Medicine and Health Sciences Commons^™

Depressive Symptoms And Alcohol-Related Problems Among College Students: A Moderated-Mediated Model Of Mindfulness And Drinking To Cope, Adrian J. Bravo, Matthew R. Pearson, Leah E. Stevens, James M. Henson

Psychology Faculty Publications

Objective: In college student samples, the association between depressive symptoms and alcohol-related problems has been found to be mediated by drinking-to-cope motives. Mindfulness-based interventions suggest that mindfulness may attenuate the conditioned response of using substances in response to negative emotional states, and trait mindfulness has been shown to be a protective factor associated with experiencing fewer alcohol-related problems. In the present study, we examined trait mindfulness as a moderator of the indirect associations of depressive symptoms on alcohol-related problems via drinking-to-cope motives. Method: Participants were undergraduate students at a large, southeastern university in the United States who drank at least …

Spatio-Temporal Progression Of Cortical Activity Related To Continuous Overt And Covert Speech Production In A Reading Task, Jonathan S. Brumberg, Dean J. Krusienski, Shreya Chakrabarti, Aysegul Gunduz, Peter Brunner, Anthony L. Ritaccio, Gerwin Schalk

Electrical & Computer Engineering Faculty Publications

How the human brain plans, executes, and monitors continuous and fluent speech has remained largely elusive. For example, previous research has defined the cortical locations most important for different aspects of speech function, but has not yet yielded a definition of the temporal progression of involvement of those locations as speech progresses either overtly or covertly. In this paper, we uncovered the spatio-temporal evolution of neuronal population-level activity related to continuous overt speech, and identified those locations that shared activity characteristics across overt and covert speech. Specifically, we asked subjects to repeat continuous sentences aloud or silently while we recorded …

Mitochondrial Function Assessed By 31p Mrs And Bold Mri In Non-Obese Type 2 Diabetic Rats, Yuchi Liu, Xunbai Mei, Jielei Li, Nicola Lai, Xin Yu

Electrical & Computer Engineering Faculty Publications

The study aims to characterize age-associated changes in skeletal muscle bioenergetics by evaluating the response to ischemia-reperfusion in the skeletal muscle of the Goto-Kakizaki (GK) rats, a rat model of non-obese type 2 diabetes (T2D). ³¹P magnetic resonance spectroscopy (MRS) and blood oxygen level-dependent (BOLD) MRI was performed on the hindlimb of young (12 weeks) and adult (20 weeks) GK and Wistar (control) rats. ³¹P-MRS and BOLD-MRI data were acquired continuously during an ischemia and reperfusion protocol to quantify changes in phosphate metabolites and muscle oxygenation. The time constant of phosphocreatine recovery, an index of mitochondrial oxidative capacity, …

Convergence Of Excitatory And Inhibitory Projections In The Mouse Medial Geniculate Body, Blaise Andre Clarke

LSU Master's Theses

The medial geniculate body (MGB) is the target of excitatory and inhibitory inputs from several neural sources. Among these, the inferior colliculus (IC) is an important nucleus in the midbrain that acts as a nexus for many auditory pathways and projections, ascending and descending, throughout the rest of the central auditory system and provides both excitatory and inhibitory projections to the MGB. In addition, the thalamic reticular nucleus (TRN) is a major source of inhibition to the MGB, particularly in rodents. Finally, the auditory cortex (AC) is a major source of descending input to the MGB, providing direct excitation and …

Iowa Conference On Communicative Disorders [Program, 2016], Iowa Conference On Communicative Disorders

Iowa Conference on Communicative Disorders Programs

The Iowa Conference on Communicative Disorders provides continuing education activities in speech- language pathology that are acceptable to the State of Iowa and the American Speech-Language and Hearing Association. Areas of emphasis include adults and pediatrics.

Interplay Between Her2, Parp1, And Nf-Κb In Breast Cancer: Potential Therapeutic Implications, Monicka Ewa Wielgos

All ETDs from UAB

We previously reported that HER2+ breast cancers are susceptible to Poly (ADP-Ribose) polymerase inhibitors (PARPi) alone, agents that are efficacious against homologous recombination (HR) deficient tumors. However, this phenomenon was determined to be independent of a HR repair deficiency but rather due to suppression of NF-κB activity and signaling by PARP inhibition. Further, HER2 overexpression itself was necessary and sufficient to confer this susceptibility. Interestingly, PARP1 and phosphorylated RelA/p65 (NF-κB) levels were found to be elevated in human HER2+ breast cancers compared to luminal breast cancers. These data suggest a possible interplay between HER2, PARP1, and NF-κB, and how this …

