Medicine and Health Sciences Commons^™

Genetic And Informatic Analyses Implicate Kif12 As A Candidate Gene Within The Mpkd2 Locus That Modulates Renal Cystic Disease Severity In The Cys1cpk Mouse., Michal Mrug, Juling Zhou, Chaozhe Yang, Bruce J Aronow, Xiangqin Cui, Trenton R Schoeb, Gene P Siegal, Bradley K Yoder, Lisa M. Guay-Woodford

Pediatrics Faculty Publications

We have previously mapped the interval on Chromosome 4 for a major polycystic kidney disease modifier (Mpkd) of the B6(Cg)-Cys1cpk/J mouse model of recessive polycystic kidney disease (PKD). Informatic analyses predicted that this interval contains at least three individual renal cystic disease severity-modulating loci (Mpkd1-3). In the current study, we provide further validation of these predicted effects using a congenic mouse line carrying the entire CAST/EiJ (CAST)-derived Mpkd1-3 interval on the C57BL/6J background. We have also generated a derivative congenic line with a refined CAST-derived Mpkd1-2 interval and demonstrated its dominantly-acting disease-modulating effects (e.g., 4.2-fold increase in total cyst area; …

Extraordinary Diversity Of Immune Response Proteins Among Sea Urchins: Nickel-Isolated Sp185/333 Proteins Show Broad Variations In Size And Charge., Lauren S. Sherman, Catherine S. Schrankel, Kristy J. Brown, L. Courtney Smith

Pediatrics Faculty Publications

Effective protection against pathogens requires the host to produce a wide range of immune effector proteins. The Sp185/333 gene family, which is expressed by the California purple sea urchin Strongylocentrotus purpuratus in response to bacterial infection, encodes a highly diverse repertoire of anti-pathogen proteins. A subset of these proteins can be isolated by affinity to metal ions based on multiple histidines, resulting in one to four bands of unique molecular weight on standard Western blots, which vary depending on the individual sea urchin. Two dimensional gel electrophoresis (2DE) of nickel-isolated protein samples followed by Western blot was employed to detect …

Mllt1 Yeats Domain Mutations In Clinically Distinctive Favourable Histology Wilms Tumours., Elizabeth J Perlman, Samantha Gadd, Stefan T Arold, Anand Radhakrishnan, Daniela S Gerhard, Jeffrey S. Dome, +19 Additional Authors

Pediatrics Faculty Publications

Wilms tumour is an embryonal tumour of childhood that closely resembles the developing kidney. Genomic changes responsible for the development of the majority of Wilms tumours remain largely unknown. Here we identify recurrent mutations within Wilms tumours that involve the highly conserved YEATS domain of MLLT1 (ENL), a gene known to be involved in transcriptional elongation during early development. The mutant MLLT1 protein shows altered binding to acetylated histone tails. Moreover, MLLT1-mutant tumours show an increase in MYC gene expression and HOX dysregulation. Patients with MLLT1-mutant tumours present at a younger age and have a high prevalence of precursor intralobar …

Acceptability Of Telepsychiatry In A Rural Kentucky Community Mental Health Clinic, Leslie Brauner

Doctor of Nursing Practice Projects

While telepsychiatry has been championed as a method to improve access to care and health care delivery to remote regions, the willingness of rural patients to receive psychiatric treatment via telehealth technology remains uncertain (Rohland, Saleh, Rohrer, & Romitti, 2000). Published studies concerning general patient satisfaction with telemedicine are available; however, there is little focus on satisfaction of specialized telepsychiatric care to rural mentally ill adults. A capstone project was conducted to examine the acceptability and satisfaction of telepsychiatry in a rural Kentucky mental health clinic. Patient satisfaction with the modality was assessed using the Telemedicine Satisfaction and Usefulness Questionnaire …

The Nurse Manager's Leadership And Nurse Satisfaction, Deborah Bryant

Doctor of Nursing Practice Projects

Nurse managers face many challenges in today's healthcare environment including how to retain staff. The purpose of this capstone was to give tools to nurse managers on specific units to develop techniques for shaping a positive culture making a difference for the nursing staff, patients, families and others on the nursing units. Culture-shaping tools were taught to five nurse managers after completion of a pre-assessment survey by bedside nurses to determine if the behaviors of the nurse managers could impact the nurse satisfaction and improve retention. Nursing staff were queried for effectiveness in nurse satisfaction after the nurse managers had …

