Medicine and Health Sciences Commons^™

A Proteinuria Cut-Off Level Of 0.7 G/Day After 12 Months Of Treatment Best Predicts Long-Term Renal Outcome In Lupus Nephritis: Data From The Maintain Nephritis Trial, F. Tamirou, B. R. Lauwerys, M. Dall'era, M. Mackay, B. Rovin, R. Cervera, F. A. Houssiau, D. Abramowicz, L. De Bruxelles, R. Westhovens, +35 Additional Authors

Journal Articles

BACKGROUND: Although an early decrease in proteinuria has been correlated with good long-term renal outcome in lupus nephritis (LN), studies aimed at defining a cut-off proteinuria value are missing, except a recent analysis performed on patients randomised in the Euro-Lupus Nephritis Trial, demonstrating that a target value of 0.8 g/day at month 12 optimised sensitivity and specificity for the prediction of good renal outcome. The objective of the current work is to validate this target in another LN study, namely the MAINTAIN Nephritis Trial (MNT). METHODS: Long-term (at least 7 years) renal function data were available for 90 patients randomised …

Sustaining The Rheumatology Research Enterprise, A. Davidson, D. Polsky

Journal Articles

No abstract provided.

Tyk2 Protein-Coding Variants Protect Against Rheumatoid Arthritis And Autoimmunity, With No Evidence Of Major Pleiotropic Effects On Non-Autoimmune Complex Traits, D. Diogo, L. Bastarache, K. P. Liao, R. R. Graham, R. S. Fulton, J. D. Greenberg, S. Eyre, A. Lee, P. K. Gregersen, R. M. Plenge, +44 Additional Authors

Journal Articles

Despite the success of genome-wide association studies (GWAS) in detecting a large number of loci for complex phenotypes such as rheumatoid arthritis (RA) susceptibility, the lack of information on the causal genes leaves important challenges to interpret GWAS results in the context of the disease biology. Here, we genetically fine-map the RA risk locus at 19p13 to define causal variants, and explore the pleiotropic effects of these same variants in other complex traits. First, we combined Immunochip dense genotyping (n = 23,092 case/control samples), Exomechip genotyping (n = 18,409 case/control samples) and targeted exon-sequencing (n = 2,236 case/controls samples) to …

Widespread Non-Additive And Interaction Effects Within Hla Loci Modulate The Risk Of Autoimmune Diseases, T. Lencz, A. J. Deutsch, B. Han, X. Hu, Y. Okada, S. Eyre, M. Knapp, A. Zhernakova, P. K. Gregersen, S. Raychaudhuri, +27 Additional Authors

Journal Articles

Human leukocyte antigen (HLA) genes confer substantial risk for autoimmune diseases on a log-additive scale. Here we speculated that differences in autoantigen-binding repertoires between a heterozygote's two expressed HLA variants might result in additional non-additive risk effects. We tested the non-additive disease contributions of classical HLA alleles in patients and matched controls for five common autoimmune diseases: rheumatoid arthritis (ncases = 5,337), type 1 diabetes (T1D; ncases = 5,567), psoriasis vulgaris (ncases = 3,089), idiopathic achalasia (ncases = 727) and celiac disease (ncases = 11,115). In four of the five diseases, we observed highly significant, non-additive dominance effects (rheumatoid arthritis, …

Pioglitazone In Early Parkinson's Disease: A Phase 2, Multicentre, Double-Blind, Randomised Trial, T. Simuni, K. Kieburtz, B. Tilley, J. J. Elm, B. Ravina, D. Babcock, M. Emborg, Andrew Feigin, R. Zweig, Parkinson Ninds Exploratory Trials, +38 Additinal Authoris

Journal Articles

Background A systematic assessment of potential disease-modifying compounds for Parkinson's disease concluded that pioglitazone could hold promise for the treatment of patients with this disease. We assessed the effect of pioglitazone on the progression of Parkinson's disease in a multicentre, double-blind, placebo-controlled, futility clinical trial. Methods Participants with the diagnosis of early Parkinson's disease on a stable regimen of 1 mg/day rasagiline or 10 mg/day selegiline were randomly assigned (1:1:1) to 15 mg/day pioglitazone, 45 mg/day pioglitazone, or placebo. Investigators were masked to the treatment assignment. Only the statistical centre and the central pharmacy knew the treatment name associated with …

