Medicine and Health Sciences Commons^™

Fear Of Fatherhood, Deborah Weatherspoon, Wendy Sponsler, Christopher Weatherspoon, Dorothy Campbell

Walden Faculty and Staff Publications

The fatherhood role is influenced by culture, religion, social factors, and economic norms. In Jamaica pregnancy is often treated as a female only event. Women are left to visit their clinics alone and have support from female family members. The man’s focus is providing financial support. In the past fathers were subjected to migrant labor and left their families for long periods. This tradition remained even when they were not working. Today, men are taking on more of the role of fatherhood, becoming involved and supportive and experiencing the privilege of pregnancy though of a secondary nature through their partner’s …

Integrating Microbial And Host Transcriptomics To Characterize Asthma-Associated Microbial Communities., Eduardo Castro-Nallar, Ying Shen, Robert J. Freishtat, Marcos Pérez-Losada, Solaiappan Manimaran, Et Al.

Pediatrics Faculty Publications

BACKGROUND: The relationships between infections in early life and asthma are not completely understood. Likewise, the clinical relevance of microbial communities present in the respiratory tract is only partially known. A number of microbiome studies analyzing respiratory tract samples have found increased proportions of gamma-Proteobacteria including Haemophilus influenzae, Moraxella catarrhalis, and Firmicutes such as Streptococcus pneumoniae. The aim of this study was to present a new approach that combines RNA microbial identification with host gene expression to characterize and validate metagenomic taxonomic profiling in individuals with asthma.

METHODS: Using whole metagenomic shotgun RNA sequencing, we characterized and compared the microbial …

Pharmacologically-Induced Mitotic Synchrony In Airway Epithelial Cells As A Mechanism Of Action Of Anti-Inflammatory Drugs, Robert J. Freishtat, Gustavo Nino, Y. Tsegaye, Sarah E. Alcala, Angela S. Benton, Alan M. Watson, E.K.M. Reeves, S. K. Haider, Jesse M. Damsker

Pediatrics Faculty Publications

Background

Mitotic synchrony is the synchronous progression of a population of cells through the cell cycle and is characteristic of non-diseased airway epithelial cells. However, we previously showed that asthmatic airway epithelial cells are characterized by mitotic asynchrony and are pro-inflammatory as a result. Glucocorticoids can induce mitotic synchrony that in turn suppresses the pro-inflammatory state of diseased cells, suggesting a novel anti-inflammatory mechanism of action. Herein, we benchmarked traditional glucocorticoids against the ability of a new clinical-stage dissociative steroidal drug, VBP15, for mitotic resynchronization and associated anti-inflammatory activity in asthmatic airway epithelial cells.

Methods

Primary airway epithelial cells differentiated …

Are Immune Modulating Single Nucleotide Polymorphisms Associated With Necrotizing Enterocolitis?, Ashanti L Franklin, Mariam Said, Clint D Cappiello, Heather Gordish-Dressman, Zohreh Tatari-Calderone, Stanislav Vukmanovic, Khodayar Rais-Bahrami, Naomi L.C. Luban, Joseph M. Devaney, Anthony D. Sandler

Pediatrics Faculty Publications

Necrotizing enterocolitis (NEC) is a devastating gastrointestinal emergency. The purpose of this study is to determine if functional single nucleotide polymorphisms (SNPs) in immune-modulating genes pre-dispose infants to NEC. After Institutional Review Board approval and parental consent, buccal swabs were collected for DNA extraction. TaqMan allelic discrimination assays and BglII endonuclease digestion were used to genotype specific inflammatory cytokines and TRIM21. Statistical analysis was completed using logistic regression. 184 neonates were analyzed in the study. Caucasian neonates with IL-6 (rs1800795) were over 6 times more likely to have NEC (p = 0.013; OR = 6.61, 95% CI 1.48-29.39), and over …

Pregnant And Postpartum Women’S Experiences And Perspectives On The Acceptability And Feasibility Of Copackaged Medicine For Antenatal Care And Pmtct In Lesotho, Michelle M. Gill, Heather J. Hoffman, Appolinaire Tiam, Florence M. Mohai, Mokone Majoalane, Anthony Isavwa, Laura Guay, +4 Additional Authors

Epidemiology Faculty Publications

Objective. To improve PMTCT and antenatal care-related service delivery, a pack with centrally prepackaged medicine was rolled out to all pregnant women in Lesotho in 2011. This study assessed acceptability and feasibility of this copackaging mechanism for drug delivery among pregnant and postpartum women.