Implementation And Evaluation Of A Team Simulation Training Program, Yvonne Rice

Doctor of Nursing Practice Projects

Trauma care, characterized by complex, shifting priorities, presents many challenges to providers. Traditionally, immediate trauma care has been provided in emergency departments. It has recently been recognized that severely injured patients receive better care with improved outcomes when they bypass the emergency department and are admitted directly to the trauma surgical intensive care unit (TSICU). To assure that TSICU nurses and interprofessional staff are prepared to handle such patients, all new registered nurses in the TSICU of a Level I Trauma Center participate in a one-day Trauma Boot Camp. Originally, the focus of the Trauma Boot Camp was solely on …

Rising Food Insecurity And Conservative Policy In The Us: Impact On The Elderly, Peter S. Arno, Kenneth Knapp, Stephan Russo, Deborah Viola

NYMC Faculty Publications

Food insecurity, a critical problem in the developing world, has recently received increased attention among wealthy nations. Food insecurity, broadly defined, is when a lack of resources prevents household members from having enough food. In the US, food insecurity has been rising while social safety net programs to ameliorate hunger among at-risk households have been targeted for cuts by conservatives. Our main objective was to assess the prevalence and impact of food insecurity among the elderly. In a survey of 500 older, homebound meal clients in New York City, we found that nearly one in five (17%) is food insecure, …

Technology In Transformative Learning Environments, Michael Hamlin

Touro College Los Angeles Publications and Research

Health science educators are increasingly bombarded with proposals to integrate instructional technology into the curriculum to enhance learning. While it may be that providing more options for delivering instruction in different formats provide instructional benefit for educators, the unique nature and goals of health science education require a systematic and integrative approach when instructional technology is introduced into the curriculum. Providing support for transformative learning pedagogies and high-level learning that assists students in developing a reflective professional identity should be a major goal of instructional technology adoption. This chapter develops a framework that health care educators can use to guide …

Treating The Cognitive And Social Dysfunctions Related To Type 2 Diabetes, Joseph Indelicato

The School of Health Sciences Publications and Research

While much has been written about the effects of diabetes on cardiovascular functioning, less attention has been paid upon the role of diabetes on cognitive functioning. While researchers are still debating the pathophysiology of the cognitive dysfunction triggered by diabetes, including the possibility that Alzheimer’s being Type III diabetes, among other possibilities. Less research has targeted addressing these problems among those with diabetes. Social problems associated with having cognitive dysfunctions in diabetics, have received very little attention. Social activities are perhaps the most difficult and complicated behaviors humans engage in, Even the concept of measurable Social Intelligence comes relatively new …

Sexual Minorities In Sports Book Review, Kristy Mccray

Health and Sport Sciences Faculty Scholarship

A Book Review of Sexual Minorities in Sports by Melanie L. Sartore-Baldwin

A Novel Approach Using Liquid Embolic Agent For The Treatment Of Pancreatic-Cutaneous Fistulas: Report Of A Case, Amye M. Farag, Priti Parikh, Tamer Malik, Shannon L. Kauffman

Department of Surgery Faculty Publications

Pancreatic fistula formation remains one of the most dreadful complications after pancreaticoduodenectomies, resulting in extended hospital stays, increased healthcare costs, along with significantly increased morbidity and mortality. Little is mentioned in the literature about the use of percutaneous techniques to resolve this complication when conservative treatments fail. Thus, we developed a novel technique for treating pancreatic-cutaneous fistulas that develop post-pancreaticoduodenectomy. This work describes a novel approach of using a liquid embolic agent to treat a high-output pancreatic-cutaneous fistula after a Whipple procedure, which to the best of our knowledge after extensive literature searches, has not been performed before.

Optimizing Antiplatelet Therapy In Acs After Pci, Mary Beth Johnson

Graduate Research Projects

No abstract provided.

Coping With Traumatic Events In The Emergency Department, Amy L. Quinn, Tricia Davis

Graduate Research Projects

No abstract provided.

Sweet Slumber: A Case For Melatonin As A Sleep Aid, Destiny L. Morris

Graduate Research Projects

No abstract provided.