Hospice Performance: Environmental And Organizational Correlates, Mengying He

All ETDs from UAB

The purpose of this dissertation is to explore hospice performance using a three paper format. Based on Structure-Conduct-Performance (SCP) and Structure-Process-Outcome (SPO) models, paper 1 conducts a systematic literature review to identify gaps in hospice performance research. Paper 2 explores the relationship between hospice market structure and inpatient services provision (Structure-Conduct). Market munificence is related to hospice inpatient services offering. Organizational factors such as hospice chain-affiliation, age, and ownership also play roles in predicting hospices’ probability in providing inpatient services. Paper 3 examines the impact of hospice inpatient service provision on service utilization and financial performance (Structure-Process-Outcome). Hospices that not …

The Role Of Glutamate In Immune Cell Infiltration And Excitotoxic Mechanisms In Autoimmune Demyelination, Kirsten Scarlett Evonuk

All ETDs from UAB

Multiple sclerosis is the most common neurological disorder in young adults. Current treatments modulate the immune system, but no treatments prevent central nervous system damage. Inflammation occurs even during disease remission, contributing to ongoing damage and resulting in disease progression. The lack of neuroprotective treatments despite continued inflammatory onslaught in the central nervous system indicates the need for therapeutic discovery in this area. One potential therapeutic target is glutamate, whose dysregulation in multiple sclerosis has been implicated in excitotoxic cellular death. Herein we describe the roles of glutamate in multiple sclerosis and explore the blockade of a source of excitotoxic …

Epigenetic Dysregulation In Levodopa-Induced Dyskinesia, David Anthony Figge

All ETDs from UAB

Levodopa-induced dyskinesia (LID) is a persistent behavioral sensitization that develops after repeated levodopa (L-DOPA) exposure in Parkinson disease (PD) patients. LID is characterized by a “priming effect”, whereby initial administrations of L-DOPA trigger a sensitized biochemical and transcriptional response upon subsequent administrations of L-DOPA. In neurons, transcriptional regulation through dynamic changes to epigenetic modifications, including DNA methylation and histone acetylation, have been shown pivotal to many long-term behavioral modifications; however, their role in LID has been minimally explored. Using a rodent model, we show LID development leads to the aberrant expression of DNA demethylating enzymes and locus-specific changes to DNA …

The Role Of Nadph Oxidase 2 (Nox2) In High-Fat Diet-Induced Adiposopathy And Brain Dysfunction In A Mouse Model, Jennifer Kathleen Pepping

LSU Master's Theses

Obesity can have numerous detrimental consequences, namely metabolic syndrome, type 2 diabetes, cardiovascular disease, cancer, and Alzheimer’s disease. The pathogenesis and physiologic consequences of obesity are unknown, but they are often associated with increased inflammation and oxidative stress in both the body and in the brain. One factor that has been implicated in causing inflammation associated with a high fat diet is the enzyme NADPH oxidase, or NOX, specifically the subunit NOX2. Two studies were performed in order to assess the effects of a high fat diet in combination with a universal NOX2 deficiency and a NOX2 deficiency targeted to …

Role Of Histone H4 Mutations In Dna Repair Pathways, Sheikh Arafatur Rahman

LSU Master's Theses

Histone H3K79 methylation has been shown to play roles in different DNA repair pathways. Histone H4 residues serine 64 to threonine 80 surround histone H3K79 residue. We have analyzed the effect of the mutations of the residues on UV sensitivity, H3K79 methylation, nucleotide excision repair, chromatin state and homologous recombination. We found that mutation of the residues 64 to 72 cause resistance to killing by UV whereas mutation of the residues 73 to 80 cause sensitivity to killing by UV compared to wild type. In general, we found that the mutations make nucleotide excision repair more proficient at the constitutively …

Treating Attention Deficits In Individuals With Parkinson's Disease, Mora Johanna Mahoney

LSU Master's Theses

Purpose: The purpose of this study was to determine the presence and degree of treatment effects found for direct attention training on three individuals with idiopathic Parkinson’s disease (PD) using the Attention Process Training, Third Edition (APT-III; Sohlberg & Mateer, 2010). APT-III was designed for use with individuals who have sustained a traumatic brain injury (TBI), and was selected for this study because of the similarities in cognitive deficits between those with TBI and those with PD. Methods: This study was designed as a phase 2, randomized baseline, A1-B-A2-A3 (baseline, treatment, post-treatment, and follow-up assessment), single-subject experimental design. The study …

