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2016

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Articles 2731 - 2760 of 12710

Full-Text Articles in Medicine and Health Sciences

Obscure Gastrointestinal Bleeding: A Case Series, Eric Nellis Md, Patrick Hickey Do, Shashin Shah Md, Hiral N. Shah Md Sep 2016

Obscure Gastrointestinal Bleeding: A Case Series, Eric Nellis Md, Patrick Hickey Do, Shashin Shah Md, Hiral N. Shah Md

Department of Medicine

No abstract provided.


A Predictive Model For Intensive Chemotherapy Outcomes In Newly Diagnosed Elderly Patients With Aml, Sameer Tolay Md, David F. Claxton Md, Junjia Zhu Md Sep 2016

A Predictive Model For Intensive Chemotherapy Outcomes In Newly Diagnosed Elderly Patients With Aml, Sameer Tolay Md, David F. Claxton Md, Junjia Zhu Md

Department of Medicine

No abstract provided.


Primary Pulmonary Meningioma Mimicking Lung Metastases, Sameer Tolay Md, Brian J. Patson Md, Sherry Li Md Sep 2016

Primary Pulmonary Meningioma Mimicking Lung Metastases, Sameer Tolay Md, Brian J. Patson Md, Sherry Li Md

Department of Medicine

No abstract provided.


Adrenal Incidentaloma In Young – A Gray Zone?, Ranjit R. Nair Md, Stacey Smith Md, Facp Sep 2016

Adrenal Incidentaloma In Young – A Gray Zone?, Ranjit R. Nair Md, Stacey Smith Md, Facp

Department of Medicine

No abstract provided.


Peritoneal Lymphomatosis: The Failure Of Occam’S Razor, Ranjit R. Nair Md, Nicole M. Agostino Do, Shereen M F Gheith Md, Usman Shah Md Sep 2016

Peritoneal Lymphomatosis: The Failure Of Occam’S Razor, Ranjit R. Nair Md, Nicole M. Agostino Do, Shereen M F Gheith Md, Usman Shah Md

Department of Medicine

No abstract provided.


Genetic Amplification: Quantitative Polymerase Chain Reaction And Its Problems And Uses, Drew Mcwilliams Sep 2016

Genetic Amplification: Quantitative Polymerase Chain Reaction And Its Problems And Uses, Drew Mcwilliams

Honors Projects

Quantitative polymerase chain reaction (qPCR), also called real-time PCR, has become a cornerstone of DNA analysis, enabling detection of minute amounts of nucleic acids (Whittwer et. al, 1997). In 1983, Kary Mullis developed a new method of genetic amplification—the polymerase chain reaction [PCR] (Bartlett & Stirling, 2003). A little over 20 years later, PCR now is a common and often crucial technique used in medical and biological research laboratories for a variety of applications. Some of these applications include DNA cloning for sequencing, DNA-based phylogeny, the diagnosis of hereditary diseases, the identification of genetic fingerprints (used in forensic sciences and …


Bilateral Triad Of Persistent Median Artery, A Bifid Median Nerve And High Origin Of Its Palmar Cutaneous Branch. A Case Report And Clinical Implications, Olutayo Ariyo, John Shea Sep 2016

Bilateral Triad Of Persistent Median Artery, A Bifid Median Nerve And High Origin Of Its Palmar Cutaneous Branch. A Case Report And Clinical Implications, Olutayo Ariyo, John Shea

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

We report the association of a persistent median artery, a bifid median nerve with a rare very high origin palmar cutaneous branch, presenting bilaterally in the upper limb of a 75-year-old female cadaver. The persistent median nerve with a bifid median nerve has been reported in patients presenting with carpal tunnel syndrome. Reports of this neurovascular anomaly occurring in association with a high origin palmar cutaneous branch however, are few. This subset of patients is at risk of inadvertent nerve transection during forearm and wrist surgery. Pre-operative magnetic resonance imaging (MRI) and high resolution sonography (HRS) can be used to …


