Medicine and Health Sciences Commons^™

What Is New In Exercise In Pregnancy? Best Articles From The Past Year, Howard A. Blanchette

NYMC Faculty Publications

This month we focus on current research in exercise in pregnancy. Dr. Blanchette discusses four recent publications, and each is concluded with a "bottom line" that is the take-home message. The complete reference for each can be found in on this page, along with direct links to the abstracts.

Induction Of Indoleamine 2,3-Dioxygenase By Borrelia Burgdorferi In Human Immune Cells Correlates With Pathogenic Potential, Andrea C. Love, Ira Schwartz, Mary M. Petzke

NYMC Faculty Publications

Borrelia burgdorferi, the bacterial agent of Lyme disease, induces the production of type I IFNs by human DCs through TLR7 and TLR9 signaling. This type I IFN response occurs in a genotype-dependent manner, with significantly higher levels of IFN-α elicited by B. burgdorferi strains that have a greater capacity for causing disseminated infection. A B. burgdorferi strain that was previously shown to induce IFN-α was found to elicit significantly higher levels of IDO1 protein and its downstream metabolite, kynurenine, compared with a B. burgdorferi mutant that lacks a single linear plasmid (lp36); this mutant is unable to induce IFN-α and …

Healthy Habits, Happy Baby!, Amanda Ocran, Suvidha Polu, Joan I. Gluch, Phd, Rdh, James D. Plumb, Md, Mph, Rickie Brawer, Mph, Phd

CwiC-PH

Cribs for Kids, a component program of the Maternity Care Coalition, provides needy families in Philadelphia with cribs and education on safe sleeping environments.

• Cribs for Kids also provides education on how to reduce the risk of sudden infant death syndrome (SIDS).
• The organization hosts workshops throughout the city and home visits for those who cannot attend the workshops.
• Cribs for Kids also increases awareness about safe sleeping habits and their program by attending community health fairs.
• In the last year Cribs for Kids has provided families the city of Philadelphia with over 2,000 safe sleeping environments.

Care With Dignity: Understanding How To Care For Hiv Positive And Formerly Incarcerated Populations, Caroline Komanecky, Terry Trudeau, Med, James D. Plumb, Md, Mph, Helen Koenig, Md

CwiC-PH

Philadelphia FIGHT is a comprehensive HIV/AIDS service organization providing primary care, consumer education, advocacy, and research on potential treatments and vaccines. FIGHT was formed as a partnership of individuals living with HIV/AIDS and clinicians, who joined together to improve the lives of people living with the disease. Today, FIGHT serves an even broader patient population and recently received designation as a Federally Qualified Health Center. FIGHT strives to address not only HIV-infected patients, but all at-risk populations through education, outreach, and preventative medicine. The annual Bridging the Gaps interns are responsible for several projects, including a client satisfaction survey, a …

Report Of The Nih Task Force On Research Standards For Chronic Low Back Pain, Richard A. Deyo, Samuel F. Dworkin, Dagmar Amtmann, Gunnar Andersson, David G. Borenstein, +15 Additional Author

Medicine Faculty Publications

Abstract

Despite rapidly increasing intervention, functional disability due to chronic low back pain (cLBP) has increased in recent decades. We often cannot identify mechanisms to explain the major negative impact cLBP has on patients' lives. Such cLBP is often termed non-specific, and may be due to multiple biologic and behavioral etiologies. Researchers use varied inclusion criteria, definitions, baseline assessments, and outcome measures, which impede comparisons and consensus. The NIH Pain Consortium therefore charged a Research Task Force (RTF) to draft standards for research on cLBP. The resulting multidisciplinary panel recommended using 2 questions to define cLBP; classifying cLBP by its …

Chhs February 2015 E-Newsletter, Dr. John Bonaguro, Dean, Vashon S. Wells, Editor, Wku College Of Health & Human Services

College of Health & Human Services Publications

No abstract provided.

Department Of Surgery Update, February 2015, Wright State University Department Of Surgery

Department of Surgery Updates

A four page newsletter created by the Department of Surgery documenting changes to the department. This issue contains note about Margaret M. Dunn, M.D., being appointed dean of the Boonshoft School of medicine, a message from the chair, a list of important dates, a call for abstracts, scholarly activity and more.

Long Term Care Nurses' Knowledge And Perceived Competency Of Palliative Care, Carol Evans

Doctor of Nursing Practice Technical Reports

Background: Palliative care is considered a right for human beings. By 2040, it is estimated that 40% of the 65 years of age and older population in the United States will die in long term care (LTC) facilities. Because of the chronicity of the geriatric population’s medical conditions, the patients may require end-of-life (EOL) care. Numerous LTC facilities are located in rural areas which may create a disparity in the provision of quality EOL care.