Inflammatory Bowel Disease As A Risk Factor For Premature Coronary Artery Disease, P. Ruisi, J. N. Makaryus, M. Ruisi, A. N. Makaryus

Journal Articles

BACKGROUND: Crohn's disease and ulcerative colitis are both systemic chronic diseases that alter bowel physiology. The central process in inflammatory bowel disease (IBD) and the associated manifestations are the result of B-cell production of IgG autoantibodies directed against self-antigens in various organ systems including coronary endothelium. Previous studies have demonstrated significant micro-vascular endothelial dysfunction in patients with IBD compared to patients not affected by the disease. We sought to analyze the relation, if any, between IBD and the development of premature coronary artery disease (CAD). METHODS: We queried our hospital database to find IBD patients admitted to the hospital from …

Health Professions Division Catalog 2015-2016, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Synapse, Alabama Health Libraries Association

Synapse - Newsletter of ALHeLa

This is the Winter, 2015 edition of the ALHeLa newsletter - Synapse.

Contents include:

• Note from the President
• ALHeLA Executive Committee
• Note from the Editor
• Conferences & Observances
• News from MLA
• Health Observances
• 2014 ALHeLA Annual Meeting
• 2014 ALHeLA Executive Board Meeting
• Alabama College of Osteopathic Medicine Starts New Academic Digital Library
• Celebrations
• Member Spotlight
• USA Biomedical Library Hosts 64th Annual SC/ MLA Meeting

Predictors Of Stress And Coping Strategies Of Us Accelerated Vs. Generic Baccalaureate Nursing Students: An Embedded Mixed Methods Study, Linda Wolf, Andrea Warner Stidham, Ratchneewan Ross

Nursing Faculty Publications

Background:Stress is an inevitable part of life and is especially pervasive in the lives of nursing students. Identifying the predictors of stress as well as coping strategies used can allow for the implementation of appropriate coping interventions to assist in the management of stress in nursing students. Mixed methods research that has been undertaken to gain an understanding about student stress, especially juxtaposing generic versus accelerated nursing students could not be identified. Objectives: (1) Identify predictors of stress between accelerated and generic Baccalaureate Nursing (BSN) students; and (2) Describe stressors and coping strategies used by accelerated students in comparison with …

Ada News Convention Daily - 2015 Day 2, American Dental Association, Publishing Division

ADA News

The ADA News Daily (also called the ADA News Convention Daily) is a special edition of the ADA News published each day during American Dental Association Annual Sessions.

Ada Constitution & Bylaws (2015), American Dental Association

Constitution & Bylaws

The ADA Commons Constitution & Bylaws archival collection comprises printed issues of the American Dental Association's Constitution and Bylaws. The collection also includes the ADA Charter and the ADA Code of Ethics issued 1924-1946.

Subanesthetic Ketamine Infusions For The Treatment Of Children And Adolescents With Chronic Pain: A Longitudinal Study, Kathy A. Sheehy, Elena A. Muller, Caroline Lippold, Mehdi Nouraie, Julia C. Finkel, Zenaide M.N. Quezado

Anesthesiology and Critical Care Medicine Faculty Publications

Background

Chronic pain is common in children and adolescents and is often associated with severe functional disability and mood disorders. The pharmacological treatment of chronic pain in children and adolescents can be challenging, ineffective, and is mostly based on expert opinions and consensus. Ketamine, an N-methyl-D-aspartate receptor antagonist, has been used as an adjuvant for treatment of adult chronic pain and has been shown, in some instances, to improve pain and decrease opioid-requirement. We examined the effects of subanesthetic ketamine infusions on pain intensity and opioid use in children and adolescents with chronic pain syndromes treated in an outpatient setting. …

Lateralization Of Mesial Temporal Lobe Epilepsy With Chronic Ambulatory Electrocorticography, David King-Stephens, Emily Mirro, Peter B. Weber, Kenneth D. Laxer, Paul C. Van Ness, Donald C. Shields, +24 Additional Authors

Neurological Surgery Faculty Publications

Objective

Patients with suspected mesial temporal lobe (MTL) epilepsy typically undergo inpatient video–electroencephalography (EEG) monitoring with scalp and/or intracranial electrodes for 1 to 2 weeks to localize and lateralize the seizure focus or foci. Chronic ambulatory electrocorticography (ECoG) in patients with MTL epilepsy may provide additional information about seizure lateralization. This analysis describes data obtained from chronic ambulatory ECoG in patients with suspected bilateral MTL epilepsy in order to assess the time required to determine the seizure lateralization and whether this information could influence treatment decisions.