Effectiveness Of Disease Modifying Osteoarthritis Agents And Carprofen For Treatment Of Canine Osteoarthritis, Irin Kwananocha, Monchanok Vijarnsorn, Narudee Kashemsant, Chalermpol Lekcharoensuk Sep 2016

Effectiveness Of Disease Modifying Osteoarthritis Agents And Carprofen For Treatment Of Canine Osteoarthritis, Irin Kwananocha, Monchanok Vijarnsorn, Narudee Kashemsant, Chalermpol Lekcharoensuk

The Thai Journal of Veterinary Medicine

A prospective, randomized, single-blinded study was conducted to evaluate and compare the effectiveness of disease modifying osteoarthritis agents (DMOAAs) and carprofen by using force plate gait analysis and orthopaedic assessment score (OAS) in osteoarthritic dogs. Forty dogs with hip and/or stifle osteoarthritis (OA) were assigned randomly into four treatment groups: PCSO-524, treated with a marine-based fatty-acid compound; GC-ASU, treated with a combination of glucosamine-chondroitin sulphate and avocado/soybean unsaponifiables; CPF, treated with carprofen; and CPF-PCSO, treated with a combination of carprofen and PCSO-524. Each group received the therapeutic agent orally for four weeks. Peak vertical force (PVF), OAS, haematology and blood …


Postnatal Ontogeny Of Small Intestinal Histomorphology, Crypt Cell Proliferation And Peptide Transporter 1 Gene Expression In Piglets, Boonrit Thongsong, Sureerat Suthongsa, Massupha Wiyaporn Sep 2016

Postnatal Ontogeny Of Small Intestinal Histomorphology, Crypt Cell Proliferation And Peptide Transporter 1 Gene Expression In Piglets, Boonrit Thongsong, Sureerat Suthongsa, Massupha Wiyaporn

The Thai Journal of Veterinary Medicine

Ontogeny of the morphology, cell proliferation, and peptide transporters in each region of the small intestine support optimal nutritional status and growth of pigs from early to later life. To assess these, growth of piglets was studied at birth (d 0), suckling (d 7), weaning (d 21) and post-weaning (d 28, 49 and 77) days. Hematology, small intestinal histomorphology, crypt cell proliferation, and peptide transporter 1 (PepT1) mRNA expression were measured from the animals at newborn, and at 7, 21, 49 and 77 days old. Among the three age groups (newborn to 21, 21 to 28 and 21 to 77 …


Quantitative-Genetic Analysis Of Growth Intensity Of Autochthonous Breeds Mangalitsa Pigs Reared In Traditional And Modern Systems, Dragomir Lukač, Radoslav Šević, Vitomir Vidović, Nikola Puvača, Vladimir Tomović, Natalija Džinić Sep 2016

Quantitative-Genetic Analysis Of Growth Intensity Of Autochthonous Breeds Mangalitsa Pigs Reared In Traditional And Modern Systems, Dragomir Lukač, Radoslav Šević, Vitomir Vidović, Nikola Puvača, Vladimir Tomović, Natalija Džinić

The Thai Journal of Veterinary Medicine

The aim of this study was to analyse growth intensity of Mangalitsa pig breed reared in two different systems, traditional and modern (intensive), which provides basic indicators of the economy of the rearing of this pig breed. The study included 13 litters (78 pigs) of Mangalitsa reared in the traditional system (MTS) and 13 litters (98 pigs) reared in the modern system (MMS). In the rearing phase there were 60 MTS piglets and 90 MMS piglets, and in the fattening phase 53 MTS pigs and 71 MMS pigs. Genetic parameters were estimated using the restricted maximum likelihood (REML) procedure based …


Effects Of Dietary Betaine Supplementation On Back Fat Thickness And Serum Igf-1 In Late Finishing Pigs, Muttarin Lothong, Kittipong Tachampa, Pornchalit Assavacheep, Kris Angkanaporn Sep 2016