A High Protein Diet (3.4 G/Kg/D) Combined With A Heavy Resistance Training Program Improves Body Composition In Healthy Trained Men And Women - A Follow-Up Investigation, Jose Antonio, Anya Ellerbroek, Tobin A. Silver, Steve Orris, Max Scheiner, Adriana Gonzalez, Corey Peacock

Department of Health and Human Performance Faculty Articles

Background

The consumption of a high protein diet (>4 g/kg/d) in trained men and women who did not alter their exercise program has been previously shown to have no significant effect on body composition. Thus, the purpose of this investigation was to determine if a high protein diet in conjunction with a periodized heavy resistance training program would affect indices of body composition, performance and health.

Methods

Forty-eight healthy resistance-trained men and women completed this study (mean ± SD; Normal Protein group [NP n = 17, four female and 13 male]: 24.8 ± 6.9 yr; 174.0 ± 9.5 cm …

Impact Of Preoperative Patient Profiles On Elective Open Intestinal Resection Outcomes, Wei Chao Chang

Health Sciences Program Student Theses, Dissertations and Capstones

There are a myriad of risk factors for surgical mortality, intraoperative and postoperative complications, and prolonged length of stay. Effectively identifying possible risk factors in the preoperative patient profiles that may impact the outcome of elective open intestinal resection has significant implications on the quality of care, the safe delivery of surgical care, and the speedy recovery of patients undergoing elective open intestinal resection. Few studies specifically focused on the construction of individual preoperative patient risk profile used only preoperative patient profiles in elective open intestinal resection. A retrospective cohort predictive study was conducted to assess the impact of preoperative …

The Effects Of Cold And Lower Body Negative Pressure On Cardiovascular Effects, David J. Kean, Corey Allen Peacock, Gabriel J. Sanders, John Mcdaniel, Lisa A.C. Colvin, E. L. Glickman

Department of Health and Human Performance Faculty Articles

Purpose. The purpose of this study is to determine how cold exposure and lower body negative pressure effected cardiovascular variables. Methods. Eleven males (20.3 years ± 2.7) underwent two 20-minute exposures to LBNP. During the 2 trials, the subjects were exposed to cold air (10°C) (COLD) and to ambient temperature (23°C) (AMB). The trials consisted of a 100-minute pre-LBNP period followed by a 20-minute exposure to LBNP and then a 15-minute recovery period. Cardiovascular variables were recorded every 30 minutes using bioimpedance. Results. When LBNP was applied during the AMB trials, stroke volume immediately decreased. During the COLD trial, there …

Bordered Silver Foam Dressings For Colorectal Surgical Patients, Jessica Maynard

Doctor of Nursing Practice Projects

Although a surgical site infection (SSI) is a risk of an operative procedure, most are preventable (Health Protection Agency, 2009). The Joint Commission National Patient Safety Goal 7 stipulates the implementation of evidence-based practice for SSI prevention in acute care facilities. The purpose of this pilot project was to implement a bordered silver foam dressing protocol for post-operative colorectal surgical patients. Using a pre- and post-comparison design, the new dressing protocol was implemented for a two-month pilot for colorectal surgical patients meeting the specified criteria at Cabell Huntington Hospital. SSI rate following the protocol was compared to the SSI rate …

The Effect Of A Facilitated Educational Program And Experiential Learning On Nursing Workplace Incivility, Nancy E. Armstrong

Doctor of Nursing Practice Projects

Workplace incivility is a well-documented issue in nursing. It has the potential to cause emotional and physical distress in victims, and potentially affect the quality of care provided. Research in acute care settings found that facilitated educational training sessions related to workplace incivility, in combination with experiential learning activities, assisted nurses in improving their understanding of workplace incivility and their communication skills. It has also been found to reduce workplace incivility. The purpose of this Capstone Project was to implement a civility training program that included education about incivility through facilitated discussions, as well as teambuilding exercises and experiential learning …

Evaluating The Effectiveness Of A Heart Improvement Toolkit Program: A Pilot Project, Cheryl L. Mitchell

