dong, Bo Li, Zhenyu Li, Sreerama Shetty, Jian Fu

Internal Medicine Faculty Publications

Dasatinib (DAS), a second-generation tyrosine kinase inhibitor, is highly effective in treating chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. However, its clinical use is limited due to serious adverse effects. DAS can disrupt endothelial barrier integrity and increase endothelial permeability which may cause peripheral edema and pleural effusion. Albumin nanoparticles (NPs) as a drug carrier may serve as a useful tool for cell-selective drug delivery to reduce DAS-induced endothelial hyperpermeability and maintain endothelial barrier integrity. In this study, we reported that DAS-loaded NPs exhibited potent anti-leukemia efficacy as DAS alone. Importantly, albumin NPs as a drug carrier markedly …

Epidemiology News, Georgia Southern University

Biostatistics, Epidemiology & Environmental Health Sciences: News & Publications (2011-2018)

• Georgia Southern Engages Rural Georgians
• Georgia Southern Examines Using the Exercise is Medicine® on Campus platform

Weight, Temperature, And Transcutaneous Bilirubin Of The Term Neonate At Discharge: A Comparative Study Between A Traditional Nursery And Rooming-In Model Of Care, Jennifer L. Pass

Master of Science in Nursing Final Projects

Purpose: The purpose of this study was to examine day of discharge term neonate outcomes of percent weight change, body temperature, and transcutaneous bilirubin from a traditional nursery and a rooming-in model of care.

Design: A retrospective, descriptive, comparative design was used, comparing two groups for differences between outcomes.

Methods: A total of 102 electronic neonate records from one hospital in north Georgia were examined and divided based on when the model of neonate care changed from the traditional nursery care setting to full rooming-in, which was early November 2010: Group 1 (traditional care) consisted of 51 …

Accelerating Design And Transforming Baccalaureate Nursing Education To Foster A Culture Of Health, Mary Bouchaud, Beth Ann Swan, Angela Gerolamo, Kathleen Black, Karen Alexander, Jennifer Bellot, Kathryn Shaffer, Catherine Levonian, Denise Brown, Susan Egger, Rachel Scherzer, Dori Taylor Sullivan

College of Nursing Faculty Papers & Presentations

Healthcare reform and changing population health demographics call for a radical transformation in healthcare delivery and the education of healthcare providers. Nurses comprise the largest proportion of healthcare providers making it necessary to ensure that they are prepared to address the challenges that arise from the evolving healthcare delivery system. A key message of the Institute of Medicine’s The Future of Nursing: Leading Change, Advancing Health, is that nurses must lead healthcare change. To accomplish this, nurses must recognize their role in educating the new nursing workforce about creating a culture of health. Specifically, nurse educators must act as …