Medicine and Health Sciences Commons^™

Recording Somatosensory Evoked Potential Of The Posterior Tibial Nerve With A Subdural Strip During Surgery For Spinal Dysraphism And Tethered Cord Syndrome, Han-Lin Wu, Muh-Lii Liang, Hsin-Hung Chen, Chen-Liang Chou, Tsui-Fen Yang

Rehabilitation Practice and Science

Objective: To investigate the feasibility of a subdural strip, placed just proximal to the surgical field, to record somatosensory evoked potentials (SSEPs) of the posterior tibial nerve (PTN) during detethering surgery for spinal dysraphism and/or tethered cord syndrome (TCS). Method: Twenty three patients (thirteen boys and ten girls; age, 4 months to 15 years) were enrolled in this study. Eleven patients had lipomyelomeningoceles, seven had TCS, two had split cord malformations, one with terminal myelocystocele, one with VACTERL syndrome, and one had a spinal tumor at the T11 to L4 level. Aside from the routine preparation needed for functional mapping …

Cervical Disc Herniation With Myelopathy Following Cervical Tuina Manipulation, Valeria Jia-Yi Chiu, Shu-Yuan Chou, Yu-Ting Hsieh, Yi-Shiung Horng

Rehabilitation Practice and Science

Complications following cervical manipulation can be classified as cerebrovascular or noncerebrovascular complications. The former complications occur more frequently, and they are usually due to vertebral artery occlusion, damage or thrombus formation. The latter include spinal cord or nerve root injuries and have seldom been reported. Herniation of the cervical disc with myelopathy following manipulation is rare. However, we have encountered two patients who developed cervical disc herniation with myelopathy secondary to cervical tuina manipulation for nuchalgia at the bone setting facilities. One of the patients suffered from shooting pain during manipulation and developed tetraparesis two days later. An MRI examination …

The Use Of Ultrasonography To Assess Outcomes And Prognostic Indicators In Carpal Tunnel Syndrome: A Study In Patients Treated With Night Splinting, Lin-Yi Wang, Mei-Yun Liaw, Yu-Chi Huang, Hsiao-Lan Chen, Yiu-Chung Lau, Ya-Ping Pong

Rehabilitation Practice and Science

Background: Controversy exists regarding the use of ultrasonography (US) to assess outcome variables and prognostic indicators of carpal tunnel syndrome (CTS). Objective: To investigate the value of US in evaluating outcomes and prognosis for CTS treated with night splinting. Methods: Fifty-eight hands with mild to moderate CTS were prospectively enrolled; 42 diseased hands completed the study. Satisfaction rating, symptom severity score (SSS), functional status score (FSS), nerve conduction study (NCS) data, and US data were evaluated as outcome variables before and after 3 and 6 months of night splinting. On an intent-to-treat basis, a binary logistic regression analysis was used …

The Performance And Occupational Therapy Intervention Effect Of Visual-Motor Integration In Adults With Prader-Willi Syndrome: A Pilot Study, Wanling Hsu, Weihsiu Chang, Meichun Lin, Kueiyu Chou, Jangting Wei, Valeria Chiu

Rehabilitation Practice and Science

Objective. This study was attempted to investigate the performance and the effect of occupational therapy intervention via visual-motor integration (VMI), visual perception and motor coordination in adults with Prader-Willi Syndrome (PWS). Methods. seven adults with PWS were included in the study. VMI, visual perception and motor coordination were assessed using the Beery Visual-Motor Integration test and VMI Supplemental tests in the beginning of the study, shortly after receiving the treatment and one month after the intervention. Treatment was scheduled for 2 hour per week for 2 months. Results. Every adult with PWS received a low age equivalent score in VMI, …

The Effect Of Wearing Compression Tights On Cardiopulmonary Function And Running Economy In Sedentary Overweight Or Obese Females, Shuming Yeh, Huangyuan Chang, Kuosheng Yang, Guanyu Lin, Souncheng Wang, Yunju Chen

Rehabilitation Practice and Science

Purpose: Previous studies conducted on pressure garments have suggested that compression garments may have positive effects on cardiopulmonary function while performing exercises by improving peripheral venous return and reducing muscle oscillation that may cause energy loss. However, most studies have not been able to prove this hypothesis and concluded that compression has no positive effect on cardiopulmonary function while performing exercises. This study was aimed at determining whether compression garments with a pressure gradient can reduce energy loss caused by muscle oscillation and subsequently promote running economy and cardiopulmonary function in sedentary overweight females. Methods: This study was conducted with …