Methods: A quantitative descriptive cross-sectional design was utilized. The purpose of this study was to examine rural and urban nurses’ knowledge of palliative care and …

Designs Of Two Randomized, Community-Based Trials To Assess The Impact Of Influenza Immunization During Pregnancy On Respiratory Illness Among Pregnant Women And Their Infants And Reproductive Outcomes In Rural Nepal, James M. Tielsch, Mark Steinhoff, Joanne Katz, Janet A. Englund, Jane Kuypers, Subarna K. Khatry, Laxman Shrestha, Steven C. Leclerq

Global Health Faculty Publications

Background: Among the most important causes of illness and death in both pregnant women and their newborn infants are respiratory infections including influenza. Pregnant women in North America have a 4 to 5 fold excess rate of hospitalization compared to non-pregnant women. Rates of infant hospitalization associated with influenza are much higher than in their mothers. Fully half of children hospitalized for influenza in the US are in the age group 0–5 months, a group where no vaccine is licensed. Data on influenza are much fewer in low income countries where the risks of serious morbidity and mortality are …

Epigenetics As An Answer To Darwin’S “Special Difficulty,” Part 2: Natural Selection Of Metastable Epialleles In Honey Bee Castes, Douglas M. Ruden, Pablo E. Cingolani, Arko Sen, Wen Qu, Luan Wang, Marie-Claude Senut, Mark D. Garfinkel, Vincent E. Sollars, Xiangyi Lu

Biochemistry and Microbiology

In a recent perspective in this journal, Herb (2014) discussed how epigenetics is a possible mechanism to circumvent Charles Darwin’s “special difficulty” in using natural selection to explain the existence of the sterile-fertile dimorphism in eusocial insects. Darwin’s classic book “On the Origin of Species by Means of Natural Selection” explains how natural selection of the fittest individuals in a population can allow a species to adapt to a novel or changing environment. However, in bees and other eusocial insects, such as ants and termites, there exist two or more castes of genetically similar females, from fertile queens to multiple …

Short-Term Cortical Plasticity Associated With Feedback-Error Learning After Locomotor Training In A Patient With Incomplete Spinal Cord Injury, Amanda E. Chisholm, Sue Peters, Michael R. Borich, Lara A. Boyd, Tania Lam

Physical Therapy Publications

Background and purpose: For rehabilitation strategies to be effective, training should be based on principles of motor learning, such as feedback-error learning, that facilitate adaptive processes in the nervous system by inducing errors and recalibration of sensory and motor systems. This case report suggests that locomotor resistance training can enhance somatosensory and corticospinal excitability and modulate resting-state brain functional connectivity in a patient with motor-incomplete spinal cord injury (SCI).

Case description: The short-term cortical plasticity of a 31-year-old man who had sustained an incomplete SCI 9.5 years previously was explored in response to body-weight-supported treadmill training with velocity-dependent resistance applied …

Reverse Innovation: An Opportunity For Strengthening Health Systems, Anne W Snowdon, Harpreet Bassi, Andrew D. Scarffe, Alexander D Smith

Health and Rehabilitation Sciences Publications

BACKGROUND: Canada, when compared to other OECD countries, ranks poorly with respect to innovation and innovation adoption while struggling with increasing health system costs. As a result of its failure to innovate, the Canadian health system will struggle to meet the needs and demands of both current and future populations. The purpose of this initiative was to explore if a competition-based reverse innovation challenge could mobilize and stimulate current and future leaders to identify and lead potential reverse innovation projects that address health system challenges in Canada.

METHODS: An open call for applications took place over a 4-month period. Applicants …

Feasibility Of A Unified Approach To Intensity-Modulated Radiation Therapy And Volume-Modulated Arc Therapy Optimization And Delivery, Jerry J. Battista, Michael Macfarlane, Eugene Wong, Jeff Z. Chen, Douglas A. Hoover

Medical Biophysics Publications

Purpose:

To study the feasibility of unified intensity-modulated arc therapy (UIMAT) which combines intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT)optimization and delivery to produce superior radiation treatment plans, both in terms of dosedistribution and efficiency of beam delivery when compared with either VMAT or IMRT alone.