Effects Of Dietary Betaine Supplementation On Back Fat Thickness And Serum Igf-1 In Late Finishing Pigs, Muttarin Lothong, Kittipong Tachampa, Pornchalit Assavacheep, Kris Angkanaporn

The Thai Journal of Veterinary Medicine

This study was performed in finishing pigs to investigate the effects of betaine HCl on carcass fat deposition and lipid metabolism in relation to growth hormone (GH) and insulin-like growth factor 1 (IGF-1) alterations. Sixty cross-bred finishing pigs (30 gilts and 30 barrows) with an average initial body weight of 74.0±1.8 kg were randomly allocated into two groups, each with six replicate pens. Each group was fed either 0% or 0.125% betaine HCl supplementation for 41 days. Results showed that the betaine HCl supplementation had no effect on growth performance (P>0.05). In the betaine-supplemented group, Lenden-speck-quotient index, average back …


Performance Analysis Of The Combined Plug-Flow Anaerobic Digester (Pfad) And Upflow Anaerobic Sludge Blanket (Uasb) For Treating Swine Wastewater In Thailand, Chackrit Nuengjamnong, Pichaya Rachdawong Sep 2016

Performance Analysis Of The Combined Plug-Flow Anaerobic Digester (Pfad) And Upflow Anaerobic Sludge Blanket (Uasb) For Treating Swine Wastewater In Thailand, Chackrit Nuengjamnong, Pichaya Rachdawong

The Thai Journal of Veterinary Medicine

The objective of this research was to analyze the overall performance, especially the removal efficiency, of the combined plug-flow anaerobic digester (PFAD) and upflow anaerobic sludge blanket (UASB) system, at a large swine farm in Thailand. Eighty-four wastewater samples from the digester were collected during the observation period of 302 days. Appropriate influent and effluent regions were selected for wastewater collection. Treatment efficiencies of the system were evaluated by key parameters such as chemical oxygen demand (COD), soluble chemical oxygen demand (SCOD), total solids (TS), total suspended solids (TSS) and total Kjeldahl nitrogen (TKN). In addition, microbiological parameters such as …


Prrsv Genetic Variation After The 2010 Hp-Prrsv Introduction In Thailand, Korakrit Poonsuk, Jirapat Arunorat, Nanthiya Iampraphat, Komkrich Teankum, Roongroje Thanawongnuwech Sep 2016

Prrsv Genetic Variation After The 2010 Hp-Prrsv Introduction In Thailand, Korakrit Poonsuk, Jirapat Arunorat, Nanthiya Iampraphat, Komkrich Teankum, Roongroje Thanawongnuwech

The Thai Journal of Veterinary Medicine

After the first introduction of porcine reproductive and respiratory syndrome virus (PRRSV) into Thailand, Thai type 1 PRRSV has existed in the Thai swine population and caused subclinical diseases while type 2 PRRSV, which most PRRSV isolates belong to, has caused moderate to severe diseases. Highly pathogenic-PRRSV (HP-PRRSV) has recently emerged in Thailand, causing significant damages since its first introduction in 2010. Genetic characterization of Thai PRRSV isolates collected from several clinically affected swine herds distributed in different geographical locations in 2012 was analyzed using a comparative analysis between 2 hyper-variable regions, NSP2 and ORF5. Eleven selected PRRSV clinical samples …


Quantitative Method For Detecting Staphylococcus Aureus Using Bio-Theta Doxtm System, Shouichi Tanno, Naoki Fukui, Yukihiro Utaka, Yumiko Itabashi, Yukio Morita, Sumalee Boonmar Sep 2016

Quantitative Method For Detecting Staphylococcus Aureus Using Bio-Theta Doxtm System, Shouichi Tanno, Naoki Fukui, Yukihiro Utaka, Yumiko Itabashi, Yukio Morita, Sumalee Boonmar