A Casereport Of Concomitant Injection Of Botulinum Toxin Type A In Detrusor And External Sphincter For Treatment Of Neurogenic Bladder Dysfunction, Sheng-Wei Zeng, Yu-Hui Huang

Rehabilitation Practice and Science

Patients with spinal cord injury above the sacral level usually have spastic type neurogenic bladder dysfunction (NBD). Spastic NBD is usually manifested with detrusor overactivity and detrusor-external sphincter dyssynergia (DESD). Botulinum toxin type A (BoNT-A) injection has been used in treating spastic NBD for long time. This injection can be performed either on the detrusor (which needs an intermittent catheterization program and a greater decrease in intravesicle pressure) or on the external sphincter (which may cause urinary incontinence and a smaller decrease in intravesicle pressure). Here we present a SCI patient receiving a new injection method involving BoNT-A injection simultaneously …

A Case Study Of Abdominal Pedicle Skin Flap Repairing And Early Intervention To The Patient Who Suffered From Severe Hot Crush Injury In Hand, Po-Yao Wang, Jan-Wei Chiu, Man-Fang Hsu, Ruo-Lan Liu

Rehabilitation Practice and Science

Machine crush injury is the most common occupational injury in Taiwan. Machines operated at high pressures and temperatures can cause severe injury to the hands. To improve functional recovery of the hands, pedicled groin flap transfer is recommended. This reconstructive option is useful and versatile for covering hand wounds. The transfer yields predictable results with a procedure that is substantially less difficult and takes less time compared with free-tissue transfer; the disadvantage is that the extremity must be immobilized. Pedicled groin flap transfer can cause some complications, such as joint stiffness and edema, which can be prevented through early intervention …

Acute Effects Of Kinesio Taping On Low Back Pain And Back Muscle Endurance In Patients With Lumbar Disc Herniation, Hsinhan Cheng, Yunshan Yen, Shengchun Kung, Peichi Hsiao, Willy Chou, Yiming Lo

Rehabilitation Practice and Science

Kinesio taping has been widely used in patients with low back pain. However, the acute effects of kinesio taping on patients with lumbar disc herniation have yet to be investigated. The aim of this study was to examine the immediate effects of applying kinesio taping to the low back area on low back pain and back muscle endurance. In total, 27 patients with lumbar disc herniation (9 women and 18 men, aged 24-63 years) were enrolled in this study through magnetic resonance imaging examination. This study used a single-group, pretest-posttest design. A Kinesio Tex tape was applied to facilitate paraspinal …

Exploration Of Parental And Therapists' Perceptions For The Family-Centeredness Of Pediatric Rehabilitation Services, Linju Kang, Chialing Chen, Liju Chen, Huiju Chen, Aiwen Hwang

Rehabilitation Practice and Science

Background and purposes: Family-centered service (FCS) has been considered as relevant in pediatric rehabilitation to children with developmental disabilities. Given that there are many challenges in practice and a lack of evidence regarding its implementation in Taiwan, the study aimed to investigate that to what extent FCS was being practiced from parents' perceptions. Methods: This study includes a total of 100 parents/caregivers whose child had a primary condition associated with developmental disabilities and aged from 2 to 12 years (Mean age=4.6 years, SD=1.8 years). Children received rehabilitation services in clinic settings. The Measure of Processes of Care-20 (MPOC-20) was used …

A Retrospective Comparative Study Of Ultrasound And Mri In The Diagnosis Of Supraspinatus Tendon Tears At A Medical Center In Taiwan, Shihhao Feng, Yuhsuan Cheng, Tyngguey Wang

Rehabilitation Practice and Science

Objective: To evaluate the diagnostic accuracy of ultrasound (US) in comparison with magnetic resonance imaging (MRI), which is the gold standard for detecting full- and partial-thickness supraspinatus (SS) tendon tears at our general practice. Methods: From January 2015 to January 2016, 107 patients suffering from shoulder pain underwent both US and MRI of the shoulder at a medical center to identify their shoulder pathology, and were included in this work. The US was performed by a physiatrist at a US laboratory, and the US findings for the SS tendon were classified as normal, tendinosis (calcific/ non-calcific), a partial-thickness tear, or …