Methods:

An inverse planning algorithm for UIMAT was prototyped within the pinnacle treatment planningsystem (Philips Healthcare). The IMRT and VMAT deliveries are unified within the same arc, with IMRT being delivered at specific gantry angles within the arc. Optimized gantry angles for the IMRT and VMAT phases are assigned automatically by the inverse …

Rapid Desiccation Hardening Changes The Cuticular Hydrocarbon Profile Of Drosophila Melanogaster., Joseph R Stinziano, Richard J Sové, Howard D Rundle, Brent J Sinclair

Medical Biophysics Publications

The success of insects in terrestrial environments is due in large part to their ability to resist desiccation stress. Since the majority of water is lost across the cuticle, a relatively water-impermeable cuticle is a major component of insect desiccation resistance. Cuticular permeability is affected by the properties and mixing effects of component hydrocarbons, and changes in cuticular hydrocarbons can affect desiccation tolerance. A pre-exposure to a mild desiccation stress increases duration of desiccation survival in adult female Drosophila melanogaster, via a decrease in cuticular permeability. To test whether this acute response to desiccation stress is due to a change …

Pulmonary Abnormalities And Carotid Atherosclerosis In Ex-Smokers Without Airflow Limitation., Damien Pike, Miranda Kirby, Tamas J Lindenmaier, Khadija Sheikh, Casey E Neron, Daniel G Hackam, J David Spence, Aaron Fenster, Nigel A M Paterson, Don D Sin, Harvey O Coxson, David G Mccormack, Grace Parraga

Medical Biophysics Publications

Abstract It is well-established that COPD patients have a burden of vascular disease that cannot be fully-explained by smoking history but the mechanistic links between atherosclerosis and pulmonary disease in COPD patients are not well-understood. Moreover, in ex-smokers without symptoms or other evidence of COPD, subclinical pulmonary and vascular disease, although potentially present, has not been described or evaluated. Hence our aim was to use sensitive three-dimensional (3D) pulmonary and carotid imaging to quantify pulmonary airway/parenchyma abnormalities and atherosclerosis in ex-smokers without airflow limitation or symptoms consistent with COPD. We evaluated 61 subjects without airflow limitation including 34 never- (72 …

Pulmonary Imaging Abnormalities In An Adult Case Of Congenital Lobar Emphysema., Damien Pike, Sindu Mohan, Weijing Ma, James F Lewis, Grace Parraga

Medical Biophysics Publications

Congenital lobar emphysema is mainly diagnosed in infants, although rare cases are reported in adults. A 20-yr-old female with acute dyspnea, chest pain and left upper lobe (LUL) chest x-ray hyperlucency underwent 3He magnetic resonance imaging (MRI) for ventilation and apparent diffusion coefficient (ADC) measurements, as well as CT for emphysema and airway wall measurements. Forced expiratory volume in 1s, residual volume, and airways-resistance were abnormal, but there was normal carbon-monoxide-diffusing-capacity. The LUL relative area of the density histogram

Himmelfarb Library Liaison Letter - February 2015, George Washington University, Himmelfarb Health Sciences Library

Himmelfarb Library Liaison Letters

No abstract provided.

Trident - February 2015, Dugoni School Of Dentistry

Trident

The newsletter of the Pacific Orthodontic Alumni Chapter at University of the Pacific, Arthur A. Dugoni School of Dentistry.

Long-Term Assessment Of Fatigue In Patients With Culture-Confirmed Lyme Disease, Gary P. Wormser, Erica Weitzner, Donna Mckenna, Robert B. Nadelman, Carol Scavarda, John Nowakowski

NYMC Faculty Publications

BACKGROUND: Fatigue is a common symptom with numerous causes. Severe fatigue is thought to be an important manifestation of post-treatment Lyme disease syndrome. The frequency with which severe fatigue occurs as a long-term sequela in prospectively followed patients with Lyme disease is unknown. METHODS: Patients with culture-confirmed Lyme disease who originally presented with erythema migrans have been evaluated annually in a prospective study to determine their long-term outcome. In 2011-2013, subjects were evaluated for fatigue using an 11-item Fatigue Severity Scale (FSS-11) that has been used in studies of post-treatment Lyme disease syndrome. An FSS-11 score of ≥4.0 is indicative …

Place Events Spring 2015, Place

PLACE Historical Documents

This document describes PLACE events at Linfield College for spring 2015.

Active Brain Regions During Sleep Using Electroencephalography-Functional Magnetic Resonance Imaging, Grace Duan '15, Sameeksha Malhotra '15, Todd B. Parrish

Student Publications & Research

Purpose: To determine the differences in functional connectivity among brain regions during the different stages of the human sleep cycle.

