Medicine and Health Sciences Commons^™

Vasculogenesis And Angiogenesis In Vegf Receptor-1 Deficient Mice, Vivienne C. Ho, Guo-Hua Fong

UCHC Articles - Research

Vascular endothelial growth factor receptor-1 (VEGFR-1)/Flt-1 is a transmembrane tyrosine kinase receptor for VEGF-A, VEGF-B, and placental growth factor (PlGF). VEGFR-1 is an enigmatic molecule whose precise role in postnatal angiogenesis remains controversial. Although many postnatal and adult studies have been performed by manipulating VEGFR-1 ligands, including competitive binding by truncated VEGFR-1 protein, neutralization by antibodies, or specific ligand overexpression or knockout, much less is known at the level of the receptor per se, especially in vivo. Perplexingly, while VEGFR-1 negatively regulates endothelial cell differentiation during development, it has been implied in promoting angiogenesis under certain conditions in adult tissues, …

Why Is Co-Infection With Influenza Virus And Bacteria So Difficult To Control?, Linda S. Cauley, Anthony T. Vella

UCHC Articles - Research

Influenza viruses are genetically labile pathogens which avoid immune detection by constantly changing their coat proteins. Most human infections are caused by mildly pathogenic viruses which rarely cause life-threatening disease in healthy people, but some individuals with a weakened immune system can experience severe complications. Widespread infections with highly pathogenic strains of influenza virus are less common, but have the potential to cause enormous death tolls among healthy adults if infection rates reach pandemic proportions. Increased virulence has been attributed to a variety of factors, including enhanced susceptibility to co-infection with common strains of bacteria. The mechanisms that facilitate dual …

Interpersonal Guilt And Substance Use In College Students, Nancy M. Petry

UCHC Articles - Research

The college years are a time for developing independence and separating from one’s family, and it is also a time in which substance use often escalates. This study examined the relationships between use of substances and interpersonal guilt, an emotion that can arise from feelings about separation, among 1,979 college students. Regular users of alcohol, cigarettes, cannabis, and other illicit drugs were compared with non-regular users of each substance. Sequential linear regression, controlling for confounding variables, examined relationships between regular use of each substance and scores on a guilt index. Risky drinkers and daily smokers had significantly more interpersonal guilt …

Imaging Submillisecond Membrane Potential Changes From Individual Regions Of Single Axons, Dendrites And Spines, Srdjan D. Antic

UCHC Articles - Research

A central question in neuronal network analysis is how the interaction between individual neurons produces behavior and behavioral modifications. This task depends critically on how exactly signals are integrated by individual nerve cells functioning as complex operational units. Regional electrical properties of branching neuronal processes which determine the input-output function of any neuron are extraordinarily complex, dynamic, and, in the general case, impossible to predict in the absence of detailed measurements. To obtain such a measurement one would, ideally, like to be able to monitor, at multiple sites, subthreshold events as they travel from the sites of origin (synaptic contacts …

Behind The Scenes Of The Nas: Human Factors Taxonomy For Investigating Service Integrity Events, Katherine A. Berry, Michael W. Sawyer, Jordan Hinson

International Symposium on Aviation Psychology - 2015

The Federal Aviation Administration (FAA) deployed the Service Integrity Risk Analysis Process (SI-RAP) with the goal of assessing the risk of technical occurrence events where the ability to provide safe air traffic management technical services is compromised. As a post-event tool, SI-RAP assesses the risk associated with an occurrence based on severity and repeatability. The SI-RAP taxonomy was developed to provide a consistent framework for supporting the assessment of event repeatability. The SI-RAP taxonomy synthesizes existing human factors taxonomies with customized factors representing the technical operations domain. The SI-RAP taxonomy is comprised of four tiers: Personnel Factors, Contextual Factors, Equipment …

Techniques For The Human Centered Evaluation Of Designs For The Future Aviation System, Philip J. Smith, Kathy Abbott, Lawrence J. Prinzel, Amy Pritchett, Tanya Yuditsky