Mesh-Glove Electrical Stimulation On Upper Extremity Function In Children With Spastic Hemiplegic Cerebral Palsy: A Pilot Study, Chienwei Peng, Chialing Chen, Kuanglin Lin, Kehchung Lin, Chingyi Wu, Wenyu Liu, Hsiehching Chen

Rehabilitation Practice and Science

Introduction: Neuromuscular electrical stimulation is one of the non-invasive treatments for improving spasticity of upper extremity (UE) and motor function in children with cerebral palsy (CP). However, some children felt uncomfortable in receiving the neuromuscular electrical stimulation. The mesh-glove electrical stimulation (MGES) is one kind of somatosensory electrical stimulation. Recently, there were few researches indicating that MGES causes positive effectiveness for the spasticity control of UE in children with CP. This study aims to investigate the treatment effects of MGES on UE function and daily function in children with CP. Methods: This controlled trial is based on a pre- and …

Cardiopulmonary Exercise Testing In Two Patients With Late-Onset Pompe Disease Receiving Enzyme Replacement Therapy: A Casereport And Mini-Reviewarticle, Chenya Yang, Chihchin Chiu, Chenliang, Chou

Rehabilitation Practice and Science

In this casereport, we present a pair of siblings, a 16-year-old boy and a 19-year-old woman, who were both diagnosed as having late-onset Pompe disease. Each underwent cardiopulmonary exercise testing (CPET) in 2013 and 2015, respectively. The major finding in these two cases was that enzyme replacement therapy (ERT) over a 24-month period improved or stabilized pulmonary function despite late-onset Pompe disease. CPET revealed improved aerobic capacity in the brother, who was physically active, but deterioration in the sister, who lived a sedentary lifestyle. The findings of our cases are compatible with the current consensus that ERT can stabilize or …

Editorial Current Treatments For Skin Cancer, Edward Yu, Patricia Tai

Edward Yu

Variants In Wfs1 And Other Mendelian Deafness Genes Are Associated With Cisplatin-Associated Ototoxicity, Heather E. Wheeler, Eric R. Gamazon, Robert Frisina, Carlos Perez-Cervantes, Omar El Charif, Brandon Mapes, Sophie D. Fossa, Darren Feldman, Robert Hamilton, David J. Vaughn, Clair Beard, Chunkit Fung, Chiristian Kollmannsberger, Jeri Kim, Taisei Mushiroda, Michiaki Kubo, Shirin Ardeshir-Rouhani-Fard, Lawrence H. Einhorn, Nancy Cox, M. Eileen Dolan, Lois Travis

Bioinformatics Faculty Publications

Cisplatin is one of the most commonly used chemotherapy drugs worldwide and one of the most ototoxic. We sought to identify genetic variants that modulate cisplatin-associated ototoxicity (CAO). Experimental Design: We performed a genome-wide association study (GWAS) of CAO using quantitative audiometry (4-12 kHz) in 511 testicular cancer survivors of European genetic ancestry. We performed polygenic modeling and functional analyses using a variety of publicly available databases. We used an electronic health record cohort to replicate our top mechanistic finding. Results: One SNP, rs62283056, in the first intron of Mendelian deafness gene WFS1 (wolframin ER transmembrane glycoprotein) and an expression …

A Brief Report: Lessons Learned And Preliminary Findings Of Progreso En Salud, An Hiv Risk Reduction Intervention For Latina Seasonal Farmworkers, Mariano Kanamori, Mario De La Rosa, Stephanie Diez, Jessica Weissman, Mary Jo Trepka, Alicia Sneij, Peter Schmidt, Patria Rojas

All Faculty

Throughout the past decade, HIV rates in Florida?particularly South Florida, where many Latina seasonal farmworkers reside and work?have ranked among the highest in the nation. In this brief report, we delineate important lessons learned and preliminary findings from the implementation of the HIV prevention intervention Progreso en Salud (Progress in Health). Among the 114 Latina seasonal farmworker participants, there were significant increases from baseline to 6-month follow-up in the percentages of overall condom use, HIV testing, HIV/AIDS-related communications with friends, HIV knowledge, condom use self-efficacy, and correct use of condoms. Lessons learned from this study can be used to inform …