The Thai Journal of Veterinary Medicine

We developed a novel quantitative method for detecting S. aureus using the DOXTM system. A total of 19 strains of S. aureus, and 36 strains of non-S. aureus containing 27 species were examined. The mean positive rate of the high- (103 CFU/ml), medium- (102 CFU/ml), and low-concentration (10 CFU/ml) S. aureus samples was all 100%. The relationship between detection time and bacterial count of the 19 S. aureus had a good linear calibration curve. For the 36 non-S. aureus samples, the mean negative rates for the high-concentration (106 CFU/ml) samples and the medium-concentration (103 CFU/ml) samples were both 94.4% (34/36). …


Detection Of Giant Fibres In Undernourished Fetal Sheep Muscle, Berjan Demirtas Sep 2016

Detection Of Giant Fibres In Undernourished Fetal Sheep Muscle, Berjan Demirtas

The Thai Journal of Veterinary Medicine

During an investigation the occurrence of giant muscle fibres was noted in fetal sheep skeletal muscle. The opportunity was, therefore, taken to clarify the histochemical and ultrastructural characteristics of these fibres and to understand if environmental stress such as maternal undernutrition during gestation affects the occurrence of these giant fibres in fetal sheep muscle. Welsh mountain ewes were randomly assigned to either the control group or the nutrient restricted group. The restricted animals received 50% of their daily nutritional requirement from the time of conception until 70 days of gestation and then 100% of their daily nutritional requirement thereafter. The …


Prevalence Of Clostridium Perfringens Β2-Toxin In Sheep And Goat Population In Punjab, Pakistan, Mudassar Mohiuddin, Zahid Iqbal, Sajjad Ur Rahman Sep 2016

Prevalence Of Clostridium Perfringens Β2-Toxin In Sheep And Goat Population In Punjab, Pakistan, Mudassar Mohiuddin, Zahid Iqbal, Sajjad Ur Rahman

The Thai Journal of Veterinary Medicine

Clostridium perfringens presents persistent threat to small animals in causing moderate to severe enterotoxemia. The pathogenicity of C. perfringens depends on the production of four major toxins. In addition to the major toxins, beta2 (β2) toxin, a minor toxin, is also produced by some strains of C. perfringens. In this study, a total of 107 fecal samples collected from healthy and diseased sheep and goats were cultured and processed for biochemical analysis. On the basis of biochemical characterization, 61 isolates were confirmed as C. perfringens. In order to detect C. perfringens types, multiplex PCR assay was carried out for the …


Perineal Hernia Containing Pregnant Uterus In A Doe, E. Sinem Ozdemir Salci, Baris Guner Sep 2016

Perineal Hernia Containing Pregnant Uterus In A Doe, E. Sinem Ozdemir Salci, Baris Guner

The Thai Journal of Veterinary Medicine

A Saanen Maltese mixed-breed doe, about 5 years old, at last gestation, was presented with a complaint of a gradually enlarging swelling on the caudo-ventral area of the abdomen and proximal part of the udders. In clinical examination, abdominal distension and enlargement, a swelling beginning at the right perineal region and extending to the caudo-ventral area of the abdomen and the dorsal site of the udders, were observed. Two fetus and their organs (extremities) were felt by palpation of the swelling. Pulsations of the yeanlings in the swelling were determined by ultrasonographic examination. Vaginal examination result was normal and cervix …


Ichthyosis Congenita In A Calf: Case Report, Saeed Azimpour, Farhang Sasani, Parham Mottaghian, Amin Anoushepour Sep 2016

Ichthyosis Congenita In A Calf: Case Report, Saeed Azimpour, Farhang Sasani, Parham Mottaghian, Amin Anoushepour

The Thai Journal of Veterinary Medicine

The purpose of this report was to present the clinical and pathological features of ichthyosis congenital observed in a cross-bred Holstein calf. The calf showed regions of alopecia and moderately thickened, fissured skin at birth. The major dermatopathological feature was diffuse lamellar orthokeratotic hyperkeratosis with severe multiple follicular keratosis along with mild acanthosis. The definitive diagnosis was based on history, physical examination, and dermatopathological findings.