Methods

Ambulatory ECoG was reviewed in patients with suspected bilateral MTL epilepsy who were …

Epidural Steroid Injections Compared With Gabapentin For Lumbosacral Radicular Pain: Multicenter Randomized Double Blind Comparative Efficacy Study, Steven P. Cohen, Steven Hanling, Mark C. Bicket, Ronald L. White, Elias Velzi, Connie Kurihara, Zirong Zhao, Salim Hayek, Kevin B. Guthmiller, Scott R. Griffith, Vitaly Gordin, Mirinda Anderson White, Yakov Vorobeychik, Paul F. Pasquina

Neurology Faculty Publications

Objective To evaluate whether an epidural steroid injection or gabapentin is a better treatment for lumbosacral radiculopathy.

Design A multicenter randomized study conducted between 2011 and 2014. Computer generated randomization was stratified by site. Patients and evaluating physicians were blinded to treatment outcomes.

Settings Eight military, Veterans Administration, and civilian hospitals.

Participants 145 people with lumbosacral radicular pain secondary to herniated disc or spinal stenosis for less than four years in duration and in whom leg pain is as severe or more severe than back pain.

Interventions Participants received either epidural steroid injection plus placebo pills or sham injection plus …

The Carcinogenic Liver Fluke Opisthorchis Viverrini Is A Reservoir For Species Of Helicobacter., Raksawan Deenonpoe, Chariya Chomvarin, Chawalit Pairojkul, Yaowalux Chamgramol, Alex Loukas, Paul J. Brindley, Banchob Sripa

Microbiology, Immunology, and Tropical Medicine Faculty Publications

There has been a strong, positive correlation between opisthorchiasis-associated cholangiocarcinoma and infection with Helicobacter. Here a rodent model of human infection with Opisthorchis viverrini was utilized to further investigate relationships of apparent co-infections with O. viverrini and H. pylori. A total of 150 hamsters were assigned to five groups: i) Control hamsters not infected with O. viverrini; ii) O. viverrini-infected hamsters; iii) non-O. viverrini infected hamsters treated with antibiotics (ABx); iv) O. viverrini-infected hamsters treated with ABx; and v) O. viverrini-infected hamsters treated both with ABx and praziquantel (PZQ). Stomach, gallbladder, liver, colonic tissue, colorectal feces and O. viverrini worms …

Comparison Of Findings Using Ultrasonography And Cystoscopy In Urogenital Schistosomiasis In A Public Health Centre In Rural Angola, Julio Santos, Jacinta Chaves, Heriberto Araujo, Nuno Vale, Jose Manuel Costa, Paul J. Brindley, Carlos Lopes, Jean Naples, Clive Shiff, Jorge Dupret, Lucio Lara Santos

Microbiology, Immunology, and Tropical Medicine Faculty Publications

Background. Schistosomiasis is a chronic disease caused by infection with parasitic worms of the genus Schistosoma. In sub-Saharan Africa, infections with S. haematobium are most common. Cystoscopic examination (CE) has been accepted as the gold-standard test for detecting the late manifestations of schistosomiasis, including urothelial cancer of the bladder. However, this procedure is invasive and 10 - 40% of tumours may remain undetected. A non-invasive examination and a new generation of biomarkers are needed for better monitoring of the disease.