The Determinants Of Health: Neighborhood Characteristics, Obesity And The Mental Health Of African-American Adolescent Girls, Roseanne L. Flores

Publications and Research

The present study examined the relationship among neighborhood characteristics, obesity, and the mental health outcomes of a nationally representative sample of African-American adolescent girls between the ages of 12 - 17. Using data from the 2011/2012 National Survey of Children’s Health, four questions were extracted to measure neighborhood amenities, neighborhood detractors, body mass index, and experience of depression. Ordinal regressions were calculated to estimate the relationships between all variables. The results indicated that over 25% of African- American girls, ages 12 - 14 were overweight and obese with fewer 15 - 17-year-old girls falling within these categories. African-American girls had …

Interprofessional Collaboration With Aphasic Patients: A Survey Based Study On Implementation And Benefits, Emily Foster, Alexa Wagner

Graduate Independent Studies - Communication Sciences and Disorders

Interprofessional practice (IPP), collaboration of professionals from different backgrounds working together to provide services, is of growing importance in speech-language pathology and across other disciplines in the vast health field (WHO, 2010). The American Speech and Hearing Association (ASHA) stresses the importance of communicating roles and responsibilities of health professionals to provide the best quality care for patients (Dixon & Oandasan, 2015). In order to understand the roles and responsibilities across disciplines, health care professionals and students need to be provided with the necessary education. Currently, an initiative for interprofessional competency is being constructed to provide more involved education for …

Stroke Outreach In The Lao Community, Noor A. Dythavon

Master's Projects and Capstones

CNL Abstract

A community health needs assessment for the service area prompted concern regarding access to quality healthcare for non-English speaking Southeast Asians (SEA) in the area. Goals of an initial investigation and subsequent implementation of sustainable stroke health fairs for non-English speaking communities were evaluated to assess primary healthcare concerns that the SEA community face and to suggest long-term solutions to these issues. Initial investigation required researching population-specific minority health statistics to quantify the prevalence of chronic diseases and conditions which were prioritized in terms of needs versus disparities. Research came from evidence base practice guidelines and personal concern …

Influence Of Maternal Breast Milk Ingestion On Acquisition Of The Intestinal Microbiome In Preterm Infants., Katherine E Gregory, Buck S Samuel, Pearl Houghteling, Guru Shan, Frederick M Ausubel, Ruslan I Sadreyev, W Allan Walker

Faculty Publications

BACKGROUND: The initial acquisition and early development of the intestinal microbiome during infancy are important to human health across the lifespan. Mode of birth, antibiotic administration, environment of care, and nutrition have all been shown to play a role in the assembly of the intestinal microbiome during early life. For preterm infants, who are disproportionately at risk of inflammatory intestinal disease (i.e., necrotizing enterocolitis), a unique set of clinical factors influence the establishment of the microbiome. The purpose of this study was to establish the influence of nutritional exposures on the intestinal microbiome in a cohort of preterm infants early …

Perbandingan Efek Larvasida Minyak Atsiri Daun Cengkeh (Syzygium Aromaticum L.) Varietas Zanzibar Dengan Temephos Terhadap Larva Nyamuk Aedes Aegypti, Ridzmullah Wishnu Pamungkas, Neneng Syarifah Syafei, Arto Yuwono Soeroto

Pharmaceutical Sciences and Research

The use of temephos as larvicides in disease prevention Dengue Hemorrhagic Fever (DHF) in Indonesia has been going on for 40 years. Larviciding very long led the resistance to temephos. Cloves, one of native Indonesia plant contains eugenol that are toxic to the insect’s body. This study aims to examine the effectiveness of Zanzibar clove leaf essential oil compared to temephos in killing the larvae of Aedes aegypti. This study uses experimental laboratory research design. The samples are larvae of Aedes aegypti stage III. The mosquito larvae were classified into six groups, each given a clove leaf essential oil with …

Efektivitas Snedds Ekstrak Kulit Manggis Terhadap Bakteri P. Mirabilis Dan S. Epidermidis Yang Terdapat Pada Ulkus Diabetik, Rafika Sari, Liza Pratiwi, Pratiwi Apridamayanti