Methods. Acceptability and feasibility were assessed in a mixed method, cross-sectional study through structured interviews (SI) and semistructured interviews (SSI) conducted in 2012 and 2013.

Results. 290 HIV-negative women and 437 HIV-positive women (n=727) participated. Nearly all SI participants found prepackaged medicines acceptable, though modifications such as size reduction of the pack were …

Association Between Dietary Patterns During Pregnancy And Birth Size Measures In A Diverse Population In Southern Us, Uriyoan Colón-Ramos, Susan B. Racette, Jody M. Ganiban, Thuy G. Nguyen, Mehmet Kocak, Kecia N. Carroll, Eszter Volgyi, Frances A. Tylavsky

Global Health Faculty Publications

Despite increased interest in promoting nutrition during pregnancy, the association between maternal dietary patterns and birth outcomes has been equivocal. We examined maternal dietary patterns during pregnancy as a determinant of offspring’s birth weight-for-length (WLZ), weight-for-age (WAZ), length-for-age (LAZ), and head circumference (HCZ) Z-scores in Southern United States (n = 1151). Maternal diet during pregnancy was assessed by seven dietary patterns. Multivariable linear regression models described the association of WLZ, WAZ, LAZ, and HCZ with diet patterns controlling for other maternal and child characteristics. In bivariate analyses, WAZ and HCZ were significantly lower for processed and processed-Southern compared to healthy …

Co2 And H2o: Understanding Different Stakeholder Perspectives On The Use Of Carbon Credits To Finance Household Water Treatment Projects., Sarah K. Summers, Rochelle Rainey, Maneet Kaur, Jay P. Graham

Global Health Faculty Publications

Background

Carbon credits are an increasingly prevalent market-based mechanism used to subsidize household water treatment technologies (HWT). This involves generating credits through the reduction of carbon emissions from boiling water by providing a technology that reduces greenhouse gas emissions linked to climate change. Proponents claim this process delivers health and environmental benefits by providing clean drinking water and reducing greenhouse gases. Selling carbon credits associated with HWT projects requires rigorous monitoring to ensure households are using the HWT and achieving the desired benefits of the device. Critics have suggested that the technologies provide neither the benefits of clean water nor …

Challenges And Opportunities Associated With Neglected Tropical Disease And Water, Sanitation And Hygiene Intersectoral Integration Programs., E. Anna Johnston, Jordan Teague, Jay P. Graham

Global Health Faculty Publications

BACKGROUND:

Recent research has suggested that water, sanitation, and hygiene (WASH) interventions, in addition to mass drug administration (MDA), are necessary for controlling and eliminating many neglected tropical diseases (NTDs).

OBJECTIVES:

This study investigated the integration of NTD and WASH programming in order to identify barriers to widespread integration and make recommendations about ideal conditions and best practices critical to future integrated programs.

METHODS:

Twenty-four in-depth, semi-structured interviews were conducted with key stakeholders in the global NTD and WASH sectors to identify barriers and ideal conditions in programmatic integration.

RESULTS:

The most frequently mentioned barriers to WASH and NTD integration …

Tracking Global Fund Hiv/Aids Resources Used For Sexual And Reproductive Health Service Integration: Case Study From Ethiopia, Sangeeta Mookherji, Samantha Ski, Dale Huntington

Global Health Faculty Publications

Objective/Background

The Global Fund to Fight AIDS, Tuberculosis & Malaria (GF) strives for high value for money, encouraging countries to integrate synergistic services and systems strengthening to maximize investments. The GF needs to show how, and how much, its grants support more than just HIV/AIDS, TB and malaria.

Sexual and Reproductive Health (SRH) has been part of HIV/AIDS grants since 2007. Previous studies showed the GF PBF system does not allow resource tracking for SRH integration within HIV/AIDS grants. We present findings from a resource tracking case study using primary data collected at country level.