Ecg Quiz, Chollada Buranakarl, Piyasiri Glangosol, Anusak Kijtawornrat, Saikaew Sutayatram Sep 2016

Ecg Quiz, Chollada Buranakarl, Piyasiri Glangosol, Anusak Kijtawornrat, Saikaew Sutayatram

The Thai Journal of Veterinary Medicine

No abstract provided.


Ophthalmology Snapshot, Nalinee Tuntivanich Sep 2016

Ophthalmology Snapshot, Nalinee Tuntivanich

The Thai Journal of Veterinary Medicine

No abstract provided.


What Is Your Diagnosis?, Nan Choisunirachon Sep 2016

What Is Your Diagnosis?, Nan Choisunirachon

The Thai Journal of Veterinary Medicine

No abstract provided.


Hearing Is Believing: Birds Learn Fear, Christopher B. Sturdy, Darren S. Proppe Sep 2016

Hearing Is Believing: Birds Learn Fear, Christopher B. Sturdy, Darren S. Proppe

University Faculty Publications and Creative Works

Although it is known that animals attend to the vocalizations of others (referred to as eavesdropping), what has been missing, or at least left experimentally unproven, until now is whether animals can learn new associations between a signal and a threat. Here Magrath and colleagues (Current Biology, 25(15), 2047–2050, 2015) have for the first time conducted a field experiment that demonstrates just this: superb fairy-wrens learned to associate a novel vocalization with a predator.


Venous Thromboembolism Following Hematopoietic Stem Cell Transplantation-A Systematic Review And Meta-Analysis, Mohammad Faizan Zahid, M Hassan Murad, Mark R. Litzow, William J. Hogan, Mrinal S. Patnaik, Alok Khorana, Alex C. Spyropoulos, Shahrukh K. Hashmi Sep 2016

Venous Thromboembolism Following Hematopoietic Stem Cell Transplantation-A Systematic Review And Meta-Analysis, Mohammad Faizan Zahid, M Hassan Murad, Mark R. Litzow, William J. Hogan, Mrinal S. Patnaik, Alok Khorana, Alex C. Spyropoulos, Shahrukh K. Hashmi

Medical College Documents

Venous thromboembolism (VTE) is a common complication of hematopoietic stem cell transplantation (HSCT). Graft-versus-host disease (GVHD) is another complication of HSCT that may modify the risk of VTE. Our objective was to explore the incidence of VTE (deep venous thrombosis and pulmonary embolism) following HSCT and to evaluate its association with GVHD. A comprehensive search of Medline In-Process & Other Non-Indexed Citations, MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, and Scopus was conducted to search for both retrospective and prospective HSCT studies which had reported VTE. Random-effects meta-analysis was used to pool incidence rates. We included 17 studies reporting …


An Adult Sepsis Identification And Resuscitation Pathway Innovative Tactics Beyond The Traditional Bundle, Lindsa Houck Msn, Rn, Nea-Bc, Cen, Cpen, Phrn, Reza Armaghan Sep 2016

An Adult Sepsis Identification And Resuscitation Pathway Innovative Tactics Beyond The Traditional Bundle, Lindsa Houck Msn, Rn, Nea-Bc, Cen, Cpen, Phrn, Reza Armaghan

Patient Care Services / Nursing

No abstract provided.