Pharmaceutical Sciences and Research

Mangosteen rind possesses the ability to conduct antibacterial activity. Under the development relating to drug delivery system, SNEDDS were known to boost the penetration of active compound. The aim of this research is to compare the effectiveness of the antibacterial activity at both SNEDDS preparation and the ethanol extract of mangosteen rind as the antibacteria against the bacteria that cause diabetic ulcers with the most prevalence whether it was Gram positive or Gram negative bacteria like Proteus mirabilis and Staphylococcus epidermidis. The research started by maceration process with the crude extract as the result continued with the phytochemical screening which …

Pengaruh Cara Pengeringan Simplisia Daun Senggani (Melastoma Malabathricum L.) Terhadap Aktivitas Antioksidan Menggunakan Metode Dpph (2,2-Difenil-1-Pikrilhidrazil), Sri Luliana, Nera Umilia Purwanti, Kris Natalia Manihuruk

Pharmaceutical Sciences and Research

Drying is the most important step to keep the compound stability in simplicia. The objective of this research is to know the effect of drying methods on antioxidant activity in Melastoma malabathricum L. The drying methods tested were oven-drying at 40°C, direct sunlight, indirect sunlight, air-drying at ± 25°C and fresh samples as control. Result revealed that the drying methods of simplicia were significant differences for antioxidant activity in Melastoma malabathricum L. (p < 0,05). Drying method that has the highest antioxidant activity was by air-drying at ± 25°C is 54.60 %.

Assessment Of Achieved Systolic Blood Pressure In Newly Treated Hypertensive Patients Aged 60-79 Years Before And After Eighth Joint National Committee Recommendations, Michael S. Kelly, Joseph J. Saseen, Joel C. Marrs

Pharmacy Faculty Articles and Research

Objective:

To determine whether patients who were newly prescribed antihypertensive therapy after the Eighth Joint National Committee (JNC 8) update were treated to a relaxed systolic blood pressure (SBP) goal compared with patients treated before the update.

Methods:

A retrospective cohort study approved by the Colorado Multiple Institutional Review Board. Patients aged 60–79 years, without diabetes or chronic kidney disease (CKD), newly treated for hypertension at a University of Colorado primary care clinics were included. The mean first-achieved and last-stable SBPs of patients newly prescribed antihypertensive medications from 1 January 2012 to 31 December 31 2013 (before cohort) were compared …

Uji Aktivitas Anti-Inflamasi Minyak Atsiri Daun Kemangi (Ocimum Americanum L.) Pada Tikus Putih Jantan Yang Diinduksi Karagenan, Fadlina Chany Saputri, Rita Zahara

Pharmaceutical Sciences and Research

Kemangi (Ocimum americanum L.) is an aromatic plant that contains citral and known as anti-inflammatory agents. The aim of this study was to determine the anti-inflammatory activity of the essential oil kemangi leaves on carrageenan-induced rat. The male rats were divided into six groups, each consisting of four rats. Group I as negative control was given 0.5% CMC solution, group II as positive control was given diclofenac sodium, group III was given sitral, groups IV, V and VI were given 40 mg/200 g BW, 80 mg/200 g BW, and 160 mg/200 g BW essential oil of Ocimum americanum L., emulsified …

Wise-Family Medicine: A Statewide Faculty Development Collaborative, Deborah Simpson, Kjersti Knox, Anne Getzin, John R. Brill, Melissa M. Stiles, Jeffrey A. Morzinski

Deborah Simpson, PhD

Background: In many states, family medicine residencies and medical schools compete clinically for patients, educationally for trainees and, more recently, for community preceptors (CPs). As Wisconsin’s medical schools and health care systems have expanded their geographic footprints, our CPs now teach trainees from competing institutions. Yet residency and medical student accrediting bodies require faculty and preceptor development.

Purpose: To evaluate the impact of a statewide collaborative of family medicine educators on meeting faculty development needs of our CPs and collaborative members.