Atp6v1c1 Enhances Breast Cancer Growth By Activating V-Atpase Mediated Mtorc1 Signaling And Metastasis By Increasing V-Atpase Activity In Cancer Cells, Matthew J. Mcconnell

All ETDs from UAB

It is known that the vacuolar ATPase has a number of functions related to tumor growth and progression such as involvement in drug resistance, pH regulation, autophagy, and lysosomal acid protease activation, as well as invasion and metastasis. Here we specifically describe the role of ATP6v1c1 in murine and human models of breast cancer. ATP6v1c1 is the dominant isoform of the coordinating subunit (ATP6v1c) involved in the assembly of the vacuolar ATPase complex which plays a key role in cancer growth and progression. We also describe how ATP6v1c1 knockdown impairs tumor nutrient signaling through mTORC1 and tumor cell proliferation, by …

Physical Activity For Adults With Visual Impairments: Impact Of Socio-Demographic Factors, Justin A. Haegele, Xihe Zhu, Jihyun Lee, Lauren J. Lieberman

Human Movement Studies & Special Education Faculty Publications

Little is known about what factors influence physical activity participation for adult-aged individuals with visual impairments. Therefore, the purpose of this study was to explore the impact of socio-demographic factors on the physical activity participation of adults with visual impairments. The international physical activity questionnaire-short form and a socio-demographic factor questionnaire were distributed to individuals with visual impairments. A total of 176 adults (M_age = 47.04, 52.8% female) completed the questionnaires. Physical activity and socio-demographic variables were analyzed descriptively and relationships were explored using correlation analysis and multiple regression analysis. On average, participants reported 413.79 minutes of moderate-to-vigorous physical …

Physical Activity/Exercise And Diabetes: A Position Statement Of The American Diabetes Association, Sheri R. Colberg, Ronald J. Sigal, Jane E. Yardley, Michael C. Riddell, David W. Dunstan, Paddy C. Dempsey

Human Movement Studies & Special Education Faculty Publications

The adoption and maintenance of physical activity are critical foci for blood glucose management and overall health in individuals with diabetes and prediabetes. Recommendations and precautions vary depending on individual characteristics and health status. In this Position Statement, we provide a clinically oriented review and evidence-based recommendations regarding physical activity and exercise in people with type 1 diabetes, type 2 diabetes, gestational diabetes mellitus, and prediabetes.

Physical activity includes all movement that increases energy use, whereas exercise is planned, structured physical activity. Exercise improves blood glucose control in type 2 diabetes, reduces cardiovascular risk factors, contributes to weight loss, and …

Physical Activity And Situational Interest In Mobile Technology Integrated Physical Education: A Preliminary Study, Xihe Zhu, Loren A. Dragon

Human Movement Studies & Special Education Faculty Publications

Background: Mobile technology permeates every aspect of student lives. The question is whether mobile technology integration can produce desirable effects in the gymnasium.

Objective: This preliminary study aimed to investigate the effects of mobile technology integration on student situational interest and physical activity fluctuation in physical education lessons.

Methods: Sixth grade students (N = 53) were randomly placed into either an experiment group by class that utilized mobile technology-integrated resources (iPad and applications), or a comparison group that did not utilize technology. Both groups received five identical physical education lessons. Student physical activity was tracked with accelerometers, and they completed …

The International Health Regulations: The Governing Framework For Global Health Security, Lawrence O. Gostin, Rebecca Katz

Georgetown Law Faculty Publications and Other Works

• The International Health Regulations (IHR) are the governing framework for global health security yet require textual and operational reforms to remain effective, particularly as parallel initiatives are developed.
• The World Health Organization (WHO) is the agency charged with oversight of the IHR, and its leadership and efficient functioning are prerequisites for the effective implementation of the IHR.
• We reviewed the historical origins of the IHR and their performance over the past 10 years and analyzed all of the ongoing reform panel efforts to provide a series of politically feasible recommendations for fundamental reform.
• This article offers proposals for fundamental reform—with …

Workplace Violence, Organizational Culture, And Registered Nurses' Incident Reporting Patterns In Acute Hospitals In California, Feodora Jacobsen

Doctoral Dissertations

The purpose of this study was to increase understanding of the reporting patterns of WPV Type II in acute hospital settings. Although some patients are abusive toward nurses, that the abuse is underreported to hospital administrators. Qualitative studies identified common themes for underreporting including fear of being blamed, abuse considered part of the job, and not having sufficient time to fill out a formal report. This study is the first quantitative study to explore the changes in mean scores of organizational-culture factors under two mutually exclusive conditions: registered nurses (RNs) who do not report hospital incidents and RNs who do …