International Symposium on Aviation Psychology - 2015

In order to evaluate new operational concepts, system designs, procedures and technologies for the future aviation system, we need to develop and validate a range of techniques to ensure the safe and effective performance of human-machine systems. This becomes increasingly important as such systems incorporate increasing levels of automation and autonomy for technologies, and as they attempt to integrate increasingly complex subsystems. It is challenging to evaluate the individual components of such systems relative to meeting their design requirements. It is orders of magnitude more challenging to evaluate performance when they are embedded in the larger system context. While there …

Pupillary Response As An Indicator Of Processing Demands Within A Supervisory Control Simulation Environment, Ciara Sibley, Joseph Coyne, Akshith Doddi, Phillip Jasper

International Symposium on Aviation Psychology - 2015

Current Unmanned Aerial Vehicle (UAV) operator task demands are highly variable and unbalanced across team members, resulting in sub-optimal operator utilization which leads to mishaps. This has driven the Department of Defense’s desire for more flexible team structures and task allocation tools. Unobtrusive and continuous measures of operator state are needed to effectively allocate tasking to operators and prevent errors. Twenty participants completed two twenty minute supervisory control sessions where task load was manipulated by varying event frequency (e.g., information requests) and eye tracking data was collected. Pupillometry data revealed increased mean and maximum pupil sizes with increased task load …

The Effects Of Bright Light Intervention On Flight Crew Behavioral Alertness And Cognitive Fatigue, Lori Brown, Geoffrey Whitehurst

International Symposium on Aviation Psychology - 2015

The study aimed to investigate the efficacy of bright light intervention to improve behavioral alertness and reduce cognitive fatigue in flight crew-members. During the four week study, crewmembers wore actigraph bands to monitor sleep behaviors. Self-assessed levels of sleepiness were recorded using the Karlosinska Sleepinees Scale (KSS), and self-assessed fatigue was measured using the Samn-Perelli (SP) fatigue scale. Participants completed psychomotor vigilance tests (PVT) to measure behavioral alertness. On the third and fourth weeks of the study, participants were exposed to short wavelength bright light (465nm blue) light intervention. The results show that there was a significant difference in alertness …

Differing Roles Of Autophagy In Hiv-Associated Neurocognitive Impairment And Encephalitis With Implications For Morphine Co-Exposure, Seth M. Dever, Myosotys Rodriguez, Jessica Lapierre, Blair N. Costin, Nazira El-Hage

Pharmacology and Toxicology Publications

We investigated the role of autophagy in HIV-infected subjects with neurocognitive impairment (NCI) ± HIV encephalitis (HIVE), many of which had a history of polysubstance abuse/dependence, using post-mortem brain tissues to determine whether differences in autophagy related factors may be more associated with NCI or NCI-encephalitis. Using qRT-PCR, we detected significant differences in gene expression levels with SQSTM1, LAMP1 higher in HIV-infected subjects without NCI while ATG5, SQSTM1 were then lower in HIV infection/NCI and ATG7, SQSTM1 being higher in NCI-HIVE. Immunohistochemical labeling of these autophagy associated proteins (also including Beclin 1 and LC3B) in Iba1-positive microglial cells showed generally …

Risk Of Disordered Eating Among Division I Female College Athletes, E. Wells, A. Chin, J. Tacke, J. Bunn

Physical Therapy

No abstract provided.

Peripheral Artery Disease And Activity-Induced Shifts In Quadriceps Median Frequency During Treadmill Walking: A Preliminary Study, D. Powell, M. Walker, P. Reneau, M Ryan, R. Reed-Jones, J. Bunn

Physical Therapy

No abstract provided.

Comparison Of Ankle Taping And Bracing On Ankle Biomechanics During Landing In Functional Ankle Instability, M. H. Ulm, B. A. Windsor, G. S. Dedrick, D. W. Powell

Physical Therapy

No abstract provided.