Methods

Ethiopia was the study …

Functional Properties Of Resting State Networks In Healthy Full-Term Newborns., Josepheen De Asis-Cruz, Marine Bouyssi-Kobar, Iordanis Evangelou, Gilbert Vezina, Catherine Limperopoulos

Radiology Faculty Publications

Objective, early, and non-invasive assessment of brain function in high-risk newborns is critical to initiate timely interventions and to minimize long-term neurodevelopmental disabilities. A prerequisite to identifying deviations from normal, however, is the availability of baseline measures of brain function derived from healthy, full-term newborns. Recent advances in functional MRI combined with graph theoretic techniques may provide important, currently unavailable, quantitative markers of normal neurodevelopment. In the current study, we describe important properties of resting state networks in 60 healthy, full-term, unsedated newborns. The neonate brain exhibited an efficient and economical small world topology: densely connected nearby regions, sparse, but …

Factors Associated With Recent Hiv Testing Among High-Risk Men Who Have Sex With Men: A Cross-Sectional Study In Cambodia, Siyan Yi, Sovannary Tuot, Pheak Chhoun, Carinne M. Brody, Khuondyla Pal, Sopheap Oum

Background: Despite remarkable success in the fight against HIV, HIV prevalence in many countries remains high among key populations including men who have sex with men (MSM), and HIV testing rates is relatively low among this hard-to-reach population. This cross-sectional study explores factors associated with recent HIV testing among MSM in Cambodia.

Methods: This study was conducted in 2014 and included 384 MSM randomly selected from two provinces of Battembang and Siem Reap, using a two-stage cluster sampling method. A structured questionnaire was used for face-to-face interviews to collect data on socio-demographic characteristics, HIV testing history, sexual behaviors, …

Improving Education Opportunity, Health, And Quality Of Life Of Orphans And Vulnerable Children: The Sustainable Action Against Hiv And Aids In Communities (Sahacom), Siyan Yi, Pheak Chhoun, Samantha Brant, Kelley Kita, Sovannary Tuot

Aims: This study evaluated the impact of the Sustainable Action against HIV and AIDS in Communities (SAHACOM) project in improving education opportunity, health, and quality of life of orphans and vulnerable children (OVC) in Cambodia.

Study Design: Operational intervention study.

Place and Duration of the Study: Five provinces in Cambodia, from 2010 to 2014.

Methodology: A two-stage cluster sampling method was used to select 756 OVC at midterm and 785 OVC at end line for face-to-face interviews. Outcome indicators from end line (2014) were compared to those obtained at midterm (2012). Where possible, the data were also compared with data …

Aids-Related Stigma And Mental Disorders Among People Living With Hiv: A Cross-Sectional Study In Cambodia, Siyan Yi, Pheak Chhoun, Samedy Suong, Carinne M. Brody, Sovannary Tuot

Background: AIDS-related stigma and mental disorders are the most common conditions in people living with HIV (PLHIV). We therefore conducted this study to examine the association of AIDS-related stigma and discrimination with mental disorders among PLHIV in Cambodia.

Methods: A two-stage cluster sampling method was used to select 1,003 adult PLHIV from six provinces. The People Living with HIV Stigma Index was used to measure stigma and discrimination, and a short version of general health questionnaire (GHQ-12) was used to measure mental disorders. Multivariate logistic regression analysis was conducted.

Results: The reported experiences of discrimination in communities …

Factors Associated With Inconsistent Condom Use Among Men Who Have Sex With Men In Cambodia, Siyan Yi, Sovannary Tuot, Pheak Chhoun, Khuondyla Pal, Khimuy Tith, Carinne M. Brody

Background: Compared to the general population, men who have sex with men (MSM) are at greater risk for HIV and less understood due to their more hidden and stigmatized nature. Moreover, the discrepancy in findings in the literature merits further investigations in MSM populations from different cultures and settings. We therefore conducted this study to explore factors associated with inconsistent condom use among high-risk MSM in Cambodia.