Methods: Faculty development leaders representing the three largest family medicine residency training sponsors in the state created the Wisconsin …

Marcks Phosphorylation Is Modulated By A Peptide Mimetic Of Marcks Effector Domain Leading To Increased Radiation Sensitivity In Lung Cancer Cell Lines, Timothy Rohrbach, Robert B. Jones, Patricia H. Hicks, Alice N. Weaver, Tiffany S. Cooper, Nicholas J. Eustace, Eddy S. Yang, John S. Jarboe, Joshua C. Anderson, Christopher D. Willey

Richard Bland Faculty Works

Lung cancer is the leading cause of cancer-associated mortality in the United States. Kinase hyperactivation is a known mechanism of tumorigenesis. The phosphorylation status of the plasma membrane-associated protein myristoylated alanine rich C-kinase substrate (MARCKS) effector domain (ED) was previously established as being important in the sensitivity of lung cancer to radiation. Specifically, when MARCKS ED was in a non-phosphorylated state, lung cancer cells were more susceptible to ionizing radiation and experienced prolonged double-strand DNA breaks. Additional studies demonstrated that the phosphorylation status of MARCKS ED is important for gene expression and in vivo tumor growth. The present study used …

Partner Influence In Diet And Exercise Behaviors: Testing Behavior Modeling, Social Control, And Normative Body Size, Brea Perry, Gabriele Ciciurkaite, Christy Freadreacea Brady, Justin Garcia

Sociology Faculty Publications

Previous research has documented social contagion in obesity and related health behaviors, but less is known about the social processes underlying these patterns. Focusing on married or cohabitating couples, we simultaneously explore three potential social mechanisms influencing obesity: normative body size, social control, and behavior modeling. We analyze the association between partner characteristics and the obesity-related health behaviors of focal respondents, comparing the effects of partners’ body type, partners’ attempts to manage respondents’ eating behaviors, and partners’ own health behaviors on respondents’ health behaviors (physical activity, fruit and vegetable consumption, and fast food consumption). Data on 215 partners are extracted …

Language Assessment In A Snap: Monitoring Progress Up To 36 Months, Jill Gilkerson, Jeffrey A. Richards, Charles R. Greenwood, Judy K. Montgomery

Communication Sciences and Disorders Faculty Articles and Research

This article describes the development and validation of the Developmental Snapshot, a 52-item parent questionnaire on child language and vocal communication development that can be administered monthly and scored automatically. The Snapshot was created to provide an easily administered monthly progress monitoring tool that enables parents to better recognize language milestones and offers professionals prompt information to fine-tune intervention strategies. Initial items were piloted by 15 families; refinement and further development of the instrument was conducted with parents of 308 typically developing children. Reliability and criterion validity metrics were examined on subsets of approximately 60 children who completed the Snapshot …

Antitumor Activity Of 2,9-Di-Sec-Butyl-1,10-Phenanthroline, Dongsheng Wang, Shifang Peng, Arm R. Amin, Mohammad Aminur Rahman, Sreenivas Nannapaneni, Yuan Liu, Dong M. Shin, Nabil F. Saba, Jack F. Eichler, Zhuo G. Chen

Pharmaceutical Science and Research

The anti-tumor effect of a chelating phen-based ligand 2,9-di-sec-butyl-1,10-phenanthroline (dsBPT) and its combination with cisplatin were examined in both lung and head and neck cancer cell lines and xenograft animal models in this study. The effects of this agent on cell cycle and apoptosis were investigated. Protein markers relevant to these mechanisms were also assessed. We found that the inhibitory effect of dsBPT on lung and head and neck cancer cell growth (IC50 ranged between 0.1–0.2 μM) was 10 times greater than that on normal epithelial cells. dsBPT alone induced autophagy, G1 cell cycle arrest, and apoptosis. Our in vivo …

The Clinical Utility Of Concomitant Pten And Fas Deletion As An Early Indicator For Prostate Adenocarcinoma Subtypes That Lead To Extracapsular Metastasis, Brendan J. Coulter, Phillip Harries

Electronic Theses & Dissertations

The utility of genes PTEN and FAS as prognostic markers for the identification of early and/or aggressive prostatic adenocarcinomas is seemingly validated in the study results we obtained using fluorescence in-situ hybridization (FISH) of archived paraffin embedded surgical prostate core biopsy samples obtained from two CLIA and CAP licensed anatomical pathology labs (Bostwick Laboratories, Uniondale, NV and GoPath Laboratories, Buffalo Grove, IL). From early benign subsets of sample cases to aggressive extracapsular invasive tumors, the presence of random deletions evolves into clonal populations of co-deletion of both genes at question. We identify independent research that demonstrates the ability of these …