Defining The Role Of Dexmedetomidine In The Prevention Of Delirium In The Intensive Care Unit (Icu), S. Nelson, A. J. Muzyk, M. Bucklin, S. Brundey, J. P. Gagliardi

Pharmacy Practice

No abstract provided.

Manifestations Of Anxiety? Explaining Tachycardia And Hypertension In A Patient With Pots, B. B. Kincaid, A. J. Muzyk, R. J. Kanter, X. A. Preud'homme

Pharmacy Practice

No abstract provided.

Inhibition Of Lapatinib-Induced Kinome Reprogramming In Erbb2-Positive Breast Cancer By Targeting Bet Family Bromodomains, T. J. Stuhlmiller, S. M. Miller, J. S. Zawistowski, K. Nakamura, A. S. Beltran, J. S. Duncan, S. P. Angus, K. A. L. Collins, D. A. Granger, R. A. Reuther, L. M. Graves, S. M. Gomez, P-F Kuan, J. S. Parker, X. Chen, N. Sciaky, L. A. Carey, H. S. Earp, J. Jin, G. L. Johnson

Pharmaceutical Sciences

No abstract provided.

Validity And Reliability Of The Patient-Reported Arthralgia Inventory; Validation Of A Newly-Developed Survey Instrument To Measure Arthralgia, L. D. Castel, K. A. Wallston, B. R. Saville, J. R. Alvarez, B. D. Shields, I. D. Feurer, D. F. Cella

Business, Lundy-Fetterman School of

No abstract provided.

The Effects Of Bag Style On Muscle Activity Of The Trapezius, Erector Spinae And Latissimus Dorsi During Walking In Female University Students, R. Hardie, R. Haskew, J. Harris, Gerwyn Hughes

Kinesiology (Formerly Exercise and Sport Science)

Back pain is common in adolescents which has been associated with carrying a bag. However, there is little research examining the effects of bag style in female adolescents. The aim of the study was to investigate the effects of different bag conditions on muscle activity of the trapezius, erector spinae and latissimus dorsi muscles in female university students during walking. Twelve female university students walked on a treadmill for 5 minutes at 1.1 m/s during five conditions; control, 1 strapped rucksack, 2 strapped rucksack, ipsilateral shoulder strap and contralateral shoulder strap, each containing 10% bodyweight. Electromyography for the trapezius, erector …

Gender Difference In Lower Limb Muscle Activity During Landing And Rapid Change Of Direction, Gerwyn Hughes, N Dally

Kinesiology (Formerly Exercise and Sport Science)

Objectives: The purpose of the study was to examine gender differences in lower limb muscle activity during jump landing and rapid change of direction. Equipment and Methods: Surface electromyography (EMG) of the rectus femoris, biceps femoris and gluteus maximus were recorded for 10 male and 10 female basketball, volleyball or netball players performing five repetitions each of two tasks; 1) landing from a maximal height vertical jump and, 2) 45º rapid change of direction on their dominant leg. Independent sample t-tests were conducted to determine sex differences and paired samples t-tests were conducted to determine task differences in peak EMG …

Assessing The Cultural In Culturally Sensitive Printed Patient-Education Materials For Chinese Americans With Type 2 Diabetes, Evelyn Y. Ho, H Tran, Catherine A. Chesla

Communication Studies

Type 2 diabetes affects Chinese Americans at an alarming rate. To address this health disparity, research in the area of cultural sensitivity and health literacy provide useful guidelines for creating culturally appropriate health education. In this article, we use discourse analysis to examine a group of locally-available, Chinese and English language diabetes print documents from a surface and deep structure level of culture. First, we compared these documents to research findings about printed health information to determine if and how these documents apply current best practices for health literacy and culturally appropriate health communication. Second, we examined how diabetes as …

Mobile Nurse Practitioner: A Pilot Program To Address Service Gaps Experienced By Homeless Individuals, Joan Alviar Fraino