Methods: This cross-sectional study was conducted in 2014 among 367 MSM randomly selected from Battembang and Siem Reap using a two-stage cluster sampling method. A structured questionnaire was used for face-to-face interviews to …

Physiological And Psychological Changes Following Liposuction Of Large Volumes Of Fat In Overweight And Obese Women, Allan Geliebter, Emily Krawitz, Tatiana Ungredda, Ella Peresechenski, Sharon Y. Giese

Lander College of Arts and Sciences Publications and Research

Background: Liposuction can remove a substantial amount of body fat. We investigated the effects of liposuction of large volumes of fat on anthropometrics, body composition (BIA), metabolic hormones, and psychological measures in overweight/obese women. To our knowledge, this is the first study to examine both physiological and psychological changes following liposuction of large volumes of fat in humans.

Method: Nine premenopausal healthy overweight/obese women (age = 35.9 ± 7.1 SD, weight = 84.4 kg ± 13.6, BMI = 29.9 kg/m2 ± 2.9) underwent liposuction, removing 3.92 kg ± 1.04 SD of fat. Following an overnight fast, height, weight, …

Ghrelin, Timo D. Müller, Rubén Nogueiras, Mark L. Andermann, Zane B. Andrews, Stefan Anker, Jesús Argente, Allan Geliebter

Lander College of Arts and Sciences Publications and Research

Background: The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence supports more complicated and nuanced roles for the hormone, which go beyond the regulation of systemic energy metabolism.

Scope of review: In this review, we discuss the diverse biological functions of ghrelin, the regulation of its secretion, and address questions that still remain 15 years after its discovery.

Major conclusions: In recent years, ghrelin has been found to have a plethora of central and peripheral actions in distinct areas including learning and memory, gut motility …

Mosquito-Borne Diseases In Mississippi, Ryan J. Rodriguez

Department of Entomology: Distance Master of Science Projects

Life Cycle:
Egg Must be exposed to water to hatch
Larvae Live in aquatic habitats
Pupa Stay near the surface of water to breath
Adults: Only females feed on blood; Males feed on nectar

Public Health •Besides being a nuisance, they cause numerous health hazards to humans (and other animals) •In some cases, they may cause severe allergic reactions •Diseases they transmit: •Eastern Equine Encephalitis •Japanese Encephalitis •La Crosse Encephalitis •St. Louis Encephalitis •West Nile Virus •Western Equine Encephalitis •Dengue Fever •Malaria •Rift Valley Fever •Yellow Fever

Mosquito-Borne Diseases in Mississippi and its Vectors •Chikungunya Virus •Aedes species •Eastern Equine …

Motor Practice Effects And Sensorimotor Integration In Adults Who Stutter: Evidence From Visuomotor Tracking Performance., Victoria Tumanova, Patricia M. Zebrowski, Shawn S. Goodman, Richard M. Arenas

Communication Sciences and Disorders - All Scholarship

Purpose—The purpose of this study was to utilize a visuomotor tracking task, with both the jaw and hand, to add to the literature regarding non-speech motor practice and sensorimotor integration (outside of auditory-motor integration domain) in adults who do (PWS) and do not (PWNS) stutter.

Method—Participants were 15 PWS (14 males, mean age = 27.0) and 15 PWNS (14 males, mean age = 27.2). Participants tracked both predictable and unpredictable moving targets separately with their jaw and their dominant hand, and accuracy was assessed by calculating phase and amplitude difference between the participant and the target. Motor practice effect was …

Using A Novel Optogenetic Approach To Directly Assess 5-Ht1a Somatodendritic Autoreceptor Function In Response To Chronic Selective Serotonin Reuptake Inhibitor Treatment, Kelly Marie Mcgregor

Wayne State University Dissertations

Antidepressant drugs are widely used but their mechanism of action remains only partially understood. One leading hypothesis holds that a key effect of chronic treatment with a Selective Serotonin Reuptake Inhibitor (SSRI) is loss of somatodendritic 5-HT1A receptor-mediated autoinhibition in serotonergic neurons of the dorsal raphe nucleus (DRN). However, technical limitations have prevented direct testing of this hypothesis. In the current study we took advantage of optogenetic strategies to assess the effects of the classic SSRI fluoxetine on 5-HT1A receptor-mediated autoinhibition. We conducted these experiments in mice expressing the light-sensitive ion channel Channelrhodopsin (ChR) in 5-HT neurons to facilitate their …