Doctor of Nursing Practice Projects

Heart failure (HF) is a chronic, debilitating disease resulting in over one million hospitalizations with an estimated 30.7 million dollars in total health care cost per year (Go et al., 2014). Evidence shows that HF education programs that promote adherence to pharmacological and non-pharmacological provider recommendations are effective in reducing 30-day HF recidivism rates, increasing self-care behavior, and decreasing adverse clinical events. The purpose of this evidence-based project was to implement the Heart Improvement Toolkit (HIT) Program which is a one-on-one, comprehensive HF-specific education program, for patients with a HF diagnosis who have been admitted to non-cardiac specialty units. Program …

Liver Sinusoid On A Chip: Long-Term Layered Co-Culture Of Primary Rat Hepatocytes And Endothelial Cells In Microfluidic Platforms, Young Bok (Abraham) Kang, Temitope R. Sodunke, Jason Lamontagne, Joseph Cirillo, Caroline Rajiv, Michael J. Bouchard, Moses Noh

Faculty Publications - Biomedical, Mechanical, and Civil Engineering

We describe the generation of microfluidic platforms for the co-culture of primary hepatocytes and endothelial cells; these platforms mimic the architecture of a liver sinusoid. This paper describes a progressional study of creating such a liver sinusoid on a chip system. Primary rat hepatocytes (PRHs) were co-cultured with primary or established endothelial cells in layers in single and dual microchannel configurations with or without continuous perfusion. Cell viability and maintenance of hepatocyte functions were monitored and compared for diverse experimental conditions. When primary rat hepatocytes were co-cultured with immortalized bovine aortic endothelial cells (BAECs) in a dual microchannel with continuous …

Loneliness And Drinking In An Hiv Positive Population, Erica Kiernan, Krishna Chhabria

Public Health Collection

Background: Loneliness is a common outcome in the HIV+ community due to the stigma associated with it leading to social isolation. Studies show HIV+ individuals who experience significant loneliness do engage in risky sexual behaviors. Alcohol use also has adverse consequences in this population, interfering with antiretroviral medication adherence thus an increased likelihood of further risky sexual behaviors.

Hypothesis: HIV+ individuals who experience an increase in loneliness will have an increase in hazardous drinking behaviors.

Methods: 100 patients from an HIV treatment clinic in Jacksonville, Florida were administered the AUDIT scale to measure drinking habits and UCLA loneliness scale. …

Suppression Of Arthritis-Induced Bone Erosion By A Crac Channel Antagonist, Harry C. Blair, Jonathan Soboloff, Lisa J. Robinson, Irina L. Tourkova, Quitterie C. Larrouture, Michelle R. Witt, Ida Holaskova, Rosana Schafer, Meenal Elliott, Raphael Hirsch, John B. Barnett

Faculty & Staff Scholarship

Objective: We have shown in vitro and in vivo that osteoclast maturation requires calcium-release activated calcium (CRAC) channels. In inflammatory arthritis, osteoclasts mediate severe and debilitating bone erosion. In the current study, we assess the value of CRAC channels as a therapeutic target to suppress bone erosion in acute inflammatory arthritis. Methods: Collagen-induced arthritis (CIA) was induced in mice. The CRAC channel inhibitor 3,4- dichloropropionaniline (DCPA) and a placebo was administered 1 day prior to collagen II booster to induce arthritis. Effects on swelling, inflammatory cell invasion in joints, serum cytokines and bone erosion were measured. Results: Assays, by blinded …

Mitochondrial Impairment In Cerebrovascular Endothelial Cells Is Involved In The Correlation Between Body Temperature And Stroke Severity, Hu Heng, Danielle N. Doll, Jiahong Sun, Sara E. Lewis, Jeffrey H. Wimsatt, Matthew J. Kessler, James W. Simpkins, Xuefang Ren

Faculty & Staff Scholarship

Stroke is the second leading cause of death worldwide. The prognostic influence of body temperature on acute stroke in patients has been recently reported; however, hypothermia has confounded experimental results in animal stroke models. This work aimed to investigate how body temperature could prognose stroke severity as well as reveal a possible mitochondrial mechanism in the association of body temperature and stroke severity. Lipopolysaccharide (LPS) compromises mitochondrial oxidative phosphorylation in cerebrovascular endothelial cells (CVECs) and worsens murine experimental stroke. In this study, we report that LPS (0.1 mg/kg) exacerbates stroke infarction and neurological deficits, in the mean time LPS causes …