The Age-Friendly Cities Project In Bowling Green: A Narrative History, Hannah Ruggles Aug 2016

The Age-Friendly Cities Project In Bowling Green: A Narrative History, Hannah Ruggles

Mahurin Honors College Capstone Experience/Thesis Projects

An age-friendly city is one that “encourages active ageing by optimizing opportunities for health, participation and security in order to enhance quality of life as people age. In practical terms, an age-friendly city adapts its structures and services to be accessible to and inclusive of older people with varying needs and capacities.” Bowling Green was the seventh city in the US to join the World Health Organization’s Global Network of Age-Friendly Cities and is currently in year three of a five-year project. The developments over the past two years have been guided by the principle that senior residents of Bowling …


Role Of Hearth Program With Undernutrition Incidence Among Toddlers In Tangerang City, Gizella Gizella, Dany Hilmanto, Dedi Rachmadi Aug 2016

Role Of Hearth Program With Undernutrition Incidence Among Toddlers In Tangerang City, Gizella Gizella, Dany Hilmanto, Dedi Rachmadi

Kesmas

Kelompok yang rentan terhadap gizi kurang adalah balita. World Health Organization (WHO) menyatakan kematian anak bawah lima tahun (balita) akibat gizi kurang sebesar 54% pada tahun 2002. Di Indonesia, prevalensinya mengalami peningkatan dari 17,9% pada tahun 2010 menjadi 19,6% pada tahun 2013. Di Kota Tangerang, terdapat 1,43% balita yang mengalami gizi buruk pada tahun 2013. Penelitian ini bertujuan untuk membuktikan secara valid hubungan antara Program Pos Gizi yang meliputi perilaku pemberian makan, perilaku kebersihan balita, perilaku mencari pelayanan kesehatan dan perilaku pengasuhan balita dengan kejadian gizi kurang pada balita. Penelitian ini merupakan penelitian kuantitatif, potong lintang, menggunakan data primer serta …


Good Corporate Governance Implementation And Performance Of Civil Servant, Muhammad Hasan, Dumilah Ayuningtyas, Misnaniarti Misnaniarti Aug 2016

Good Corporate Governance Implementation And Performance Of Civil Servant, Muhammad Hasan, Dumilah Ayuningtyas, Misnaniarti Misnaniarti

Kesmas

Dalam rangka mencapai visi dan misi, setiap rumah sakit harus menjalankan tata kelola perusahaan yang baik (Good Corporate Governance/GCG). Penerapan GCG sendiri bertujuan untuk meningkatkan kinerja pegawai secara optimal, yang akhirnya akan meningkatkan kinerja organisasi. Penelitian ini bertujuan untuk menganalisis hubungan penerapan prinsip-prinsip GCG terhadap kinerja pegawai negeri sipil (PNS) Rumah Sakit Umum Lapangan Natuna Kabupaten Kepulauan Anambas. Jenis penelitian ini adalah deskriptif analitik dengan desain potong lintang pada 56 PNS. Pengumpulan data dilakukan pada tahun 2012 dengan kuesioner terstruktur. Digunakan analisis dengan uji kai kuadrat dan regresi logistik, dan untuk penyederhanaan model dilakukan eliminasi terhadap faktor perancu dengan menggunakan …


Environmental, Behavioral Factors And Filariasis Incidence In Bintan District, Riau Islands Province, Zainul Ikhwan, Lucky Herawati, Suharti Suharti Aug 2016

Environmental, Behavioral Factors And Filariasis Incidence In Bintan District, Riau Islands Province, Zainul Ikhwan, Lucky Herawati, Suharti Suharti

Kesmas

Tingkat mikrofilaria filariasis di Kabupaten Bintan masih tinggi, khususnya di Kecamatan Teluk Bintan, Teluk Sebong, dan Sri Kuala Lobam. Penelitian ini bertujuan untuk mengetahui hubungan faktor risiko lingkungan (faktor fisik, biologi, kimia, sosial budaya, ekonomi) dan faktor perilaku dengan kejadian filariasis. Jenis penelitian observasional analitik yang dilakukan pada Mei – September 2015 dengan desain kasus kontrol, yang terdiri dari jumlah kasus 33 orang penderita filariasis dan kontrol 65 orang bukan penderita filariasis dengan teknik cluster sampling. Populasi penelitian adalah masyarakat di Kabupaten Bintan. Data yang diperoleh dianalisis menggunakan uji kai kuadrat dan regresi logistik. Hasil menunjukkan adanya hubungan pengetahuan (nilai …