Objective. To assess the usefulness of ultrasound (US) scans for monitoring of structural urinary tract disease by local public health …

A Simple Method For Discovering Druggable, Specific Glycosaminoglycan-Protein Systems. Elucidation Of Key Principles From Heparin/Heparan Sulfate-Binding Proteins, Aurijit Sarkar, Umesh R. Desai

Psychology Publications

Glycosaminoglycans (GAGs) affect human physiology and pathology by modulating more than 500 proteins. GAG-protein interactions are generally assumed to be ionic and nonspecific, but specific interactions do exist. Here, we present a simple method to identify the GAG-binding site (GBS) on proteins that in turn helps predict high specific GAG–protein systems. Contrary to contemporary thinking, we found that the electrostatic potential at basic arginine and lysine residues neither identifies the GBS consistently, nor its specificity. GBSs are better identified by considering the potential at neutral hydrogen bond donors such as asparagine or glutamine sidechains. Our studies also reveal that an …

Developing An Online Direct-Assessment Competency-Based Masters Of Healthcare Administration: Insights, Challenges, And Lessons Learned, Lisa Monica Mcintyre-Hite, Mountasser Kadrie Dr., Heather Pederson, Terry Hudgins

Walden Faculty and Staff Publications

In response to the increasing complexity in healthcare delivery environments, there is evidence from literature and the healthcare industry to indicate healthcare employers are seeking graduates in healthcare administration programs who have strong core competencies and proven problem solving skills. The purpose of this article is to describe the unique challenges and opportunities related to developing a direct-assessment, competency-based online Master’s in Healthcare Administration program. The United States Department of Education (2013) provided general guidelines for direct-assessment programs noting that, instead of measuring student learning via credit hours, learning is measured via direct assessment measures like “projects, papers, examinations, presentations, …

The Association Between Sleep Loss And Women’S Wellness Decisions, Gudeta D. Fufaa, Amber S. Linde

Walden Faculty and Staff Publications

Sleep loss is an important determinant of health status owing to its relationships with molecular, immune, and neural changes; these changes, in turn, are important etiological mechanisms for the development of cardiovascular, metabolic diseases and increased risk of accident related injuries. While the association between sleep loss and risk of weight gain is established, studies on the association between sleep loss and nutrition and physical activity are limited. The purpose of this research was to determine if there are significant associations between reported sleep variations and nutrition and physical activity level while recognizing the association between body mass index (BMI) …

Doctor Of Pharmacy-Philosophy Of Pharmacy 2015, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Undergraduate Nursing, Nova Southeastern University

Health Professions Divisions Course Catalogs and Course Descriptions

No abstract provided.

Early Intervention Of Non-Invasive Positive Pressure Ventilation In Elderly Patients With Rib Fractures, Jaclyn Gosnell

Nursing Theses and Capstone Projects

Rib fractures in the elderly population, 65 years and older, is more prevalent than any other population. Mortality increases with each year over the age of 65 and with each number of ribs fractured. Rib fractures are painful and can lead to a decreased respiratory effort. This results in complications such as pneumonia, respiratory depression, respiratory failure, Acute Respiratory Distress Syndrome (ARDS), and respiratory infections. Non-Invasive Positive Pressure Ventilation (NIPPV) assists with reducing the patient efforts to breathe while also ensuring spontaneous lung expansion. NIPPV can assist with promoting positive outcomes in patients with respiratory complications. The purpose of this …

The Use Of Peer Video Via M-Learning To Teach Essential Nursing Skills, Elizabeth Hall Carver

Nursing Theses and Capstone Projects

The purpose of this project was to compare adding an additional educational intervention (the use of an instructional peer video on a mobile device) to standard practice in the skills lab to teach the skill of male and female urinary catheterization and the removal of a urinary catheter. The project had a quasi-experimental design, without control, and utilized a convenience sample of 31 pre-licensure nursing students. Failure rates at skills evaluation were compared between the previous semester A (fall 2014) and semester B (spring 2015). Semester B was subdivided into two groups, with approximately half in the traditional instructional B1 …

Exploration Of Work Environmental Factors That Affect Nurse Job Satisfaction In A Hospital Setting, Mary L. Peeler

Nursing Theses and Capstone Projects

Nurses are experiencing increased stress and dissatisfaction in the health care arena. The work environment impacts nurses’ perception and loyalty to organizations based on satisfaction versus dissatisfaction, including quality patient care. The purpose of this study was to explore work environmental factors that affect nurse job satisfaction in a hospital setting. Marilyn Ray’s Theory of Bureaucratic Caring was the theoretical framework for this study. The research utilized the McCloskey/Mueller Satisfaction Scale (MMSS) to examine factors in an acute care hospital associated with nurse job satisfaction. The study invited 130 nurses from a hospital in rural South Carolina to participate electronically …