Organizational Culture And Organization Based Self- Esteem As Predictors Of Spirit At Work, Zeynep Merve Ünal, Tülay Turgut

Khazar Journal of Humanities and Social Sciences

This study aims to investigate the relationships between organizational cultures, spirit at work, and organization based self-esteem among academicians, and whether organization based self-esteem mediates the relationship between organizational culture and spirit at work. A cross-sectional design was employed, and data were collected through a questionnaire-based survey. Based on the convenience sampling, 417 academicians answered the questionnaire in public and private universities located in Turkey. To analyze the data descriptive statistics, Pearson coefficient, simple and multiple regression analyses were conducted. Feminine organizational culture has more positive contribution on experiencing spirit at work than masculine organizational culture. Moreover, organization based self-esteem …

Transitions To Assisted Living Within A Continuing Care Retirement Community, Judith H. Scott

Dissertations

Purpose/Aims: The purpose of this study was to explore the lived experience of older single women who moved from their independent homes to the assisted living setting, both situated within a Continuing Care Retirement Community (CCRC).

Rationale: Anecdotally, CCRC transitions have been viewed as either one dreaded possible step toward the end of life or a supportive place to open a new chapter in older adults’ lives. However, no studies have actually examined this experience among older single women, who comprise a large proportion of people making this transition.

Background: Older adults move to assisted living within a CCRC when …

Symptom Experience And Influenza-Like Illness In A Military Population, Monique Bouvier

Dissertations

AIMS: The primary objective of this study was to identify if symptom presentation expressed over the course of an influenza-like illness (ILI) can predict virus type by use of unsupervised machine learning. The secondary objective was to describe clinical characteristics of strain specific coronavirus. Finally, examine the psychometric properties of the Canadian Acute Respiratory Illness and Flu Scale (CARIFS).

BACKGROUND: ILI outbreaks have been a significant source of non-battle injury among military personnel. Many different viruses cause ILI, and it is difficult to determine which virus is causing the illness. Recent studies have examined the etiology and epidemiology of ILIs. …

A Systematic Review Of The Treatment And Management Of Pre-Eclampsia And Eclampsia In Pakistan, Saleem Shaikh, Ali M. Mir

Reproductive Health

Pakistan is one of the six countries that account for more than 50 percent of the world’s maternal deaths. According to Population Council estimates, each year nearly 8.6 million women become pregnant in the country. Of these, 1.2 million women are likely to face obstetric complications. Each year, there are nearly 14,000 pregnancy-related deaths. Information is lacking on context-specific health-system barriers that prevent optimal use of the lifesaving medicine magnesium sulfate (MgSO4) in Pakistan. Although efforts in Pakistan both at the national and subnational level are ongoing on the prevention and treatment of pre-eclampsia and eclampsia (PE/E), results are generally …

Coordination Of Rna Polymerase Ii Pausing And 3' End Processing Factor Recruitment With Alternative Polyadenylation, Becky Fusby, Soojin Kim, Benjamin Erickson, Hyunmin Kim, Martha L. Peterson, David L Bentley

Microbiology, Immunology, and Molecular Genetics Faculty Publications

Most mammalian genes produce transcripts whose 3' ends are processed at multiple alternative positions by cleavage/polyadenylation (CPA). Poly(A) site cleavage frequently occurs cotranscriptionally and is facilitated by CPA factor binding to the RNA polymerase II (Pol II) C-terminal domain (CTD) phosphorylated on Ser2 residues of its heptad repeats (YS₂PTSPS). The function of cotranscriptional events in the selection of alternative poly(A) sites is poorly understood. We investigated Pol II pausing, CTD Ser2 phosphorylation, and processing factor CstF recruitment at wild-type and mutant IgM transgenes that use alternative poly(A) sites to produce mRNAs encoding the secreted and membrane-bound forms of …

Ending The Medicalization Of Female Genital Mutilation/Cutting In Egypt, Sarah Ghattass, Nahla G. Abdel-Tawab, Salma Abou Hussein

Reproductive Health

This policy brief examines the extent of medicalization of female genital mutilation/cutting (FGM/C) in Egypt, the characteristics of girls who were cut by medical personnel, factors that may have contributed to increased medicalization, and potential interventions that could influence both physicians and the public to completely abandon the practice. The data show that younger cohorts of women, those from higher wealth quintiles, higher levels of education, and living in urban regions are more likely to have been cut by medical personnel. More importantly, the analysis shows that despite medicalization being more common among young women with the above-mentioned characteristics, it …