Nursing and Health Professions Student Research and Publications

An estimated 2.3 to 3.5 million individuals are homeless in the United States, many of whom have chronic medical and mental illnesses. Underserved individuals who are homeless experience gaps in services, resulting in poor health care outcomes and readmission to the hospital setting, often presenting in crisis through the emergency department. The financial state of hospitals is negatively impacted by the burden of patients returning to the hospital due to unresolved issues. The current article presents the role of a psychiatric-mental health nurse practitioner as part of a pilot program, Opportunity Village Mobile Health, that provides a comprehensive approach to …

A Multidimensional Data Warehouse For Community Health Centers., Kislaya Kunjan, Tammy Toscos Phd, Ayten Turkcan, Brad N Doebbeling

Mirro Center Articles

Community health centers (CHCs) play a pivotal role in healthcare delivery to vulnerable populations, but have not yet benefited from a data warehouse that can support improvements in clinical and financial outcomes across the practice. We have developed a multidimensional clinic data warehouse (CDW) by working with 7 CHCs across the state of Indiana and integrating their operational, financial and electronic patient records to support ongoing delivery of care. We describe in detail the rationale for the project, the data architecture employed, the content of the data warehouse, along with a description of the challenges experienced and strategies used in …

"Catholic" Healthcare: A Universal Right, Elizabeth Braun

Ethics and Social Justice Center Essay Prizes

This essay presents an argument as to why healthcare is a universal right and examines why governments should be expected to provide healthcare access to their citizens.

Nursing Annual Report Fy14-Fy15, Children's Mercy Hospital

Nursing Annual Reports

Annual report for nursing services for Fiscal Years 14 and 15 (July 2013-June 2015) at Children's Mercy Kansas City.

Male And Female Runners Demonstrate Different Sagittal Plane Mechanics As A Function Of Static Hamstring Flexibility, D. S. Blaise Williams Iii, Lee M. Welch

Physical Therapy Publications

Background:

Injuries to runners are common. However, there are many potential contributing factors to injury. While lack of flexibility alone is commonly related to injury, there are clear differences in hamstring flexibility between males and females.

Objective:

To compare the effect of static hamstring length on sagittal plane mechanics between male and female runners.

Method:

Forty subjects (30.0±6.4 years) participated and were placed in one of 4 groups: flexible males (n=10), inflexible males (n=10), flexible females (n=10), and inflexible females (n=10). All subjects were free of injury at the time of data collection. Three-dimensional kinematics and kinetics were collected while …

Anticancer Activity Of A Thymidine Quinoxaline Conjugate Is Modulated By Cytosolic Thymidine Pathways, Qiong Wei, Haijuan Liu, Honghao Zhou, Dejun Zhang, Zhiwei Zhang, Qibing Zhou

Medicinal Chemistry Publications

Background

High levels of thymidine kinase 1 (TK1) and thymidine phosphorylase (TYMP) are key molecular targets by thymidine therapeutics in cancer treatment. The dual roles of TYMP as a tumor growth factor and a key activation enzyme of anticancer metabolites resulted in a mixed outcome in cancer patients. In this study, we investigated the roles of TK1 and TYMP on a thymidine quinoxaline conjugate to evaluate an alternative to circumvent the contradictive role of TYMP.

Methods

TK1 and TYMP levels in multiple liver cell lines were assessed along with the cytotoxicity of the thymidine conjugate. Cellular accumulation of the thymidine …

6-Hydroxyflavone And Derivatives Exhibit Potent Anti-Inflammatory Activity Among Mono-, Di- And Polyhydroxylated Flavones In Kidney Mesangial Cells, Xing Wang, Zhiwei Wang, Preetpal Singh Sidhu, Umesh R. Desai, Qibing Zhou