The Effect Of Community Education On Osteoporosis Knowledge, Avis O. Morrow

Nursing Theses and Capstone Projects

Osteoporosis is a metabolic disorder characterized by the loss of bone mass, increased bone fragility, and the increased risk of fractures. Bone loss is accelerated when the diet is deficient in vitamin D and calcium. The National Osteoporosis Foundation estimates that 57 million Americans are at risk for this disorder. The risk depends on the amount of bone mass achieved between ages 25-35 and how much bone loss occurs after that age. Bone loss increases after menopause. Lifestyle modifications needed include knowledge of vitamin D, calcium, and exercise recommendations.

Perceived Patient Satisfaction With Hospital Services And Interventions, Marietta Abernathy

Nursing Theses and Capstone Projects

The patient and family voice should be heard in the healthcare setting. Gaining knowledge and insight from a parent of a pediatric patient will allow hospital staff and administrators to see the hospital experience from the vantage point of a patient and family member (Uhl, Fisher, Docherty, & Brandon, 2013). It is important to continually review feedback and suggestions from families of pediatric patients to improve the care of future patients. Ultimately, this will improve patient satisfaction scores, but most importantly, it will improve the experience of pediatric patients (Creating patient and family advisory councils, 2010). The investigator interviewed ten …

Final Semester Associate Degree Nursing Student Stress And Comprehensive Nclex-Rn® Predictor Exam Results, Brittany Hudgins

Nursing Theses and Capstone Projects

This study assessed perceived stress among graduating nursing students and explored the relationship between perceived stress and scores on a comprehensive NCLEX-RN® predictor exam. The goal was to provide data for educators to examine the correlation between student stress levels and comprehensive NCLEX-RN® predictor exam scores. Findings indicated that nursing students had higher than average stress levels based on established averages reported for the Perceived Stress Scale (PSS) three weeks prior to graduation. No relationship was found in regards to stress and ATI Comprehensive Predictor Scores administered two days after students completed the PSS questionnaire. Implications for nurse educators based …

Timeliness Of Patient Discharges: A Comparison Of The Acute Care Discharge Process For Medical And Surgical Patients, Robert Moore

Nursing Theses and Capstone Projects

Patient flow is becoming increasingly important to the efficient operations of an acute healthcare setting. Multiple factors peaking in their influence on the number of patients seeking healthcare services are on a collision course. When the true impact is felt in healthcare the potential for record numbers of patients to seek acute medical care are high. It is imperative to streamline patient flow processes to ensure healthcare facilities have the ability to provide the care sought by patients in a timely manner. This study’s purpose was to assist in increasing the number of patients an acute care facility can provide …

Incorporating Simulation Into Advanced Cardiac Life Support, Lorraine Calwile

Nursing Theses and Capstone Projects

The knowledge and practical skills of the Basic Life Support (BLS) and the Advanced Cardiac Life Support (ACLS) are among the most important determining factors of the cardiopulmonary resuscitation (CPR) success rates. Every year there are millions of healthcare workers that dread coming to ACLS class for fear of failure of the written exam or the mega code. Many of these participants haven’t participated in a code situation since they left class the previous two years. Participants sit in class for two days listening to lectures and going through practice mega codes to prepare them for the final mega code. …

Utilizing Motivational Interviewing To Promote Condom Use Self-Efficacy, Ann Maria Bell

Nursing Theses and Capstone Projects

Condom use is one of the most important preventive mechanisms available to combat sexually transmitted diseases and unintended pregnancies, yet over 70% of adolescents and young adults lack education on the proper use of condoms. Lack of education and confidence in using condoms contributes to a decrease in condom usage, resulting in increased rates of sexually transmitted diseases and unintended pregnancies. The purpose of Project Motivate was to determine if motivational interviewing significantly improves self-efficacy related to condom use among patients presenting for screening of sexually transmitted diseases. The project sought to determine if motivational interviewing is an effective intervention …