Ending The Medicalization Of Female Genital Mutilation/Cutting In Egypt [Arabic], Sarah Ghattass, Nahla G. Abdel-Tawab, Salma Abou Hussein

Reproductive Health

[In Arabic] This policy brief examines the extent of medicalization of female genital mutilation/cutting (FGM/C) in Egypt, the characteristics of girls who were cut by medical personnel, factors that may have contributed to increased medicalization, and potential interventions that could influence both physicians and the public to completely abandon the practice. The data show that younger cohorts of women, those from higher wealth quintiles, higher levels of education, and living in urban regions are more likely to have been cut by medical personnel. More importantly, the analysis shows that despite medicalization being more common among young women with the above-mentioned …

Evidence To End Fgm/C: Research To Help Girls And Women Thrive [Arabic], Population Council

Reproductive Health

[In Arabic] This factsheet describes a new Population Council–led research program, funded by the United Kingdom’s Department for International Development, which will join the UNFPA-UNICEF Joint Programme on FGM/C: Accelerating Change and the Girl Generation in the Campaign to End Female Genital Mutilation/Cutting (FGM/C) within One Generation. The program will generate high-quality evidence to influence strategic investment, policy, and programming to end FGM/C. This five-year program will work in 6–9 sub-Saharan African countries to dramatically expand the body of evidence on the most effective approaches to ending FGM/C. The research program will be organized around four themes: building the picture …

Evidence To End Fgm/C: Research To Help Girls And Women Thrive, Population Council

Reproductive Health

This factsheet describes a new Population Council–led research program, funded by the United Kingdom’s Department for International Development, which will join the UNFPA-UNICEF Joint Programme on FGM/C: Accelerating Change and the Girl Generation in the Campaign to End Female Genital Mutilation/Cutting (FGM/C) within One Generation. The program will generate high-quality evidence to influence strategic investment, policy, and programming to end FGM/C. This five-year program will work in 6–9 sub-Saharan African countries to dramatically expand the body of evidence on the most effective approaches to ending FGM/C. The research program will be organized around four themes: building the picture of where, …

Intrahepatic Cholestasis Of Pregnancy With Severe Elevation Of Bile Acids In The Setting Of Acute Hepatitis C Infection, Megan L. Lawlor, Agatha S. Critchfield

Obstetrics and Gynecology Faculty Publications

Intrahepatic cholestasis of pregnancy (ICP) is a complication of pregnancy resulting in elevation of serum bile acid levels. ICP is often associated with underlying liver disease, including hepatitis C. Bile acids in relationship to the acute infection of hepatitis C virus have not yet been delineated in the literature. A 26-year-old gravida 4 para 2103 with dichorionic, diamniotic twin gestation and history of intravenous drug abuse developed ICP in the setting of acute hepatitis C infection. In addition to clinical symptoms of pruritus and right upper quadrant pain, she developed severe elevation in bile acids, 239 micromol/L, and transaminitis aspartate …

Pharmacy Workers In Kenya Need Training And Support On Medical Abortion Information And Referrals To Prevent Unsafe Service Provision, Jesse Njunguru, A. Finnie, Katharine Footman, Wilson Liambila, Kate Reiss

Reproductive Health

Despite the centrality of pharmacists in the provision of abortion services in Kenya, little is known about their medical abortion (MA) knowledge, attitudes, or practices. This policy brief reports on a study that set out to bridge this gap in the evidence. The report concludes that comprehensive training for pharmacy workers could improve the quality of MA provision and referrals, and help pharmacy workers identify opportunities to simultaneously provide clients with information on contraception and STI prevention. Such efforts would be in line with current Kenyan government policies to reduce the public health burden caused by the prevalence of unsafe …

Kenya: Helping Adolescent Mothers Remain In School Through Strengthened Implementation Of School Re-Entry Policies, Esther Lwanga Walgwe, Nancy Termini Lachance, Harriet Birungi, Chi-Chi Undie

Reproductive Health

By applying robust evidence, securing the support of decisionmakers, and engaging stakeholders, STEP UP enabled national and local decisionmakers to better understand the consequences of unintended pregnancy for adolescent girls’ schooling in Homa Bay County, Kenya. STEP UP is playing an important role in informing the implementation of policies within the Kenyan educational sector that will improve educational opportunities for school-age mothers. Through early stakeholder engagement, strong partnerships, the support of implementers and policymakers, effective communication and dissemination strategies, decisionmaker capacity, and the dedication of the adolescent mothers themselves, evidence generated by STEP UP was successfully utilized by key stakeholders. …