Medicinal Chemistry Publications

Inflammatory responses by kidney mesangial cells play a critical role in the glomerulonephritis. The anti-inflammatory potential of nineteen mono-, di- and polyhydroxylated flavones including fisetin, quercetin, morin, tricetin, gossypetin, apigenin and myricetin were investigated on rat mesangial cells with lipopolysaccharide (LPS) as the inflammatory stimuli. 6-Hydroxyflavone and 4′,6-dihydroxyflavone exhibited high activity with IC50 in the range of 2.0 μM, a much better inhibition potential in comparison to the well-studied polyhydroxylated flavones. Interestingly, the anti-inflammatory activity was not due to direct quenching of NO radicals. Investigation on derivatives with methylation, acetylation or sulfation of 6-hydroxyl group revealed that 6-methoxyflavone was the …

Inhibitory Behavioral Control: A Stochastic Dynamic Causal Modeling Study Comparing Cocaine Dependent Subjects And Controls, Liangsuo Ma, Joel L. Steinberg, Kathryn A. Cunningham, Scott D. Lane, James M. Bjork, Harshini Neelakantan, Amanda E. Price, Ponnada A. Narayana, Thomas R. Kosten, Antoine Bechara, F. Gerard Moeller

Radiology Publications

Cocaine dependence is associated with increased impulsivity in humans. Both cocaine dependence and impulsive behavior are under the regulatory control of cortico-striatal networks. One behavioral laboratory measure of impulsivity is response inhibition (ability to withhold a prepotent response) in which altered patterns of regional brain activation during executive tasks in service of normal performance are frequently found in cocaine dependent (CD) subjects studied with functional magnetic resonance imaging (fMRI). However, little is known about aberrations in specific directional neuronal connectivity in CD subjects. The present study employed fMRI-based dynamic causal modeling (DCM) to study the effective (directional) neuronal connectivity associated …

Evaluation Of Methyl-Binding Domain Based Enrichment Approaches Revisited, Karolina A. Aberg, Linying Xie, Robin F. Chan, Min Zhao, Ashutosh K. Pandey, Gaurav Kumar, Shaunna L. Clark, Edwin Jcg Van Den Oord

Biomarker Research and Personalized Medicine Publications

Methyl-binding domain (MBD) enrichment followed by deep sequencing (MBD-seq), is a robust and cost efficient approach for methylome-wide association studies (MWAS). MBD-seq has been demonstrated to be capable of identifying differentially methylated regions, detecting previously reported robust associations and producing findings that replicate with other technologies such as targeted pyrosequencing of bisulfite converted DNA. There are several kits commercially available that can be used for MBD enrichment. Our previous work has involved MethylMiner (Life Technologies, Foster City, CA, USA) that we chose after careful investigation of its properties. However, in a recent evaluation of five commercially available MBD-enrichment kits the …

Successful Management Of Barth Syndrome: A Systematic Review Highlighting The Importance Of A Flexible And Multidisciplinary Approach, Stacey E. Reynolds

Occupational Therapy Publications

This review describes and summarizes the available evidence related to the treatment and management of Barth syndrome. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards were used to identify articles published between December 2004 and January 2015. The Cochrane Population, Intervention, Control, Outcome, Study Design (PICOS) approach was used to guide the article selection and evaluation process. Of the 128 articles screened, 28 articles matched the systematic review inclusion criteria. The results of this review indicate the need for a flexible and multidisciplinary approach to manage the symptoms most commonly associated with Barth syndrome. It is recommended …

Medical Literary Messenger (Vol. 2, No. 2, Spring 2015)

Medical Literary Messenger

Briars / Laura Apol -- Something’s Missing Here / John M. Trumbo -- Diagnosis / Tzivia Gover -- Distance / Priscilla Frake -- Body and Blood / Peter Schmitt -- Anything But Superior Medicine / Julia Hones -- Trading Qintars for Qiviuts in Qatar / Peter Schmitt -- What We Tell Ourselves / Jennifer Campbell -- Did I Register? / Ann Silverthorn -- The Color of Voice / Carol J. Jennings -- Death Wish / Carol LaChapelle -- Dementia Unit Visit / Theresa Wyatt -- what they talk about before their meds kick in / Laurence Carr -- On Learning …