Sleep Occupation Quality And Occupation-Based Hand Function In Carpal Tunnel Syndrome, Angela M. Goorman Ms, Otr/L

Occupational Therapy Doctorate Capstone Projects

Sleep disturbance is considered a health crisis by Centers for Disease Control and Prevention (2013). It is not uncommon for clients with carpal tunnel syndrome (CTS) to also have poor sleep (Patel et al., 2014). The purpose of this study was to investigate the impact of sleep quality on hand function, while controlling for pain level and CTS diagnostic electromyography severity in CTS clients at a Southern Arizona orthopedic practice. This study tested the following hypothesis: Sleep quality is positively associated with hand function above and beyond the association of pain and CTS severity to occupation-based hand function in CTS …

Using Heart Models For Physiology Teaching And Learning, Sowmya Anjur

Faculty Publications & Research

Over the last few decades, there has been a shift in the classroom from a teacher-centered learning environment, with its emphasis on content delivery, to a student-centered environment focused on inquiry learning (http://www.nsta.org/docs/ PositionStatement_Scienti cInquiry.pdf). With the Next Generation Science Standards (NGSS, 2012) being adopted by many states, students are no longer passive listeners, but actively participate in and initiate class discussions (Weimar, 2013). Additionally, recent technological advances have allowed students to acquire information from sources such as the internet which no longer necessitates the teacher giving lectures (Silver- thorn, 2006). The more student-centered learning environment allows students to better …

Exploring And Examining Sensory Processing And Social Participation In Gifted Students, Gwendolyn Goodman

MOT Student Capstones

The purpose of this project was to examine and explore the relationship of sensory processing and social anxieties among the gifted in order to better inform occupational intervention and education. With limited research regarding the sensory processing of this specific group, understanding where sensory and social characteristics intersect can assist in understanding occupation based needs. Gifted students have historically been labeled with oddities of social norm presentation and sensory idiosyncrasies. Occupational therapists, educators and parents can be empowered and broaden student diversity to increase participation in occupation for students that are otherwise deemed "self sufficienf' due to their intelligence yet …

Reaping The Rewards Of Gardening: A One Day Workshop Demonstrating The Holistic Effects Of Incorporating Horticulture And Gardening Into Long Term Care Facilities, Annah Furr

MOT Student Capstones

As the American population continues to age the number of individuals ages 60 and over that will need full-time care will eventually outweigh the number of people 15 and under needing care. The total cost of care for the elderly individual will continue to rise due to an increased need for assist in institutional care. The elderly entering institutional care will experience physical, mental, emotional, and social changes that will influence their overall health and wellbeing. These changes can potentially start a domino effect that can lead to multiple comorbidities and global decline in abilities. Finding ways to promote positive …

Occupation Based And Compensatory Techniques To Promote Functional Independence In Clients With Chemotherapy Induced Peripheral Neuropathy, Kathryn W. Mckinnell

MOT Student Capstones

The origin of this project was derived from a personal desire to acquire more knowledge related to a population where occupational therapy is an emerging area of practice. Coinciding with this craving for more comprehension was the great need for occupational therapy program development within the oncology service line at an area hospital. These factors provided an excellent forum for the development of personal and professional growth. As the project developed, it became increasingly apparent that the topic population would also greatly benefit from the outcomes of the literature synthetization required to fulfill the first two needs. These factors combined …

Higher Education: Opinions And Participation Among Nonmetropolitan Nebraskans: 2015 Nebraska Rural Poll Results, Rebecca J. Vogt, Cheryl A. Burkhart-Kriesel, Randolph L. Cantrell, Bradley Lubben, L. J. Mcelravy