Double Inferior Venacava With Anomalous Hemiazygos Vein – A Case Report, Sumathilatha Sakthi Velavan, Bedia Castellanos, Sushama Rich, Robert B. Goldberg, Carlos Quinteros, Ramona Baez

Touro College of Osteopathic Medicine (New York) Publications and Research

Objective: Duplication of the inferior vena cava (IVC) is a rare variation that is caused by an alteration in the embryogenesis of the cardinal venous system. It is found in 0.3 to 3% of the population. There are various types of double IVC and this case is reported since it is unique among them. Materials and methods: During dissection of an eighty seven year old female cadaver, presence of an IVC was noted on either side of the abdominal aorta. The course and the termination of both the IVCs were dissected. The azygos and the hemiazygos veins were traced into …

Pulmonary Rehabilitation And Exercise In Pulmonary Arterial Hypertension: An Underutilized Intervention, Sonu Sahni, Barbara Capozzi, Asma Iftikhar, Vasiliki Sgouras, Marcin Ojrzanowski, Arunabh Talwar

Touro College of Osteopathic Medicine (New York) Publications and Research

Pulmonary arterial hypertension (PAH) is a rare and devastating disease characterized by progressive increases in pulmonary arterial pressure and pulmonary vascular resistance which eventually leads to right ventricular failure and death. Early thought process was that exercise and increased physical activity may be detrimental to PAH patients however many small cohort trials have proven otherwise. In addition to the many pharmaceutical options, exercise and pulmonary rehabilitation have also been shown to increase exercise capacity as well as various aspects of psychosomatic health. As pulmonary and exercise rehabilitation become more widely used as an adjuvant therapy patient outcomes improve and physicians …

Clinical Relevance Of The Incidentaloma: A Clinician’S Viewpoint, Sonu Sahni, Sameer Verma, Reeju S. Thomas, Barbara Capozzi, Arunabh Talwar

Touro College of Osteopathic Medicine (New York) Publications and Research

Background: CT scanning remains one of the most routinely used diagnostic tools in a setting of InterstitialLung Disease (ILD). New and improved technologies, such as High Resolution Computer Tomography (HRCT) have revolutionized the quality of imaging, leading to a prominent increase in number of incidental findings that may or may not be of any clinical significance. The aim of this study was to evaluate the prevalence of incidental findings on thoracic CT and their clinical significance.

Methods: Retrospective analysis was conducted on a cohort of 84 patients referred to our academic center as cases of ILD. Patients were …

The Evidence Does Not Speak For Itself: The Role Of Research Evidence In Shaping Policy Change For The Implementation Of Publicly Funded Syringe Exchange Programs In Three Us Cities, Sean T. Allen, Monica S. Ruiz, Allison O'Rourke

Prevention and Community Health Faculty Publications

BACKGROUND:

A breadth of literature exists that explores the utilization of research evidence in policy change processes. From this work, a number of studies suggest research evidence is applied to change processes by policy change stakeholders primarily through instrumental, conceptual, and/or symbolic applications, or is not used at all. Despite the expansiveness of research on policy change processes, a deficit exists in understanding the role of research evidence during change processes related to the implementation of structural interventions for HIV prevention among injection drug users (IDU). This study examined the role of research evidence in policy change processes for the …

Caregiver Perceptions Of Their Influence On Cancer Treatment Decision Making: Intersections Of Language, Identity, And Illness, Janice L. Krieger, Angela L. Palmer-Wackerly, Jessica L. Krok-Schoen, Phokeng M. Dailey, Julianne C. Wojno, Nancy Schoenberg, Electra D. Paskett, Mark Dignan

Department of Communication Studies: Faculty Publications

Serious illness of a loved one can disrupt a caregiver’s sense of self and relationships. We examined the language caregivers use to describe the cancer treatment decision making of a loved one to understand how caregivers frame their own identity relative to a patient’s illness. We analyzed transcripts from in-depth interviews conducted with caregivers (N = 58) of cancer patients to examine the intersection among language, identity, and illness. Caregivers with a patient-level personal identity frame used phrases such as their body, their decision. Caregivers with a relational identity frame used plural pronouns such as we or our when describing …

Chhs January 2015 E-Newsletter, Dr. John Bonaguro, Dean, Vashon S. Wells, Editor, Wku College Of Health & Human Services

College of Health & Human Services Publications

No abstract provided.