Cytometric Characterization Of Circulating Tumor Cells Captured By Microfiltration And Their Correlation To The Cellsearch(®) Ctc Test., Daniel L Adams, Steingrimur Stefansson, Christian Haudenschild, Stuart S Martin, Monica Charpentier, Saranya Chumsri, Massimo Cristofanilli, Cha-Mei Tang, R Katherine Alpaugh

Pathology Faculty Publications

Recent studies reporting hundreds, to thousands, of circulating tumor cells (CTCs) in the blood of cancer patients have raised questions regarding the prevalence of CTCs, as enumerated by the CellSearch(®) CTC Test. Although CellSearch has been shown to consistently detect clinically relevant CTCs; the ability to only capture EpCAM positive cells has led to speculation that it captures limited subsets of CTCs. In contrast, alternative approaches to CTC isolation are often cited as capturing large numbers of CTCs from patient blood. Not surprisingly the number of cells isolated by alternative approaches show poor correlations when compared to CellSearch, even when …

Chiral Symmetry Breaking And Chiral Polarization: Tests For Finite Temperature And Many Flavors, Andrei Alexandru, Ivan Horváth

Anesthesiology Faculty Publications

It was recently conjectured that, in SU(3) gauge theories with fundamental quarks, valence spontaneous chiral symmetry breaking is equivalent to condensation of local dynamical chirality and appearance of chiral polarization scale Λ_ch. Here we consider more general association involving the low-energy layer of chirally polarized modes which, in addition to its width (Λ_ch), is also characterized by volume density of participating modes (Ω) and the volume density of total chirality (Ω_ch). Few possible forms of the correspondence are discussed, paying particular attention to singular cases where Ω emerges as the most versatile …

Risk Of Gastrointestinal Bleeding Associated With Oral Anticoagulants: Population Based Retrospective Cohort Study, Hsien-Yen Chang, Meijia Zhou, Wenze Tang, G. Caleb Alexander, Sonal Singh

Epidemiology Faculty Publications

Objectives To determine the real world safety of dabigatran or rivaroxaban compared with warfarin in terms of gastrointestinal bleeding.

Design Retrospective cohort study.

Setting Large administrative database of commercially insured people in United States from 1 October 2010 through 31 March 2012.

Participants Enrollees with a prescription of warfarin, dabigatran, or rivaroxaban between 1 October 2010 and 31 March 2012, who were aged 18 years or older, had continuous enrollment and no oral anticoagulant use during the six months before the entry date, with known age and sex, and with no gastrointestinal bleeding for at least six months before the …

Polio - An Endemic Disease In Pakistan: Literature Review, Savera Aziz Ali, Nadir Suhail, Hunaina Hadi, Mohsina Hussain, Marium Manji, Jaweria Bano, Abdul Salam, Sajida Naseer, Sumera Aziz Ali

School of Nursing & Midwifery

Poliomyelitis is a highly contagious and incurable disease, which mainly affects children under five years of age leading to irreversible paralysis and possibly death. For decades, both private and government organizations have been putting efforts through their partnership to eradicate polio completely from the different parts of the globe and as a result of those efforts there are left only three countries which are currently polio endemic. Since Pakistan is one of those three countries which still remain polio endemic along with Afghanistan and Nigeria, it is significant to address this issue and work on the preventive measures to control …

2014 Brings New Drugs, Rodney Richmond

Faculty Research ​and Publications

No abstract provided.

The Stethoscoop, February 2015, Mennonite College Of Nursing

The Stethoscoop

The Stethoscoop is the newsletter for Mennonite College of Nursing students.

Moyamoya Disease And Acute Inpatient Rehabilitation In A 17-Month Old Previously Healthy Male, Cassandra Coleman, Nicole Marcantuono

CwiC-PH

Case Diagnosis

17-month old male with newly diagnosed MoyaMoya after presenting with new onset seizures and right-sided weakness.

Case Description

MoyaMoya is a rare cerebrovascular condition predisposing patients to stroke in association with progressive stenosis of the intracranial internal carotid arteries and their proximal branches.

The patient presented initially after a fall with subsequent inability to bear weight on his right leg along with minimized use of his right arm. Patient was treated for a suspected tibial Salter-Harris II and nursemaid’s elbow. He presented four days later to the ED with new onset seizures. CT of the brain showed loss …

Health Care In Bolivia: A First Hand Experience, Sanchi Malhotra

CwiC-PH

This research project is based on a one month work experience in Cochabamba, Boliva through the NGO Sustainable Bolivia at Hosptial Viedma, a major public hospital and Centre de Salud Pacata, a rural outpatient health clinic. The information presented below is derived from both research and personal experience. This trip was partially funded by Jefferson Office of International Affairs with the goal of gaining experience and knowledge about the Bolivian health care system.

Universal Healthcare: Costa Rica As A Model, Annie J. Ferris

CwiC-PH

What it Looks Like in Costa Rica

• Run by the Costa Rican Social Security Administration
• Financed by employers, employees, and the Ministry of Health. Employer and employee contributions together make up over 90% of contributions.
• Costa Rica is divided into 105 health areas, which are further divided up into primary care units called Basic Provision Units of Integrated Healthcare, or EBAIS. There are 947 of these primary care centers throughout Costa Rica, and everyone is assigned to one.
• The EBAIS clinics provide a wide range of services to cover the general and specific health needs of the community, including primary …