Rural Futures Institute: Publications

Includes

Executive Summary

Introduction

Education or Training Taken

Participation in Education or Training Activities during Past Two Years

Types of Education or Training Taken in Past Two Years

Satisfaction with Types of Education or Training

Satisfaction with Types of Education or Training

Opinions about Education

Challenges To Breastfeeding Infants With Phenylketonuria, Sandra Banta-Wright

Faculty Publications - College of Nursing

Breastfeeding duration for infants with phenylketonuria (PKU) is less than other full-term infants. However, no study has examined the challenges encountered by mothers' breastfeeding infants with PKU. In 75 mothers of a child with PKU, three categories of breastfeeding challenges were identified: common breastfeeding issues, breastfeeding and PKU, and no challenges. The common breastfeeding issues can be identified in the literature but for these mothers, the issues are heightened due to frequent phenylalanine (Phe) monitoring. Even so, many mothers adapt breastfeeding to maintain desired Phe levels. A few mothers had no issues and were the exception, not the norm.

Perceptions Of Physician Assistant Students ’ Readiness With System-Based Vs. Problem-Based Physical Diagnosis Curriculum, Carl Garrubba, Kelly Donkers, Laura Daniel, Carol Ennulat

Physician Assistant Studies | Faculty Scholarship

Purpose: The purpose of this study was to identify students’ perceptions of the curriculum in two different cohorts who received two different delivery styles (system-based or problem-based) of physical diagnosis curriculum to determine if significant differences were present, and to identify how each cohort performed on their clinical experiences (CEs). Methods: One-hundred and sixteen students at one physician assistant (PA) program from two cohorts of students were surveyed using a true/false survey (analyzed by chi-square) regarding their perceptions of their preparedness for clinical rotations with regard to the ability to perform physical examinations. Clinical preceptor evaluations were also analyzed for …

Clinical Significance Of Left Atrial Anatomic Abnormalities Identified By Cardiac Computed Tomography, Ara V. Vehian, Brian G. Choi, Satinder Rekhi, Heather A. Young, Raman S. Dusaj, Robert K. Zeman

Epidemiology Faculty Publications

Purpose: The clinical significance of newly identified left atrial anatomic abnormalities (LAAA)— accessory appendages, diverticula, septal pouches—by multidetector CT (MDCT) remains unclear. Similar anatomical outpouchings, i.e., the left atrial appendage, have been associated with cardioembolisms and arrhythmia. To test the hypothesis that LAAA are also associated with increased risk of these events, we performed a retrospective analysis to examine the association of LAAA in patients undergoing CT with embolic events and arrhythmia.

Methods: 242 patients (mean age 56 SD 12 years, 41% female) were selected who had CT coronary angiography performed with 64-row MDCT between 2007 and 2012 if complete …

Parity And Diabetes Risk Among Hispanic Women From Colombia: Cross-Sectional Evidence, Pablo Cure, Heather J. Hoffman, Carlos Cure-Cure

Epidemiology Faculty Publications

Objective

The association between parity and type 2 diabetes has been studied in developed countries and in Singapore and Chinese women but not in Hispanics. Herein we evaluated the association between parity (number of live births) with diabetes in a group of Hispanic postmenopausal women from Colombia.

Research design and methods

Herein we evaluated the association between parity and diabetes in a population of 1,795 women from Colombia. Women were divided in birth categories (0 [referent], 1 or 2, 3–5, 6 or > births). Medical history of diabetes and anthropometric characteristics were recorded. Logistic regressions were performed in order to find …

Implementation Of Point-Of-Care Diagnostics Leads To Variable Uptake Of Syphilis, Anemia And Cd4+ T-Cell Count Testing In Rural Maternal And Child Health Clinics., Caroline De Schacht, Carlota Lucas, Nádia Sitoe, Rhoderick Machekano, Patrina Chongo, Laura Guay, Et Al.

Epidemiology Faculty Publications

INTRODUCTION: Anemia, syphilis and HIV are high burden diseases among pregnant women in sub-Saharan Africa. A quasi-experimental study was conducted in four health facilities in Southern Mozambique to evaluate the effect of point-of-care technologies for hemoglobin quantification, syphilis testing and CD4+ T-cell enumeration performed within maternal and child health services on testing and treatment coverage, and assessing acceptability by health workers.

METHODS: Demographic and testing data on women attending first antenatal care services were extracted from existing records, before (2011; n = 865) and after (2012; n = 808) introduction of point-of-care testing. Study outcomes per health facility were compared …