Multi-Focal Control Of Mitochondrial Gene Expression By Oncogenic Myc Provides Potential Therapeutic Targets In Cancer., Amanda R. Oran, Clare M. Adams, Xiao-Yong Zhang, Victoria J. Gennaro, Harla K. Pfeiffer, Hestia S. Mellert, Hans E. Seidel, Kirsten Mascioli, Jordan Kaplan, Mahmoud R. Gaballa, Chen Shen, Isidore Rigoutsos, Michael P. King, Justin L Cotney, Jamie J. Arnold, Suresh D. Sharma, Ubaldo E. Martinez-Outshoorn, Christopher R. Vakoc, Lewis A. Chodosh, James E. Thompson, James E. Bradner, Craig E. Cameron, Gerald S. Shadel, Christine M. Eischen, Steven B. Mcmahon Aug 2016

Multi-Focal Control Of Mitochondrial Gene Expression By Oncogenic Myc Provides Potential Therapeutic Targets In Cancer., Amanda R. Oran, Clare M. Adams, Xiao-Yong Zhang, Victoria J. Gennaro, Harla K. Pfeiffer, Hestia S. Mellert, Hans E. Seidel, Kirsten Mascioli, Jordan Kaplan, Mahmoud R. Gaballa, Chen Shen, Isidore Rigoutsos, Michael P. King, Justin L Cotney, Jamie J. Arnold, Suresh D. Sharma, Ubaldo E. Martinez-Outshoorn, Christopher R. Vakoc, Lewis A. Chodosh, James E. Thompson, James E. Bradner, Craig E. Cameron, Gerald S. Shadel, Christine M. Eischen, Steven B. Mcmahon

Department of Cancer Biology Faculty Papers

Despite ubiquitous activation in human cancer, essential downstream effector pathways of the MYC transcription factor have been difficult to define and target. Using a structure/function-based approach, we identified the mitochondrial RNA polymerase (POLRMT) locus as a critical downstream target of MYC. The multifunctional POLRMT enzyme controls mitochondrial gene expression, a process required both for mitochondrial function and mitochondrial biogenesis. We further demonstrate that inhibition of this newly defined MYC effector pathway causes robust and selective tumor cell apoptosis, via an acute, checkpoint-like mechanism linked to aberrant electron transport chain complex assembly and mitochondrial reactive oxygen species (ROS) production. Fortuitously, MYC-dependent …


The Role Of Phospholipid As A Solubility- And Permeability-Enhancing Excipient For The Improved Delivery Of The Bioactive Phytoconstituents Of Bacopa Monnieri, Suprit Saoji, Vivek S. Dave, Pradip W. Dhore, Yamini S. Bobde, Connor Mack, Deepak Gupta, Nishikant Raut Aug 2016

The Role Of Phospholipid As A Solubility- And Permeability-Enhancing Excipient For The Improved Delivery Of The Bioactive Phytoconstituents Of Bacopa Monnieri, Suprit Saoji, Vivek S. Dave, Pradip W. Dhore, Yamini S. Bobde, Connor Mack, Deepak Gupta, Nishikant Raut

Pharmacy Faculty/Staff Publications

In an attempt to improve the solubility and permeability of Standardized Bacopa Extract (SBE), a complexation approach based on phospholipid was employed. A solvent evaporation method was used to prepare the SBE-phospholipid complex (Bacopa Naturosome, BN). The formulation and process variables were optimized using a central-composite design. The formation of BN was confirmed by photomicroscopy, Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), and Powder X-ray Diffraction (PXRD). The saturation solubility, the in-vitro dissolution, and the ex-vivo permeability studies were used for the functional evaluation of the prepared complex. BN exhibited a significantly higher aqueous …